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| 1 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 2 | Model of nonlinear coupled thermo-hydro-elastodynamics response for a saturated poroelastic medium显示文摘Based on the Biot’s wave equation and theory of thermodynamic, Darcy law of fluid and the modified Fourier law of heat conduction, a nonlinear fully coupled thermo-hydro-elastodynamic response model (THMD) for saturated porous medium is derived. The compressibility of the medium, the influence of fluid flux on the heat flux, and the influence of change of temperature on the fluid flux are considered in this model. With some simplification, the coupled nonlinear thermo-hydro-elastodynamic response model can be reduced to the thermo-elastodynamic (TMD) model based on the traditional Fourier law and, further more, to the Biot’s wave equation without considering the heat phase. At last, the problem of one dimensional cylindrical cavity subjected to a time-dependent thermal/mechanical shock is analyzed by using the Laplace technique, the numerical results are used to discuss the influence of Biot’s modulus M and coefficient of thermoos-mosis on displacement and to compare with the results of thermo-elastodynamic response to ascertain the validity of this model. | LIU GanBin XIE KangHe ZHENG RongYue | 2009 | Science China(Technological Sciences)2009，52，8： | 9 |
| 3 | Research on Radiation Characteristics of Polymeric Plastic Fiber显示文摘The anti-radiation mechanism of polymeric plastic fiber is analyzed. The radiation characteristic of this type fiber is studied. Our experimental results indicate that under the low radiation dosage (below 1 kGy) the plastic optical fiber’s transmission rate rises instead of descends while this type of fiber is radiated by γ ray, electron beam and proton beam respectively. After a period of time, it gradually reaches a constant value. But under the high radiation dosage (above 1 kGy) the fiber’s transmission rate descends after radiation. Later, it gradually goes up to a constant value. | 殷宗敏 Li Rongyu Ge Wenping Liu Rui | 2001 | High Technology Letters2001，7，2： | 5 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | Recent Advances and Applications Toward Emerging Lithium–Sulfur Batteries:Working Principles and Opportunities显示文摘Lithium–sulfur(Li-S)batteries have been considered as promising candidates for large-scale high energy density devices due to the potentially high energy density,low cost,and more pronounced ecological compatibility.However,the complex Li-S conversion reactions,unsatisfactory battery performance,and unsafe metallic Li anode restrict the development of Li-S batteries to achieve commercialization.This review mainly focuses on three aspects which are the remaining challenges,recent advances,and applications in Li-S batteries.Firstly,this review portrays Li-S conversion chemistry involving the multi-step and multi-electron reaction mechanism,as well as the remaining challenges.Then,the scientific strategies and very recent advances of the cathode,electrolyte,lithium anode,and other constituent parts of Li-S batteries are detailly summed up,as well as their advantages and limitations.For the sake of promoting the Li-S batteries practicalization,next section is primarily concerned with problems,the corresponding solutions,and application scenarios of practical pouch cells.Finally,the important findings as guidelines and some future directions as trends for developing emerging Li-S batteries are briefly summarized. | Rongyu Deng Meng Wang Huanyu Yu Shunrui Luo Jinhui Li Fulu Chu Bin Liu Feixiang Wu | 2022 | Energy & Environmental Materials2022，5，3： | 3 |
| 6 | FROST RESISTANCE OF POLYVINYL ALCOHOL FIBER REINFORCED CEMENTITIOUS COMPOSITES显示文摘This article studies the frost resistance of polyvinyl alcohol (PVA) fiber reinforced cementitious composites. The test samples contain different PVA fiber volume fractions such as 0, 0.5%, 1% and 2%. The freeze-thaw test is carried on in TDR type apparatus. The outward appearance, the weight loss factor and the relative dynamic elastic modulus are analyzed, and conclusions are drawn that PVA fibers can significantly improve the frost resistance of cementitious composites and frost resistance of PVA fiber reinforced cementitious composites with fiber volumetric fraction of 1% is better. | Jianwen Bai 1 Shuguang Liu 1 Rongyue Guo 2 Rong Xu 3 ( 1 Institute of Mining Technology, Inner Mongolia University of Technology, Hohhot 010051, China) ( 2 Testing Center of China Railway Group Six Hohhot Railway Bureau Construction CO. LTD, Hohhot 010050, China) ( 3 Civil Engineering and Architectural, Inner Mongolia Institute of Architectural Technology, Hohhot 010070, China) | 2011 | Acta Mechanica Solida Sinica2011，24，S1： | 3 |
| 7 | Preparation of superhydrophobic silica film on Mg–Nd–Zn–Zr magnesium alloy with enhanced corrosion resistance by combining micro-arc oxidation and sol–gel method显示文摘 | Shaohua Wang Xingwu Guo Yijun Xie Lihua Liu Haiyan Yang Rongyu Zhu Jia Gong Liming Peng Wenjiang Ding | 2012 | Surface & Coatings Technology2012，，： | 2 |
