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| 1 | Heavy metal concentrations of agricultural soils and vegetables from Dongguan, Guangdong显示文摘118 农业土壤和 43 件蔬菜样品的一个总数从 Dongguan 城市被收集,广东,中国。空间分发,来源,累积特征和在农业土壤和蔬菜的重金属的潜在的风险被三条不同途径在细节描绘,包括在土壤和蔬菜的八个金属元素的全部的内容,在在学习的土壤的重金属的 GIS 地图和 multivariate 分析。结果证明在农业土壤有象 Cu , Zn , Ni , Pb , Cd 和 Hg 那样的重金属的更高的累积,并且 Pb 的内容( 65.38 mg kg ? 2 )并且 Hg ( 0.24 mg kg ? 2 )分别地是在广东省的土壤的相应重金属的背景内容的 1.82 和 2.82 次。有在附近的 3.4% Cu, 5.9% Ni, 1.7% Cd 和 28% Hg 在所有从有的所有调查地点收集了土壤样品溢出为为土壤标准的中国环境质量的重金属的内容(GB15618-1995,等级 II ) 。在土壤的多金属的污染特征被 Hg 主要反映。到在土壤的八个金属元素有不同来源, Cu, Zn, Ni, Cr 并且这是主要源于父母材料,并且 Pb, Hg 和 Cd 被人为的活动影响。空间分发表演 Cu, Zn, Ni, Cr, Pb 并且农业土壤的 Hg 内容在西方高并且在东方,和 Cd 内容低在西北高,东南并且在在 Dongguan 的西南低。Ni 的蔬菜样品的比率, Pb 并且作为比最大值高的集中,在食物(GB2762-2005 ) 的沾染物的层次分别地是 4.7% , 16.3% 和 48.8% 。在蔬菜的重金属的简历集中因素(BCF ) 的顺序是 Cd > Zn > Cu > 作为 > Ni > Hg > Cr > Pb。在 Dongguan 城市里从农业土壤和蔬菜为食物安全和人健康集中于重金属的潜在的风险是必要的,广东省。 | CAI Limei HUANG Lanchun ZHOU Yongzhang XU Zhencheng PENG Xiaochun YAO Ling'ai ZHOU Yang PENG Ping'an | 2010 | Journal of Geographical Sciences2010，20，1： | 23 |
| 2 | Phylogenetic diversity and specificity of bacteria associated with Microcystis aeruginosa and other cyanobacteria显示文摘Interactions between bacteria and cyanobacteria have been suggested to have a potential to influence harmful algal bloom dynamics; however, little information on these interactions has been reported. In this study, the bacterial communities associated with five strains of Microcystis aeruginosa, three species of other Microcystis spp., and four representative species of non-Microcystis cyanobacteria were compared. Bacterial 16S rDNA fragments were amplified and separated by denaturing gradient gel electrophoresis (DGGE) followed by DNA sequence analysis. The similarities among bacterial communities associated with these cyanobacteria were compared to the digitized DGGE profiles using the cluster analyses. The bacterial community structure of all cyanobacterial cultures differed. Cluster analysis showed that the similarity values among M. aeruginosa cultures were higher than those of other cyanobacterial cultures. Sequence analysis of DGGE fragments indicated the presence of bacteria including, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Bacteroidetes and Actinobacteria in the cyanobacterial cultures. Members of the Sphingomonadales were the prevalent group among the Microcystis-associated bacteria. The results provided further evidence for species-specific associations between cyanoabcteria and heterotrophic bacteria, which are useful for understanding interactions between Microcystis and their associated bacteria. | SHI Limei CAI Yuanfeng YANG Hualin XING Peng LI Pengfu KONG Lingdong KONG Fanxiang | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 3 | Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents显示文摘Chronic hepatitis C virus(HCV)infection has become a major public health burden worldwide.Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro.The structure-activity analysis revealed that(i)sophocarpinic acids with a D-seco 3-ring structure scaffold were more favorable than matrines with a 4-ring scaffold;(ii)the introduction of an electron-withdrawing group on the phenyl ring in 12-N-benzenesulfonylΔβγsophocarpinic acids was beneficial for the antiviral activity against HCV.Among them,compounds 9h and 9j exhibited the most potent inhibitory activities on HCV replication with selectivity indies of 70.3 and 30.9,respectively.Therefore,both were selected as antiviral candidates for further investigation. | Yinghong Li Zonggen Peng Limei Gao Danqing Song | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 4 |
