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| 1 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis显示文摘Dear Editor,Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid.derived reactive oxygen species(ROS).The small-molecule compo und erastin in duces ferroptosis via in hibiti ng the cystineglutamate antiporter system x_(c).which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).^(1-4) | Renhong Yan Enjun Xie Yaning Li Jin Li Yuanyuan Zhang Ximin Chi Xueping Hu Lei xu Tingjun Hou Brent R.Stockwell Junxia Min Qiang Zhou Fudi Wang | 2022 | Cell Research2022，32，7： | 4 |
| 2 | An HDR Imaging Method With DTDI Technology for Push-Broom Cameras显示文摘通常,高动态范围(HDR ) 成像基于拿二或有不同暴露的一样的景色的更多的图画。由于在照相机和景色之间的一个高速度的相对运动,然而,要用于推扫帚遥感照相机,为这种技术是难的。为在推扫帚遥感应用的 HDR 成像的缘故,现在的纸建议没有冗余的图象传感器或光部件,能产生 HDR 图象的一个创新方法。明确地,这份报纸与数字领域 time-delay-integration (DTDI ) 采用一个区域数组互补金属氧化物半导体(互补金属氧化物半导体) 为成像的技术而不是多于一个排图象传感器采用,从而与不同暴露拍摄超过一张照片。然后由与一个简单算法熔化二幅原来的图象的一幅新 HDR 图象能被完成。由进行实验,图象的动态范围(医生) 由 26.02 dB 增加。建议方法被证明有效并且在在照相机和场面之间有一个相对运动的另外的成像应用有潜力。 | Wu SUN Chengshan HAN Xucheng XUE Hengyi LV Junxia SHI Changhong HU Xiangzhi LI Yao FU Xiaonan JIANG Liang HUANG Hongyin HAN | 2018 | Photonic Sensors2018，8，1： | 4 |
| 3 | Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Background:Leucine-rich glioma-inactivated protein 1(LGI1)antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy,which is associated with autoimmunity against the neuronal plasma membrane proteins.The characteristic symptoms of this disease are memory dysfunction,seizures,faciobrachial dystonic seizures,cognitive deficits,neuropsychiatric disturbances,and intractable hyponatremia.The diagnosis of this disease mainly depends on the presence of anti-LGI1 antibody in serum or cerebrospinal fluid of patients.LGI1 antibody encephalitis has been reported mostly in adults,with rare occurrences in children.Case presentation:In this report,we described a 4-year-old girl with typical seizures.Seizure types included focal seizures and generalized tonic-clonic seizures.The electroencephalogram findings showed focal discharges.Brain magnetic resonance imaging(MRI)showed normal.The cerebrospinal fluid(CSF)levels of cells,glucose,and chloride were within the normal range,and the culture did not reveal growth of any pathogen.Test of serum LGI1-Ab was positive,while the tests for autoimmune encephalitis antibody series in CSF were negative.The seizures of the patient were completely controlled after the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs(AEDs),and the mental state almost returned to normal.Conclusion:To our knowledge,the patient described here may be the youngest case of LGI1 antibody encephalitis reported to date.Children with the LGI1 antibody-associated encephalitis may present only with single symptoms such as epileptic seizures and have good response to the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs.Our case report will provide hints for pediatricians in the diagnosis and treatment of LGI1-antibody encephalitis. | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 1 |
| 4 | Taming quantum dots’nucleation and growth enables stable and efficient blue-light-emitting devices显示文摘Controlling quantum dots’emission,nanostructure,and energy level alignment to achieve stable and efficient blue emission is of great significance for electroluminescence devices but remains a challenge.Here,a series of blue ZnCdSeS/ZnS quantum dots was optimized in preparation by taming their nucleation and growth kinetics.Controlling anion precursor reactive properties to modulate quantum dots’nucleation and growth tailors their alloy core and continuous gradient energy band nanostructure.These results not only elevate the thermal stability of blue quantum dots but also further enhance the injection/transportation of carriers and improve the radiative recombination efficiency in the device.The blue ZnCdSeS/ZnS quantum dots applied in light-emitting devices show superior performance,including maximum current efficiency and external quantum efficiency of,respectively,8.2 cd/A and 15.8%for blue,2.6 cd/A and 10.0%for blue-violet,and 10.9 cd/A and 13.4%for sky-blue devices.The blue and sky-blue devices exhibit lifetimes of more than 10,000 h.The proposed methodology for tailoring quantum dots is expected to pave new guidelines for further facilitating visible optoelectronic device exploration. | ZHIWEI MA JUNXIA HU LIPING TANG BINGBING LYU | 2022 | Photonics Research2022，10，10： | 0 |
