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| 1 | Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion显示文摘(MALAT1 ) 联系转移的肺腺癌抄本 1 被建议是一长(7 kb ) 非编码的 RNA。MALAT1 是在许多人的癌的 overexpressed,但是它的功能仍然保持未知。在人的颈的癌症前进调查 MALAT1 的角色,我们设计了并且使用了短发卡 RNA 在 CaSki 房间禁止 MALAT1 表示并且在房间增长和侵略上验证了它的效果。在基因表示的变化被反向的 transcriptasepolymerase 链反应分析。我们的数据证明 MALAT1 通过基因表示的规定涉及颈的癌症房间生长,房间周期前进,和侵略,例如 caspase-3, -8, Bax, Bcl-2,和 Bcl-xL,建议 MALAT1 能有在颈的癌症生物学的重要含意。我们的调查结果在颈的癌症前进说明 MALAT1 的生物意义并且提供 MALAT1 可以在人的颈的癌症的预防作为一个治疗学的目标服务的新奇证据。 | Fengjie Guo Yalin Li Yan Liu Jiajia Wang Yuehui Li Guancheng Li | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 89 |
| 2 | Optimal proportion of wind and PV capacity in provincial power systems based on bilevel optimization algorithm under low-carbon economy显示文摘In order to boost contributions of power systems to a low-carbon economy,the installed capacity of renewable power generation,such as wind and photovoltaic(PV)power generation should be well planned.A bilevel formulation is presented to optimize the proportion of wind and PV capacity in provincial power systems,in which,carbon emissions of generator units and features of renewable resources are taken into account.In the lowerlevel formulation,a time-sequence production simulation(TSPS)model that is suitable for actual power system has been adopted.In order to maximize benefits of energy conservation and emissions reduction resulting from renewable power generation,the commercial software called General Algebraic Modeling System(GAMS)is employed to optimize the annual operation of the power system.In the upper-level formulation,the optimal pattern search(OPS)algorithm is utilized to optimize the proportion of wind and PV capacity.The objective of the upper-level formulation is to maximize benefits of energy conservation and carbon emissions reductions optimized in the lowerlevel problem.Simulation results in practical provincial power systems validate the proposed model and corresponding solving algorithms.The optimization results can provide support to policy makers to make the polices related to renewable energy. | Yue YUAN Yang CAO Xinsong ZHANG Chun LIU Yuehui HUANG Peng LI Kejun QIAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，1： | 11 |
| 3 | Differentiation potential of bone marrow mesenchymal stem cells in duck显示文摘The bone marrow mesenchymal stem cells(MSCs) are multipotent stem cells which can differentiate into mesenchymal cells in vitro.In this study,MSCs in duck were isolated from bone marrow by density gradient centrifuge separation,purified and expanded in the me-dium.The primary MSCs were expanded for 11 passages.The different-passage MSCs were induced to differentiate into osteoblasts and neuron-like cells.Karyotype analysis indicated that MSCs kept diploid condition and the hereditary feature was stable.The different-passage MSCs expressed CD44,ICAM-1 and SSEA-4,but not CD34,CD45 and SSEA-1 when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 2,6 and 8(P > 0.05),but a significant difference existed among those of passages 2,6,8 and 11(P < 0.05).After the osteogenic inducement was added,the induced different-passage MSCs expressed high-level alkaline phosphatase(ALP),and are positive for tetracycline staining,Alizarin Red staining and Von Kossa staining.After the neural inducement was added,about 70% cells exhibited typical neuron-like phenotype,the induced different-passage MSCs expressed Nestin,neuron-specific enolase(NSE) and glial fibrillary acidic protein(GFAP) when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 3,4 and 6(P>0.05),but a significant difference existed among those of passages 3,4,6 and 8(P<0.05).These results suggest that MSCs in duck were capable of differentiating into osteoblasts and neuron-like cells in vitro. | Linfeng Li Xiujuan Bai Xuelian Gong Hongkun Liu Lina Chen Weijun Guan Yuehui Ma | 2009 | Journal of Genetics and Genomics2009，36，3： | 8 |
| 4 | A COMPUTERIZED SYSTEM FOR ANALYSING CHAOTIC CHARACTERISTICS OF HEART PERIOD SIGNAL显示文摘ACOMPUTERIZEDSYSTEMFORANALYSINGCHAOTICCHARACTERISTICSOFHEARTPERIODSIGNALACOMPUTERIZEDSYSTEMFORANALYSINGCHAOTICCHARACTERISTICS... | Xu Ziaohong Xie Zhengxiang Chen Liangchi Li Zenggao Yin Yuehui(Dept. BME, Chongqing University of Medical Sciences,Chongqing, 630046, China) | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，3： | 7 |
