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| 1 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 2 | Scaling all-fiber mid-infrared supercontinuum up to 10 W-level based on thermal-spliced silica fiber and ZBLAN fiber显示文摘We demonstrate an integrated all-fiber mid-infrared(mid-IR)supercontinuum(SC)source generated by a 1.95μm master oscillator power amplifier system and a single-mode ZBLAN(ZrF_4–BaF_2–LaF_3–AlF_3–NaF)fiber.The maximum average output power is 10.67 W with spectral bandwidth covering from~1.9 to 4.1μm.The single-mode ZBLAN fiber and silica fiber are thermal-spliced to enhance the robustness and practicability of the system.It is,to the best of our knowledge,the first high-power integrated compacted all-fiber mid-IR SC source based on thermal-spliced silica fiber and ZBLAN fiber. | Zhijian Zheng Deqin Ouyang Junqing Zhao Minqiu Liu Shuangchen Ruan Peiguang Yan Jinzhang Wang | 2016 | Photonics Research2016，4，4： | 13 |
| 3 | Study on law of raw coal seepage during loading process at different gas pressures显示文摘In order to reveal the law of raw coal seepage at different gas pressures, the gravity constant load seepage experimental system was developed and used. The law of raw coal seepage at different gas pressures with He, N2 and CO2was investigated. The results show that, in a given state of stress during the experiment, with the increase of gas pressure, the permeability of raw coal sample prone to outburst exhibits a significantly decrease, and then exhibits an increasing trend when reaching the extreme point.The law of Klingberg coefficient related to the stress state and the gas adsorption properties was also obtained. Under the same experimental conditions, the Klingberg coefficient of He is greater than that of N2; and the Klingberg coefficient of CO2 has minimum value; so the stronger the gas adsorption is,the smaller the Klingberg coefficient of gas goes. Klinkenberg coefficient decreases with the increase of effective stress. Under the same conditions, the permeability of He is greater than that of N2; the permeability of CO2 has minimum value; so the stronger the gas adsorption is, the lower the permeability of the coal sample goes. The results have important significance in revealing the mechanism of gas seepage, predicting coal mine gas disaster, and gas drainage and safety production. | Meng Junqing Nie Baisheng Zhao Bi Ma Yechao | 2015 | International Journal of Mining Science and Technology2015，25，1： | 8 |
| 4 | Hepatocyte growth factor improves right ventricular remodeling in pulmonary arterial hypertensive rats via decreasing neurohormonal activation and inhibiting apoptosis显示文摘 | Wang Xiaolin Wang Yongjin Rong Shuling Ma Hongbiao Ma Qing Zhao Junqing | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 5 | Simulation of electro-slag re-melting process of 120t large ingot for nuclear power station and its application显示文摘Further research on metallic materials for the super critical rotator and the main pipe line of a nuclear power station is very important for developing the nuclear power industry. In this study, the mathematical model for 120 t large ingot was established, and the computer program ESR3D was developed to simulate the whole electro-slag re-melting (ESR) process. This includes the electrode melting, metallic droplet falling, metal pool forming, metal pool and slag pool rising and moving, installation of top crystallizer, ingot solidifying, etc. The simulated average melting rate of the electrode was in good agreement with that in practical production. The optimized parameters were used to produce 80-120 t large ingots, and the quality of the ingots satisfied the specifications of nuclear power and the super critical generating unit. | Liu Xihai Wang Junqing Jia Weiguo Gao Jianjun Zhao Lin Tang Zuobin | 2011 | China Foundry2011，8，4： | 6 |