| 4 | Lead-bismuth-free piezoceramics (Na_(0.5)K_(0.44)Li_(0.06))Nb_(0.95)Sb_(0.05)O_3-Na_(5.6)Cu_(1.2)Sb_(10)O_(29)显示文摘Newly developed sintering aid Na5.6Cu1.2Sb10O29 (NCS) and lead-bismuth-free piezoceramics (Na0.5K0.44Li0.06) Nb0.95Sb0.05O3 (NKLNS) were prepared by the conventional solid state reaction. The effects of sintering aid NCS on the electrical properties of NKLNS were investigated. It was found that the addition of a proper amount of sintering aid NCS to NKLNS is effective not only on improving the density and the piezoelectric activity, but also on reducing the dielectric loss of NKLNS. The NKLNS doped with 0.4 mol% NCS has a piezoelectric constant d33 as high as 261pC/N and an electromechanical coupling factor k33 above 60%. These results show that NCS-doped NKLNS is a promising and practicable candidate for lead-bismuth-free piezoceramics. | ZHENG LiMei WANG JinFeng ZANG GuoZhong ZHAO MingLei QI Peng DU Juan SU WenBin MING BaoQuan | 2007 | Chinese Science Bulletin2007，52，4： | 2 |
| 5 | Characterization of a Novel Weak Allele of RGA1/D1 and Its Potential Application in Rice Breeding显示文摘Semi-dwarfing improves the lodging resistance and yield of rice,and the vast majority of modern rice varieties harbor the sd1 allele to decrease plant height,resulting in reduced genetic diversity and negative agronomic traits.Thus,exploring alternative sources of dwarfism is imperative for rice breeding.Here,we identified a novel RGA1 allele,d1-w,from a local indica variety Xiaolixiang(XLX)using a map-based cloning approach.Compared with other rice varieties,RGA1 in XLX contained a unique single nucleotide polymorphism that resulted in an additional transcript and reduced functional RGA1 transcript level.The RGA1 from Nipponbare was introduced into XLX to estimate the value of d1-w in rice breeding.Compared with transgenic XLX plants(XLX^(D1)),XLX exhibited reduced plant height,increased stem strength,lower reactive oxygen species accumulation,delayed senescence,stronger photosynthesis,higher grain yield and quality(including external,milling and nutritional qualities),and enhanced resistance to drought and Rhizoctonia solani.Therefore,we proposed that the d1-w allele has potential as an excellent dwarfism resource for rice breeding. | LIU Yantong LI Ting JIANG Zhishu ZENG Chuihai HE Rong QIU Jiao LIN Xiaoli PENG Limei SONG Yongping ZHOU Dahu CAI Yicong ZHU Changlan FU Junru HE Haohua XU Jie | 2022 | Rice science2022，29，6： | 2 |
| 6 | Investigation on static routing and resource assignment of elastic all-optical switched intra-datacenter networks显示文摘In this paper, we explore the issue of static routing and spectrum/IT resource assignment(RSIA)of elastic all-optical switched intra-datacenter networks(intra-DCNs) by proposing anycast- and manycastbased integer linear programming(ILP) models. The objective is to jointly optimize the DCN resources, i.e.,network transmission bandwidth and IT resources, under different situations. First, for given service-request matrices with unknown network transmission bandwidth and IT resources, we propose anycast and manycast ILP models to minimize the maximum numbers of required network and IT resources to accommodate all the service requests. For anycast RSIA issue, we proposed two different ILP models that are based on node-arc and link-path methods, respectively. Node-arc based manycast ILP model is also proposed for the first time to our knowledge. Second, for given network transmission bandwidth and IT resources and known servicerequest matrices, we propose node-arc based anycast ILP models to maximize the total number of successfully served service requests. To evaluate the efficiency of anycast and manycast models, all proposed ILP models are evaluated and compared with unicast ILP models. Simulation results show that anycast and manycast ILP models perform much better in efficiently using DCN resources and successfully accommodating more service requests when compared to unicast ILP models under the same network conditions. | Limei PENG Kiejin PARK Chan-Hyun YOUN | 2016 | Science China(Information Sciences)2016，59，10： | 2 |
