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| 1 | Distribution and Accumulation Characteristics of Heavy Metals in Sediments in Southern Sea Area of Huludao City, China显示文摘The southern sea area of the Huludao City, Liaoning Province might be polluted by heavy metals because it is close to the Jinzhou Bay, one of the heaviest sea area polluted by heavy metals in China. The undisturbed modern sediment core can be used to analyze the accumulation and source of the pollutants using 137 Cs and 210 Pb ex . Thirty-five samples of surface sediment and two core sediments were collected from the southern sea area of Huludao City. The concentrations of copper (Cu), lead (Pb), chrome (Cr), zinc (Zn), arsenic (As) and mercury (Hg) in the surface sediments as well as Cu, Pb, Zn, Cr, 137 Cs and 210 Pb ex in the core sediments were determined to research the spatial distribution and accumulation characteristics, and to analyze the sources and the potential risks of heavy metals. The results show that the pollution levels of Zn and Hg are serious, and 26 stations are at moderate or heavy ecological risks. The concentrations of the heavy metals increase from east to west, as well as from open sea to offshore marine area. The concentrations of heavy metals are not high in the sediments adjacent to the Jinzhou Bay, and the influence caused by the seawater exchange with the Jinzhou Bay is little. The concentrations of the heavy metals in the core sediments show low-high-low characteristic, and it coincides with the pollution history of Huludao City. The atmospheric deposition of heavy metals from the Huludao Zinc Plant is likely to be the main source of pollution without direct discharge of wastewater. The high concentrations of heavy metals appear on the upper sediment of 20 cm. The shallow sediment with high heavy metal contents might be exposed to surface when it was disturbed by the ocean engineering and big storm surge, then cause risk to the safety of aquaculture and human healthy. | WANG Yan LIU Ruhai FAN Dejiang YU Ping WANG Jinyu TANG Aikun | 2013 | Chinese Geographical Science2013，23，2： | 12 |
| 2 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 3 | Quantum Communication Networks and Trust Management: A Survey显示文摘This paper summarizes the state of art in quantum communication networks and trust management in recent years.As in the classical networks,trust management is the premise and foundation of quantum secure communication and cannot simply be attributed to security issues,therefore the basic and importance of trust management in quantum communication networks should be taken more seriously.Compared with other theories and techniques in quantum communication,the trust of quantum communication and trust management model in quantum communication network environment is still in its initial stage.In this paper,the core technologies of establishing secure and reliable quantum communication networks are categorized and summarized,and the trends of each direction in trust management of quantum communication network are discussed in depth. | Shibin Zhang Yan Chang Lili Yan Zhiwei Sheng Fan Yang Guihua Han Yuanyuan Huang Jinyue Xia | 2019 | Computers, Materials & Continua2019，，9： | 3 |
| 4 | Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair显示文摘The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.Blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation. | Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang | 2021 | Bioactive Materials2021，6，11： | 2 |