| 5 | Correction to:Leucine-rich gliomainactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Correction to:Acta Epileptologica 3,4(2021)http://gffzzd3cc09b8251d45dfsn6x5xqn6owcq6vkn.ffgz.tsg.suse.edu.cn/10.1186/s42494-021-00039-z After publication of this article[1],it is reported the below corrections need to be made with it.1.The following sentence need to be added to the end of‘Background’section:“This study was approved by the Institutional Ethics Committee of Qilu Children’s Hospital of Shandong University and informed consent has been obtained from the guardian of patient prior to analysis.” | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 6 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 7 | HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation显示文摘Ultra-stable fibrous structure is a hallmark of amyloids.In contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed‘functional amyloids’,contribute to signal transduction as temporal signaling hubs in humans.However,it is unclear how these functional amyloids are effectively disassembled to terminate signal transduction.RHIM motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian cells.Here,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as‘amyloidase’—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and mice.Different from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X_(1))φ(X_(3)).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional monomers.Notably,HSPA8’s amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone system.Using this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis activation.The discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo. | Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun | 2023 | Cell Research2023，33，11： | 0 |
| 8 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform constructing at IMP.It is a 5-year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in material sciences,astrophysics,atomic physics and highly charged ion physics,LEAF has been designed and constructed with the state-of-the-art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals.The layout of LEAF is given in Fig.1. | Sun Liangting Lu Liang Jia Huan Yang Yao Zhang Bin Guo Yuhui Gao Zheng Ma Hongyi Jin Xiaofeng Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jing Long Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Liu Xiaojun Li Jiaqing Lu Wang Guo Junwei Yang Long Li Libin Sun Liepeng Shi Longbo Li Chenxing Ma Wei Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 9 | 6-13 25 MeV High Energy Beam Transport Line for CADS Demo Facility显示文摘The CADS demo facility is aimed to build a prototype linac for the low energy part of the continuous wave(CW)superconducting proton linac and demonstrate technology in this section[1].In the CADS roadmap,the realization of 25 MeV 10 mA beam is a key point.Thus,based on the 10 MeV CADS Injector II at IMP,IMP and IHEP will both contribute a cryomodule to reach 25 MeV at the site of IMP[2].To dump the beam from the linac,we build a new high energy beam transport line with bending angle of 90°,to avoid back-scattering gamma and neutron beams to damage the linac.Fig.1 shows the layout of the 25 MeV demo facility. | Jia Huan Qin Yuanshuai Yuan Chenzhang Wu Junxia Zhang Yong Wang Zhijun Hu Qiang Yao Qinggao He Yuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 10 | Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity显示文摘Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve function.While the formation of myelin by Schwann cells(SCs)is critical for the function of the peripheral nervous system,the temporal dynamics and regulatory mechanisms that control the progress of the s lineage through myelination require further elucidation.Here,using in vitro co-culture models,gene expression profiling of laser capture-microdissected SCs at various stages of myelination,and multilevel bioinformatic analysis,we demonstrated that SCs exhibit three distinct transcriptional characteristics duringmyelination:the immature,promyelinating,and myelinating states.We showed that suppressor interacting 3a(Sin3A)and 16 other transcription factors and chromatin regulators play important roles in the progress of myelination.Sin3A knockdown in the sciatic nerve or specifically in SCs reduced or delayed the myelination of regenerating axons in a rat crushed sciatic nerve model,while overexpression of Sin3A greatly promoted the remyelination of axons.Further,in vitro experiments revealed that Sin3A silencing inhibited SC migration and differentiation at the promyelination stage and promoted SC proliferation at the immature stage.In addition,SC differentiation and maturation may be regulated by the Sin3A/histone deacetylase2(HDAC2)complex functionally cooperating with Sox10,as demonstrated by rescue assays.Together,these results complement the recent genome and proteome analyses of SCs during peripheral nerve myelin formation.The results also reveal a key role of Sin3A-dependent chromatin organization in promoting myelinogenic programs and SC differentiation to control peripheral myelination and repair.These findings may inform new treatments for enhancing remyelination and nerveregeneration. | Bin Zhang Wenfeng Su Junxia Hu Jinghui Xu Parizat Askar Shuangxi Bao Songlin Zhou Gang Chen Yun Gu | 2022 | Neuroscience Bulletin2022，38，7： | 0 |
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