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| 1 | LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption显示文摘Activation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement.However,the key regulatory molecules involved in osteoclastogenesis during this process remain unclear.Long noncoding RNAs(lnc RNAs)are a newly identified class of functional RNAs that regulate cellular processes,such as gene expression and translation regulation.Recently,lnc RNAs have been reported to be involved in osteogenesis and bone formation.However,as the most abundant noncoding RNAs in vivo,the potential regulatory role of lnc RNAs in osteoclast formation and bone resorption urgently needs to be clarified.We recently found that the lnc RNA Nron(long noncoding RNA repressor of the nuclear factor of activated T cells)is highly expressed in osteoclast precursors.Nron is downregulated during osteoclastogenesis and bone ageing.To further determine whether Nron regulates osteoclast activity during orthodontic treatment,osteoclastic Nron transgenic(Nron c TG)and osteoclastic knockout(Nron CKO)mouse models were generated.When Nron was overexpressed,the orthodontic tooth movement rate was reduced.In addition,the number of osteoclasts decreased,and the activity of osteoclasts was inhibited.Mechanistically,Nron controlled the maturation of osteoclasts by regulating NFATc1 nuclear translocation.In contrast,by deleting Nron specifically in osteoclasts,tooth movement speed increased in Nron CKO mice.These results indicate that lnc RNAs could be potential targets to regulate osteoclastogenesis and orthodontic tooth movement speed in the clinic in the future. | Ruilin Zhang Junhui Li Gongchen Li Fujun Jin Zuolin Wang Rui Yue Yibin Wang Xiaogang Wang Yao Sun | 2020 | International Journal of Oral Science2020，12，2： | 9 |
| 2 | Analysis of the efficacy of transcatheter arterial infusion chemotherapy in the treatment of pancreatic carcinoma显示文摘Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December 2014.Nine patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after surgery.In all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric artery.We administered 500 mg/m2 GEM and 500 mg/m2 5-FU.Observational data included data on clinical efficacy and survival rates during the follow-up period of 3-72 months.Results:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,respectively.Conclusion: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC. | Chunhui Nie Yuelin Zhang Guanhui Zhou Tanyang Zhou Tongyin Zhu Baoquan Wang Shengqun Chen Hongliang Wang Ziniu Yu Li Jing Junhui Sun | 2021 | Journal of Interventional Medicine2021，4，1： | 4 |
| 3 | Secure and Efficient Computing Resource Management in Blockchain-Based Vehicular Fog Computing显示文摘In vehicular fog computing(VFC),the resource transactions in the Internet of Vehicles(IoV)have become a novel resource management scheme that can improve system resource utilization and the quality of vehicle services.In this paper,in order to improve the security and fairness of resource transactions,we design a blockchain-based resource management scheme for VFC.First,we propose the concept of resource coin(RC)and develop a blockchain-based secure computing reource trading mechanism in terms of RC.As a node of the blockchain network,the roadside unit(RSU)participates in verifying the legitimacy of transactions and the creation of new blocks.Next,we propose a resource management scheme based on contract theory,encouraging parked vehicles to contribute computing resource so that RSU could complete proof of work(PoW)quickly,improve the success probability of block creation and get RC rewards.We use the gradient descent method to solve the computing resource utilization that can maximize the RC revenue of RSUs and vehicles during the block creation.Finally,the performance of this model is validated in simulation result and analysis. | Ming Kong Junhui Zhao Xiaoke Sun Yiwen Nie | 2021 | China Communications2021，18，4： | 3 |
| 4 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 5 | Reduced Number and Activity of Circulating Endothelial Progenitor Cells from Patients with Hyperhomocysteinemia显示文摘 | Zhu JunHui Wang XingXiang Chen JunZhu Sun Jian Zhang FuRong | 2006 | Archives of Medical Research2006，，4： | 1 |
