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| 1 | Materials evolution of bone plates for internal fixation of bone fractures:A review显示文摘Bone plates play a vital role in bone fracture healing by providing the necessary mechanical fixation for fracture fragments through modulating biomechanical microenvironment adjacent to the fracture site.Good treatment effect has been achieved for fixation of bone fracture with conventional bone plates,which are made of stainless steel or titanium alloy.However,several limitations still exist with traditional bone plates including loosening and stress shielding due to significant difference in modulus between metal material and bone tissue that impairs optimal fracture healing.Additionally,due to demographic changes and non-physiological loading,the population suffering from refractory fractures,such as osteoporosis fractures and comminuted fractures,is increasing,which imposes a big challenge to traditional bone plates developed for normal bone fracture repair.Therefore,optimal fracture treatment with adequate fixation implants in terms of materials and design relevant to special conditions is desirable.In this review,the complex physiological process of bone healing is introduced,followed by reviewing the development of implant design and biomaterials for bone plates.Finally,we discuss recent development of hybrid bone plates that contains bioactive elements or factors for fracture healing enhancement as a promising direction.This includes biodegradable Mg-based alloy used for designing bone screw-plates that has been proven to be beneficial for fracture healing,an innovative development that attracts more and more attention.This paper also indicates that the tantalum bone plates with porous structure are also emerging as a new fracture internal fixation implants.The reduction of the stress shielding is verified to be useful to accelerate bone fracture healing.Potential application of biodegradable metals may also avoid a second operation for implant removal.Further developments in biometals and their design for orthopedic bone plates are expected to improve the treatment of bone fracture,especially the refractory fractures. | Junlei Li Ling Qin Ke Yang Zhijie Ma Yongxuan Wang Liangliang Cheng Dewei Zhao | 2020 | Journal of Materials Science & Technology2020，36，1： | 5 |
| 2 | 儿童福利机构中的类家庭养育显示文摘创设类家庭养育模式
类家庭养育与传统机构养育的不同
类家庭养育模式在很多方面的优势对幼童的健康成长是至关重要的。从结构角度来看,家庭由相对较小的团体构成,尤其是相对少的儿童。如果孩子不止一个,那么不同年龄、性别、或者有特殊需要的儿童都住在一起。 | Robert B.McCall Christina J.Groark Junlei Li 曾凡林 | 2009 | 社会福利(实务版)2009，，12： | 3 |
| 3 | Multi-example feature-constrained back-projection method for image super-resolution显示文摘Example-based super-resolution algorithms,which predict unknown high-resolution image information using a relationship model learnt from known high- and low-resolution image pairs, have attracted considerable interest in the field of image processing. In this paper, we propose a multi-example feature-constrained back-projection method for image super-resolution. Firstly, we take advantage of a feature-constrained polynomial interpolation method to enlarge the low-resolution image. Next, we consider low-frequency images of different resolutions to provide an example pair. Then, we use adaptive k NN search to find similar patches in the low-resolution image for every image patch in the high-resolution low-frequency image, leading to a regression model between similar patches to be learnt. The learnt model is applied to the low-resolution high-frequency image to produce high-resolution high-frequency information. An iterative back-projection algorithm is used as the final step to determine the final high-resolution image.Experimental results demonstrate that our method improves the visual quality of the high-resolution image. | Junlei Zhang Dianguang Gai Xin Zhang Xuemei Li | 2017 | Computational Visual Media2017，3，1： | 2 |