| 7 | MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean显示文摘Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production.However,molecular mechanisms potentially underlying such a system in soybean were unclear.Here,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the PHD-finger.Transgenetic analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate metabolism.Strikingly,the fertility of mutant ms3 can restore under longd conditions.The mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production. | Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi Zhao Bao Peng Limei Zhao Chunbao Zhang Lianjun Sun | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 8 | Design and Surface/Interfacial Properties of Asymmetric Triazine Carboxyl Betaine Surfactants显示文摘 | Lishuai Jing Weihong Qiao Limei Luo Huan Peng | 2014 | Journal of Surfactants and Detergents2014，，4： | 1 |
| 9 | OPPORTUNITIES AND APPROACHES FOR MANIPULATING SOIL-PLANT MICROBIOMES FOR EFFECTIVE CROP NITROGEN USE IN AGROECOSYSTEMS显示文摘Soil microbiomes drive the biogeochemical cycling of nitrogen and regulate soil N supply and loss,thus,pivotal nitrogen use efficiency(NUE).Meanwhile,there is an increasing awareness that plant associated microbiomes and soil food web interactions is vital for modulating crop productivity and N uptake.The rapid advances in modern omics-based techniques and biotechnologies make it possible to manipulate soil-plant microbiomes for improving NUE and reducing N environmental impacts.This paper summarizes current progress in research on regulating soil microbial N cycle processes for NUE improvement,plant-microbe interactions benefiting plant N uptake,and the importance of soil microbiomes in promoting soil health and crop productivity.We also proposes a potential holistic(rhizosphere-root-phyllosphere)microbe-based approach to improve NUE and reduce dependence on mineral N fertilizer in agroecosystems,toward nature-based solution for nutrient management in intensive cropping systems. | Jingjing PENG Olatunde OLADELE Xiaotong SONG Xiaotang JU Zhongjun JIA Hangwei HU Xuejun LIU Shuikuan BEI Anhui GE Limei ZHANG Zhenling CUI | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 1 |
| 10 | Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain显示文摘 | Limei Shan Jianmin Li Meng Wei Jian Ma Li Wan Wei Zhu Ying Li Huaqing Zhu J. Malcolm O. Arnold Tianqing Peng | 2010 | Free Radical Biology and Medicine2010，，11： | 1 |
| 11 | Two Successful Livebirths from Both Hemiuteruses After Laparoscopic Cervical Cerclage in a Uterus Didelphys Patient with Cervical Insufficiency显示文摘Uterus didelphys occurs in~0.4%of females and is found in~11%-20%of all uterus defects.It is a risk factor for cervical insufficiency,consequently contributing to late miscarriage or preterm birth.Thus far,only two prior cases of uterus didelphys accompanied by cervical insufficiency treated through laparoscopic cervical cerclage have been reported;however,livebirth only occurred in one hemiuterus.Herein,we report a case of uterus didelphys in a patient diagnosed with cervical insufficiency.Following the placement of a modified laparoscopic cervical cerclage,the patient had two successful livebirths through both hemiuteruses,respectively,with longer gestation age(ie,>36 weeks).The aim of this case report was to provide useful information for clinical practitioners to make better decisions on the management of cervical insufficiency in patients with uterus didelphys,and identify obstetric complications that clinicians should pay attention to during pregnancy. | Limei Zhang Xue Zhong Yuqing Chen Tianyu Peng Liyun Yu Jian Cai Shuzhong Yao Zilian Wang | 2022 | Maternal-Fetal Medicine2022，4，2： | 1 |
| 12 | Piezoelectric Properties of(Na0.5K0.5-xLix)NbO3 Ceramics显示文摘无铅的压电的陶艺(Na_(0.5 )K_(0.5x ) Li_x;) NbO_3 (x=0.057-0.066 ) 被一种平常的 sintering 技术综合。为 K 的代替的李能导致结构的失真,它极大地改进居里温度(Tc ) 。由增加适当 LiNbO3 内容,平面模式的压电的经常的 d33 价值活动范围 202-212 pC/N.Electromechanical 系数比报导到达绝缘的损失低于 2.6% 的 44.4%-46.8%.The,它低得多(大约 50%) 。Tc (Na0.5K_(0.5x ) Li_x;) NbO3 (x=0.057-0.066 ) 在 490-510 ° C 的范围,比的高的至少 70 ° C 纯(Na0.5K0.5 ) NbO3 陶艺。结果显示出那(Na0.5K_(0.5x ) Li_x ) NbO3 陶器是一种好无铅的高温度的压电的材料。 | Peng QI Jinfeng WANG Baoquan MING Juan DU Xinghua LIANG Limei ZHENG | 2007 | Journal of Materials Science & Technology2007，23，6： | 0 |
