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| 1 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 2 | The radioactive abnormality characteristics of typical regions in Ordos Basin and its geological implications显示文摘There are many results of single mineral enrichment characteristic, such as oil, gas, coal and uranium, but little is known about the synergistic research of these important minerals and the study of uranium enrichment features in the deep basin. So, the study on the paragenesis regularity and coexisting relation of many minerals in the basin will promote the integrated forecast and cooperative exploitation of the basin. Based on the plentiful logging data and geological data, this paper studies the distributing feature of higher Gamma abnormality. The analysis on 33 core samples' test results indicates that the increasing of Gamma abnormality is due to the increasing of the uranium element, and the enrichment of uranium is a result of the activation and conglomeration of uranium. On the basis of the recognization of radioactive abnormality and the study about the reality of oil,gas,coal or uranium coexisting in a basin and its mechanism, the paper shows that there is a certain mutual promotion in oil, gas, coal and uranium in the basin, which provides an important theory basis for cooperative exploitation of energy resources. | TAN ChengQian LIU ChiYang ZHAO JunLong ZHANG RongRong | 2007 | Science China Earth Sciences2007，50，z2： | 6 |
| 3 | Parametric modeling of hypersonic ballistic data based on time varying auto-regressive model显示文摘For describing target motion in hypersonic vehicle defense,a parametric analyzing and modeling method on ballistic data is proposed based on time varying auto-regressive method.Ballistic data are regarded as non-stationary random signal,where the hidden internal law is studied.Firstly,ballistic data are decomposed into smooth linear trend signal and non-stationary periodic skip signal with ensemble empirical mode decomposition method to avoid mutual interference between different modal data.Secondly,the linear trend signal and the periodic skip signal are modeled separately.The linear trend signal is approximated by power function regressive estimator and the periodic skip signal is modeled based on time varying auto-regressive method.In order to determine optimal model orders,a novel method is presented based on information theoretic criteria and the criteria of minimizing the mean absolute error.Finally,the consistency test is conducted by investigating the time-frequency spectrum characteristics and statistical properties of outputs of the parametric model established above and dynamics model under the same initial condition.Simulation results demonstrate that the parametric model established by the proposed method shares a high consistency with the original dynamics model. | HU YuDong LI JunLong ZHANG Zhao JING WuXing GAO ChangSheng | 2020 | Science China(Technological Sciences)2020，63，8： | 3 |
| 4 | Structural variation during dog domestication: insights from gray wolf and dhole genomes显示文摘Several processes like phenotypic evolution, disease susceptibility and environmental adaptations, which fashion the domestication of animals, are largely attributable to structural variations(SVs) in the genome.Here, we present high-quality draft genomes of the gray wolf(Canis lupus) and dhole(Cuon alpinus) with scaffold N50 of 6.04 Mb and 3.96 Mb, respectively. Sequence alignment comprising genomes of three canid species reveals SVs specific to the dog, particularly 16 315 insertions, 2565 deletions, 443 repeats, 16 inversions and 15 translocations. Functional annotation of the dog SVs associated with genes indicates their enrichments in energy metabolisms, neurological processes and immune systems. Interestingly, we identify and verify at population level an insertion fully covering a copy of the AKR1 B1(Aldo-Keto Reductase Family 1 Member B) transcript. Transcriptome analysis reveals a high level of expression of the new AKR1 B1 copy in the small intestine and liver, implying an increase in de novo fatty acid synthesis and antioxidant ability in dog compared to gray wolf, likely in response to dietary shifts during the agricultural revolution. For the first time, we report a comprehensive analysis of the evolutionary dynamics of SVs during the domestication step of dogs. Our findings demonstrate that retroposition can birth new genes to facilitate domestication, and affirm the importance of large-scale genomic variants in domestication studies. | Guo-Dong Wang Xiu-Juan Shao Bing Bai Junlong Wang Xiaobo Wang Xue Cao Yan-Hu Liu Xuan Wang Ting-Ting Yin Shao-Jie Zhang Yan Lu Zechong Wang Lu Wang Wenming Zhao Bing Zhang Jue Ruan Ya-Ping Zhang | 2019 | National Science Review2019，6，1： | 3 |
