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| 1 | Optimal Linear Array Tradeoff for Configuration and DOF MIMO-SAR显示文摘 | WANG Libao XU Jia PENG Shibao YUAN Junquan MA Xiaoyan | 2011 | Chinese Journal of Electronics2011，20，2： | 7 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | 自然杀伤T细胞对小鼠肝癌移植瘤的抑制作用(英文)显示文摘Objective:The aim of this study was to investigate the inhibition effect of natural killer T(NKT) cells on transplantation hepatocellular carcinoma in mice.Methods:α-galactosylceramide(α-GalCer)-pulsed DC and Hep S were prepared as stimulus.Hepatoma xenograft model was established and mice were randomly divided into 4 groups(n=13 each group):(1) control group,intravenous injection of the same volume of saline.(2) mature DC group,intravenous injection of mature DC cells(4×106 cells).(3) α-GalCer-pulsed HepS group,intravenous injection of α-GalCer-pulsed HepS(4×106 cells).(4) α-GalCer-pulsed mature DC group,intravenous injection of α-GalCer-pulsed DC(4×106 cells).The changes of tumor volume in mice and survival period were measured every 2 days.Percentage of NKT cells in spleens and cytotoxicity of spleen cells were detected by flow cytometry.Tumor tissues were analyzed by histopathological examination.Results:In α-GalCer-pulsed Heps and DC groups,the average survival period was prolonged and tumor volume was markedly decreased,spleen cells and NKT cells were significantly increased,and tumor necrosis was evident,compared to the control group.Conclusion:α-GalCer-pulsed DC and HepS could activate NKT cells in vivo,also increase NKT cells cytotoxicity,inhibit the growth of hepatomas and prolong survival period. | Fuxing Chen Hongdan Zhao Nanzheng Zhang Junquan Liu Zhonghai Zhou Leiqing Sun Yu Zhou | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，5： | 3 |
| 4 | Characterization of Electroless Ni-P Deposits on Surface of AZ91D Magnesium Alloy显示文摘Characterization of electroless nickel deposits on magnesium alloys was investigated by X-ray diffraction(XRD),scanning electron microscope(SEM),energy dispersive spectrometer(EDS)and electrochemical potentiodynamic polarization analysis.The result of XRD showed that the electroless nickel deposits on magnesium alloys were composed mostly of amorphous Ni-P and partially of microcrystalline nickel.The phosphorus content in the Ni-P deposits was 10.8%by the calculation of EDS.SEM micrographs showed that morphology of electroless nickel deposits on magnesium alloys was a typical cellular structure,and the growth of cellular structure was influenced by surface condition of substrate.Zinc layer between substrate and electroless nickel deposits was not found by the results of SEM and EDS,which indicated that the zinc layer on the surface of magnesium alloy was very thin,and the zinc would dissolved while being immersed in electroless nickel plating solution.The thin zinc layer was almost dissolved completely before Ni-P plating.The result of electrochemical potentiodynamic polarization analysis showed that the corrosion potential Ecorr of electroless nickel deposits in 3.5%NaCl solution was about-0.53 V,which was 1 V higher than that of magnesium alloys substrate.And corrosion current density of Ni-P deposits in 3.5%NaCl solution was much smaller than that of magnesium alloys substrate at the same potential value,which indicated that corrosion resistance of electroless Ni-P deposits was excellent.Discoloration time of concentrated nitric acid test for electroless nickel deposits on magnesium alloys was 445 s,which also indicated excellent corrosion resistance. | Li Jiansan Guo Yanting Liu Junquan | 2012 | 稀有金属材料与工程2012，41，S1： | 3 |
| 5 | Electromotive Force Calculation of Fifteen-phase Induction Motors With Non-sinusoidal Supply显示文摘非正弦供电十五相感应电机基波磁动势正幅值与3次谐波磁动势负幅值不在同一位置时的叠加磁动势波形称为常规磁动势波形,此种情况下感应电动势的计算是该种电机电磁性能分析与优化设计的前提。与正弦磁动势或理想叠加磁动势不同,常规磁动势下电机的感应电动势与激磁电流相位因磁路饱和不再相差/2,为此提出把感应电动势作为激磁电流流控电压源的处理方法。鉴于电机每半个极下气隙磁密波形不再相同的情况,提出基于电机1个极距区域的拓展分布磁路法计算气隙磁密,进而求出基波感应电动势与3次谐波感应电动势。非正弦供电十五相感应电机样机的感应电动势计算值与实测值相互吻合,说明了拓展分布磁路法计算感应电动势有效且具有较高的准确度。 | WANG Dong WU Xinzhen GUO Yunjun CHEN Junquan | 2013 | 中国电机工程学报2013，33，9： | 3 |
