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| 1 | Predictive findings forHelicobacter pylori-uninfected, -infected and -eradicated gastric mucosa: Validation study显示文摘AIM:To validate the usefulness of screening endoscopy findings for predictingHelicobacter pylori (H. pylori) infection status. METHODS:H. pylori infection status was determined by histology, serology, and the urea breast test in 77 consecutive patients who underwent upper endoscopy. Based on the findings, patients were categorized as H. pylori -uninfected, -infected, or -eradicated cases. Using six photos of certain sites in the stomach per case, we determined the presence or absence of the following endoscopic findings:regular arrangement of collecting venules (RAC), linear erythema, hemorrhage, fundic gland polyp (FGP), atrophic change, rugal hyperplasia, edema, spotty erythema, exudate, xanthoma, and mottled patchy erythema (MPE). The diagnostic odds ratio (DOR) and inter-observer agreement (Kappa value) for these 11 endoscopic findings used in the determination of H. pylori infection status were calculated. RESULTS:Of the 77 patients [32 men and 45 women; mean age (SD), 39.7 (13.4) years] assessed, 28 were H. pylori uninfected, 28 were infected, and 21 were eradicated. DOR values were significantly high (< 0.05) for the following H. pylori cases:uninfected cases with RAC (11.5), linear erythema (24.5), hemorrhage (4.1), and FGP (34.5); for infected cases with atrophic change (8.67), rugal hyperplasia (15.8), edema (14.2), spotty erythema (11.5), and exudate (3.52); and for eradicated cases with atrophic change (32.4) and MPE (103.0). Kappa values were excellent for FGP (0.93), good for RAC (0.63), hemorrhage (0.79), atrophic change (0.74), and MPE (0.75), moderate for linear erythema (0.51), rugal hyperplasia (0.49), edema (0.58), spotty erythema (0.47), and exudate (0.46), and poor for xanthoma (0.19). CONCLUSION:The endoscopic findings of RAC, hemorrhage, FGP, atrophic change, and MPE will be useful for predicting H. pylori infection status. | Kazuhiro Watanabe Naoyoshi Nagata Ryo Nakashima Etsuko Furuhata Takuro Shimbo Masao Kobayakawa Toshiyuki Sakurai Koh Imbe Ryota Niikura Chizu Yokoi Junichi Akiyama Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，27： | 17 |
| 2 | Post-polypectomy bleeding and thromboembolism risks associated with warfarin vs direct oral anticoagulants显示文摘AIM To verify the validity of the endoscopy guidelines for patients taking warfarin or direct oral anticoagulants(DOAC).METHODS We collected data from 218 patients receiving oral anticoagulants(73 DOAC users, 145 warfarin users) and 218 patients not receiving any antithrombotics(age-and sexmatched controls) who underwent polypectomy.(1) We evaluated post-polypectomy bleeding(PPB) risk in patients receiving warfarin or DOAC compared with controls;(2) we assessed the risks of PPB and thromboembolism between three AC management methods: Discontinuing AC with heparin bridge(HPB)(endoscopy guideline recommendation), continuing AC, and discontinuing AC without HPB.RESULTS PPB rate was significantly higher in warfarin users and DOAC users compared with controls(13.7% and 13.7% vs 0.9%, P < 0.001), but was not significantly different between rivaroxaban(13.2%), dabigatran(11.1%), and apixaban(13.3%) users. Two thromboembolic events occurred in warfarin users, but none in DOAC users. Compared with the continuing anticoagulant group, the discontinuing anticoagulant with HPB group(guideline recommendation) had a higher PPB rate(10.8% vs 19.6%, P = 0.087). These findings were significantly evident in warfarin but not DOAC users. One thrombotic event occurred in the discontinuing anticoagulant with HPB group and the discontinuing anticoagulant without HPB group; none occurred in the continuing anticoagulant group.CONCLUSION PPB risk was similar between patients taking warfarin and DOAC. Thromboembolism was observed in warfarin users only. The guideline recommendations for HPB should be re-considered. | Naohiro Yanagisawa Naoyoshi Nagata Kazuhiro Watanabe Tatsuhiro Iida Mariko Hamada Sakurako Kobayashi Takuro Shimbo Junichi Akiyama Naomi Uemura | 2018 | World Journal of Gastroenterology2018，24，14： | 6 |
| 3 | Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat显示文摘 | Takeshi Kashimura Makoto Kodama Yuko Hotta Junichi Hosoya Kaori Yoshida Takuya Ozawa Ritsuo Watanabe Yuji Okura Kiminori Kato Haruo Hanawa Ryozo Kuwano Yoshifusa Aizawa | 2004 | Virchows Archiv2004，，3： | 2 |
| 4 | SJWD14101600000482显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | J Gastroenterol Hepatol2014，，10： | 2 |
| 5 | Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 6 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 7 | 20-Hour preprocedural hydration is not superior to 5-hour preprocedural hydration in the prevention of contrast-induced increases in serum creatinine and cystatin C显示文摘 | Kumie Torigoe Akira Tamura Toru Watanabe Junichi Kadota | 2012 | International Journal of Cardiology2012，，： | 1 |