| 5 | Angiotensin Ⅱ upregulates fibroblastmyofibroblast transition through Cx43- dependent CaMKⅡ and TGF-β1 signaling in neonatal rat cardiac fibroblasts显示文摘 | Li Cao Yunlin Chen Li Lu Yihao Liu Yaowen Wang Jinqi Fan Yuehui Yin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 6 |
| 6 | A 23 GHz high-temperature superconducting microstrip filter for radio astronomy显示文摘This paper reports a 6-pole high-temperature superconducting (HTS) microstrip bandpass filter for radio astronomy applications. The filter has a center frequency of 23 GHz and a bandwidth the 2 GHz. We have made many efforts, such as adopting 0.25-mm-thick substrate, carefully designing the housing box and filter layout, to solve the problems in realizing a K-band planar filter. A special straight-line half-wavelength resonator (center-widen resonator) was also designed to reduce the insertion loss of the filter. The measured results showed a midband insertion loss of 0.11 dB with a ripple of 0.4 dB, and a return loss better than 11.5 dB. Good agreement was obtained between simulated and measured results. | GAO Lu GUO Jin WANG YueHui YU Tao ZHANG Qiang LI ChunGuang ZHANG XueQiang LI Hong LI JunJie LI WuXia GU ChangZhi MENG JiBao FENG Ji HE YuSheng | 2009 | Chinese Science Bulletin2009，54，19： | 6 |
| 7 | Brassinosteroid Signaling Recruits Histone 3 Lysine-27 Demethylation Activity to FLOWERING LOCUS C Chromatin to Inhibit the Floral Transition in Arabidopsis显示文摘类固醇荷尔蒙 brassinosteroid (BR ) 在工厂生长和开发起一个宽广作用。当在 BR 感觉迟钝、 BR 缺乏的异种的延迟的生长在天内引起强壮的延期到 flowering,发信号的 BR 被认为在 Arabidopsis 支持花的转变。在这研究,用 flowering 时间的一项发展措施,我们证明发信号的 BR 禁止花的转变并且在 Arabidopsis 就职哥伦比亚和 Enkheim-2 支持植物的生长。我们发现发信号的 BR 支持有势力的表示花的抑压者 FLOWERING 地点 C (FLC ) 和三 FLC 禁止 flowering 的相当或相同的事物。面对 BR ,抄写因素 BRASSINAZOLE-RESISTANT1 ( BZR1 )和 交往BES1 象MYC一样蛋白质( BIM ),明确地绑?在 FLC 的第一 intron 的一个BR-应答的元素?并且进一步的成员 histone 3 离氨酸 27 ( H3K27 )到 downregulate 的 demethylase 压抑的 H3K27 trimethylation 铺平在 FLC 标记并且因此反对 Polycomb silencing ,导致它的激活。一起拿,我们的调查结果证明发信号的 BR 由 BR 信号是进 FLC 激活和作为结果的花的压抑的 transduced 的新奇分子的在机制在 Arabidopsis 禁止花的转变。 | Zicong Li Yang Ou Zhicheng Zhang Jianming Li Yuehui He | 2018 | Molecular Plant2018，11，9： | 5 |
| 8 | Effects of Forest Roads on Habitat Pattern for Sables in Da Hinggan Mountains, Northeasten China显示文摘The anthropogenic managements of forest have created a network of roads resulting in the loss and alternation of habitat. To better understand road′s impact on animal habitats, we assessed the habitat pattern of sables(Martes zibellina), one of rodents within national first-class protected species, when roads are considered in Huzhong area in Da Hinggan Mountains, northeastern China. Employing published literatures about behavior ecology, aerial photographs and forest stand maps, we classified the study area into three habitat types including best-suitable, suitable and unsuitable habitats based on sable habitat requirements at the landscape scale including four variables derived from forest source map with attribute database. Results indicated the loss and significant fragmentation of best-suitable habitat and home range habitat when roads, especially 150 m avoidance distance of roads, were considered. The roads reduced and fragmented highly suitable habitats more significantly during earlier development period than the later development period. Additionally, the suitable area percentage increased with increasing distance to roads. This study helped to identify the suitable area for sables and location of sable population. Also, this study suggested the passage construction and road management involving road closure and removal will reduce the fragmentation functionally and benefit the sable population. | LI Yuehui WU Wen XIONG Zaiping HU Yuanman CHANG Yu XIAO Duning | 2014 | Chinese Geographical Science2014，24，5： | 4 |
| 9 | The role of MALAT1 correlates with HPV in cervical cancer显示文摘 | Yan Jiang Yuehui Li Shujuan Fang Binyuan Jiang Changfei Qin Pingli Xie Guohua Zhou Guancheng Li | 2014 | Oncology Letters2014，，6： | 3 |