| 6 | Effect of calycosin on left ventricular ejection fraction and angiogenesis in rat models with myocardial infarction显示文摘OBJECTIVE:To evaluated the effect of calycosin on left ventricular ejection fraction and angiogenesis.METHODS:Adult male Sprague-Dawley rats were randomly assigned into calycosin-treated groups(0.5,1,2,and 4 mg/kg qd),a dimethyl sulfoxide(DMSO),or a sham-operated control group.The myocardial ischaemia(Ml) model was intraperitoneally administered calycosin for 28 days.The survival rates and left ventricular ejection fractions(LVEF)were compared between groups.The expression levels of vascular endothelial growth factor(VEGF)and cluster of differentiation 31(CD31) in ischaemic myocardium were also measured and compared.RESULTS:The construction of MI model resulted in a LVEF reduction of 50% compared with the sham-control.After 28 days,the LVEF value was 10% higher when calycosin(4 mg/kg) was administered compared with the DMSO group.The expression of VEGF and CD31 showed a dose-dependent manner when calycosin was administrated.The calycosin-treated(4 mg/kg) group displayed a twofold increase in VEGF expression at both the mRNA and protein levels compared with the DMSO group.In addition,CD31 expression in the microvascular increased 1.5-fold in the 4 mg/kg calycosin-treated group.CONCLUSION:Calycosin improved left ventricular ejection fraction in the MI rat models,induced VEGF expression in the ischaemic myocardium,increased CD31 expression and promoted angiogenesis. | Gao Junqing Chen Tao Jin Huigen Liu Zongjun Zhao Deqiang | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 6 |
| 7 | Tunable and switchable harmonic h-shaped pulse generation in a 3.03 km ultralong mode-locked thulium-doped fiber laser显示文摘We experimentally demonstrated a type of tunable and switchable harmonic h-shaped pulse generation in a thulium-doped fiber(TDF) laser passively mode locked by using an ultralong nonlinear optical loop mirror.The total cavity length was ~3.03 km, the longest ever built for a TDF laser to our best knowledge, which resulted in an ultralarge anomalous dispersion over -200 ps^2 around the emission wavelength. The produced h-shaped pulse can operate either in a fundamental or in a high-order harmonic mode-locking(HML) state depending on pump power and intra-cavity polarization state(PS). The pulse duration, no matter of the operation state, was tunable with pump power. However, pulse breaking and self-organizing occurred, resulting in high-order HML,when the pump power increased above a threshold. At a fixed pump power, the order of HML was switchable from one to another by manipulating the PS. Switching from the 8 th up to the 48 th order of HML was achieved with a fixed pump power of ~4.15 W. Our results revealed the detailed evolution and switching characteristics of the HML and individual pulse envelope with respect to both the pump power and PS. We have also discussed in detail the mechanisms of both the h-shaped pulse generation and the switching of its HML. This contribution would be helpful for further in-depth study on the underlying dynamics of long-duration particular-envelope pulses with ultralarge anomalous dispersion and ultralong roundtrip time. | JUNQING ZHAO LEI LI LUMING ZHAO DINGYUAN TANG DEYUAN SHEN LEI SU | 2019 | Photonics Research2019，7，3： | 4 |
| 8 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 9 | Intrinsically Stretchable Organic-Tribotronic-Transistor for Tactile Sensing显示文摘Stretchable electronics are of great significance for the development of the next-generation smart interactive systems.Here,we propose an intrinsically stretchable organic tribotronic transistor(SOTT)without a top gate electrode,which is composed of a stretchable substrate,silver nanowire electrodes,semiconductor blends,and a nonpolar elastomer dielectric.The drain-source current of the SOTT can be modulated by external contact electrification with the dielectric layer.Under 0-50%stretching both parallel and perpendicular to the channel directions,the SOTT retains great output performance.After being stretched to 50%for thousands of cycles,the SOTT can survive with excellent stability.Moreover,the SOTT can be conformably attached to the human hand,which can be used for tactile signal perception in human-machine interaction and for controlling smart home devices and robots.This work has realized a stretchable tribotronic transistor as the tactile sensor for smart interaction,which has extended the application of tribotronics in the human-machine interface,wearable electronics,and robotics. | Junqing Zhao Tianzhao Bu Xiaohan Zhang Yaokun Pang Wenjian Li Zhi Zhang Guoxu Liu Zhong Lin Wang Chi Zhang | 2020 | Research2020，，1： | 4 |