| 13 | B-Site Nanoscale-Ordered Structure Enables Ultra-High Tunable Performance显示文摘Tunable devices constructed by ferroelectric thin flms are often desired to possess a low dielectric loss while maintainging a high dielectric tunability over a broad operating temperature range in applications,for example,resonators,filters,or phase shifters.However,it is dificult to simultaneously achieve these characteristics by traditional strategies,such as doping and strain modifying.Here,we demonstrate that the dielectric tunability of the sol-gel-prepared Pb(Sc_(1/2)Nb_(1/2))_(0.9)(Mg_(1/3)Nb_(2/3))_(0.O3)(PSNMN)thin film can be almost doubled from~47%to~80.0%(at 10kHz)at a low electric field(~530kV/cm),and the dielectric loss can be sharply reduced by more than an order of magnitude,from~0.50 to~0.037(at 1 kHz)when the thin flm was annealed in air at 650℃ for 15h under the help of an atmosphere-compensating-block(ACB)made from the proto-PSNMN gel.Moreover,the PSNMN thin flm annealed with ACB also exhibited an extremely high thermally-stable dielectric tunability in an ultrabroad temperature range(>130 K),which could be attributed to the Maxwell-Wagner(MW)effect generated by the interface between the PSNMN disordered matrix and the B-site nanoscale-ordered structure formed during the long-term annealing process.The reduced dielectric loss is mainly benefited from the reduced concentration of oxygen vacancy and the possibie MW efects,and the enhanced dielectric tunability could be ascribed to the weaker domain-pinning effect by oxygen vacancy.The breakthrough provides a new universal strategy to achieve utrahigh tunable performance in A(B'_(1/2)B'_(1/2))O3 ferroelectric thin films with a B-site nanoscale-ordered structure,meanwhile it paves the way for ultraintergrated tunable thin-flm-devices with great phase shifter performance in practical applications. | Biaolin Peng Qiuping Lu Yi-Chi Wang Jing-Feng Li Qi Zhang Haitao Huang Laijun Liu Chao Li Limei Zheng Zhong Lin Wang | 2023 | Research2023，，1： | 0 |
| 14 | Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies显示文摘Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders. | Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 15 | Mutations of MSH5 in nonobstructive azoospermia(NOA)and rescued via in vivo gene editing显示文摘Dear Editor,Male infertility is a multifactorial heterogeneous pathological condition affecting∼7%of men.Nonobstructive azoospermia(NOA)is one of the most severe male reproductive diseases and occurs in∼1%of men of reproductive age.1 However,its etiology remains elusive. | Min Chen Chencheng Yao Yingying Qin Xiuhong Cui Peng Li Zhiyong Ji Limei Lin Haowei Wu Zhi Zhou Yaoting Gui Zheng Li Fei Gao | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 16 | A Novel Dominant Allele from 93-11, ES(4), Represses Reactive Oxygen Species Scavenging and Leads to Early-Senescence in Rice显示文摘Senescence is the last developmental process in plant,which has an important impact on crop yield and quality.In this study,a stable hereditary early-senescence line BC64 was isolated from the high-generation recombinant inbred lines of 93-11 and Wuyunjing7(W7).Genetic analysis showed that the premature aging phenotype was controlled by a dominant gene derived from 93-11.By linkage analysis,the gene was primarily mapped in the region between marker B4 and B5 near the centromere of chromosome 4,described as ES(4).Through multiple backcrossing with W7,the near-isogenic line of ES(4)(NIL-ES(4))was obtained.Compared with wild-type W7,NIL-ES(4)plants showed more sever senescence phenotype in both nature and dark conditions.In NIL plants,leaves turned yellow at the fully tillering stage;photosynthetic rate,pollen fertility and seed setting rate were decreased.Moreover,the malondialdehyde,proline content and relative conductivity in NIL-ES(4)were significantly higher than those in W7;both transcript level and activities of reactive oxygen species scavenging enzymes were repressed;H2O2 and O^(2−)were significantly accumulated.This study provides a basis for further cloning and function identification of ES(4). | Zhishu Jiang Cong Gan Yulian Liu Xiaoli Lin Limei Peng Yongping Song Xiaowei Luo Jie Xu | 2023 | Phyton-International Journal of Experimental Botany2023，92，3： | 0 |
