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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 3 | Dielectric Materials for Window Applications显示文摘 | KAREN A C SUBHASH H R | | 0，，04： | 1 |
| 4 | On modeling claim frequency data in general insurance with extra zeros 显示文摘 | Karen C H Yip Kelvin K W and Yau | 2005 | Insurance: Mathematics and Economics2005，，36： | 1 |
| 5 | TNP-470 inhibits intra-abdominal adhision formation显示文摘 | Stephanie C Chistopher H Karen S | 2000 | Pediatr Surg2000，135，2： | 1 |
| 6 | Calcium signaling and oxidant stress in the vasculature显示文摘 | Karen M Lounsbury H Q Ziegelstein R C | 2000 | Free Radical Biology & Medicine2000，28，9： | 1 |
| 7 | Some complexes of glycerol and their applications 显示文摘 | HAZIMAH A H BADRIM M KAREN A C | 2001 | Malaysian Palm Oil Board2001，35，1： | 1 |
| 8 | Cross-species amplification of human microsatellite markers using noninvasive samples from whit-handed gibbons (Hylobates lar) 显示文摘 | KAREN E C ULRICH H R ASJA M | 2004 | American Journal of Primatology2004，64，： | 1 |
| 9 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 10 | Nutrition knowledge, attitude and practices of older and younger elderly in rural alias 显示文摘 | Coleen A F Susan J C Karen E H | 1991 | J Am Diet Assoc1991，91，11： | 1 |
| 11 | Transgenic plants with enhanced resistance to the fungal pathogen Rhizoctonia solani显示文摘 | Karen B Ilan C Mark H et a l | 1991 | Science1991，254，： | 1 |
| 12 | Solid acids and their use as environmentally friendly catalysts in organic synthesis显示文摘 | KAREN W JAMES H C | 2000 | J Pure Appl Chem2000，72，7： | 1 |
| 13 | Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Es- cherichia coli O157:H7 adhesion to epithelial cells cellular显示文摘 | KATHENE C J H KAREN E H MAHSA G | 2007 | Microbiol2007，9，2： | 1 |
| 14 | TNP-470 inhibits intraabdominal adhesion formation 显示文摘 | Stephanie C Christopher H Karen S | 2000 | J Pediat Surg2000，135，2： | 1 |
| 15 | The Inflammatory and Immune Response to Helicobacter Pylori Infection显示文摘 | Karen Robinson Richard H Argent John C Atherton | 2007 | Best Practice & Research Clinical Gastroenterology2007，21，2： | 1 |
| 16 | Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women 显示文摘 | KAREN H C JAE H K ELIZABETH W K | 2010 | Am J Epidemiol2010，172，： | 1 |
| 17 | On Modeling Claim Frequen- y data in General Insurance with Extra Zeros 显示文摘 | Karen C H Kelvin K Y Yau W | 2005 | Insurance: Mathmatics and Economics2005，，36： | 1 |
| 18 | Grazing management effects on plant species diversity in tallgrass prairie显示文摘 | Karen R H David C H Robert C C etal | 2004 | Journal of Range Management2004，57，： | 1 |
| 19 | Multi-scale variability in tropical soil nutrients following land-cover change显示文摘 | Phaedon C K Oliver A | 2005 | Biogeochemistry2005，74，： | 1 |
| 20 | Some complexes of glycerol and their applications显示文摘 | Hazimah A H Badrim M Karen A C | 2001 | Malaysian Palm Oil Board2001，35，： | 1 |
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