| 4 | Microstructure design of C/C composites through electrochemical corrosion for brazing to Nb显示文摘Surface structure of C/C composites has been regulated through electrochemical corrosion at room temperature to modify the residual stress and improve the joining strength when brazed to Nb.The unique crevice corrosion in C/C composites is investigated to reveal the change of corrosion depth and fiber size.The interlacing zone of carbon fiber reinforced brazing alloy replaces the reaction layer in the original joint.Joining area is increased dramatically and the continuous crack will be hindered.The interlacing zone eliminates the stress concentration and relieves the residual stress through reducing the property mismatch.All advantages contribute to the joining quality of C/C–Nb.Shear strength of C/C–Nb joint with 80μm depth reached 37.7 MPa,which was 1.2 times higher than that of original joint.Surface structure design of C/C composites not only expands the application in structure component,but also exhibits the promising application in energy field. | Jin Ba Xu Ji Bin Wang Peixin Li Jinghuang Lin Jian Cao Junlei Qi | 2022 | Journal of Materials Science & Technology2022，，9： | 2 |
| 5 | Porous tantalum-composited gelatin nanoparticles hydrogel integrated with mesenchymal stem cell-derived endothelial cells to construct vascularized tissue in vivo显示文摘The ideal scaffold material of angiogenesis should have mechanical strength and provide appropriate physiological microporous structures to mimic the extracellular matrix environment.In this study,we constructed an integrated three-dimensional scaffold material using porous tantalum(pTa),gelatin nanoparticles(GNPs)hydrogel,and seeded with bone marrow mesenchymal stem cells(BMSCs)-derived endothelial cells(ECs)for vascular tissue engineering.The characteristics and biocompatibility of pTa and GNPs hydrogel were evaluated by mechanical testing,scanning electron microscopy,cell counting kit,and live-cell assay.The BMSCs-derived ECs were identified by flow cytometry and angiogenesis assay.BMSCs-derived ECs were seeded on the pTa-GNPs hydrogel scaffold and implanted subcutaneously in nude mice.Four weeks after the operation,the scaffold material was evaluated by histomorphology.The superior biocompatible ability of pTa-GNPs hydrogel scaffold was observed.Our in vivo results suggested that 28 days after implantation,the formation of the stable capillary-like network in scaffold material could be promoted significantly.The novel,integrated pTa-GNPs hydrogel scaffold is biocompatible with the host,and exhibits biomechanical and angiogenic properties.Moreover,combined with BMSCs-derived ECs,it could construct vascular engineered tissue in vivo.This study may provide a basis for applying pTa in bone regeneration and autologous BMSCs in tissue-engineered vascular grafts. | Zhenhua Zhao Mang Wang Fei Shao Ge Liu Junlei Li Xiaowei Wei Xiuzhi Zhang Jiahui Yang Fang Cao Qiushi Wang Huanan Wang Dewei Zhao | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 6 | Atomic-scale structural and chemical evolution of Li3V2(PO4)3 cathode cycled at high voltage window显示文摘Here,by using atomically resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we investigate the structural and chemical evolution of Li3V2(PO4)3 (LVP) upon the high-voltage window (3.0-4.8 V).We find that the valence of vanadium gradually increases towards the core corresponding to the formation of electrochemically inactive Li3-xV2(PO4)3 (L3-xVP) phases.These Li-deficient phases exhibit structure distortion with superstructure stripes,likely caused by the migration of the vanadium,which can slow down the lithium ion diffusion or even block the diffusion channels.Such kinetic limitations lead to the formation of Li-deficient phase along with capacity loss.Thus,the LVP continuously losses of electrochemical activity and Li-deficient phases gradually grow from the particle core towards the surface during cycling.After 500 cycles,the thickness of active LVP layer decreases to be - 5-20 nm.Moreover,the micromorphology and chemical composition of solid electrolyte interphase (SEI) have been investigated,indicating the thick SEI film also contributes to the capacity loss.The present work reveals the structural and chemical evolution in the cycled electrode materials at an atomic scale,which is essential to understand the voltage fading and capacity decaying of LVP cathode. | Shulin Chen Jian Zou Yuehui Li Ning Li Mei Wu Jinghuang Lin Jingmin Zhang Jian Cao Jicai Feng Xiaobin Niu Jianming Bai Junlei Qi Peng Gao Liping Wang Hong Li | 2019 | Nano Research2019，12，7： | 1 |
