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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 3 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 4 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
| 5 | Alkaloid from Dicranostigma leptopodum(Maxim) Fedde显示文摘Fedde 有的 Dicranostigma leptopodum (格言) 的整个植物的 Phytochemical 调查导致五碱的隔离:dicranostigmine (1 ) , isocorydine (2 ) , corydine (3 ) , protopine (4 ) 和 sinoacutine (5 ) 。Oxomorphine 碱(5 ) 第一次从类 Dicranostigma 被孤立,新复合结构(1 ) 被各种各样的分光镜的方法包括 2D NMR 技术(gCOSY, HMQC, HMBC 和 NOESY ) 和 HRESIMS 阐明。 | Yan Dang Hong Fei Gong Jun Xi Liu Si Jiu Yu | 2009 | Chinese Chemical Letters2009，20，10： | 19 |
| 6 | Pathogenesis of acute lung injury in rats with severe acute pancreatitis显示文摘BACKGROUND: Acute lung injury (ALI) is the most common and severe complication of severe acute pancreatitis (SAP). The elucidation of the mechanism of ALI contributes to the diagnosis and treatment of the illness. In this study, we studied the pathogenesis of ALI in rats with severe acute pancreatitis. METHODS: The rats were sacrificed at 1, 3, 5, 6, 9 and 12 hours after the establishment of the model of SAP. Pancreas and lung tissues were obtained for pathological study, and examination of microvascular permeability and myeloperoxidase (MPO) examination. The gene expressions of tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) in the pancreas and lung tissues were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: After the establishment of the SAP model, the degree of pancreatic and lung injury increased gradually along with the gradual increase of MPO activity and micro-vascular permeability. Gene expressions of TNF-α and ICAM-1 in the pancreas rose at 1 hour and peaked at 7 hours. In contrast, their gene expression in the lungs rose slightly at 1 hour and peaked at 9-12 hours. CONCLUSION: An obvious time window existed between SAP and lung injury, which is beneficial to the early prevention of the development of ALI. | Xue-Min Liu, Jun Xu and Zi-Fa Wang Department of Hepatobiliary Surgery, First Hospital, Xi’an Jiaotong University, Xi’an 710061 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，4： | 18 |
| 7 | A single Eu^(2+)-activated high-color-rendering oxychloride white-light phosphor for white-light-emitting diodes显示文摘Single-phased,high-color-rendering index(CRI)white-light phosphors are emerging as potential phosphor-converted white-light-emitting diodes(WLEDs)and as an alternative to blends of tricolor phosphors.However,it is a challenge to create a high CRI white light from a single-doped activator.Here,we present a high CRI(Ra 591)white-light phosphor,Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:Eu^(2+),composed of Sr5(PO4)3Cl as the beginning member and Sr_(5)(BO_(3))_(3)Cl as the end member.This work utilized the solid-solution method,and tunable Eu^(2+) emission was achieved.Color-tunable Eu^(2+) emissions in response to structural variation were observed in Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl solid solutions.This was further confirmed using X-ray Rietveld refinement,electron paramagnetic resonance spectroscopy,and in the photoluminescence spectra.The color-tunable emissions included the white light that originated from the combination of the blue emission of Sr_(5)(PO_(4))_(3)Cl:Eu^(2+) and an induced Eu^(2+) yellow emission at approximately 550 nm in the solid solution.Importantly,the white-light phosphors showed a greater R9590.2 under excitation at 365 nm.This result has rarely been reported in the literature and is greater than that of(R9514.3)commercial Y_(3)A_(l5)O_(12):Ce^(3+)-based WLEDs.These findings demonstrate the great potential of Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:0.04Eu^(2+) as a white-light phosphor for near-UV phosphor-converted WLEDs.These results also provide a shortcut for developing a high CRI white-light phosphor from a single Eu^(2+)-doped compound. | Peng-Peng Dai Cong Li Xin-Tong Zhang Jun Xu Xi Chen Xiu-Li Wang Yan Jia Xiaojun Wang Yi-Chun Liu | 2016 | Light(Science & Applications)2016，5，1： | 14 |
| 8 | Two new diarylheptanoids from the pericarps of Juglans regia L.显示文摘二新周期的 diarylheptanoids juglanin A (1 ) 和 juglanin B (2 ) 从 Juglans regia L 的果皮被孤立。他们的结构被各种各样的分光镜的方法包括 2D NMR 技术阐明(舒适, HMQC, HMBC, NOESY ) 并且 HR-ESIMS。 | Jun Xi Liu Duo Long Di Xin Yi Huang Chen Li | 2007 | Chinese Chemical Letters2007，18，8： | 14 |
| 9 | Synthesis and Characterization of Phosphated Konjac Glucomannan Hydrogels显示文摘Konjac glucomannan (KGM) was crosslinked with sodium tripolyphosphate (STPP) to synthesize hydrogels. The crosslinking reaction was confirmed by FT-IR. The results of degradation test show that the hydrogels retain the enzymatic degradation character of KGM and can be degraded for 74.45% in 5 days by cellulase E0240. | Li Gui CHEN Zhi Lan LIU Ying Jun CHEN Ren Xi ZHUO | 2005 | Chinese Chemical Letters2005，16，12： | 13 |