| 5 | QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars显示文摘The soybean E1 gene is a major regulator that plays an important role in flowering time and maturity.However,it remains unclear how cultivars carrying the dominant E1 allele adapt to the higher latitudinal areas of northern China.We mapped the novel quantitative trait locus QNE1(QTL near E1) for flowering time to the region proximal to E1 on chromosome 6 in two mapping populations.Positional cloning revealed Glyma.06G204300,encoding a TCP-type transcription factor,as a strong candidate gene for QNE1.Association analysis further confirmed that functional single nucleotide polymorphisms(SNPs) at nucleotides 686 and 1,063 in the coding region of Glyma.06G204300 were significantly associated with flowering time.The protein encoded by the candidate gene is localized primarily to the nucleus.Furthermore,soybean and Brassica napus plants overexpressing Glyma.06G204300 exhibited early flowering.We conclude that despite their similar effects on flowering time,QNE1 and E4 may control flowering time through different regulatory mechanisms,based on expression studies and weighted gene co-expression network analysis of flowering time-related genes.Deciphering the molecular basis of QNE1 control of flowering time enriches our knowledge of flowering gene networks in soybean and will facilitate breeding soybean cultivars with broader latitudinal adaptation. | Zhengjun Xia Hong Zhai Yanfeng Zhang Yaying Wang Lu Wang Kun Xu Hongyan Wu Jinglong Zhu Shuang Jiao Zhao Wan Xiaobin Zhu Yi Gao Yingxiang Liu Rong Fan Shihao Wu Xin Chen Jinyu Liu Jiayin Yang Qijian Song Zhixi Tian | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 6 | Rapid clonal propagation of Dioscorea zingiberensis显示文摘 | Yongqin Chen Jinyu Fan Fei Yi Zhongxun Luo Yunsheng Fu | 2003 | Plant Cell Tissue and Organ Culture2003，，1： | 1 |
| 7 | Rapid clonal propagation of Dioscorea zingiberensis显示文摘 | Chen Yongqin Fan Jinyu | 2003 | Plant Cell Tissue and Organ Culture2003，73，： | 1 |
| 8 | Moisture-preventing MAPbI_(3) solar cells with high photovoltaic performance via multiple ligand engineering显示文摘Perovskite solar cells present one of the most prominent photovoltaic technologies,yet their stability,and engineering at the molecular level remain challenging.We have demonstrated multifunctional molecules to improve the operating stability of perovskite solar cells while depicting a high-power conversion efficiency.The multifunctional molecule 4-[(trifluoromethyl)sulphanyl]-aniline(4TA)with trifluoromethyl(-CF_(3))and aniline(-NH_(2))moieties is meticulously designed to modulate the perovskite.The-CF_(3) and-NH_(2) functional groups have strong interaction with perovskite to suppress surface defects to improve device stability,as well as obtain large crystal grains through delaying crystallization.Moreover,this-CF_(3) forms a hydrophobic barrier on the surface of the perovskite to prevent cell decomposition.Consequently,the performance of the perovskite solar cells is remarkably improved with the efficiency increased from 18.00% to 20.24%.The perovskite solar cells with multifunctional molecular maintaining 93% of their original efficiency for over 30 days(-55%humidity)in air without device encapsulation,exhibiting a high long-term stability.Moreover,the lead leakage issue of perovskite solar cells has also been suppressed by the built-in 4TA molecule,which is beneficial to environment-friendly application.Ultimately,we believe this multifunctional small molecule provides an available way to achieve high performance perovskite solar cells and the related design strategy is helpful to further develop more versatile materials for perovskite-based optoelectronic devices. | Xin Li Jinyue Du Hui Duan Haoyan Wang Lin Fan Yunfei Sun Yingrui Sui Jinghai Yang Fengyou Wang Lili Yang | 2022 | Nano Research2022，15，2： | 1 |
| 9 | Rapid clonal propagation of Dioscorea zingiberensis 显示文摘 | Yongqin Chen Jinyu Fan | 2003 | Plant Cell Tissue and Organ Culture2003，73，： | 1 |
| 10 | Full-scale chemical and field-effect passivation:21.52% efficiency of stable MAPbI_(3) solar cells via benzenamine modification显示文摘Organic-inorganic metal halide perovskite solar cells have achieved high efficiency of 25.5%.Finding an effective means to suppress the formation of traps and correlate stability losses are thought to be a promising route for further increasing the photovoltaic performance and commercialization potential of perovskite photovoltaic devices.Herein,we report a facile passivation model,which uses a multi-functional organic molecule to simultaneously realize the chemical passivation and field-effect passivation for the perovskite film by an upgraded anti-solvent coating method,which