| 10 | The novel gene BrMYB2,located on chromosome A07,with a short intron 1 controls the purple-head trait of Chinese cabbage(Brassica rapa L.)显示文摘Anthocyanins are important secondary metabolites in plants,but information on anthocyanin biosynthesis mechanisms in Chinese cabbage is limited.The new purple head Chinese cabbage cultivar 11S91 was analyzed,and an R2R3-MYB regulatory gene BrMYB2,located on chromosome A07,controlling the dominant purple-head trait was isolated.High expression of BrMYB2 generated a large accumulation of anthocyanins in 11S91,accompanied by highly upregulated BrTT8,BrF3′H,BrDFR1,BrANS1,BrUGTs,BrATs,and BrGSTs.11S91 inherited the purple locus from purple trait donor 95T2-5,and they shared consensus CDSs and gDNAs with those of BrMYB2(cBrMYB2 and gBrMYB2).Two SNPs in cBrMYB2 in 11S91 did not cause loss of function;in addition to several SNPs at both ends of intron 1,a large deletion had occurred in intron 1 of gBrMYB2 in 11S91.Genetic transformation of Arabidopsis showed that gBrMYB2 overexpression lines presented deeper purple color and higher expression than did the cBrMYB2 and cBrmyb2 lines,whereas gBrmyb2 with a long intron 1 did not cause the purple phenotype.We first show that BrMYB2 promotes anthocyanin biosynthesis under the control of the short intron 1 of gBrMYB2 in purple head Chinese cabbage,and gBrmyb2 with a long intron 1 represses anthocyanin production in white head Chinese cabbage.This evidence provides a new understanding of anthocyanin biosynthesis and purple germplasm generation in Brassica vegetables. | Qiong He Junqing Wu Yihua Xue Wenbin Zhao Ru Li Lugang Zhang | 2020 | Horticulture Research2020，7，1： | 4 |
| 11 | Genetic Analysis and Mapping of the Purple Gene in Purple Heading Chinese Cabbage显示文摘To analyze genetic linkage and map purple gene(Br Pur) controlling purple inner leaves trait of Chinese cabbage, a F2 population was constructed by selfing a F1 plant from homozygous purple heading line ‘14S839' and homozygous orange heading line ‘14S162'. The phenotype investigation of head color showed that the segregation ratio of purple to non-purple individuals was consistent with the expected ratio of 3:1,which indicated that purple inner leaves trait is controlled by a single dominant gene. A total of 297 SSRs in whole genome of Chinese cabbage were tested by modified Bulked Segregant Analysis(BSA) method. Two linked markers flanking Br Pur, A710 and A714, were obtained and Br Pur was mapped on linkage group A07 based on the sequence of these two markers. Subsequently, two new markers flanking Br Pur, CL-12 and B214-87, were developed based on two known anthocyanins-related genes, Br4CL3 and Bra004214. Genetic mapping of all markers in the F2 mapping population showed CL-12 and B214-87 linked to Br Pur with the genetic distance of 3.1 c M and 3.5 c M, respectively. | WU Junqing ZHAO Jing QIN Meiling REN Yanjing ZHANG Huamin DAI Zihui HAO Lingyu ZHANG Lugang | 2016 | Horticultural Plant Journal2016，2，6： | 3 |
| 12 | Biomimetic synthesis of nanovesicles for targeted drug delivery显示文摘Targeted drug delivery to the site of disease is of both fundamental and practical importance in the development of personalized and precision nanomedicine.How to design a drug carrier that can specifically deliver drugs to tumors and other cell populations has long been a formidable challenge in clinical practice.With the development of nanotechnology,increasing effort has been dedicated to exploring the application of many nanoformulations in biology and medical science,such as nanoparticles, | Zhao Lei Junqing Wang Peng Lv Gang Liu | 2018 | Science Bulletin2018，63，11： | 3 |
| 13 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
| 14 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 2 |
| 15 | Switching emissions of two tetraphenylethene derivatives with solvent vapor, mechanical, and thermal stimuli显示文摘Two derivatives of tetraphenylethene (TPE) were synthesized through one step cross McMurry coupling reaction. Both luminogens exhibit aggregation-induced emission (AIE) and crystallization induced emission enhancement (CIEE). The emissions of both luminogens could be switched between blue and green through reversible modulation of morphology with thermal, organic solvent fuming and mechanical stimuli. Thus we provide a possible design strategy for emission switching materials. | SHI JunQing ZHAO WeiJun LI CuiHong LIU ZhengPing BO ZhiShan DONG YuPing DONG YongQiang TANG Ben Zhong | 2013 | Chinese Science Bulletin2013，58，22： | 2 |