| 10 | Anti-HBV effect of TAT-HBV targeted ribonuclease显示文摘AIM: To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 cells.METHODS: The prokaryotic expression vector pTAT containing TR gene was used in transforming E. coli BL21(DE3) LysS and TR was expressed with the induction of IPTG. The TAT-TR fusion protein was purified using Ni-NTA-agrose and PD-10 desalting columns, and analyzed by SDSPAGE. Transduction efficiency of TAT-TR was detected with immunofluorescence assay and the concentration of HBeAg in the supernatant of the 2.2.15 cells was determined via solid-phase radioimmunoassay (spRIA). MTT assay was used to detect the cytotoxicity of TAT-TR.RESULTS: The SDS-PAGE showed that the TAT-TR fusion protein was purified successfully, and the purity of TAT-TR was 90 %. The visualization of TAT-TR by immunofiuorescence assay indicated its high efficiency in transducing 2.2.15 cells.RIA result suggests that TAT-TR could inhibit the replication of HBV effectively, it didn′t affect cell growth and had no cytotoxicity.CONCLUSION: TAT-TR possesses a significant anti-HBV activity and the preparation of TAT-TR fusion protein has laid the foundation for the use of TR in the therapeutic trial of HBV infection. | Jin Ding Jun Liu Cai-Fang Xue Wei-Dong Gong Ying-Hui Li Ya Zhao Department of Etiology,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，7： | 12 |
| 11 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 12 | Epidemiology,clinical and laboratory characteristics of currently alive HIV-1 infected former blood donors naive to antiretroviral therapy in Anhui Province,China显示文摘Background Unregulated commercial blood/plasma collection among farmers occurred between 1992 and 1995 in central China and caused the second major epidemic of human immunodeficiency virus type 1 (HIV-1) infection in China. It is important to characterize HIV-1-infected former blood donors and to study characteristics associated with disease progression for future clinical intervention and vaccine development. Methods A cross-sectional study was performed on HIV-1-infected former blood donors (FBDs) and age-matched HIV-seronegative local residents. Demographic, epidemiologic, clinical and key laboratory data were collected from all study participants. Both unadjusted and adjusted multivariate linear regressions were employed to analyze the association of the decrease of CD4+ T-cell counts with other characteristics. Results Two hundred and ninety-four HIV-1-infected FBDs and 59 age-matched HIV-seronegative local residents were enrolled in this study. The unregulated blood/plasma collection occurred more than a decade (10.8 -12.8 years) ago, which caused the rapid spread of HIV-1 infection and the high prevalence of co-infection with hepatitis C virus (HCV, 89.5%); hepatitis B virus (HBV) co-infection was observed in only 11 HIV+participants (3.7%). Deterioration in both clinical manifestation and laboratory parameters and increase of viral loads were observed in parallel with the decrease of CD4+ T-cell counts. The decrease of total lymphocyte counts (P<0.001) and hemoglobin levels (P<0.001) and the appearance of dermatosis (P=0.03) were observed in parallel with the decrease of CD4+ T-cell counts whereas viral loads (P<0.001) and CD8+ T-cell counts (P=0.01) were inverselyassociated with CD4+ T-cell counts. Conclusions Co-infection with HCV but not HBV is highly prevalent among HIV-1-infected FBDs. CD4+ T-cell counts is a reliable indicator for disease progression among FBDs. Total lymphocyte counts, hemoglobin level and appearance of dermatosis were positively associated with CD8+ T-cell counts and viral loads were inversely associated with the decreased CD4+ T-cell counts. | XU Jian-qing WANG Jian-jun HAN Li-feng XU Chen RUAN Yu-hua XU Zhen-hou CHEN Xi LIU Zhen-dong WANG Jun SU Bing DING Xin-ping GAO Bing GU Yong-bin CAO Xiao-yun XING Hui HONG Kun-xue PENG Hong ZHAO Quan-bi YUAN Lin FENG Yi ZHANG Gui-yun MA Li-ying WU Lan SHAO Yi-ming | 2006 | Chinese Medical Journal2006，，23： | 9 |
| 13 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 14 | Reaction decoupling in thermochemical fuel conversion and technical progress based on decoupling using fluidized bed显示文摘Thermochemical conversion of fuels via pyrolysis/carbonization,cracking,gasification and combustion has to involve a number of individual reactions called attribution reactions to form an intercorrelated reaction network for any conversion process.By separating one or some attribution reactions from the others to decouple their interactions existing in the reaction network,the so-called reaction decoupling enables a better understanding of the complex thermal conversion process and further the optimization of the conditions for attribution reactions as well as the entire conversion process to realize advanced performances.The dual bed conversion and two-stage conversion are the two representative types of fuel conversion technologies developed in recent years based on reaction decoupling.Many technical advantages have been proven for such decoupling fuel conversion technologies,such as poly-generation of products,low-cost production of high-grade products,elimination of undesirable products or pollutants,easy operation and control,and so on.The treated fuels with decoupling conversion technologies mainly include solid biomass and coal,as well as liquid petroleum oil.This paper is devoted to reiteration of the reaction decoupling concept and further to reviewing the research,developments and successful applications of several decoupling fuel conversion technologies of two such types by using fluidized bed as their major reactors. | Zhennan Han Sulong Geng Xi Zeng Shipei Xu a Ping An Jiguang Cheng Jun Yang Feng Li Suyi Zhang Miao Liu Guoqing Guan Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，2： | 8 |
