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| 1 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 2 | Building highly active hybrid double-atom sites in C_(2)N for enhanced electrocatalytic hydrogen peroxide synthesis显示文摘Two-electron(2 e^(-))oxygen reduction reaction(ORR)shows great promise for on-site electrochemical synthesis of hydrogen peroxide(H_(2)O_(2)).However,it is still a great challenge to design efficient electrocatalysts for H_(2)O_(2)synthesis.To address this issue,the logical design of the active site by controlling the geometric and electronic structures is urgently desired.Therefore,using density functional theory(DFT)computations,two kinds of hybrid double-atom supported on C_(2)N nanosheet(RuCu@C_(2)N and PdCu@C_(2)N)are screened out and their H_(2)O_(2)performances are predicted.PdCu@C_(2)N exhibits higher activity for H_(2)O_(2)synthesis with a lower overpotential of 0.12 V than RuCu@C_(2)N(0.59 V),Ru_(3)Cu(110)facet(0.60 V),and PdCu(110)facet(0.54 V).In aqueous phase,the adsorbed O_(2)is further stabilized with bulk H_(2)0 and the thermodynamic rate-determining step of 2 e^(-) ORR change.The activation barrier on PdCu@C_(2)N is 0.43 eV lower than the one on RuCu@C_(2)N with 0.68 eV.PdCu@C_(2)N is near the top of 2 e^(-) ORR volcano plot,and exhibits high selectivity of H_(2)O_(2.)This work provides guidelines for designing highly effective hybrid double-atom electrocatalysts(HDACs)for H_(2)O_(2)synthesis. | Yongyong Cao JinYan Zhao Xing Zhong Guilin Zhuang Shengwei Deng Zhongzhe Wei Zihao Yao Jianguo Wang | 2021 | Green Energy & Environment2021，6，6： | 2 |
| 3 | Impacts of Vegetation Change on the Regional Surface Climate: A Scenario-Based Analysis of Afforestation in Jiangxi Province, China显示文摘 | Enjun Ma Anping Liu Xing Li Feng Wu Jinyan Zhan Xiangzheng Deng | 2013 | Advances in Meteorology2013，，： | 1 |
| 4 | A first-principles study of reaction mechanism over carbon decorated oxygen-deficient TiO_(2) supported Pd catalyst in direct synthesis of H_(2)O_(2)显示文摘The choice of support is one of the most significant components in the direct synthesis of H_(2)O_(2).Aiming to improvement of activity and selectivity of H_(2)O_(2) on Pd/TiO_(2) surface,we systematically investigated the important elementary steps on Pd/TiO_(2)-Vo@C,Pd/TiO_(2)-Vo,Pd/TiO_(2)-2 Vo,Pd/TiO_(2),and Pd/C using the first-principles calculations.The Bader charge analysis and charge density difference of O_(2) adsorption elucidate the relationship between the electronic distribution and chemisorption energy.The effective barrier analysis further enables to quantitatively estimate the reactivity of H_(2)O_(2) and H2O.We demonstrate unambiguously that the selectivity of H2O formation is boosted as the oxygen vacancy concentration raised.Moreover,the introduction of C into a TiO_(2) with appropriate oxygen vacancies can slightly reduce the effective barrier for H_(2)O_(2) formation and increase the effective barrier for H2O formation leading to a higher activity and selectivity of H_(2)O_(2) formation.Our finding suggests that carbon-doped oxygen vacancy TiO_(2) supported Pd is potential alternative catalyst compared with the Pd/TiO_(2). | Zihao Yao Jinyan Zhao Chenxia Zhao Shengwei Deng Guilin Zhuang Xing Zhong Zhongzhe Wei Yang Li Shibin Wang Jianguo Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，3： | 1 |
| 5 | Cultural Tourism Enlightenment from France for Hebei Province, China显示文摘French is one of the best cultural tourism destinations in the world. Its development experiences in terms of cultural tourism are valuable for Hebei, whose competitiveness of cultural tourism is weak comparatively in spite of rich cultural resources. Specifically, France achieves great successes of cultural tourism through scientific planning, producing tourism products injected by cultures, and developing tourism festivals. On this basis, four suggestions are recommended to improve cultural tourism in Hebei Province based on its actual situation, namely building cultural brand of tourism, strengthening government management, and developing tourism derivatives, and reinforcing talent training. | WANG Lei WANG Jinyan XING Huibin Azizan Marzuki | 2012 | Journal of Landscape Research2012，4，12： | 1 |
| 6 | Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases显示文摘Cardiovascular diseases(CVDs)are a leading factor driving mortality worldwide.Iron,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for decades.Iron-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and CVDs.Furthermore,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to CVDs.This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in CVDs.Furthermore,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs.Collectively,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets. | Yi LUAN Yang YANG Ying LUAN Hui LIU Han XING Jinyan PEI Hengdao LIU Bo QIN Kaidi REN | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，1： | 0 |
