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| 1 | Management of gastric and duodenal neuroendocrine tumors显示文摘Gastrointestinal neuroendocrine tumors(GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs(G-NETs) and duodenal NETs(D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type?Ⅰ, Ⅱ, and Ⅲ. Type?Ⅰ?G-NETs, which are the most common subtype(70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type Ⅱ G-NETs(5%-6%) are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome(MEN1-ZES). Both type?Ⅰ?and Ⅱ G-NETs are related to hypergastrinemia, are small in size, occur in multiple numbers, and are generally benign. In contrast, type Ⅲ G-NETs(10%-15%) are not associated with hypergastrinemia, are large-sized single tumors, and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type Ⅲ G-NETs, while endoscopic resection and followup, which are acceptable for the treatment of most type?Ⅰ?and Ⅱ G-NETs, are only acceptable for small and well differentiated type Ⅲ G-NETs. D-NETs include gastrinomas(50%-60%), somatostatin-producing tumors(15%), nonfunctional serotonin-containing tumors(20%), poorly differentiated neuroendocrine carcinomas(< 3%), and gangliocytic paragangliomas(< 2%). Most D-NETs are located in the first or second part of the duodenum, with 20% occurring in the periampullary region. Therapy for D-NETs is based on tumor size, location, histological grade, stage, and tumor type. While endoscopic resection may be considered for small nonfunctional D-NETs(G1) located in the higher papilla region, surgical resection is necessary for most other D-NETs. However, there is no consensus regarding the ideal treatment of D-NETs. | Yuichi Sato Satoru Hashimoto Ken-ichi Mizuno Manabu Takeuchi Shuji Terai | 2016 | World Journal of Gastroenterology2016，22，30： | 10 |
| 2 | Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment显示文摘Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience. | Hiroki Sato Manabu Takeuchi Satoru Hashimoto Ken-ichi Mizuno Koichi Furukawa Akito Sato Junji Yokoyama Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，12： | 3 |
| 3 | Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers显示文摘AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 patients.Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group.Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD.Endoscopic images just after ESD,on day 8,and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers.The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups.RESULTS The shrinking rates of ESD ulcers on day 8 [vonoprazangroup: 61.8%(range: 24.0%-91.1%),lansoprazole group: 71.3%(range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3%(range: 76.2%-100%),lansoprazole group: 97.2%(range: 81.1%-99.8%)] were not statistically different between the 2 groups.On day 28,most of the ulcers in both groups healed to more than 90%,whereas 3 of 14(21.4%) in the vonoprazan group and 1 of 12(8.3%) in the lansoprazole group had delayed ulcer healing,which was not statistically different(P = 0.356).The frequency of delayed bleeding was 0 in the both groups.Taken together,there were no significant differences between the two drug groups.CONCLUSION Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective. | Kazuya Takahashi Yuichi Sato Junji Kohisa Jun Watanabe Hiroki Sato Kenichi Mizuno Satoru Hashimoto Shuji Terai | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 3 |
| 4 | Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Katsutoshi Tokushige Keiko Shiratori | 2009 | Journal of Gastroenterology2009，，19： | 3 |
| 5 | The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection显示文摘 | Satoru Hashimoto Masaaki Kobayashi Manabu Takeuchi Yuichi Sato Rintaro Narisawa Yutaka Aoyagi | 2011 | Gastrointestinal Endoscopy2011，，6： | 3 |
| 6 | Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis显示文摘AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue samples.RESULTS In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo E.CONCLUSION Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs. | Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao Hayashi Yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，13： | 2 |
| 7 | Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C显示文摘 | Katsutoshi Tokushige Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Keiko Shiratori | 2010 | Journal of Gastroenterology2010，，9： | 2 |
| 8 | Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Katsutoshi Tokushige Keiko Shiratori | 2009 | Journal of Gastroenterology2009，，19： | 2 |
| 9 | Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Etsuko Hashimoto Satoru Yatsuji Maki Tobari Makiko Taniai Nobuyuki Torii Katsutoshi Tokushige Keiko Shiratori | 2009 | Journal of Gastroenterology2009，，19： | 1 |
