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| 1 | Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis显示文摘AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS: Fifteen patients in HCV-group developedIPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients ≥ 55 years (P < 0.001); (2) patients who had smoking index (package per day × year) of ≥ 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042). CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients. | Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada | 2008 | World Journal of Gastroenterology2008，14，38： | 8 |
| 2 | Gastrointestinal stromal tumor presenting with prominent calcification显示文摘We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism. | Naoki Izawa Takeshi Sawada Ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh | 2012 | World Journal of Gastroenterology2012，18，39： | 2 |
| 3 | Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from Lake Tai, Hangzhou Bay and Shanghai city region, China显示文摘 | Haruhiko Nakata Yuko Hirakawa Masahiro Kawazoe Tetsuji Nakabo Koji Arizono Shin-Ichi Abe Takeshi Kitano Hideaki Shimada Izumi Watanabe Weihua Li Xucheng Ding | 2004 | Environmental Pollution2004，，3： | 2 |
| 4 | Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases显示文摘 | Akuta Norio Suzuki Fumitaka Arase Yasuji Hirakawa Miharu Kawamura Yusuke Yatsuji Hiromi Sezaki Hitomi Suzuki Yoshiyuki Hosaka Tetsuya Kobayashi Masahiro Kobayashi Mariko Saitoh Satoshi Ikeda Kenji Kumada Hiromitsu | 2010 | Intervirology2010，，3： | 1 |
| 5 | Sustained virological response reduces incidence of onset of type 2 diabetes in chronic hepatitis C显示文摘 | Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Kenji Ikeda Hiromitsu Kumada | 2009 | Hepatology2009，，3： | 1 |
| 6 | Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Masahiro Hirakawa Hiroyuki Ohnuma Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koichi Okamoto Hisashi Takeuchi Junji Kato | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 7 | Rho-Kinase Inhibition With Intracoronary Fasudil Prevents Myocardial Ische- mia in Patients With Coronary Microvascular Spasm显示文摘 | Masahiro Mohri Hiroaki Shimokawa Yoji Hirakawa | 2003 | JACC2003，41，1： | 1 |
| 8 | Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy显示文摘 | Yoshihisa Ohta Tadashi Nariai Kenji Ishii Kiichi Ishiwata Masahiro Mishina Michio Senda Kimiyoshi Hirakawa Kikuo Ohno | 2008 | Annals of Nuclear Medicine2008，，： | 1 |
| 9 | Rho-Ki- nase Inhibition With Intraeoronary Fasudil Prevents Myocardial Ischemia in Patients With Coronary Mierovaseular Spasm显示文摘 | Masahiro Mohri Hiroaki Shimokawa Yoji Hirakawa | 2003 | JACC2003，41，1： | 1 |
| 10 | Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from Lake Tai, nangzhou Bay and Shanghai city region, China显示文摘 | Haruhiko Nakata Yuko Hirakawa Masahiro Kawazoe | 2005 | Environmental Pollution2005，133，3： | 1 |
| 11 | Concentrations and compositions of organochlorine contaminants in sediments, soils, crustaceans, fishes and birds collected from Lake Tai, Hangzhou Bay and Shanghai city region, China 显示文摘 | Haruhiko Nakata Yuko Hirakawa Masahiro Kawazoe | 2005 | Environmental Pollution2005，133，3： | 1 |
| 12 | Formation of singlet molecular oxygen associated with the formation of superoxide radicals in aqueous suspensions of TiO 2 photocatalysts显示文摘 | Toshihiro Daimon Tsutomu Hirakawa Masahiro Kitazawa Junya Suetake Yoshio Nosaka | 2008 | Applied Catalysis A, General2008，，2： | 1 |
| 13 | Anti-ischemic Effects of Fasudil, a Specific Rho-Kinase Inhibitor, in Patients With Stable Effort Angina显示文摘 | Yoshihiro Fukumoto Masahiro Mohri Kosuke Inokuchi Akira Ito Yoji Hirakawa Akihiro Masumoto Yoshitaka Hirooka Akira Takeshita Hiroaki Shimokawa | 2007 | Journal of Cardiovascular Pharmacology2007，，3： | 1 |