| 10 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 11 | Thermo-Calc based multi-component micro-segregation model and solidification paths calculations显示文摘On the basis of a multi-length scale modeling, a mixture-averaged multi-component /multiphase micro-segregation model was proposed without pre-set function for the micro-scale solute profile. The model explains the effect of morphologies of solidifying phases and solid back diffusion (SBD) on segregation, and covers the two limiting solidification cases of Scheil and Lever-rule models. A commercial Thermo-Calc software package/database was linked to the algorithms via its TQ6-interface for instantaneous determination of the related thermodynamic data of the multi-component alloys. The influences of cooling rate and other parameters on the solidification path and micro-segregation behavior were numerically investigated by sample calculation of the ternary Al-Cu-Mg alloys. A parallel experimental investigation on Al-Cu-Si alloys solidified under different cooling conditions was conducted to validate the theoretical model. Reasonable agreements were gained between the predicted solidification paths and the measured results. | Zhao Guangwei Li XinZhong Xu Daming Guo Jingjie Fu Hengzhi Du Yong He Yuehui | 2012 | China Foundry2012，9，3： | 3 |
| 12 | Simultaneous Optimization of Renewable Energy and Energy Storage Capacity with the Hierarchical Control显示文摘To fully consider the complementary role of different energy sources and reduce the curtailment of renewable energy(RE)in high RE penetration systems,a hierarchical optimization algorithm is proposed to simultaneously optimize the capacity of RE generation and energy storage systems(ESS).Time sequence simulation(TSS)technology is adopted to fully consider the regional RE resource characteristics and make the model more reliable.An optimization model for evaluating ESS capacity is established at a lower level.To overcome the high dimensional complexity of time sequence data,this paper re-formulates this sub-model as a consensus problem,which can be solved by a distributed approach to minimize the system’s total investment costs.At the upper level,the model for assessing the proportion of wind and solar capacity is developed by maximizing the RE generation.The golden section Fibonacci tree optimization(GSFTO)algorithm is utilized to improve the efficiency and solution accuracy.The results show that the algorithm and model are feasible and applicable for the identified purposes,which can provide a useful guidance for the development of power generation and the energy storage capacity in high RE penetration systems. | Zhaodi Shi Weisheng Wang Yuehui Huang Pai Li Ling Dong | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 3 |
| 13 | Intensification of the East Asian Monsoon in Southern China at about300-400 kaBP Inferred from Eolian Deposits in the Middle-lower Reaches of the Yangtze River显示文摘In the East Asian monsoon region,eolian deposits widely distributed in the middle-lower reaches of the Yantgze River are among the best materials available for studies on Quaternary climate change in the subtropical zone of Southern China.Typical eolian deposits in this region include upper Xiashu Loess(XL) and underlying Vermiculated Red Soil(VRS) layers.In this paper,chronological and paleoclimatic studies are conducted on an eolian deposit sequence near Jiujiang(JJ) city in northern Jiangxi province.A magnetostratigraphic study,combined with optically stimulated luminescence(OSL) dating,is conducted on the JJ section and provides further evidence that eolian deposits in the middle-lower reaches of the Yangtze River have been formed since the late Early Pleistocene,and that the boundary age between the XL and VRS layers is about 300-400 kaBP.In grain-size records of the JJ section,the median grain-size and content of the >30 μm size fraction increase sharply after 300-400 kaBP,representing an East Asian winter monsoon intensification event.Further pollen analysis reveals differing pollen assemblages before and after 300-400 kaBP:there is an evident increase in plants adapted to grow in a warm humid environment after 300-400 kaBP,implying an increase in precipitation caused by intensification of the East Asian summer monsoon.Global ice volume and uplift of the Tibet Plateau(TP) are regarded as crucial factors influencing variations of the East Asian monsoon on a long-term scale.The deep-sea δ^(18)O record,which reflects variations in global ice volume,shows no obvious change after 300-400 kaBP.Moreover,the influence of global ice volume changes on the East Asian summer and winter monsoons is inverse;the global ice volume increase(decrease) implies a strengthened(weakened) winter monsoon and weakened(strengthened) summer monsoon.We therefore interpret the coupled intensifications of the East Asian summer and winter monsoons at about 300-400 kaBP to the uplift of the TP in the Middle Pleistocene.This climate event is also documented in eolian deposits from the southern margin of the Chinese Loess Plateau(CLP) and from the desert-loess transitional belt.However,it is not recorded in the loess-paleosol sequences from the central part of the CLP,thereby indicating differing climate responses to TP uplift in different regions,which requires further study. | QI Lin QIAO Yansong LI Yuehui WANG Yan PENG Shasha HE Zexin YANG Shuaibin HAN Chao ZHANG Xujiao | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 3 |