| 7 | The calculation ofsimilarity and its application in data mining 显示文摘 | Teng Shaohua Li Junlei Li Rigui | 2014 | LectureNotes in Computer Science2014，8351，： | 1 |
| 8 | Functionalization of bismuth sulfide nanomaterials for their application in cancer theranostics显示文摘Multifunctional bismuth sulfide(Bi_(2)S_(3))nanomate rials exhibit significant potential as na no medicines for the diagnosis and treatment of cancer.These nanomaterials act as excellent photothermal agents and radiation sensitizers for the treatment of tumors,and they can also act as contrast agents for computed tomography(CT)imaging,photoacoustic imaging(PA),and other forms of imaging to provide real-time tumor monitoring and testing guidance.Compared with other nanomaterials,Bi2S3 nanomaterials can readily adapt to different applications by virtue of the fact that they can be easily functionalized.However,these nanomaterials have some limitations that cannot be ignored and need to be addressed,such as poor biocompatibility,toxicity,and low chemical stability.It is widely believed that appropriate functionalization of Bi_(2)S_(3) nanomaterials could remedy such defects and significantly improve performance.This review summarizes the ways in which Bi_(2)S_(3) nanomaterials can be functionalized and discusses their applications in cancer theranostics over the last few years,focusing particularly on imaging and therapy.We also discuss issues relating to how Bi_(2)S_(3) nanomaterials can be analyzed,including how we might be able to use these systems to inhibit and treat tumors and how current limitations might be ove rcome to improve treatment efficacy.Finally,we hope to provide inspiration and guidance as to how we might create a mo re optimized multifunctio nal nano-system for the diagnosis and treatment of tumors. | Hui Wang Junlei Yang Penghui Cao Ning Guo Yuhao Li Yuefeng Zhao Shuang Zhou Ruizhuo Ouyang Yuqing Miao | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 9 | A retrospective analysis of mature T-and NK-cell lymphomas显示文摘Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according to a US report~1. | Junlei Jia Xiaohui Wang Zheng Song Shen Meng Yue Fei Jingwei Yu Xia Liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qiani Shiyong Zhou Wenchen Gong Bin Meng Xiubao Ren Xianhuo Wang Huilai Zhang | 2024 | Cancer Biology & Medicine2024，21，3： | 0 |
| 10 | Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7显示文摘Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1. | Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 11 | Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation显示文摘Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages.However,high elastic modulus can cause stress shielding and lead to bone embrittlement.This study used an electron beam melting method to prepare personalized porous Ti6Al4V(pTi)bone plates.Then,chemical vapor deposition(CVD)technology coats tantalum(Ta)metal on the pTi bone plates.The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone,and no stress shielding occurred.In vitro experiments showed that compared with pTi plates,Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold.To better evaluate the function of the Ta-coated bone plate,animal experiments were conducted using a coat tibia fracture model.Our results showed that the Ta-coated bone plate could effectively fix the fracture.Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation.Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone.Therefore,this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications. | Baoyi Liu Zhijie Ma Junlei Li Hui Xie Xiaowei Wei Benjie Wang Simiao Tian Jiahui Yang Lei Yang Liangliang Cheng Lu Li Dewei Zhao | 2022 | Bioactive Materials2022，7，4： | 0 |