| 15 | Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications显示文摘Alzheimer’s disease is characterized by sustained neuroinflammation leading to memory loss and cognitive decline.The past decade has witnessed tremendous efforts in Alzheimer’s disease research;however,no effective treatment is available to prevent disease progression.An increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer’s disease pathogenesis,alongside the classical pathological hallmarks such as misfolded and aggregated proteins(e.g.,amyloid-beta and tau).Firstly,this review summarized the clinical and pathological characteristics of Alzheimer’s disease.Secondly,we outlined key aspects of glial cell-associated inflammation in Alzheimer’s disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer’s disease pathology.Then,we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer’s disease.In addition,the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer’s disease were also discussed through these mechanisms.In the final section,the remaining key problems according to the current research status were discussed. | Zi-Zhen Si Chen-Jun Zou Xi Mei Xiao-Fang Li Hu Luo Yao Shen Jun Hu Xing-Xing Li Lun Wu Yu Liu | 2023 | Neural Regeneration Research2023，18，4： | 7 |
| 16 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 17 | Novel estimators of equivalent number of looks in polarimetric SAR imagery based on sub-matrices显示文摘The equivalent number of looks(ENL) is an important parameter in the multilook statistical model of polarimetric synthetic aperture radar(Pol-SAR). Recently, the maximum likelihood(ML) method was proposed and gave a good performance in the Gaussian model case by using the full covariance matrix instead of the intensity of Pol-SAR data, but it generated underestimates in the product model case. In this paper several novel ENL estimators are presented via certain cumulants of the log-determinant of the sub-matrices of the multilook polarimetric covariance matrix. The texture effect to the ENL estimates is eliminated, and the analytic estimators are derived. The estimators use the full covariance matrix and sub-matrices information, rather than the intensities of polarization channels. All the novel estimators are suitable for any texture model and thus provide more accurate results than many existing ones. Experiments using simulated data and real data are presented to evaluate the performance of different estimators. The results show that the second log-determinant moment(SLDM3)-based method is the best one among the novel estimators. At the same time this estimator has much less computational complexity. In addition, a novel distribution classification method is proposed by coloring the image via second- and third-order log-cumulants of the covariance matrix(MLC), which is helpful to assess the estimation result. | Tao LIU Haogui CUI Zemin XI Jun GAO | 2016 | Science China(Information Sciences)2016，59，6： | 7 |
| 18 | Accumulation of cadmium and copper by female Oxya chinensis (Orthopera: Acridoidea) in soil-plant-insect system显示文摘One purpose of this research is to present accumulation of cadmium(Cd) and copper(Cu) by female Oxya chinensis(Orthopera: Acridoidea) in a simulated s oil-plant-insect ecosystem treated with Cd. Fourth-instar nymphs of O. chinensis had been fed on wheat(Triticum aestivum) seedlings contaminated with Cd and Cu for one month. In the ecosystem, the Cd concentration in wheat seedlings rose gr eatly with the increasing of Cd in the soil, but the Cu concentration in wheat s eedlings was not found elevated. There was a highly significant difference(P<0. 05) in Cd concentrations of wheat seedlings and not any significant difference(P >0.05) in Cu concentrations of wheat seedlings. The Cd and Cu concentration in different body part-head, thorax, abdomen, and hind femur, varied under differen t Cd concentrations in soil. There were significant differences(P<0.05) in the four parts of Cd and Cu accumulations with all treatments. The order of Cd accum ulation was thorax>abdomen>head>hind femur and the Cu was abdomen>thorax>he ad>hind femur. The results indicated that Cd and Cu were accumulated from the s oil to grasshoppers through the plant; that is to say, Cd and Cu in environment could be transported to animal or human via food chain. | LI Li-jun LIU Xue-mei DUAN Yi-hao GUO Ya-ping CHENG Bin GUO Jun XI Yu-ying MA En-bo | 2006 | Journal of Environmental Sciences2006，18，2： | 7 |
| 19 | Multicenter Clinical Study for Evaluation of Efficacy and Safety of Transdermal Fentanyl Matrix Patch in Treatment of Moderate to Severe Cancer Pain in 474 Chinese Cancer Patients显示文摘Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life. | Yu-lin Zhu Guo-hong Song Duan-qi Liu Xi Zhang Kui-feng Liu Ai-hua Zang Ying Cheng Guo-chun Cao Jun Liang Xue-zhen Ma Xin Ding Bin Wang Wei-lian Li Zuo-wei Hu Gang Feng Jiang-jin Huang Xiao Zheng Shun-chang Jiao Rong Wu Jun Ren | 2011 | Chinese Journal of Cancer Research2011，23，4： | 6 |
| 20 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
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