| 14 | Physicochemical bases for protein folding,dynamics,and protein-ligand binding显示文摘Proteins are essential parts of living organisms and participate in virtually every process within cells.As the genomic sequences for increasing number of organisms are completed,research into how proteins can perform such a variety of functions has become much more intensive because the value of the genomic sequences relies on the accuracy of understanding the encoded gene products.Although the static three-dimensional structures of many proteins are known,the functions of proteins are ultimately governed by their dynamic characteristics,including the folding process,conformational fluctuations,molecular motions,and protein-ligand interactions.In this review,the physicochemical principles underlying these dynamic processes are discussed in depth based on the free energy landscape(FEL)theory.Questions of why and how proteins fold into their native conformational states,why proteins are inherently dynamic,and how their dynamic personalities govern protein functions are answered.This paper will contribute to the understanding of structure-function relationship of proteins in the post-genome era of life science research. | LI HuiMin XIE YueHui LIU CiQuan LIU ShuQun | 2014 | Science China(Life Sciences)2014，57，3： | 2 |
| 15 | High-efficient generation algorithm for large random active shield显示文摘Dear editor,Security integrated circuits play important roles in trusted platform modules[1],embedded devices,etc.However,invasive attacks[2]are serious threats on such circuits.Active shield is regard('d as an effective method against invasive attacks.Active shield is a mesh of dense metal wires covering the surface of an integrated circuit(IC)[3].The security level of IC increases with the geometric difficulty of the mesh.The active shield proposed in[4,5]has a complex geonietry based on random Hamiltonian path.Given this randomness,it is difficult to recognize the geometry of the shield.However,the available generation algorithms are agonizingly slow. | Ruishan XIN Yidong YUAN Jiaji HE Yuehui LI Yiqiang ZHAO | 2019 | Science China(Information Sciences)2019，62，3： | 2 |
| 16 | Review on Effects of Sunlight on the Internal Quality of Peach Fruit显示文摘On the basis of referring plenty of literatures, we summed up the research advance in effects of sun light on the internal quality of peach fruit. This paper discussed the effect of light on the internal quality of peach fruit under the conditions of open cultivation, protected cultivation, bagging and surface covering with reflective film, the mechanism of occurrence and the technical measures to improve the utilization rate of light and light energy, and prospected the future research work. | Zhisheng MA Yuehui WANG Ruixia BAI Jianming LI Yunyun JIA | 2021 | Agricultural Biotechnology2021，10，1： | 2 |
| 17 | LncRNA H19 inhibits oxidative stress injury of cochlear hair cells by regulating miR-653-5p/SIRT1 axis显示文摘Oxidative stress is one of the important mechanisms of inner ear cell damage,which can lead to age-related hearing loss(ARHL).LncRNA H19 is significantly downregulated in the cochlea of old mouse,however,the role of H19 in the development of ARHL remains unclear.In this study,we aim to investigate the expression and function of H19 in oxidative stress injury of cochlear hair cells induced by H_(2)O_(2).RT-qPCR and western blot analysis confirms that HEI-OC1 cells stimulated with H_(2)O_(2) decreases the expressions of H19 and SIRT1,but increases the expression of miR-653-5p.Overexpression of H19 could increase cell viability,ATP level and mitochondrial membrane potential,but reduce mitochondrial ROS generation and cell apoptosis ratio in H2O2-stimulated HEI-OC1 cells.MiR-653-5p is a target of H19,which can bind to the 3'-UTR of SIRT1.H19 is found to regulate the expression of SIRT1 through miR-653-5p.Further experiments demonstrates that H19 regulates HEI-OC1 cell viability,ATP level,mitochondrial membrane potential,mitochondrial ROS generation,and cell apoptosis ratio via the miR-653-5p/SIRT1 axis.In conclusion,lncRNA H19 inhibits oxidative stress injury of cochlear hair cells via the miR-653-5p/SIRT1 axis. | Wen Xie Ting Shu Haisen Peng Jiali Liu Chunhua Li Meiqun Wang Ping Wu Yuehui Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 2 |