reduces the trap states density of the perovskite,improves interface charge transfer,and thus promotes device performance.In addition,the hydrophobic groups of the molecules can form a moisture-repelling barrier on the perovskite grains,which apparently promotes the humidity stability of the solar cells.Therefore,the optimal power conversion efficiency(PCE)of perovskite solar cells after synergistic passivation reaches 21.52%,and it can still retain 95%of the original PCE when stored in-40%humidity for 30 days.Our findings extend the scope for traps passivation to further promote both the photovoltaic performance and the stability of the perovskite solar cells. | Fengyou Wang Meifang Yang Yuhong Zhang Jinyue Du Shuo Yang Lili Yang Lin Fan Yingrui Sui Yunfei Sun Jinghai Yang | 2021 | Nano Research2021，14，8： | 1 |
| 11 | Task-Attribute-Based Access Control Scheme for IoT via Blockchain显示文摘As a new form of network,the Internet of things(IoT)is becoming more widely used in people’s lives.In this paper,related theoretical research and practical applications of the IoT are explored.The security of the IoT has become a hot research topic.Access controls are methods that control reasonable allocations of data and resources and ensure the security of the IoT.However,most access control systems do not dynamically assign users’rights.Additionally,with some access control systems,there is a risk of overstepping other user’s authority,and there may exist a central authority that is a single point of failure.Therefore,to solve these problems,this paper proposes a Task-Attribute-Based Access Control scheme for the IoT via blockchain that combines the access control technologies of both the IoT and blockchain.This model,which merges the advantages of task-based access controls and attribute-based access controls,is perfectly integrated with blockchain technology.This model uses hash functions and digital signature algorithms to ensure the authenticity and integrity of the data,and it can dynamically allocate users’minimum privileges and thus perfectly solves the single point of failure problem.The model is implemented using a Geth client and solidity code,and the simulation results demonstrate the effectiveness of the model. | Hao Chen Wunan Wan Jinyue Xia Shibin Zhang Jinquan Zhang Xizi Peng Xingjie Fan | 2020 | Computers, Materials & Continua2020，，12： | 1 |
| 12 | Rapid clonal propagation of Dioscorea zingiberensis 显示文摘 | Chert Yongqin Fan Jinyu Yi Fei | 2003 | PCTOC2003，73，1： | 1 |
| 13 | A survey of green plant tRNA 3 '-end processing enzyme tRNase Zs,homologs of the candidate prostate cancer susceptibility protein ELAC2显示文摘 | Lijuan Fan Zhikang Wang Jinyu Liu | | 0，，： | 1 |
| 14 | Tetrahedral DNA nanostructures synergize with MnO_(2) to enhance antitumor immunity via promoting STING activation and M1 polarization显示文摘Stimulator of interferon genes(STING) is a cytosolic DNA sensor which is regarded as a potential target for antitumor immunotherapy. However, clinical trials of STING agonists display limited anti-tumor effects and dose-dependent side-effects like inflammatory damage and cell toxicity. Here,we showed that tetrahedral DNA nanostructures(TDNs) actively enter macrophages to promote STING activation and M1 polarization in a size-dependent manner, and synergized with Mn^(2+) to enhance the expressions of IFN-β and iNOS, as well as the co-stimulatory molecules for antigen presentation. Moreover, to reduce the cytotoxicity of Mn^(2+),we constructed a TDN-MnO_(2) complex and found that it displayed a much higher efficacy than TDN plus Mn^(2+) to initiate macrophage activation and anti-tumor response both in vitro and in vivo. Together, our studies explored a novel immune activation effect of TDN in cancer therapy and its synergistic therapeutic outcomes with MnO_(2).These findings provide new therapeutic opportunities for cancer therapy. | Siping Liang Jiaying Li Zhengyu Zou Miao Mao Siqi Ming Fan Lin Ziyan Zhang Can Cao Jinyu Zhou Yuanqing Zhang Jiaping Li Minhao Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 15 | Rapid elonal propagation of Dioscorea zingiberensis 显示文摘 | Yongqin Chen Jinyu Fan Fei Yi | 2003 | Plant Cell Tissue and Organ Culture2003，73，： | 1 |
