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| 1 | Mass flow during unloading of agricultural bulk materials from silos depending on particle form, flow properties and geometry of the discharge opening显示文摘 | Jochen Mellmann Thomas Hoffmann Christian Fürll | 2014 | Powder Technology2014，，： | 1 |
| 2 | Solid-phase PCR in a picowell array for immobilizing and arraying 100 000 PCR products to a microscope slide 显示文摘 | Jochen Hoffmann Martin Trotter Felix von Stetten | | Lab Chip0，12，： | 1 |
| 3 | Stroke MRI in Intracerebral Hemorrhage: Is There a Perihemorrhagic Penumbra?显示文摘 | Peter D. Schellinger Jochen B. Fiebach Katrin Hoffmann Kristina Becker Berk Orakcioglu Rainer Kollmar Eric Jüttler Peter Schramm Stefan Schwab Klaus Sartor Werner Hacke | 2003 | Stroke: Journal of the American Heart Association2003，，7： | 1 |
| 4 | Fusing MEMS technology with lab-on-chip: nanoliter-scale silicon microcavity arrays for digital DNA quantification and multiplex testing显示文摘We report on the development of a microfluidic multiplexing technology for highly parallelized sample analysis via quantitative polymerase chain reaction(PCR)in an array of 96 nanoliter-scale microcavities made from silicon.This PCR array technology features fully automatable aliquoting microfluidics,a robust sample compartmentalization up to temperatures of 95°C,and an application-specific prestorage of reagents within the 25nl microcavities.The here presented hybrid silicon–polymer microfluidic chip allows both a rapid thermal cycling of the liquid compartments and a real-time fluorescence read-out for a tracking of the individual amplification reactions taking place inside the microcavities.We demonstrate that the technology provides very low reagent carryover of prestored reagents<6×10^(−2) and a cross talk rate<1×10^(−3) per PCR cycle,which facilitate a multi-targeted sample analysis via geometric multiplexing.Furthermore,we apply this PCR array technology to introduce a novel digital PCR-based DNA quantification method:by taking the assay-specific amplification characteristics like the limit of detection into account,the method allows for an absolute gene target quantification by means of a statistical analysis of the amplification results. | Daniel Podbiel Franz Laermer Roland Zengerle Jochen Hoffmann | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 5 | Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects显示文摘 | Jochen Meyburg Georg F. Hoffmann | 2010 | Molecular Genetics and Metabolism2010，，： | 1 |
| 6 | Cryoballoon versus RF Ablation in Paroxysmal Atrial Fibrillation: Results from the German Ablation Registry显示文摘 | MARTIN SCHMIDT UWE DORWARTH DIETRICH ANDRESEN JOHANNES BRACHMANN KARL‐HEINZ KUCK MALTE KUNISS THORSTEN LEWALTER STEFAN SPITZER STEPHAN WILLEMS JOCHEN SENGES CLAUS JüNGER ELLEN HOFFMANN | 2014 | J Cardiovasc Electrophysiol2014，，1： | 1 |
| 7 | Heart Rate Variability from Underwater Spiroergometry:How Meaningful?显示文摘Cardiovascular fitness of divers is overwhelmingly performed using bicycle ergometry.A more sport-specific alternative presents fit2dive,an underwater spiroergometry system.Purpose of this exploratory study:using fit2dive to investigate the diagnostic value of measures of heart rate variability(HRV)after markedly increasing physical load.Ten scuba divers employed the fit2dive system and increased fin-swimming speed until exhaustion.Breathing gas consumption(VE)and heart rate(HR)were measured.A three-lead ECG was recorded to analyze for time and frequency domain HRV-measures.VE increased from 16.5±6.5 to 68.3±26.6 L/min.HR increased from 96±13 beats/min(mean±SD)at rest to 170±14 beats/min before exhaustion.Global variability(SDNN:132±42 vs.54±17 ms)decreased along with two measures of parasympathetic activity(RMSSD:59±31 vs.24±16 ms;pNN50:22%±12%vs.3%±3%).Measures from the frequency domain decreased[low frequency(LF):3167±2651 vs.778±705 ms_(2)]or remained unaltered[high frequency(HF):885±652 vs.431±463 ms^(2)].Thus,LF/HF decreased from 4.3±2.3 to 2.5±1.4.The sports-specific fit2dive can help assessing diving fitness by employing HRV measures.However,this study supports the view that these measures much depend on HR.Thus,HRV measures regarding altered autonomic control during exercise will lead to serious misinterpretation:as HR increases,variability decreases. | Andreas Koch Fabian Möller Elena Jacobi Thomas Muth Clark Pepper Uwe Hoffmann Jochen D.Schipke | 2023 | Journal of Science in Sport and Exercise2023，5，2： | 0 |
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