| 6 | Role of CXCL16 in mice with adriamycin induced nephropathy and the protective effects of simvastatin显示文摘 | WANG Cong SUN Shuzhen ZHEN Junhui | 2015 | Journal of Shandong University(Health Sciences)2015，53，9： | 1 |
| 7 | Role of CXCL16 and ox-LDL in mice with adriamycin induced nephropathy显示文摘 | XU Yihuai SUN Shuzhen ZHEN Junhui | 2014 | Journal of Shandong University(Health Sciences)2014，52，5： | 1 |
| 8 | Near-infrared quantum cutting in Eu 2+ , Yb 3+ co-doped Sr 3 Gd(PO 4 ) 3 phosphor显示文摘 | Jiayue Sun Yining Sun Junhui Zeng Haiyan Du | 2013 | Optical Materials2013，，6： | 1 |
| 9 | Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma显示文摘Background:Increased hypoxia-inducible factor 2α(HIF2α)activation is a common event in clear cell renal cell carcinoma(ccRCC)progression.However,the function and underlying mechanism of HIF2α in ccRCC remains uninvestigated.We conducted this study to access the potential link between junction plakoglobin(JUP)and HIF2αin ccRCC.Methods:Affinity purification and mass spectrometry(AP-MS)screening,glutathione-s-transferase(GST)pull-down and co-immunoprecipitation(Co-IP)assays were performed to detect the interacting proteins of HIF2α.Quantitative PCR(qPCR)and Western blotting were used to detect the expression of JUP in human ccRCC samples.Luciferase reporter assays,chromatin immunoprecipitation(ChIP),cycloheximide chase assays,and ubiquitination assays were conducted to explore the regulation of JUP on the activity of HIF2α.Cell Counting Kit-8(CCK-8)assays,colony formation assays,transwell assays,and xenograft tumor assays were performed to investigate the effect of JUP knockdown or overexpression on the tumorigenicity of renal cancer cells.Results:We identified JUP as a novel HIF2α-binding partner and revealed an important role of JUP in recruiting von Hippel-Lindau(VHL)and histone deacetylases 1/2(HDAC1/2)to HIF2α to regulate its stability and transactivation.JUP knockdown promoted and overexpression suppressed the tumorigenicity of renal cell carcinoma in vitro and in vivo.Importantly,the low expression of JUP was found in clinical ccRCC samples and correlated with enhanced hypoxia scores and poor treatment outcomes.Conclusion:Taken together,these data support a role of JUP in modulating HIF2α signaling during ccRCC progression and identify JUP as a potential therapeutic target. | Ke Chen Jin Zeng Yi Sun Wei Ouyang Gan Yu Hui Zhou Yangjun Zhang Weimin Yao Wei Xiao Junhui Hu Jinchun Xing Kefeng Xiao Lily Wu Zhiqiang Chen Zhangqun Ye Hua Xu | 2021 | Cancer Communications2021，41，4： | 1 |
| 10 | Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport 显示文摘 | Sun Junhui Morgan Meghan Shen Rong-Fong | 2007 | Circ Res2007，101，11： | 1 |
| 11 | Temperature and precipitation control of the spatial variation of terrestrial ecosystem carbon exchange in the Asian region显示文摘 | Zhi Chen Guirui Yu Jianping Ge Xiaomin Sun Takashi Hirano Nobuko Saigusa Qiufeng Wang Xianjin Zhu Yiping Zhang Junhui Zhang Junhua Yan Huimin Wang Liang zhao Yanfen Wang Peili Shi Fenghua Zhao | 2013 | Agricultural and Forest Meteorology2013，，： | 1 |
| 12 | Evaluation of the performance of GNSS-based velocity estimation algorithms显示文摘Global Navigation Satellite System(GNSS)based velocity estimation is one of the most cost-effective and widely used methods in determining velocity in geodesy and transport applications.Highly accurate and reliable velocity measurements can be obtained by exploiting the raw Doppler,carrier phase,and pseudorange measurements with a GNSS receiver.There are several approaches to GNSS-based velocity determination.This paper investigates the characteristics of the approaches which are currently popular and applicable to the observations of Global Positioning System(GPS),BeiDou Navigation Satellite System(BDS),and their combination(GPS/BDS).Specifically,it evaluates the performance of the velocity estimated based on the Raw Doppler method,the Time-Differenced Pseudorange method,the Time-Differenced Carrier Phase method,and the Double-Differenced Carrier Phase method,in both static and dynamic modes and in open and urban scenarios.The experiments show that BDS has the advantages in delivering accurate velocity determinations over GPS in the Asia–Pacific region,and the effectiveness of the GPS/BDS in improving the overall accuracy of velocity determination in complex urban scenarios. | Li Ji Rui Sun Qi Cheng Junhui Wang | 2022 | Satellite Navigation2022，3，3： | 1 |