| 5 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 6 | Twelve years' experience and clinical results of using the radial artery for coronary revascularization显示文摘 | Cheng Zhaoyun Zhao Ziniu Quan Xiaoqiang Wang Sheng Zhao Jian Sun Junjie Hu Junlong Gao Chuanyu Song Yongping | 2014 | Chinese Medical Journal2014，，5： | 1 |
| 7 | Structure and antioxidant activities of sulfated guar gum: Homogeneous reaction using DMAP/DCC catalyst显示文摘 | Junlong Wang Baotang Zhao Xiaofang Wang | 2012 | International Journal of Biological Macromolecules2012，50，： | 1 |
| 8 | Structural features and hypoglycaemic effects of Cynomorium songaricum polysaccharides on STZ-induced rats显示文摘 | Junlong Wanga Ji Zhang Baotang Zhao | 2010 | Carbohydrate Polymers2010，120，： | 1 |
| 9 | Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro显示文摘 | WANG Junlong ZHAO Baotang WANG Xiaofang | | 0，，： | 1 |
| 10 | Structural features and hypoglycaemic effects of Cynomorium songaricum polysaccharides on STZ - induced rats 显示文摘 | Junlong Wang Ji Zhang Baotang Zhao | 2010 | Food Chemistry2010，120，2： | 1 |
| 11 | In-situ synthesis and microstructure of TiC–Fe36Ni composite coatings by reactive detonation-gun spraying显示文摘 | JingLei Zhu JiHua Huang HaiTao Wang JunLong Xu XingKe Zhao Hua Zhang | 2007 | Materials Letters2007，，12： | 1 |
| 12 | Synthesis of se- lenium-containing polysaccharides and evaluation of antioxidant activity in vitro显示文摘 | Junlong Wang Baotang Zhao Xiaofang Wang | 2012 | International Journal of Biological Macromolecules2012，51，： | 1 |
| 13 | Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia显示文摘Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted nitric oxide(NO)-donorβelemene derivatives were designed,withβ-elemene as the foundational compound,and subsequently synthesized to evaluate their therapeutic potential against leukemia.Notably,the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line,with a high NO release.In vivo studies indicated that compound 13d could effectively inhibit tumor growth,exhibiting no discernible toxic manifestations.Specifically,a significant tumor growth inhibition rate of 62.9%was observed in the K562 xenograft tumor mouse model.The accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia. | ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 1 |
| 14 | Acid-induced tunable white light emission based on triphenylamine derivatives显示文摘A series of triphe nylamine(TPA)derivatives with various substituent groups were prepared and showed different absorption and fluorescence characteristics due to the substituent effect.On account of the existence of pyridine units,these TPA derivatives exhibited acid-induced tunable multicolor fluorescence emission including white light emission.In addition,acid-induced fluorescence regulation of these compounds has been also realized in the solid state,which enable them to be successfully constructed the stimuli-responsive fluorescent films and fluorescent inks for inkjet printing. | Xi Liu Yi Qin Junlong Zhu Xiaoli Zhao Tanyu Cheng Yanrong Jiang Haitao Sun Lin Xu | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 15 | Study of micro-trichome (mict) reveals novel connections between transcriptional regulation of multicellular trichome development and specific metabolism in cucumber显示文摘Trichomes that cover the epidermis of aerial plant organs play multiple roles in plant protection.Compared with a unicellular trichome in model plants,the development mechanism of the multicellular trichome is largely unclear.Notably,variations in trichome development are often accompanied by defects in the biosynthesis of cuticle and secondary metabolites;however,major questions about the interactions between developmental differences in trichomes and defects in metabolic pathways remain unanswered.Here,we characterized the glabrous mutant mict/csgl1/cstbh via combined metabolomic and transcriptomic analyses to extend our limited knowledge regarding multicellular trichome development and metabolism in cucumber.Mict was found to be explicitly expressed within trichome cells.Transcriptomic analysis indicated that genes involved in flavonoid and cuticle metabolism are significantly downregulated in mict mutants.Further metabolomic analysis confirmed that flavonoids,lipids,and cuticle compositions are dramatically altered in mict mutants.Additional studies revealed that Mict regulates flavonoid,lipid,and cuticle biosynthesis by likely directly binding to downstream functional genes,such as CsTT4,CsFLS1,CsCER26,and CsMYB36.These findings suggest that specific metabolic pathways(e.g.,flavonoids and cuticle components)are co-regulated by Mict and provide insights into transcriptional regulation mechanisms of multicellular trichome development and its specific metabolism in cucumber. | Jian Pan Leyu Zhang Guanqun Chen Haifan Wen Yue Chen Hui Du Junlong Zhao Huanle He Hongli Lian Huiming Chen Jianxin Shi Run Cai Gang Wang Junsong Pan | 2021 | Horticulture Research2021，8，1： | 1 |