| 8 | Impact of discontinuing non-steroidal antiinflammatory drugs on long-term recurrence in colonic diverticular bleeding显示文摘AIM: To determine the effect of discontinuing nonsteroidal antiinflammatory drugs(NSAIDs) on recurrence in long-term follow-up patients with colonic diverticular bleeding(CDB).METHODS: A cohort of 132 patients hospitalized for CDB examined by colonoscopy was prospectively enrolled. Comorbidities, lifestyle, and medications(NSAIDs, low-dose aspirin, antiplatelet agents, anticoagulants, acetaminophen, and corticosteroids) were assessed. After discharge, patients were requested to visit the hospital on scheduled days during the followup period. The Kaplan-Meier method was used to estimate recurrence.RESULTS: Median follow-up was 15 mo. The probability of recurrence at 1, 6, 12, and 24 mo was 3.1%, 19%, 27%, and 38%, respectively. Of the 41 NSAID users on admission, 26(63%) discontinued NSAID use at discharge. Many of the patients who could discontinue NSAIDs were intermittent users, and could be switched to alternative therapies, such as acetaminophen or an antiinflammatory analgesic plaster. The probability of recurrence at 12 mo was 9.4% in discontinuing NSAID users compared with 77% in continuing users(P < 0.01, log-rank test). The hazard ratio for recurrence in the discontinuing NSAIDs users was 0.06 after adjusting for age > 70 years, right-sided diverticula, history of hypertension, and hemodialysis. No patients developed cerebrocardiovascular events during follow-up.CONCLUSION: There is a substantial recurrence rate after discharge among patients hospitalized for diverticular bleeding. Discontinuation of NSAIDs is an effective preventive measure against recurrence. This study provides new information on risk reduction strategies for diverticular bleeding. | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Katsunori Sekine Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2015 | World Journal of Gastroenterology2015，21，4： | 1 |
| 9 | Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters显示文摘 | Yuji Iimuro Toru Kashiwagi Junichi Yamanaka Tadamichi Hirano Shinichi Saito Takaaki Sugimoto Shinichiro Watanabe Nobukazu Kuroda Toshihiro Okada Yasukane Asano Naoki Uyama Jiro Fujimoto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 10 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 11 | Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate显示文摘 | Nozomi Sugimoto Kenichiro Watanabe Kazuyo Watanabe Shinichi Ogata Ryo Shimoda Hiroyuki Sakata Yuichiro Eguchi Toshihiko Mizuta Seiji Tsunada Ryuichi Iwakiri Junichi Nojiri Masanobu Mizuguchi Sho Kudo Kohji Miyazaki Kazuma Fujimoto | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 12 | Preparation and Characterization of an Optically- Detectable Hydrogen Gas Sensor Consisting of Pd/WO3 Thin Films显示文摘 | Yong-su Oh Junichi Huamgami Yuichi Watanabe Masasuke Takata | 1993 | Sensors and Actuators B1993，1314，： | 1 |
| 13 | Pathological complete response of locally advanced gastric cancer after four courses of neoadjuvant chemotherapy with paclitaxel plus cisplatin: report of a case显示文摘 | Takafumi Watanabe Takaki Yoshikawa Yoichi Kameda Toru Aoyama Tsutomu Hayashi Takashi Ogata Haruhiko Cho Akira Tsuburaya Satoshi Morita Yumi Miyashita Junichi Sakamoto | 2012 | Surgery Today2012，，10： | 1 |
| 14 | Cloning and characterization of heat shock protein DnaJ homologues from Plasmodium falciparum and comparison with ring infected erythrocyte surface antigen显示文摘 | Junichi Watanabe | 1997 | Moleculer and biochemical parasitology1997，88，1997： | 1 |
| 15 | Association between coronary spastic angina pectoris and obstructive sleep apnea显示文摘 | Akira Tamura Yoshiyuki Kawano Shinichi Ando Toru Watanabe Junichi Kadota | 2010 | Journal of Cardiology2010，，2： | 1 |
| 16 | Fatigue properties of (100)/(001) and (111) oriented Pb(Zr,Ti)O3 thin film capaeitors显示文摘 | Mitsuteru Mushiga Junichi Watanabe | 2001 | Japan Journal of Applied Physics2001，41，11： | 1 |
| 17 | The CFD application for efficient designing in the automotive engineering显示文摘 | Norihiko Watanabe Shinya Miyamoto Masayuki Kuba Junichi Nakanishi | 2003 | SAE2003，，： | 1 |
| 18 | Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters显示文摘 | Yuji Iimuro Toru Kashiwagi Junichi Yamanaka Tadamichi Hirano Shinichi Saito Takaaki Sugimoto Shinichiro Watanabe Nobukazu Kuroda Toshihiro Okada Yasukane Asano Naoki Uyama Jiro Fujimoto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 19 | Surgical approach for hepatitis C virus-related hepatocellular carcinoma显示文摘Hepatitis C is a strong prognostic factor for patients with hepatocellular carcinoma(HCC). Although liver resection and liver transplantation offer the chance of a cure for HCC,adequate management of co-existing infection with hepatitis C virus(HCV) is important to enable better long-term outcomes after surgery for HCV-related HCC. For patients undergoing liver resection,perioperative anti-viral treatment is recommended,since a decreased HCV viral load itself is reportedly associated with a lower tumor recurrence rate and a longer overall survival. For patients undergoing transplanatations for HCC complicated by end-stage liver disease,the post-transplant management of HCV infection is also necessary to prevent progressive graft injury caused by active hepatitis under the immunosuppressive condition that is needed after liver transplantation. Although only a few lines of solid evidence are available for postoperative antiviral treatment because of the limited indication and frequent adverse events caused by conventional high-dose combination interferon therapy,new direct acting anti-viral agents would enable interferon-free anti-viral treatment with a higher virologic response and minimal side effects. | Junichi Shindoh Masaji Hashimoto Goro Watanabe | 2015 | World Journal of Hepatology2015，7，1： | 1 |
| 20 | SJWD14090900000816显示文摘 | Naoyoshi Nagata Kayo Sakamoto Tomohiro Arai Ryota Niikura Takuro Shimbo Masafumi Shinozaki Tomonori Aoki Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Mitsuhiko | 2014 | Cancer2014，，10： | 1 |
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