| 13 | Research Progress of Seafloor Pockmarks in Spatio-Temporal Distribution and Classification显示文摘Seafloor pockmarks are important indicators of submarine methane seepages and slope instabilities.In order to promote the understanding of submarine pockmarks and their relationship with sediment instabilities and climate changes,here we summarize the research results of pockmarks in the spatio-temporal distributions and shaping factors.Most of pockmarks occur along active or passive continental margins during the last 25 kyr B.P..Circular and ellipse are the most common forms of pockmarks,whereas pockmarks in a special crescent or elongated shape are indicators of slope instabilities,and ring-shape pockmarks are endemic to the gas hydrate zones.Further researches should be focused on the trigger mechanism of climate changes based on the pockmarks in the high latitudes formed during the deglaciation periods,and the role of gas hydrates in the seafloor evolution should be elucidated.In addition,the feature of pockmarks at their early stage(e.g.,developing gas chimneys and gas driving sedimentary doming)and the relations between pockmarks and mass movements,mud diapirs could be further studied to clarify the influences of rapid methane release from submarine sediments on the atmospheric carbon contents. | XU Cuiling XU Guoqiang XING Junhui SUN Zhilei WU Nengyou | 2020 | Journal of Ocean University of China2020，19，1： | 1 |
| 14 | UU_* filtering of nighttime net ecosystem CO_2 exchange flux over forest canopy under strong wind in wintertime显示文摘 | ZHANG Junhui, HAN Shijie, SUN Xiaomin & TANG Fengde Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Department of Environment and Life Sciences, Liaoning University, Shenyang 110036, China | 2005 | Science China Earth Sciences2005，48，z1： | 1 |
| 15 | Hypercontractile Female Hearts Exhibit Increased S-Nitrosylation of the L-Type Ca2+ Channel α1 Subunit and Reduced Ischemia/Reperfusion Injury显示文摘 | Junhui Sun Eckard Picht Kenneth S. Ginsburg Donald M. Bers Charles Steenbergen Elizabeth Murphy | 2006 | Circulation Research2006，，： | 1 |
| 16 | Improvement of hepatitis B surface antigen expression by dimethyl sulfoxide in the culture of recombinant Chinese hamster ovary cells 显示文摘 | Li Junhui Sun Xiangming Zhang Yuanxing | 2006 | Process Biochem2006，41，： | 1 |
| 17 | Biochar pyrolyzed at low temperature enhanced acidophilous plant growth by promoting rhizospheric microbes in a slightly alkaline urban soil显示文摘Biochar has been considered as a potential way to enhance acidophilous plant growth in alkaline soils.However,whether such enhancements are closely linked with biochar pyrolysis temperature and its improvements in rhizospheric soil fertility and microbial activities remains largely unknown.We performed a pot experiment to investigate changes in azalea(Rhodo-dendron)morphology and physiology,as well as its rhizosphere soil chemical and biological properties in a slightly alkaline urban soil under the amendment of biochars that pyrolyzed at three temperatures(i.e.,350,550 and 700°C).Our results showed that the effects of biochars on plant growth and soil properties depended on pyrolysis temperature.In comparison with the non-amended control,350 and 550°C biochars showed significant promotions on the azalea growth in terms of photosynthetic characteristics,biomass,root morphology,and N and P uptake.Whereas,700°C biochar showed an inhibi-tion effect on them.350°C biochar decreased soil pH and increased soil available P and K contents and the activities ofα-glucosidase,N-β-glucosaminidase,phosphatase and sulfatase.In addition,350°C biochar significantly enhanced bacterial 16S rRNA and fungal 18S rRNA gene abundances in the rhizosphere soil of azalea and mycorrhizal infection.Correlation analysis indicated that soil pH,available nutrients and fungal abundance had positive associations with the enhanced plant growth parameters.Therefore,our findings suggest that biochar produced at low temperature could be a feasible strategy for enhancing acidophilous azalea growth and improving urban soil quality. | Huimin Zhou Xiaoying Li Chang Li Lisi He Xiaoqing Liu Zheng Xiao Xiaobo Sun Gaoling Shi Jiale Su Junhui Chen | 2021 | Biochar2021，3，4： | 1 |