| 8 | Fabrication and characterization of implantable silicon neural probe with microfluidic channels显示文摘In this paper,a silicon-based neural probe with microfluidic channels was developed and evaluated.The probe can deliver chemicals or drugs to the target neurons while simultaneously recording the electrical action of these neurons extracellularly.The probe was fabricated by double-sided deep reactive ion etching(DRIE) from a silicon-on-insulator(SOI) wafer.The flu-idic channels were formed with V-shape groove etching on the silicon probe and sealed with silicon nitride and parylene-C.The shank of the probe is 4 mm long and 120 μm wide.The thickness of the probe is 100 μm.The probe has two fluidic chan-nels and two recording sites.The microfluidic channels can withstand a pressure drop as much as 30 kPa and the flow resistiv-ity of the microfluidic channel is 0.13 μL min-1 kPa-1.The typical impedance of the neural electrode is 32.3 kΩ at 1 kHz at room temperature. | GUO Kai PEI WeiHua LI XiaoQian GUI Qiang TANG RongYu LIU Jian CHEN HongDa | 2012 | Science China(Technological Sciences)2012，55，1： | 1 |
| 9 | Grafting of 4-Vinyl Pyridine onto Nylon-6 Initiated by Co(Ⅲ) 显示文摘 | Liu Yinghai Zhang Jianping Zhang Rongyue | 2007 | Journal of Macromolecular Science Part A: Pure and applied chemistry2007，44，： | 1 |
| 10 | Dynamic process of phagocytosis and forms of macrophage cell death induced by ingestion of apoptotic neutrophils显示文摘Clearance of apoptotic neutrophils by macrophages is important for both the successful resolution of acute inflammation and homeostasis.However,the dynamic process of phagocytosis of apoptotic neutrophils by macrophages and the fate of macrophages after the ingestion of apoptotic neutrophils has not been well documented.In the present study,we staged the recognition and tethering,internalization,digestion and exocytosis steps of phagocytosis of apoptotic neutrophils.Furthermore,we found that after the ingestion of apoptotic cells,a subset of macrophages underwent cell death by autophagy,apoptosis or oncosis as revealed by transmission electron microscopy and confocal microscopy combined with specific dyes.The percentage of autophagic,apoptotic and oncotic macrophages were 8.00%±2.00%,12.33%±2.08%,and 3.66%±1.50%,respectively.These results indicated that after ingestion of apoptotic neutrophils,a subset of macrophages undergoes autophagy and apoptosis.We propose that autophagy of macrophages after the ingestion of apoptotic cells may be a new mechanism present in the resolution of inflammation. | WANG Jiong HUANG WeiLin WANG Cheng LIU RongYu | 2014 | Science China(Life Sciences)2014，57，10： | 1 |
| 11 | Chemistry of Materials显示文摘 | Ge Xingbo Wang Rongyue Liu Pengpeng | 2007 | 19: 58272007，19，： | 1 |
| 12 | Uti- lization of lime mud from paper mill as CO2 sorbent in calcium looping process 显示文摘 | Sun Rongyue LiYingjie Liu Changtian | 2013 | Chem Eng J2013，221，1： | 1 |
| 13 | Involvement of annexin Ⅰ in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils 显示文摘 | Wang Cheng Wang Jiong Liu Rongyu | 2007 | Immunology Letters2007，111，2： | 1 |
| 14 | The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma显示文摘 | Hu Xiangbing Zhang Yankai Lin Ming Lu Yong Zhang Yu Zhang Huiyong Chen Yingying Hou Jing Xing Yun Jin Liang Cao Rongyue Liu Jingjing | 2009 | International Immunopharmacology2009，，： | 1 |
| 15 | Vaccination with the repeat β-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects显示文摘 | Jie Yang Yankai Zhang Huaqian Wang Zhenqiu Gao Zeyu Wang Bin Liu Xiuhua Zhang Mingzhu Du Xiao Huang Maolei Xu Jie Wu Taiming Li Jingjing Liu Rongyue Cao | 2012 | Tumor Biology2012，，： | 1 |
| 16 | Administration of heat shock protein 65 inhibits murine melanoma growthin vivo显示文摘 | Jie Yang Yanfei Xie Huaqian Wang Yi Yao Jing Hou Yanjun Ma Qing Zhang Yun Xing Jie Wu Taiming Li Junnian Zheng Jingjing Liu Rongyue Cao | 2013 | Molecular Medicine Reports2013，，： | 1 |
| 17 | Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol 显示文摘 | LIU Rongyu ZHANG Yili BAXTER D A | 2013 | J Neurosci2013，33，16： | 1 |
| 18 | Immunotherapy of Autoimmune Diabetes by Nasal Administration of Tandem Glutamic Acid Decarboxylase 65 Peptides显示文摘 | Huaqian Wang Jie Yang Liang Jin Jiao Feng Yong Lu Yunxiao Sun Taiming Li Rongyue Cao Jie Wu Hao Fan Jingjing Liu | 2009 | Immunological Investigations2009，，8： | 1 |
| 19 | CO2 capture performance of calcium-based sorbent doped with manganese salts during calcium looping cycle显示文摘 | Sun Rongyue Li Yingjie Liu Hongling | 2011 | Appl Energy2011，89，1： | 1 |
| 20 | Cyclic CO2 capture behavior of limestone modified with pyroligneous acid(PA) during calcium looping cycles显示文摘 | Li Yingjie Sun Rongyue Liu Hongling | 2011 | Ind Eng Chem Res2011，50，17： | 1 |
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