| 6 | Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma显示文摘Simultaneous silencing of multiple upregulated genes is an attractive and viable treatment strat-egy for many incurable diseases including cancer.Herein we used a dual gene-targeted siRNA conjugate composed of VEGF and Survivin siRNA sequences in the same backbone to inhibit proliferation and angiogenesis in two human osteosarcoma cell lines.We synthesized siRNA sequences targeting the VEGF and Survivin genes individually (VEGF siRNA and Survivin siRNA) or simultaneously (one-chain-double-target siRNA:dual siRNA).VEGF and Survivin mRNA and protein expression levels in human osteosarcoma MG-63 and Saos-2 cells were detected by qRT- PCR and western blot analysis.VEGF and Survivin protein location and expression were evaluated by immunohistochemistry and immunofluorescence staining.MG-63 and Saos-2 cell migration,proliferation,apoptosis,and angiogenesis were detected by scratch test,MTT assay,flow cytometry,and capillary tube assay respectively.The dual siRNA induced similar downregulation of VEGF and Survivin mRNA and protein levels,compared with VEGF siRNA or Survivin siRNA alone.The dual siRNA caused greater suppression of MG-63 and Saos-2 cell migration,proliferation and angiogenesis,and promoted more cell apoptosis than VEGF siRNA or Survivin siRNA alone,suggesting that the effects of the dual siRNA on inhibiting cell proliferation,migration,and angiogenesis and promoting apoptosis were superior to those of the single-target siRNAs.Simultaneous silencing of VEGF and Survivin using the dual siRNA may be an advantageous alternative for the development of therapeutic strategies against human osteosarcoma. | Junquan Gu Zhoujing Ji Dong Li Qirong Dong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 2 |
| 7 | Economic analysis of freeway town of Yunnan显示文摘Freeway town in Yunnan is driving to promote the economic development ties. The development along the highway in the town will become the central point of the performance the high-intensive economy in space and will increase new economic growth point along highway the vertical and horizontal development of the area around the gradient the proliferation Point and Area. The highway town will develop to speed up the urbanization process and China should accelerate the development of the freeway town. Encouraging farmers will shift the highway town where some good conditions will build to form a regional economic development and growth. This will be the promotion an inevitable choice of progress and rational way of China's rural economic and social prosperity. In particular, freeway town will bring more added value of other social services of accommodation and catering industry of whole-sale and retail of transportation and warehousing. Highway town and agriculture industrialization development will increase agriculture industry chain to improve agricultural products value and will enhance agricultural eff iciency in Yunnan. The concentration of the non-agricultural industries of the speedway town will form pillar industries of highway town and will promote of tertiary industry development of hotels of insurance of f inance of business of sports of culture of education of communications of transportation. Rural areas of Yunnan will adjust to optimize the industrial structure. It is estimated that a total 10 construction of the highway town of Yunnan will increase 0.8-1 billion yuan revenue each year. | Zhao Junquan Zhang Haixiang | 2009 | Ecological Economy2009，5，1： | 2 |
| 8 | Process-based drying temperature and humidity integration control enhances drying kinetics of apricot halves显示文摘 | Dai Jianwu Rao Junquan Wang Dong | 2015 | Drying Technology2015，33，12： | 1 |