| 17 | Asymmetric Traffic Provisioning in Integrated Cloud-Fog Based on Flexible Multi-Flow Optical Transponder显示文摘To accommodate the asymmetric characteristic of Internet traffic, we propose a flexible node architecture based on multiflow optical transponders(MF-OTP) under the integrated Cloud-Fog framework. The proposed MF-OTP architecture is flexible in the following two degrees. Firstly, it can be flexibly adjusted to transmit either downstream or upstream traffic according to the timely traffic demand distribution. Secondly, it allows multiple sub-channels using flexible(i.e., same/different) modulation formats to serve the same traffic demand. To evaluate the efficiency of the flexible MT-OTP in serving asymmetric traffic, we propose two integer linear programming(ILP) models to address the routing, modulation and spectrum assignment(RMSA), with one aiming at minimizing the required number of sub-channels and another aiming at maximizing the volume of traffic transmission. Numerical simulations are conducted and the results show that the proposed models based on the flexible MF-OTP architecture requires less number of sub-channels and can serve more traffic demands. | Geun-soo Kim Jae-Hoon Kim Limei Peng | 2019 | China Communications2019，16，3： | 0 |
| 18 | Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia显示文摘Immune thrombocytopenia(ITP)is an autoimmune disorder,in which megakaryocyte dysfunction caused by an autoimmune reaction can lead to thrombocytopenia,although the underlying mechanisms remain unclear.Here,we performed single-cell transcriptome profiling of bone marrow CD34+hematopoietic stem and progenitor cells(HSPCs)to determine defects in megakaryopoiesis in ITP.Gene expression,cell-cell interactions,and transcriptional regulatory networks varied in HSPCs of ITP,particularly in immune cell progenitors.Differentially expressed gene(DEG)analysis indicated that there was an impaired megakaryopoiesis of ITP.Flow cytometry confirmed that the number of CD9+and HES1+cells from Lin−CD34+CD45RA−HSPCs decreased in ITP.Liquid culture assays demonstrated that CD9+Lin−CD34+CD45RA−HSPCs tended to differentiate into megakaryocytes;however,this tendency was not observed in ITP patients and more erythrocytes were produced.The percentage of megakaryocytes differentiated from CD9+Lin−CD34+CD45RA−HSPCs was 3-fold higher than that of the CD9−counterparts from healthy controls(HCs),whereas,in ITP patients,the percentage decreased to only 1/4th of that in the HCs and was comparable to that from the CD9−HSPCs.Additionally,when co-cultured with pre-B cells from ITP patients,the differentiation of CD9+Lin−CD34+CD45RA−HSPCs toward the megakaryopoietic lineage was impaired.Further analysis revealed that megakaryocytic progenitors(MkP)can be divided into seven subclusters with different gene expression patterns and functions.The ITP-associated DEGs were MkP subtype-specific,with most DEGs concentrated in the subcluster possessing dual functions of immunomodulation and platelet generation.This study comprehensively dissects defective hematopoiesis and provides novel insights regarding the pathogenesis of ITP. | Yan Liu Xinyi Zuo Peng Chen Xiang Hu Zi Sheng Anli Liu Qiang Liu Shaoqiu Leng Xiaoyu Zhang Xin Li Limei Wang Qi Feng Chaoyang Li Ming Hou Chong Chu Shihui Ma Shuwen Wang Jun Peng | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
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