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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 3 | Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer: the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors显示文摘痊愈不能与经历激进的治疗的临床上局部性的前列腺癌症为所有人被保证。如果他们能改进秘密变形疾病的预言,分子的标记将是无价的。这研究被执行在激进的前列腺切除术标本调查 BCL-2, Ki-67, p53 和 E-cadherin 的表示。我们寻求了估计他们的能力在一个特定的治疗学的背景预言早生物化学的恶化。包括 41 案例对的 82 个病人为病理学的舞台,格利森等级和外科手术前的前列腺特定的抗原(PSA ) 被匹配集中。在每对的一个病人有生物化学的复发(在 2 年外科以内定义为 PSA 0.2 ng mL-1 ) 并且其它没有疾病生物化学地留下了(至少 3 年在外科以后定义同样无法发现的 PSA ) 。Immunohistochemical 分析被执行在四上估计标记表示复制从每个激进的前列腺切除术标本与良性、恶意的织物构造的织物 microarrays。Ki-67, p53 和 BCL-2,然而并非 E-cadherin,显著地在前列腺腺癌的 upregulated 与良性的前列腺织物相比(P < 0.01 ) 。然而,当比较与没有生物化学的复发的病人一起开发了早生物化学的恶化的病人时,在任何标记的表示的重要差别都没被观察。这研究证明 p53, BCL-2 和 Ki-67 的那表情与良性的前列腺织物相比是在临床上局部性的前列腺癌症的 upregulated,没有在 E-cadherin 表示的改变。Biomarker upregulation 没在激进的前列腺切除术以后为生物化学的复发有预示的价值,甚至在考虑病理学的舞台,整个瘤格利森等级和外科手术前的浆液 PSA 水平以后。 | Joseph Nariculam Alex Freeman Simon Bott Phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark Feneley | 2009 | Asian Journal of Andrology2009，11，1： | 5 |
| 4 | Deep basin gas trap, Western Canada显示文摘 | MASTERS JOHN A | 1979 | AAPG Bulletin1979，63，2： | 1 |
| 5 | Tracking the re-emergence of epidemic chikungunya virus in Indonesia显示文摘 | Kanti Laras Nono C. Sukri Ria P. Larasati Michael J. Bangs Rizal Kosim Djauzi Tony Wandra John Master Herman Kosasih Sri Hartati Charmagne Beckett Endang R. Sedyaningsih H. James Beecham Andrew L. Corwin | 2004 | Transactions of the Royal Society of Tropical Medicine and Hygiene2004，，2： | 1 |
| 6 | Renal cell carcinoma in patients with end‐stage renal disease has favorable overall prognosis显示文摘 | Adam B. Shrewsberry Adeboye O. Osunkoya Kun Jiang Ruth Westby Daniel Canter John Pattaras Nicole Turgeon Viraj A. Master Kenneth Ogan | 2014 | Clin Transplant2014，，： | 1 |
| 7 | Interferon re- duces cell surface expression of Annexin 2 and suppresses the invasive capacity of prostate cancer cells 显示文摘 | Claire Hastie John R Masters Stephen E Moss | 2008 | Biological Chemistry2008，283，18： | 1 |
| 8 | Relationship Between Natriuretic Peptides and Inflammation: Proteomic Evidence Obtained During Acute Cellular Cardiac Allograft Rejection in Humans显示文摘 | Yael F. Meirovich John P. Veinot Mercedes L. Kuroski de Bold Haissam Haddad Ross A. Davies Roy G. Masters Paul J. Hendry Adolfo J. de Bold | 2008 | Journal of Heart and Lung Transplantation2008，，1： | 1 |
| 9 | Too Frail for Surgery?: Initial Results of a Large Multidisciplinary Prospective Study Examining Pre-operative Variables Predictive of Poor Surgical Outcomes显示文摘 | Louis M. Revenig Daniel J. Canter Maxwell D. Taylor Caroline Tai John F. Sweeney Juan M. Sarmiento David A. Kooby Shishir K. Maithel Viraj A. Master Kenneth Ogan | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 10 | Species Richness and Patterns of Invasion in Plants, Birds, and Fishes in the United States*显示文摘 | Thomas J. Stohlgren David Barnett Curtis Flather Pam Fuller Bruce Peterjohn John Kartesz Lawrence L. Master | 2006 | Biological Invasions2006，，3： | 1 |
| 11 | Hela cells 50 years on:the good,the bad and the ugly显示文摘 | Masters John R | 2002 | Nat Rev Cancer2002，2，4： | 1 |
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