| 12 | Residual stress distribution as a function of depth in graphite/copper brazing joints via X-ray diffraction显示文摘The residual stress distributions as a function of depth in three different graphite/copper brazing joints:with no interlayer,with a copper interlayer and with a niobium interlayer are measured via X-ray diffraction by transmission geometry.The residual stress in all the joints is found to be generally compressive and increasing from the surface to the interface.Copper and niobium interlayers are both effective in alleviating the residual stress in the joint and the stress value in the joint with a niobium interlayer appearing to be the lowest.The strength of the joint is demonstrated to be closely related to the residual stress and the fracture position of the joint corresponds well with the highest residual stress. | Chun Li Xiaoqing Si Jian Cao Junlei Qi Zhibo Dong Jicai Feng | 2019 | Journal of Materials Science & Technology2019，35，11： | 0 |
| 13 | Antibodies against ribosomal protein S29(RPS29)fused with glutathione's transferase specially react with native RPS29 in mouse and human cells显示文摘也作为 RPS29 知道的 ribosomal 蛋白质 S29,是核糖体的 40S 子单元的一个部件不仅,而且在胚胎的开发, oncogenesis 和另外的病理学的条件包含了。然而,对 RPS29 的稀罕商业抗体限制这蛋白质的精确生理、病理学的功能的发现。在这研究,整个 RPS29 基因被插入到 plasmid pGEX-6p-1 表示谷胱甘肽的 transferase (GST ) 在 Escherichia coli 的熔化蛋白质(E。coli ) 紧张 BL21。可溶的 recombinant 蛋白质的高收益被获得。老鼠与 recombinant RPS29 蛋白质被使免疫。从使免疫的老鼠的浆液能特殊由西方的弄污, immunofluorescence 染色和流动 cytometric 分析在 CCE 房间与净化的 recombinant RPS29 蛋白质和本国的 RPS29 蛋白质反应。进一步更 polyclonal 抗体也与人的房间紧张 ECV304 明确地反应了,它显示出典型 cytoplasmatic 荧光。我们准备了的 polyclonal 抗体将是为在胚胎的开发和人的疾病学习 RPS29 的角色的一个可得到的工具。 | Liu Jia Han Junfeng Li Dongying Jian Rui Rao XianCai Chen Wei Wang Jiali Xu Xiaofeng Hu Zhen Zhang Junlei | 2011 | Journal of Medical Colleges of PLA(China)2011，26，1： | 0 |
| 14 | Silver particle interlayer with high dislocation density for improving the joining of BaZr_(0.1)Ce_(0.7)Y_(0.1)Yb_(0.1)O_(3-δ) electrolyte and AISI 441 interconnect显示文摘One of the critical challenges for the protonic ceramic fuel cell stack is sealing electrolytes and interconnects.However,the traditional AgeCuO sealant will aggravate the oxidation along the interconnect surface and result in brittle compound layers at the BaZr_(0.1)Ce_(0.7)Y_(0.1)Yb_(0.1)O_(3-δ)(BZCYYb)electrolyte interface.The present work demonstrates that a silver particle interlayer with high dislocation density can be adopted to join BZCYYb electrolyte to the interconnect(AISI 441 stainless)in air instead of traditional AgeCuO sealant.Elevating temperatures result in a sufficient bonding at the Ag/BZCYYb interface,and a defect-free joint is obtained at 950℃.Atomic bonding at Ag/BZCYYb interface is confirmed by TEM.Also,a dense and thin oxide layer(2-3 μm)is formed along the AISI 441 interface.Ag particles in the interlayer provide the main driving force for the sintering joining.The massive dislocations promote the recovery and recrystallization of the Ag interlayer,as well as the interdiffusion of BZCYYb/Ag.After aging in the wet oxidizing atmosphere at 600℃ for 300 h,joints remain intact and dense,indicating superior oxidation resistance and aging performance.Besides,the joint shear strength(25.3 MPa)is 59%higher than that of the joint brazed by traditional AgeCuO. | Xiaoyang Wang Chun Li Qihan Zhou Mingshen Li Mushi Zheng Junlei Qi Xiaoqing Si Jian Cao | 2022 | Journal of Materiomics2022，8，5： | 0 |
| 15 | Evaluation of the performance of Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating on biodegradable high-purity magnesium in a femoral condyle defect model in rabbits显示文摘The two most critical factors in promoting the clinical translation of magnesium(Mg)are reducing its degradation rate and improving its osteogenesis.In this study,a Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating was prepared on high-purity magnesium(HP Mg)rods by fluorination and hydrothermal treatment.Scanning electron microscope showed that the thickness of the bilayer coating was 3.78 lm and that the surface morphology was nanoscale.In an in vivo experiment on femoral condyle defects in rabbits,the serum magnesium ion levels of rabbits were always in the normal range after surgery,and the liver and kidney functions were not abnormal,which indicated that the CDHA/MgF_(2)bilayer coating has good biosafety.Micro-CT showed that the CDHA/MgF_(2)bilayer coating significantly reduced the degradation rate of the HP Mg rods and enhanced the promotion of bone formation.Hard tissue sections showed that the CDHA/MgF_(2)bilayer coating gave the bone tissue a tight contact interface with the HP Mg rod and improved the