| 10 | Analysis of cell characterization using cell surface markers in the dermis显示文摘 | Yuichi Hasebe Seiji Hasegawa Noriko Hashimoto Masashi Toyoda Kenji Matsumoto Akihiro Umezawa Akiko Yagami Kayoko Matsunaga Hiroshi Mizutani Satoru Nakata Hirohiko Akamatsu | 2011 | Journal of Dermatological Science2011，，2： | 1 |
| 11 | Endoscopic ultrasound-guided fine-needle aspiration for diagnosing a rare extraluminal duodenal gastrointestinal tumor显示文摘Duodenal gastrointestinal stromal tumors(GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography(EUS) and fine-needle aspiration(FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan. EUS showed a well-defined hypoechoic mass in the pancreatic uncus that connected to the duodenal proper muscular layer and was followed by endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA). Histological examination showed spindle-shaped tumor cells positively stained for c-kit. Based on these findings, the tumor was finally diagnosed as a duodenal GIST of the extraluminal type, and the patient underwent successful mass resection with partial resection of the duodenum. This case suggests that EUS and EUS-FNA are effective for diagnosing the extraluminal type of duodenal GISTs, which is difficult to differentiate from pancreatic head tumor, and for performing the correct surgical procedure. | Kazunao Hayashi Kenya Kamimura Kazunori Hosaka Satoshi Ikarashi Junji Kohisa Kazuya Takahashi Kentaro Tominaga Kenichi Mizuno Satoru Hashimoto Junji Yokoyama Satoshi Yamagiwa Kazuyasu Takizawa Toshifumi Wakai Hajime Umezu Shuji Terai | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，12： | 1 |
| 12 | High Twist expression is involved in infiltrative endometrial cancer and affects patient survival显示文摘 | Satoru Kyo Junko Sakaguchi Satoshi Ohno Yasunari Mizumoto Yoshiko Maida Manabu Hashimoto Mitsuhiro Nakamura Masahiro Takakura Miki Nakajima Kenkichi Masutomi Masaki Inoue | 2006 | Human Pathology2006，，4： | 1 |
| 13 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 14 | Diagnosing autoimmune hepatitis in nonalcoholic fatty liver disease: is the International Autoimmune Hepatitis Group scoring system useful?显示文摘 | Satoru Yatsuji Etsuko Hashimoto Hiroyuki Kaneda Makiko Taniai Katsutoshi Tokushige Keiko Shiratori | 2005 | Journal of Gastroenterology2005，，12： | 1 |
| 15 | Nonalcoholic steatohepatitis: cirrhosis, hepatocellular carcinoma, and burnt-out NASH显示文摘 | Yoko Yoshioka Etsuko Hashimoto Satoru Yatsuji Hiroyuki Kaneda Makiko Taniai Katsutoshi Tokushige Keiko Shiratori | 2004 | Journal of Gastroenterology2004，，12： | 1 |
| 16 | Stromal cell derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis显示文摘 | Hideyasu Sakihama Taro Masunaga Kenichiro Yamashita Taku Hashimoto Manabu Inobe Satoru Todo | 2004 | Circulation2004，110，： | 1 |
| 17 | The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection显示文摘 | Satoru Hashimoto Masaaki Kobayashi Manabu Takeuchi Yuichi Sato Rintaro Narisawa Yutaka Aoyagi | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 18 | Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury显示文摘 | Masayuki Shibasaki Mika Sasaki Mayumi Miura Keiko Mizukoshi Hiroshi Ueno Satoru Hashimoto Yoshifumi Tanaka Fumimasa Amaya | 2010 | Pain2010，，3： | 1 |
| 19 | Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib:A case report显示文摘BACKGROUND Concomitant ulcerative colitis (UC) and idiopathic thrombocytopenic purpura(ITP) is a rare phenomenon. The management of UC with ITP can be challenging,since a decreased platelet count augments UC.CASE SUMMARY A 24-year-old man with UC and steroid-resistant ITP experienced UC flare.Although continuous infusion of cyclosporine was initiated, UC did not improve.The administration of tofacitinib subsequently led to the induction of remission.The patient has maintained remission of UC and ITP for over one year ontofacitinib treatment. Whole transcriptomic sequencing was performed forinflamed rectal mucosae obtained before and after the initiation of Janus kinase(JAK) inhibitor, suggesting that distinct molecular signatures seemed to beregulated by JAK inhibitors and other conventional therapies including tumornecrosis factor lockers.CONCLUSION Tofacitinib should be considered in refractory cases of UC with ITP. | Yoriaki Komeda Toshiharu Sakurai Arito Hashimoto Tomoyuki Nagai Satoru Hagiwara Masatoshi Kudo Kazuko Sakai Kazuto Nishio Yasuyoshi Morita Itaru Matsumura | 2020 | World Journal of Clinical Cases2020，8，24： | 1 |
| 20 | Diagnosing autoimmune hepatitis in nonalcoholic fatty liver disease: is the International Autoimmune Hepatitis Group scoring system useful?显示文摘 | Satoru Yatsuji Etsuko Hashimoto Hiroyuki Kaneda Makiko Taniai Katsutoshi Tokushige Keiko Shiratori | 2005 | Journal of Gastroenterology2005，，12： | 1 |
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