| 9 | Fabrication of high-performance pervaporation composite membrane for alkaline wastewater reclamation显示文摘Pervaporation desalination has a unique advantage to recycle concentrated salt solutions.The merit can be applied to treat alkaline wastewater if the membrane has superior alkali-resistance.In this paper,we used polyethylene microfiltration membrane as the substrate and deposited a glutaraldehyde crosslinked sodium carboxymethylcellulose layer by spray-coating.Pervaporation flux of the composite membrane reached 352 kg·m^(-2)·h^(-1) with a sodium chloride rejection of 99.9%0.1%when separating a 3.5 wt-%sodium chloride solution at 70℃.The desalination performance was stable after soaking the membrane in a 20 wt-%NaOH solution at room temperature for 9 d and in a 10 wt-%NaOH solution at 60℃ for 80 h.Moreover,the membrane was stable in 4 wt-%sulfuric acid and a 500 mg·L^(-1) sodium hypochlorite solution.In a process of concentrating a NaOH solution from 5 to 10 wt-%at 60℃,an average water flux of 23 kg·m^(-2)·h^(-1) with a NaOH rejection over 99.98%was obtained. | Guiqin Bai Jianzhong Xia Bing Cao Rui Zhang Junquan Meng Pei Li | 2022 | Frontiers of Chemical Science and Engineering2022，16，5： | 1 |
| 10 | Molecular characterization of a KIF3B like kinesin gene in the testis of Octopus tankah- keei 显示文摘 | Dang Ran Zhu Junquan Tan Fuqing | | Mol Biol Rep0，35，5： | 1 |
| 11 | KIFC1 participates in acrosomal biogenesis, with discussion of its importance for the perfo ratorium in the Chinese mitten crab Eriocheir sinensis 显示文摘 | Yu Keming Hou Lin Zhu Junquan | 2009 | Cell Tissue Res2009，337，1： | 1 |
| 12 | KIFC1 like motor protein associates with the cephalopod manchette and participates in sperm nuclear morphogenesis in Octopus tankahkeei 显示文摘 | Wang Wei Zhu Junquan Yu Keming | | Plos One0，5，12： | 1 |
| 13 | Molecular cloning and characterization of KIFCl-like kinesin gene (ot-kifcl) from Octopus tan kahkeei显示文摘 | Wang Wei Zhu Junquan Yang Wanxi | 2010 | Comp Biochem Physiol B Biochem Mol Biol2010，156，3： | 1 |
| 14 | Multispectroscopic studies for the identification of archaeological frankincense excavated in the underground palace of Bao’en Temple, Nanjing: near infrared, midinfrared, and Raman spectroscopies显示文摘 | Lei Zhou Dawa Shen Junquan He Yuhui Wei Qinglin Ma Zhide Hu | 2012 | J Raman Spectrosc2012，，10： | 1 |
| 15 | A study on corrosion behavior of carbon steel in south China acidic soil显示文摘 | LIAO Jingyu LIU Junquan SUN Jiarui | 2001 | Journal of South China University of Technology:Natural Science Edition2001，29，4： | 1 |
| 16 | Ethylene polymerizael phenylenedimethylene bridged homobinuclear titunocene/ MAO systems 显示文摘 | Liu Xijie Sun Junquan Zhang Haiying | 2005 | European Polymer Journal2005，41，： | 1 |
| 17 | Methylene Bridged Binuclear Bis(Imino) Pyridyl Iron(Ⅱ) Complexes and Their Use as Cata- lysts Together with Al(i-Bu)3 for Ethylene Polymerization 显示文摘 | Wang Lincai Sun Junquan | 2008 | lnorganica Chimica Acta2008，361，7： | 1 |
| 18 | Image fragile watermarking based on fusion of multi-resolution tamper detection 显示文摘 | Hu Junquan Huang Jiwu Huang Daren | 2002 | Electronics Letters2002，38，24： | 1 |
| 19 | CPT1C promotes the potential of gastric cancer ovarian metastasis through up-regulating fatty acid oxidation显示文摘Ovarian metastasis(OM)of gastric cancer(GC),a common form of distant metastasis in female patients,frequently leads to the treatment failure and poor prognosis[1].However,the molecular basis underlying the OM of GC remains largely unknown.With the recent advancement in transcriptome sequencing or RNA sequencing(RNA-seq)techniques,specific molecular features of metastatic malignancies have been uncovered[2].In particular,RNA-seq of paired primary and metastatic lesions has identified metastasisspecific molecules which potentially serve as therapeutic targets and prognostic biomarkers[3].In GC,the key promoters of peritoneal and hepatic metastasis have been identified by comparative transcriptome profiling of primary and metastatic lesions[4,5].Unfortunately,such techniques have not been applied in the distant OM of GC to date. | Jianpeng Gao Junquan Song Yu Zhang Zhenglun Zhu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，5： | 1 |
| 20 | Image fragile watermarking based on fusion of multi-resolution tamper detection显示文摘 | Junquan Hu Jiwu Huang Daren Huang | 2002 | Electronics letters2002，38，24： | 1 |
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