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| 1 | 哮喘治疗的新进展显示文摘没有强有力的循证医学证据表明饮食方法或Buteyko技术对哮喘的临床管理有很大益处需要进一步研究确定当哮喘控制欠佳时患者应该怎么做小剂量吸入皮质激素可以和长效β2激动剂联合应用,以提供安全有效的哮喘控制静脉镁制剂和白三烯受体拮抗剂对急性哮喘可能具有一些作用,但仍需进一步评价将来哮喘治疗是否能得到炎症生物标志或患者基因型认识的帮助。 | Graeme P Currie Graham S Devereux Daniel K C Lee Jon G Ayres 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 2 | Advanced Reproductive Age and Fertility显示文摘 | Kimberly Liu Allison Case Anthony P. Cheung Sony Sierra Saleh AlAsiri Belina Carranza-Mamane Allison Case Cathie Dwyer James Graham Jon Havelock Robert Hemmings Francis Lee Kimberly Liu Ward Murdock Vyta Senikas Tannys D.R. Vause Benjamin Chee-Man Wong | 2011 | International Journal of Gynecology and Obstetrics2011，，1： | 1 |
| 3 | Are dental anomalies risk factors for apical root resorption in orthodontic patients显示文摘 | Rosa Y Lee Jon Artun Todd A | 1999 | Am J Orthod Dentofacial1999，25，18： | 1 |
| 4 | IIDS:Intelligent Information Dissemination Server显示文摘 | Jon Dukes-Schlossberg Lee Yongwon | 1997 | IEEE MILCOM1997，，2： | 1 |
| 5 | Determinants of Changes in Linear Growth and Body Composition in Incident Pediatric Crohn’s Disease显示文摘 | Meena Thayu Lee A. Denson Justine Shults Babette S. Zemel Jon M. Burnham Robert N. Baldassano Krista M. Howard Anne Ryan Mary B. Leonard | 2010 | Gastroenterology2010，，2： | 1 |
| 6 | Bacteriostasis of nanosized colloidal silver on polyester nonwovens显示文摘 | Hoon Jon Lee Sung Hoon Jeong | 2004 | Textile Research Journal2004，74，5： | 1 |
| 7 | Fabrication and implementation of a multi-to-single mode converter based on a taperd multimode fiber 显示文摘 | Yi Yang Jon Lee Karl Reichard | 2005 | Optics Communications2005，249，1： | 1 |
| 8 | Acute Care Surgery Performed by Sleep Deprived Residents: Are Outcomes Affected? 1显示文摘 | Arezou Yaghoubian Amy H. Kaji Brandon Ishaque Jon Park David K. Rosing Steven Lee Bruce E. Stabile Christian de Virgilio | 2010 | Journal of Surgical Research2010，，： | 1 |
| 9 | Fabrication and implementation of a multi-single mode converter based on a taperd multimode fiber 显示文摘 | Yi Yang Jon Lee Karl Reichard | 2005 | Optics Communications2005，249，1： | 1 |
| 10 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 11 | Axillary staging prior to neoadjuvant chemotherapy:the roles of sentinel lymph node biopsy and axillary ultrasonography显示文摘 | Lee MC Jon JE Chau A | 2011 | Cancer Control2011，19，4： | 1 |
| 12 | An adaptive service grid architecture using dynamic replica management显示文摘 | Byoung-Dai Lee Jon B Weissman | 2001 | GRID2001，，： | 1 |
| 13 | Constrained maximum-entropy sampling 显示文摘 | Jon Lee | 1998 | Operations Research1998，46，5： | 1 |
| 14 | Narcolepsy in orexin Knockout Mice显示文摘 | Richard M. Chemelli Jon T. Willie Christopher M. Sinton Joel K. Elmquist Thomas Scammell Charlotte Lee James A. Richardson S.Clay Williams Yumei Xiong Yaz Kisanuki Thomas E. Fitch Masamitsu Nakazato Robert E. Hammer Clifford B. Saper Masashi Yanagisawa | 1999 | Cell1999，，4： | 1 |
| 15 | Direction function to cucurbituril :synthesis of perhydroxylcucurbiturll and it' s further usage显示文摘 | Jon S Y Selvapalam N Oh D H Kang J K Kim S Y Jeon Y J Lee J W Kim K | 2003 | J Am Chem Soc 20032003，，： | 1 |
| 16 | Expression of E - cadherin, beta - catenin,CD44s and CD44v6 in gastric adenocarcinoma: relationship ,with lymph node metastasis显示文摘 | Jon M Lee HK Kang YK | 2003 | Anticancer Res2003，23，2： | 1 |
| 17 | A pseudorotaxane on gold:Formation of self-assembled monolayers,reversible dethreading and rethreading of the ring,and ion'gating behavior显示文摘 | KIM KYUNGPIL JEON WOO SUNG KANG JIN-KOO LEE JAE WOOK JON SANG YONG KIM TAISUN KIM KIMOON | 2003 | Angewandte Chemie International Edition2003，42，20： | 1 |
| 18 | Fast digital image stabilizer based on gray-coded bit-plane matching 显示文摘 | KO S LEE S JON S | 1999 | IEEE Transactions on Consumer Electronics1999，45，3： | 1 |
| 19 | Synthesis and characterization of hollow silica microspheres functionalized with magnetic particles using W/O emulsion method显示文摘 | Oh C Lee Y G Jon C U | 2009 | Colloids and Surfaces A: Physico- chemical and Engineering Aspects2009，337，1： | 1 |
| 20 | Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both显示文摘 | Atsunori Nakao David J. Kaczorowski Yinna Wang Jon S. Cardinal Bettina M. Buchholz Ryujiro Sugimoto Kimimasa Tobita Sungsoo Lee Yoshiya Toyoda Timothy R. Billiar Kenneth R. McCurry | 2010 | Journal of Heart and Lung Transplantation2010，，5： | 1 |
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