| 16 | Synthesis and Characterization of Novel Schiff Base Macrocyclic Compounds Containing Thiophene显示文摘 | DONG Xin LI Yuan GOU Xiaofeng ZHAO Junlong HUA Chengwen | 2014 | Chemical Research in Chinese Universities2014，30，3： | 0 |
| 17 | A study on the flowability of gas displacing water in low-permeability coal reservoir based on NMR technology显示文摘Flowability of gas and water through low-permeability coal plays crucial roles in coalbed methane(CBM)recovery from coal reservoirs.To better understand this phenomenon,experiments examining the displacement of water by gas under different displacement pressures were systematically carried out based on nuclear magnetic resonance(NMR)technology using low-permeability coal samples of medium-high coal rank from Yunnan and Guizhou,China.The results reveal that both the residual water content(W_(r))and residual water saturation(S_(r))of coal gradually decrease as the displacement pressure(P)decreases.When P is 0-2 MPa,the decline rates of W_(r) and S_(r) are fastest,beyond which they slow down gradually.Coal samples with higher permeability exhibit higher water flowability and larger decreases in W_(r) and S_(r).Compared with medium-rank coal,high-rank coal shows weaker fluidity and a higher proportion of irreducible water.The relationship between P and the cumulative displaced water content(W_(c))can be described by a Langmuir-like equation,W_(c)=WLP/(PL+P),showing an increase in W_(c) in coal with an increase in P.In the low-pressure stage from 0 to 2 MPa,W_(c) increases most rapidly,while in the high-pressure stage(P>2 MPa),W_(c) tends to be stable.The minimum pore diameter(d′)at which water can be displaced under different displacement pressures was also calibrated.The d′value decreases as P increases in a power relationship;i.e.,d′the coal gradually decreases with the gradual increase in P.Furthermore,the d′values of most of the coal samples are close to 20 nm under a P of 10 MPa. | Minfang Yang Zhaobiao Yang Bin Sun Zhengguang Zhang Honglin Liu Junlong Zhao | 2020 | Frontiers of Earth Science2020，14，4： | 0 |
| 18 | Silver nanowires for anti-counterfeiting显示文摘Silver nanowire(AgNW)films have been widely used as flexible transparent electrodes due to the high electrical conductance and high transmittance in the visible range.The infrared(IR)properties of AgNW films,however,are seldom discussed.Here,we show that ultrathin AgNWs present high transmittance in the visible range(~95%)and high reflectance(60-70%)in the IR range of 8e14 mm.Such a significant difference makes AgNW films invisible to naked eyes but visible under an IR camera,being an ideal selection for anti-counterfeit technologies,while no excitation is required.We have demonstrated that AgNW films can be spray-coated on either flat or microstructured surfaces with high conformability and high scratch-resistance,and thus these anti-counterfeiting materials can be applied to a variety of applications.The AgNW-based anti-counterfeiting may be helpful for combating counterfeiting crimes in the fields of medicines,artwork,banknotes,brand luxuries,industrial parts,and so on. | Yan Wang Ningning Bai Junlong Yang Zhiguang Liu Gang Li Minkun Cai Lingyu Zhao Yuan Zhang Jianming Zhang Chunhua Li Yunlong Zhou Chuan Fei Guo | 2020 | Journal of Materiomics2020，6，1： | 0 |
| 19 | Cellulose sub-nanometric ribbons:A new generation of nanocellulose and platform for biomaterials显示文摘With the tremendous progress of research in nanoscience,much attention has been paid to the bottom of the“nano world”:scales around one nanometer or even smaller.In order to describe materials at this scale,a new concept called“sub-nanometric material(SNM)”has emerged(Ni and Wang,2016;Ni et al.,2018). | Shaomin Kang Yang Zhao Junlong Song Huining Xiao | 2024 | Journal of Bioresources and Bioproducts2024，9，1： | 0 |
| 20 | Discussion on the paper‘A review of distributed statistical inference’显示文摘Distributed statistical inferences have attracted more and more attention in recent years with the emergence of massive data.We are grateful to the authors for the excellent review of the litera-ture in this active area.Besides the progress mentioned by the authors,we would like to discuss some additional development in this interesting area.Specifically,we focus on the balance of communication cost and the statistical efficiency of divide-and-conquer(DC)type estimators in linear discriminant analysis and hypothesis testing.It is seen that the DC approach has different behaviours in these problems,which is different from that in estimation problems.Furthermore,we discuss some issues on the statistical inferences under restricted communication budgets. | Junlong Zhao | 2022 | Statistical Theory and Related Fields2022，6，2： | 0 |
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