bone mass.Immunohistochemistry showed that the expression of vascular endothelial growth factor and BMP-2 was more obvious.These results confirm that the CDHA/MgF_(2)bilayer coating can improve the properties of HP Mg and provide a basis for the further transformation of HP Mg in the future.It also provides a new reference for the surface modification of magnesiummetal. | Shibo Huang Junlei Li Kairong Qin Zhiqiang Wang Jiahui Yang Fang Cao Weirong Li Yupeng Liu Lipeng Liu Dewei Zhao | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 16 | Single-cell transcriptome atlas reveals spatiotemporal developmental trajectories in the basal roots of moso bamboo (Phyllostachys edulis)显示文摘Roots are essential for plant growth and development.Bamboo is a large Poaceae perennial with 1642 species worldwide.However,little is known about the transcriptional atlas that underpins root cell-type differentiation.Here,we set up a modified protocol for protoplast preparation and report single-cell transcriptomes of 14279 filtered single cells derived from the basal root tips of moso bamboo.We identified four cell types and defined new cell-type-specific marker genes for the basal root.We reconstructed the developmental trajectories of the root cap,epidermis,and ground tissues and elucidated critical factors regulating cell fate determination.According to in situ hybridization and pseudotime trajectory analysis,the root cap and epidermis originated from a common initial cell lineage,revealing the particularity of bamboo basal root development.We further identified key regulatory factors for the differentiation of these cells and indicated divergent root developmental pathways between moso bamboo and rice.Additionally,PheWOX13a and PheWOX13b ectopically expressed in Arabidopsis inhibited primary root and lateral root growth and regulated the growth and development of the root cap,which was different from WOX13 orthologs in Arabidopsis.Taken together,our results offer an important resource for investigating the mechanism of root cell differentiation and root system architecture in perennial woody species of Bambusoideae. | Zhanchao Cheng Changhong Mu Xiangyu Li Wenlong Cheng Miaomiao Cai Chongyang Wu Jutang Jiang Hui Fang Yucong Bai Huifang Zheng Ruiman Geng Junlei Xu Yali Xie Yuping Dou Juan Li Shaohua Mu Jian Gao | 2023 | Horticulture Research2023，10，8： | 0 |
| 17 | Gut-on-a-chip for exploring the transport mechanism of Hg(II)显示文摘Animal models and static cultures of intestinal epithelial cells are commonly used platforms for exploring mercury ion(Hg(II))transport.However,they cannot reliably simulate the human intestinal microenvironment and monitor cellular physiology in situ;thus,the mechanism of Hg(II)transport in the human intestine is still unclear.Here,a gut-on-a-chip integrated with transepithelial electrical resistance(TEER)sensors and electrochemical sensors is proposed for dynamically simulating the formation of the physical intestinal barrier and monitoring the transport and absorption of Hg(II)in situ.The cellular microenvironment was recreated by applying fluid shear stress(0.02 dyne/cm^(2))and cyclic mechanical strain(1%,0.15 Hz).Hg(II)absorption and physical damage to cells were simultaneously monitored by electrochemical and TEER sensors when intestinal epithelial cells were exposed to different concentrations of Hg(II)mixed in culture medium.Hg(II)absorption increased by 23.59%when tensile strain increased from 1%to 5%,and the corresponding expression of Piezo1 and DMT1 on the cell surface was upregulated. | Li Wang Junlei Han Weiguang Su Anqing Li Wenxian Zhang Huimin Li Huili Hu Wei Song Chonghai Xu Jun Chen | 2023 | Microsystems & Nanoengineering2023，9，1： | 0 |