| 16 | Degradation-resistant implanted biomaterials establish an immunosuppressive microenvironment that induces T cell exhaustion by recruiting myeloid cells显示文摘Implanted biomaterials have transformed healthcare and the treatment of injury and disease,but their infuence on the local immune landscape remains unclear.Here we discovered that degradation-resistant titanium-based implants establish an immunosuppressive microenvironment by recruiting myeloid cells,including monocytes,macrophages,neutrophils,and myeloid-lineage dendritic cells.Unlike normal tissues,the tissues nearby implants exhibit an chronic inflamed and immunosuppressive status characterised by myeloid-rich,T cell-exhaustion gene signature by single-cell RNA sequencing.Vitamin C treatment provides an effective strategy to rescue the immunosuppressive microenvironment,which can be used as a regular supplement to reduce the risk of malignant cell survival around the implants. | Qin Fan Huaxing Dai Jinyu Bai Jialu Xu Qingle Ma Ziying Fei Xiaozhong Zhou Kam W.Leong Chao Wang | 2022 | Fundamental Research2022，2，4： | 0 |
| 17 | Laser-enhanced thermal effects during focused ultrasound radiation on biological tissues显示文摘 | ZHAO Jinyu TAO Chao ZHANG Shuyi FAN Li SHUI Xiuji | 2018 | Chinese Journal of Acoustics2018，37，4： | 0 |
| 18 | Observation of the early blood vessels of cutaneous malignant melanoma using Swept Source Optical Coherence Tomography A ngiography(SS-OCTA)显示文摘Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant. | Jingxuan Liu Jinyu Fan Quan Wang Wen He Caihua Dong Minxuan Sun Guohua Shi | 2019 | Journal of Innovative Optical Health Sciences2019，，4： | 0 |
| 19 | Laser-enhanced thermal effect of moderate intensity focused ultrasound on bio-tissues显示文摘For avoiding extra-damage to healthy tissues surrounding the focal point during high intensity focused ultrasound(HIFU) treatment in medical therapy, to reduce the ultrasonic intensity outside the focal point is expected. Thus, the heating processes induced by moderate intensity focused ultrasound(MIFU) and enhanced by combined irradiation of laser pulses for bio-tissues are studied in details. For fresh bio-tissues, the enhanced thermal effects by pulsed laser combined with MIFU irradiation are observed experimentally. To explore the mechanisms of these effects, several tissue-mimicking materials composed of agar mixed with graphite powders are prepared and studied for comparison, but the laser-enhanced thermal effects in these mimicking materials are much less than that in the fresh bio-tissues. Therefore, it is suggested that the laser-enhanced thermal effects may be mainly attributed to bio-activities and related photo-bio-chemical effects of fresh tissues. | JinYu Zhao ShuYi Zhang XiuJi Shui Li Fan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，9： | 0 |
| 20 | Control of vertical phase separation in high performance non-fullerene organic solar cell by introducing oscillating stratification preprocessing显示文摘Non-fullerene organic solar cell(NFOSC)has attracted tremendous attention due to their great potential for commercial applications.To improve its power conversion efficiency(PCE),generally,sequential solution deposition(SSD)methods have been employed to construct the graded vertical phase separation(VPS)of the bulk-heterojunction(BHJ)active layer for efficient exciton separation and charge transition.However,a variety of orthogonal solvents used in the SSD may lead to the unpredicted change in the BHJ morphology and introduce additional defects inside the BHJ bulk thus complicate the fabrication process.Here,a simple oscillating stratification preprocessing(OSP)is developed to facilitate the formation of graded VPS among the BHJ layer.As a result,a significant improvement is obtained in PCE from 10.96%to 12.03%,which is the highest value reported among PBDB-T:ITIC based NFOSC. | Dayong Zhang Pu Fan Jinyu Shi Yifan Zheng Jian Zhong Junsheng Yu | 2021 | Nano Research2021，14，5： | 0 |
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