|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 2 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 3 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 4 | Deep reactive ion etching of silicon using an aluminum etching mask显示文摘 | Ho Joe Reinhall Per | 2003 | SPIE2003，4876，： | 1 |
| 5 | Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe显示文摘 | Bradley L. Urquhart Joseph A. Ware Rommel G. Tirona Richard H. Ho Brenda F. Leake Ute I. Schwarz Hani Zaher Joe Palandra Jamie C. Gregor George K. Dresser Richard B. Kim | 2008 | Pharmacogenetics and Genomics2008，，5： | 1 |
| 6 | Documentation of variations in sinonasal anatomy by intraoperative nasal endoscopy 显示文摘 | Joe JK Ho SY Yanagisawa E | 2000 | Laryngoscope2000，110，2： | 1 |
| 7 | Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury显示文摘 | Soo Ryeong Jeong Min Jung Kwon Hwan Goo Lee Eun Hye Joe Jae Ho Lee Sung Soo Kim Haeyoung Suh-Kim Byung G. Kim | 2011 | Experimental Neurology2011，，1： | 1 |
| 8 | Raf and PI3K are the Molecular Targets for the Anti‐metastatic Effect of Luteolin显示文摘 | Ho Young Kim Sung Keun Jung Sanguine Byun Joe Eun Son Mi Hyun Oh Jihoon Lee Min Jeong Kang Yong‐Seok Heo Ki Won Lee Hyong Joo Lee | 2013 | Phytother. Res2013，，10： | 1 |
| 9 | Using Workflow Technology to Manage Flexible e-Learning Serviees显示文摘 | Joe Lin Charley Ho | 2002 | Edueational Technology & Society2002，5，4： | 1 |
| 10 | Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe显示文摘 | Bradley L. Urquhart Joseph A. Ware Rommel G. Tirona Richard H. Ho Brenda F. Leake Ute I. Schwarz Hani Zaher Joe Palandra Jamie C. Gregor George K. Dresser Richard B. Kim | 2008 | Pharmacogenetics and Genomics2008，，5： | 1 |
| 11 | Documentation of variations in sinonasal anatomy by intraoperative nasal endoscopy 显示文摘 | Joe JK Ho SK Yanagisawa E | 2000 | laryngoscope2000，110，21： | 1 |
| 12 | Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients显示文摘 | Stacie L. Daugherty J. David Powers David J. Magid Heather M. Tavel Frederick A. Masoudi Karen L. Margolis Patrick J. O?Connor Joe V. Selby P. Michael Ho | 2012 | Circulation2012，，13： | 1 |
| 13 | Documentation of variationsin sinonnsal anatomy by intraoperative nasal endoscopy显示文摘 | Joe JK Ho SY Yanagisawa E | 2000 | Laryngoscope2000，110，21： | 1 |
| 14 | Photoelectron spectroscopy of metal cluster anions: Cun^-, Agn^-, and Aun^- 显示文摘 | Joe Ho Ervin K M Lineberger W C | 1990 | J Chem Phys1990，93，10： | 1 |
| 15 | Inhibition of NF-κB Acetylation and its Transcriptional Activity by Daxx显示文摘 | Jinhwi Park Jae Ho Lee Muhnho La Moon Jung Jang Gil Woo Chae Seung Beom Kim Heejae Tak Yunhwa Jung Boohyeong Byun Jeong Keun Ahn Cheol O. Joe | 2007 | Journal of Molecular Biology2007，，2： | 1 |
| 16 | What do we know about housing supply?The case of Hong Kong SAR显示文摘The house price in the Hong Kong SAR of China is well-known to be‘unaffordable’.This paper relates the macroeconomy with the housing market of Hong Kong and argues that the housing supply plays a vital role in explaining the phenomenon.This paper also shows that there are some practical challenges in understanding the housing supply of Hong Kong,including the potentially complicated ownership structure of real estate development.While the discussion centres on the situation of Hong Kong,its lesson may also apply to housing markets in other small open economies. | Charles Ka Yui Leung Joe Cho Yiu Ng Edward Chi Ho Tang | 2020 | Economic and Political Studies2020，8，1： | 0 |
| 17 | FEM for Design of Balloon Expandable Stent for Coronary Artery Using Co-Cr Alloy显示文摘 | Chul Woo Park Ho Sung Joe | 2012 | Journal of Mechanics Engineering and Automation2012，2，4： | 0 |