| 18 | Two-dimensional NMR inversion based on fast norm smoothing method显示文摘Two-dimensional(2D)nuclear magnetic resonance(NMR)inversion operates with massive echo train data and is an ill-posed problem.It is very important to select a suitable inversion method for the 2D NMR data processing.In this study,we propose a fast,robust,and effective method for 2D NMR inversion that improves the computational efficiency of the inversion process by avoiding estimation of some unneeded regularization parameters.Firstly,a method that combines window averaging(WA)and singular value decomposition(SVD)is used to compress the echo train data and obtain the singular values of the kernel matrix.Subsequently,an optimum regularization parameter in a fast manner using the signal-to-noise ratio(SNR)of the echo train data and the maximum singular value of the kernel matrix are determined.Finally,we use the Butler-Reeds-Dawson(BRD)method and the selected optimum regularization parameter to invert the compressed data to achieve a fast 2D NMR inversion.The numerical simulation results indicate that the proposed method not only achieves satisfactory 2D NMR spectra rapidly from the echo train data of different SNRs but also is insensitive to the number of the final compressed data points. | Youlong Zou Jun Li Song Hu Junlei Su Mi Liu Jun Zhang | 2022 | Energy Geoscience2022，3，1： | 0 |
| 19 | Research progress and clinical translation of three-dimensional printed porous tantalum in orthopaedics显示文摘With continuous developments in additive manufacturing technology, tantalum (Ta) metal has been manufactured into orthopaedic implants with a variety of forms, properties and uses by three-dimensional printing. Based on extensive research in recent years, the design, processing and performance aspects of this new orthopaedic implant material have been greatly improved. Besides the bionic porous structure and mechanical characteristics that are similar to human bone tissue, porous tantalum is considered to be a viable bone repair material due to its outstanding corrosion resistance, biocompatibility, bone integration and bone conductivity. Numerous in vitro, in vivo, and clinical studies have been carried out in order to analyse the safety and efficacy of these implants in orthopaedic applications. This study reviews the most recent advances in manufacturing, characteristics and clinical application of porous tantalum materials. | Jiawei Ying Haiyu Yu Liangliang Cheng Junlei Li Bin Wu Liqun Song Pinqiao Yi Haiyao Wang Lingpeng Liu Dewei Zhao | 2023 | Biomaterials Translational2023，4，3： | 0 |
| 20 | Synergetic treatment of oxygen microcapsules and lenvatinib for enhanced therapy of HCC by alleviating hypoxia condition and activating anti-tumor immunity显示文摘Hypoxia is a typical characteristic of hepatocellular carcinoma(HCC), which causes tremendous obstacles to tumor treatments. Current first-line treatment may further deteriorate tumor hypoxia. For example,Lenvatinib, a receptor tyrosine kinase inhibitor(RTKI), suppresses tumor growth via blocking vascular endothelial growth factor(VEGF) signaling, and can also inhibit angiogenesis, thus limiting oxygen supply to tumor sites. Therefore, alleviating tumor microenvironment(TME) hypoxia holds great potential for enhancing the therapeutic effect of RTKI. Here, nanoparticle-stabilized oxygen microcapsules, a stable and biocompatible oxygen-loaded delivery system, are successfully prepared through interfacial polymerization of polydopamine nanoparticles. The microcapsules with a large loading capacity of oxygen in the core show excellent bioavailability and dispersity, which could effectively improve the hypoxic TME when they serve as oxygen delivery vehicles. Synergetic treatments of Lenvatinib and oxygen microcapsules could induce the transition of “cold tumor” in an immune-suppressed state to “hot tumor” in an immune-activated state by improving tumor hypoxic TME and reducing angiogenesis in HCC. It is revealed that combined treatments of oxygen microcapsules and Lenvatinib could polarize tumor-associated macrophages(TAMs) to anti-tumor M1 cells and activate T cell-mediated anti-tumor immune responses.The results suggest that synergetic therapy using oxygen microcapsules and Lenvatinib could alleviate the hypoxic TME and enhance the therapeutic performance of RTKI, demonstrating a promising anti-tumor strategy for enhanced therapy of HCC. | Jianpeng Sheng Jiangchao Wu Xianghong Yin Zhu Sun Xun Wang Junlei Zhang Jianghui Tang Yongtao Ji Jinyuan Song Xiaobao Wei Lin Wang Yaxing Zhao Hui Zhang Taohong Li Qi Zhang Xueli Bai Li Chen Dong Chen Tingbo Liang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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