| 14 | A Phase 1/2 Study of Definitive Chemoradiation Therapy Using Docetaxel, Nedaplatin, and 5-Fluorouracil (DNF-R) for Esophageal Cancer显示文摘 | Hiroyuki Ohnuma Yasushi Sato Masahiro Hirakawa Yutaka Okagawa Takahiro Osuga Tsuyoshi Hayashi Tsutomu Sato Koji Miyanishi Masayoshi Kobune Rishu Takimoto Tamotsu Sagawa Masakazu Hori Masanori Someya Kensei Nakata Koh-ichi Sakata Tetsuji Takayama Junji Kat | 2015 | International Journal of Radiation Oncology, Biol2015，，2： | 1 |
| 15 | The diameter of the inferior vena cava provides a noninvasive way of calculating central venous pressure in neonates显示文摘 | Yoshiaki Sato Motoyoshi Kawataki Akihiro Hirakawa Katsuaki Toyoshima Taichi Kato Yasufumi Itani Masahiro Hayakawa | 2013 | Acta Paediatr2013，，6： | 1 |
| 16 | More efficient induction of genotoxicity by high-LET Fe-particle radiation than low-LET X-ray radiation at low doses显示文摘Objective:To understand differential effects on induction of genotoxicity and genomic instability(GI)by high-LET particle radiation and low-LET photon radiation,based on ground-based experiments using total body irradiation(TBI)of mice with Fe-particle radiation and X-ray radiation.Methods:TBI was delivered to C57BL/6J Jms strain female mice of 8 weeks old at a dose ranging from 0.1 to 3.0 Gy of Fe-particle radiation or at a dose ranging from 0.1 to 5.0 Gy of X-ray radiation.Induction of genotoxicity and GI by TBI was determined respectively at 1 and 2 months after exposure using frequency of micronuclei in bone marrow erythrocytes as the endpoint.Inhibition of bone marrow cell proliferation by TBI was measured as reduced erythropoiesis.Physiological conditions were also investigated.Results:TBI,regardless of the type of radiation,caused statistically significant increase in genotoxicity at 1 month after exposure,but did not induce GI at 2 months after exposure even at higher doses(>1.0 Gy).The doseresponse curve for the frequency of micronucleated polychromatic erythrocytes induced by Fe-particle radiation and X-ray radiation was y=0.7798 t 1.7889x–0.5978x^(2)(R^(2)=0.8109)and y=0.7421 t 1.3792x–0.2588 x^(2)(R^(2)=0.8081),respectively.The dose-response curve for the frequency of micronucleated normochromatic erythrocytes induced by Fe-particle radiation and X-ray radiation was y=0.7191 t 1.4545x–0.4978x^(2)(R^(2)=0.7047)and y=0.658 t 1.344x–0.2531x^(2)(R^(2)=0.7853),respectively.In general,high-LET Fe-particle radiation was more efficient in inducing genotoxicity than low-LET X-ray radiation at lower doses(<0.5 Gy).Conclusions:These results further confirm that exposure to TBI,even at higher doses and regardless the type of radiation,does not induce GI in C57BL/6J strain mice measured as increased micronuclei in bone marrow erythrocytes.These findings indicate that radiation-induced GI is mouse strain dependent and suggest that more comprehensive studies should be done to explore the late health consequences from exposure to high-LET radiation at low doses. | Bing Wang Takanori Katsube Kaoru Tanaka Yasuharu Ninomiya Hirokazu Hirakawa Cuihua Liu Kouichi Maruyama Masahiro Murakami Tetsuo Nakajima Akira Fujimori Mitsuru Nenoi | 2023 | Radiation Medicine and Protection2023，4，1： | 0 |
| 17 | Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature显示文摘BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 gene.However,the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries.Herein,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese family.CASE SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric cancer.After genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric mucosa.Genetic analysis revealed a CDH1 c.1679C>G variant in all three patients.CONCLUSION It is important for individuals suspected of having HDGC to be actively offered genetics evaluation.This report will contribute to an increased awareness of HDGC. | Masahiro Hirakawa Kohichi Takada Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki Ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa Akihiro Sakurai Junji Kato | 2020 | World Journal of Gastroenterology2020，26，42： | 0 |
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