| 18 | Changes in the relationship between species richness and belowground biomass among grassland types and along environmental gradients in Xinjiang, Northwest China显示文摘The association between biodiversity and belowground biomass(BGB) remains a central debate in ecology.In this study, we compared the variations in species richness(SR) and BGB as well as their interaction in the top(0–20 cm), middle(20–50 cm) and deep(50–100 cm) soil depths among 8 grassland types(lowland meadow, temperate desert, temperate desert steppe, temperate steppe desert, temperate steppe, temperate meadow steppe, mountain meadow and alpine steppe) and along environmental gradients(elevation, energy condition(annual mean temperature(AMT) and potential evapotranspiration(PET)), and mean annual precipitation(MAP)) based on a 2011–2013 survey of 379 sites in Xinjiang, Northwest China.The SR and BGB varied among the grassland types.The alpine steppe had a medium level of SR but the highest BGB in the top soil depth, whereas the lowland meadow had the lowest SR but the highest BGB in the middle and deep soil depths.The SR and BGB in the different soil depths were tightly associated with elevation, MAP and energy condition;however, the particular forms of trends in SR and BGB depended on environmental factors and soil depths.The relationship between SR and BGB was unimodal in the top soil depth, but SR was positively related with BGB in the middle soil depth.Although elevation, MAP, energy condition and SR had significant effects on BGB, the variations in BGB in the top soil depth were mostly determined by elevation, and those in the middle and deep soil depths were mainly affected by energy condition.These findings highlight the importance of environmental factors in the regulations of SR and BGB as well as their interaction in the grasslands in Xinjiang. | YANG Yuling LI Minfei MA Jingjing CHENG Junhui LIU Yunhua JIA Hongtao LI Ning WU Hongqi SUN Zongjiu FAN Yanmin SHENG Jiandong JIANG Ping'an | 2019 | Journal of Arid Land2019，11，6： | 0 |
| 19 | Running-in behavior of a H‒DLC/Al_(2)O_(3) pair at the nanoscale显示文摘Diamond-like carbon(DLC)film has been developed as an extremely effective lubricant to reduce energy dissipation;however,most films should undergo running-in to achieve a super-low friction state.In this study,the running-in behaviors of an H–DLC/Al_(2)O_(3) pair were investigated through a controllable single-asperity contact study using an atomic force microscope.This study presents direct evidence that illustrates the role of transfer layer formation and oxide layer removal in the friction reduction during running-in.After 200 sliding cycles,a thin transfer layer was formed on the Al2O3 tip.Compared with a clean tip,this modified tip showed a significantly lower adhesion force and friction force on the original H–DLC film,which confirmed the contribution of the transfer layer formation in the friction reduction during running-in.It was also found that the friction coefficient of the H–DLC/Al_(2)O_(3) pair decreased linearly as the oxygen concentration of the H–DLC substrate surface decreased.This phenomenon can be explained by a change in the contact surface from an oxygen termination with strong hydrogen bond interactions to a hydrogen termination with weak van der Waals interactions.These results provide new insights that quantitatively reveal the running-in mechanism at the nanoscale,which may help with the design optimization of DLC films for different environmental applications. | Pengfei SHI Junhui SUN Yunhai LIU Bin ZHANG Junyan ZHANG Lei CHEN Linmao QIAN | 2021 | Friction2021，9，6： | 0 |
| 20 | Microengineered platforms for characterizing the contractile function of in vitro cardiac models显示文摘Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic discovery.Challenges still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue models.Changes to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive models.Developing new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac diseases.In this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac tissues.The characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and limitations.In addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease modeling.Furthermore,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed. | Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes Yu Sun | 2022 | Microsystems & Nanoengineering2022，8，1： | 0 |
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