| 18 | Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells显示文摘Dear Editor,Tyrosine phosphatase SHP2/PTPN11 plays an important role in cell signaling.Activation mutation of SHP2 causes cancer,which makes the enzyme an anti-cancer drug target.Several selective and potent SHP2 inhibitors have been discovered.SHP099,the best known SHP2 inhibitor currently in clinical trials,has been shown to be effective for receptor tyrosine kinase-driven and oncogenic KRAS-driven cancers1,2.We employed a colorectal cancer cell line HCT-116 that carries a KRAS-G13D mutation in this study.Interestingly,SHP2 inhibitors failed to inhibit HCT-116 growth and ERK1/2 activation but in contrast had the opposite effect.We then generated SHP2 knockout cells by using the CRISPR technique and provided further evidence that loss of SHP2 activity promotes growth of HCT-116 cells in vitro and in vivo.Our study suggests that targeting SHP2 may have adverse effects on certain cancers,which may have major implications for further development of anti-cancer drugs targeting SHP2. | Xin Chen Xueqi Fu Wanke Zhao Wan-Ting Tina Ho Shu Xing Zhizhuang Joe Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 19 | Transcriptomic analyses of localized prostate cancers of East Asian and North American men reveal race-specific luminal-basal and microenvironmental differences显示文摘Dear editor,Prostate cancer(PCa)remains a major healthcare burden in men globally[1].Most patients present with localized disease,and treatment is recommended based on risk classification systems like the National Comprehensive Cancer Network(NCCN)[2].However,these methods are imprecise for estimating metastasis-free survival and prostate cancer-specific mortality and thus biomarkers that can predict tumor aggression are needed[3–5].Several studies have since characterized the molecular landscape of localized PCa in White[4,5]and Black/African-American men[6],but data is lacking in Asian men.The Chinese Prostate Cancer Genome and Epigenome Atlas(CPGEA)reported on the genomic and epigenomic landscape of 208 PCa of men from China[7].Comparative analyses between the CPGEA cohort and data from The Cancer Genome Atlas(TCGA)revealed higher frequencies of Forkhead box A1(FOXA1)and chromodomain-helicase DNA-binding 1(CHD1)mutations,and lower frequencies of phosphatase and tensin homolog(PTEN)mutations and transmembrane protease serine 2-E26 transformationspecific related gene(TMPRSS2-ERG)fusion in Chinese compared with White men[7].These preliminary findings highlight the presence of race-specific differences in molecular phenotypes of PCa. | Melvin L.K.Chua Alexander K.Hakansson Enya H.W.Ong Boon Hao Hong Jing Jing Miao Adelene Y.L.Sim Janice S.H.Tan Kah Min Tan Gabrielle C.J.Lee Kar Perng Low Jeffrey K.L.Tuan Terence W.K.Tan Michael L.C.Wang Joe P.S.Yeong Michael C.S.Tan Lui Shiong Lee Ravindran Kanesvaran Xin Zhao Julian Ho Daniel E.Spratt Edward M.Schaeffer Kae-Jack Tay Yang Liu Elai Davicioni Li Yan Khor | 2023 | Cancer Communications2023，43，10： | 0 |
| 20 | Traditional Chinese medicine poisoning in the emergency departments in Hong Kong: Trend, clinical presentation and predictors for poor outcome显示文摘Dear editor,Traditional Chinese medicine (TCM) is popular in many countries,especially in the Chinese population.^([1,2]) In Hong Kong,it has been estimated that around 15%of the population consumed Chinese medicine products/herbs in the preceding month.Common reasons for consumption include regulating bodily functions,curing disease,and building up health. | Rex Pui Kin Lam Eric Ho Yin Lau Wai Lam Yip Joe Kai Shing Leung Matthew Sik Hon Tsui | 2021 | World Journal of Emergency Medicine2021，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员