| 16 | Mechanical properties and mechanism of damage tolerance for Ti 3 SiC 2显示文摘 | Shibo Li Jianxin Xie Junqing Zhao Litong Zhang | 2002 | Materials Letters2002，，1： | 1 |
| 17 | Superior performance porous carbon nitride nanosheets for helium separation from natural gas:Insights from MD and DFT simulations显示文摘Increasing helium(He)demand in fundamental research,medical,and industrial processes necessitates efficient He purification from natural gas.However,most theoretically available membranes focus on the separation of two or three kinds of gas molecules with He and the underlying separation mechanism is not yet well understood.Using molecular dynamic(MD)and first-principle density function theory(DFT)simulations,we systematically demonstrated a novel porous carbon nitride membrane(g-C_(9)N_(7))with superior performance for He separation from natural gas.The structure of g-C_(9)N_(7) monolayer was optimized first,and the calculated cohesive energy confirmed its structural stability.Increasing temperature from 200 to 500 K,the g-C_(9)N_(7)membrane revealed high He permeability,as high as 1.48×10^(7) GPU(gas permeation unit,1 GPU=3.35×10^(-10) mol·s^(-1)·Pa^(-1)·m^(-2))at 298 K,and also exhibited high selectivity for He over other gases(Ar,N_(2),CO_(2),CH_(4),and H_(2)S).Then,the selectivity of He over Ne was found to decrease with increasing the total number of He and Ne molecules,and to increase with increasing He to Ne ratio.More interestingly,a tunable He separation performance can be achieved by introducing strain during membrane separation.Under the condition of 7.5%compressive strain,the g-C_(9)(N_(7)(membrane reached the highest He over Ne selectivity of 9.41×10^(2).It can be attributed to the low energy barrier for He,but increased energy barrier for other gases passing through the membrane,which was subject to a compressive strain.These results offer important insights into He purification using g-C_(9)N_(7)membrane and opened a promising avenue for the screening of industrial grade gas separation with strain engineering. | Zilong Liu Ge Zhao Xiao Zhang Lei Gao Junqing Chen Weichao Sun Guanggang Zhou Guiwu Lu | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 18 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | 2013 (6146)2013，，6146： | 1 |
| 19 | Evaluation of Ecological Environment Quality of Typical Forest Parks显示文摘Forest tourist areas have an excellent ecological environment,which is conducive to people's physical and mental health.In this study,Fuzhou National Forest Park and Wuying National Forest Park were selected as typical representatives of the southern and northern forest parks,respectively,which were compared by qualitative and quantitative research methods from such five aspects as air quality,climate quality,water environment quality,acoustic environment quality and biological population in some forest areas.The results showed that Fuzhou National Forest Park has a concentration of negative oxygen ions much higher than Wuying National Forest Park,and is thus more conducive to people's health;and it has the characteristics of warm and comfortable climate throughout the year and high biodiversity,but the noise is 4.35 db higher than Wuying National Forest Park,and the water quality is slightly poorer than that of Wuying National Forest Park.And its DO value is about 3.89 smaller in autumn than in summer.In Wuying National Forest Park,the concentration of negative oxygen ions is 53.6% lower than Fuzhou National Forest Park,but it is also above the national standard.The climate is only comfortable in June-August,and is colder or cooler in other months.The water quality is better than that of Fuzhou National Forest Park.In particular,the PH value is about 0.38 lower than that of Fuzhou National Forest Park.It has its own unique biological characteristics.The number of tourists in summer is higher,resulting in higher noise in summer than in autumn.The two forest parks in the north and the south are both good places for people to relax and enjoy. | Dongmei ZHANG Shuzhen PENG Weijun ZHAO Mengyuan GAO Junqing HAN | 2019 | Agricultural Biotechnology2019，8，5： | 1 |
| 20 | Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction显示文摘 | Xibao Shi Li Wang Xuewu Li Gaiping Zhang Junqing Guo Dong Zhao Shujun Chai Ruiguang Deng | 2011 | Molecular Immunology2011，，12： | 1 |
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