| 18 | Whole-genome sequencing reveals selection signals among Chinese,Pakistani,and Nepalese goats显示文摘The goat(Capra hircus)is one of the oldest domesticated animal species,with archeological evidence indicating that its earliest domestication from the wild ancestor(bezoar)occurred in the Fertile Crescent 10,000 calibrated calendar years ago(Zeder and Hesse,2000).A variety of well-adapted goat breeds with excellent economic traits have been selected artificially and naturally for human needs in China,Pakistan,and Nepal.For example,cashmere goat breeds produce fine cashmere wool and are mainly distributed on the Himalayan Plateau(e.g.,Nepal and Tibet)and in cold northern China(e.g.,Inner Mongolia and Liaoning).The Toggenburg dairy goat is the most productive breed of dairy goat and is distributed in at least 50 countries on all continents(Ferro et al.,2017).Pakistani ewes are reared mostly for meat and wool purposes,but some are used as dairy goats,such as the Bugi Toori goat and Pateri goat(Bilal et al.,2018).Additionally,indigenous goats of the southern Asian regions are well adapted to the local hot environment.Their unique traits and biodiversity serve as genetic resources that can be used for the artificial breeding of goats.Recently,several studies have provided patterns of genome-wide characteristics in goat populations to explore the underlying genetic basis of trait formation and environmental adaptability in China(Zhang et al.,2018),Pakistan(Kumar et al.,2018),and Nepal(Sasazaki et al.,2021),respectively.However,due to the proximity of these geographic regions,the profiles of genetic differences,gene flow,and common genes related to high trait performance between goat populations from China,Pakistan,and Nepal remain unclear. | Yefang Li Ying Gong Zhengkai Zhang Ling Li Xuexue Liu Xiaohong He Qianjun Zhao Yabin Pu Yuehui Ma Lin Jiang | 2023 | Journal of Genetics and Genomics2023，50，5： | 2 |
| 19 | Atomic-scale structural and chemical evolution of Li3V2(PO4)3 cathode cycled at high voltage window显示文摘Here,by using atomically resolved scanning transmission electron microscopy and electron energy loss spectroscopy,we investigate the structural and chemical evolution of Li3V2(PO4)3 (LVP) upon the high-voltage window (3.0-4.8 V).We find that the valence of vanadium gradually increases towards the core corresponding to the formation of electrochemically inactive Li3-xV2(PO4)3 (L3-xVP) phases.These Li-deficient phases exhibit structure distortion with superstructure stripes,likely caused by the migration of the vanadium,which can slow down the lithium ion diffusion or even block the diffusion channels.Such kinetic limitations lead to the formation of Li-deficient phase along with capacity loss.Thus,the LVP continuously losses of electrochemical activity and Li-deficient phases gradually grow from the particle core towards the surface during cycling.After 500 cycles,the thickness of active LVP layer decreases to be - 5-20 nm.Moreover,the micromorphology and chemical composition of solid electrolyte interphase (SEI) have been investigated,indicating the thick SEI film also contributes to the capacity loss.The present work reveals the structural and chemical evolution in the cycled electrode materials at an atomic scale,which is essential to understand the voltage fading and capacity decaying of LVP cathode. | Shulin Chen Jian Zou Yuehui Li Ning Li Mei Wu Jinghuang Lin Jingmin Zhang Jian Cao Jicai Feng Xiaobin Niu Jianming Bai Junlei Qi Peng Gao Liping Wang Hong Li | 2019 | Nano Research2019，12，7： | 1 |
| 20 | Radiofrequency Ablation Versus Antiarrhythmic Medication for Treatment of Ventricular Premature Beats From the Right Ventricular Outflow Tract: Prospective Randomized Study显示文摘 | Zhiyu Ling Zengzhang Liu Li Su Vadim Zipunnikov Jinjin Wu Huaan Du Kamsang Woo Shaojie Chen Bin Zhong Xianbin Lan Jinqi Fan Yanping Xu Weijie Chen Yuehui Yin Saman Nazarian Bernhard Zrenner | 2014 | Circulation: Arrhythmia and Electrophysiology2014，，2： | 1 |
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