| 7 | Characterization of full-length transcriptome and mechanisms ofsugar accumulation in Annona squamosa fruit显示文摘Annona squamosa is a multipurpose fruit tree employed in nutritional,medicinal,and industrial fields.Its fruit is significantly enriched in sugars,making it an excellent species to study sugar accumulation in fruit.However,the scarcity of genomic resources hinders genetic studies in this species.This study aimed at generating large-scale genomic resources in A.squamosa and deciphering the molecular basis of its high sugar content.Herein,we sequenced and characterized the full-length transcriptome of A.squamosa fruit using PacBio Iso-seq.In addition,we analyzed the changes in sugar content over five fruit growth and ripening stages,and we applied RNA-sequencing technology to investigate the changes in gene expression related to sugar accumulation.A total of 783,647 circular consensus sequences were generated,from which we obtained 48,209 high-quality,full-length transcripts.Additionally,1,838 transcription factors and 1,768 long non-coding RNAs were detected.Furthermore,we identified 10,400 alternative splicing events from 2,541 unigenes having on average 2–4 isoforms.A total of 15,061 simple sequence repeat(SSR)motifs were discovered and up to three primer pairs were designed for each SSR locus.Sugars mainly accumulate during the ripening stage in A.squamosa.Most of the genes involved in sugar transport and metabolism in the fruit were progressively repressed overgrowth and ripening stages.However,sucrose phosphate synthase involved in sucrose synthesis and more importantly,isoamylase,alpha-amylase,beta-amylase,4-alphaglucanotransferase genes involved in starch degradation displayed positive correlations with sugar accumulation in fruit.Overall,we provide here a high-quality,full-length transcriptome assembly which will facilitate gene discovery and molecular breeding of A.squamosa.We found that starch degradation during fruit ripening was the main channel for sugar accumulation in A.squamosa fruit,and the key genes positively linked to sugar accumulation could be further studied to identify targets for controlling sugar content in A.squamosa fruit. | REN FANG WEIXIONG HUANG JINYAN YAO XING LONG JI ZHANG SHUANGYUN ZHOU BIAO DENG WENZHONG TANG ZHENYU AN | 2020 | BIOCELL2020，44，4： | 0 |
| 8 | Current situation,efficacy,and safety of extracorporeal cardiopulmonary resuscitation in China显示文摘To the Editor:The survival rate from conventional cardiopulmonary resuscitation(CCPR)of out-of-hospital and in-hospital cardiac arrest ranges from 9%to 20%.[1]Without returning of spontaneous circulation(ROSC)after CCPR,the chance of recovery is very poor.Initiating venoarterial extracorporeal membrane oxygenation in those patients may provide adequate organ perfusion that allows for longer organ viability and permit time for therapies seeking to correct the inciting pathologic event,which is termed extracorporeal cardiopulmonary resuscitation(ECPR).[2]Time to treatment,ECPR-related complications,as well as etiology,have been recognized as the main predictors of survival for ECPR patients.[3]ECPR has been carried out more and more in China,but the information on ECPR application remains unknown.Therefore,we conducted a retrospective survey about the usage of ECPR in China,including patient selection,initiation and management of extracorporeal mechanical ventilation(ECMO),patient outcome,and compared the status during 2017 and 2020. | Ying Liu Xiaoning Han Qi Qi Zhiyong Yuan Fuhua Wang Kai Song Xiaotong Hou Jinyan Xing | 2022 | Chinese Medical Journal2022，135，23： | 0 |
| 9 | Tuning the ratio of Bi/Bi_(2)O_(3)in Bi/PNC nanosheet for highefficiency electrosynthesis hydrogen peroxide显示文摘Electrocatalytic two-electron oxygen reduction reaction(2e-ORR)is a promising method for producing green and sustainable H_(2)O_(2)but lacks high selectivity and yields electrocatalysts.And it is critical to develop catalysts that meet industrial demands.Herein,we report the different ratios of Bi0/Bi^(3+)supported on a phosphorus,nitrogen,and carbon nanosheet(Bi/PNC),which can reduce O_(2) to H_(2)O_(2)with high selectivity(up to 97.75%at 0.4 VRHE)in 0.1 M KOH electrolyte and retain 97%selectivity even after 100 h electrolysis.Then a homemade flow-cell system was built for electrocatalytic production of H_(2)O_(2)under an O_(2) atmosphere using an improved gas diffusion electrode.The Bi/PNC-4 can achieve a high H_(2)O_(2)yield of 2.76 mol·gcatalyst^(-1)·h^(-1)(alkaline),5.29 mol·gcatalyst^(-1)·h^(-1)(neutral),and 3.50 mol·gcatalyst^(-1)·h^(-1)(acid)in universal pH conditions.The in-situ generated H_(2)O_(2)can function as a degradation agent for efficiently degrading pesticides and antibiotics.The outstanding selectivity and activities are attributed to the synergistic effects of Bi0 and Bi^(3+)that promote proton-coupled reduction of O_(2) to OOH^(*)(ΔGOOH^(*)=4.27 eV),and the formation of H_(2)O_(2).The fast yield of H_(2)O_(2)on Bi/PNC catalysts in flow-cell provides a promising path of electrocatalytic 2e-ORR for practical H_(2)O_(2)production. | Zhikang Bao Jinyan Zhao Shijie Zhang Xiaoge Peng Yizhen Shao Chenghang Jiang Zaixiang Xu Xing Zhong Zihao Yao Jianguo Wang | 2023 | Nano Research2023，16，7： | 0 |
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