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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia显示文摘 | Katrina M Daria M R | 1999 | J Biol Chem1999，274，10： | 2 |
| 3 | Thymoma: trends over time显示文摘 | Katrina H Moore Paul R McKenzie Catherine W Kennedy Brian C McCaughan | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 4 | Breast Cancer Subtypes as De?ned by the Estrogen Receptor(ER),Progesterone Receptor(PR),and the Human Epidermal Growth Factor Receptor 2 (HER-2) among Women with Invasive Breast Cancer in California,1999 -2004显示文摘 | Carol A Parise Katrina R | 2009 | The Breast J2009，15，： | 1 |
| 5 | A study of urinary endogenous gamma-hydrobutyrate ( GHB ) levels 显示文摘 | Dustin TY Katrina R | 2003 | J Anal Toxicol2003，27，： | 1 |
| 6 | Iron deficiency显示文摘 | Katrina P Jennifer R Nick B | 2011 | Paediat Child Health2011，21，8： | 1 |
| 7 | Recreational benefits of urban forests: Ex- plaining visitor's willingness to pay in the context of the theory of planned behavior 显示文摘 | Katrina B Anna R | 2008 | Journal of Environmental management2008，89，： | 1 |
| 8 | DNA isolation from small tissue samples using salt and spermine显示文摘 | Jeffrey A R Garret B N Katrina L H | 1991 | Nucleic Acids Research1991，19，21： | 1 |
| 9 | Analysis of imprinted messenger RNA expression during bovine preirnplantation development显示文摘 | Nancy T R Katrina J W Melissa A C | 2004 | Bio Reprod2004，70，： | 1 |
| 10 | Adenoid cystic carci- noma of the breast 显示文摘 | Katrina NG Carol R Smith RL | 2010 | AJR2010，194，5： | 1 |
| 11 | Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis显示文摘 | Ian R van Driel Alan G Baxter Karen L Laurie Tricia D Zwar Nicole L La Gruta Louise M Judd Katrina L Scarff Pablo A Silveira Paul A Gleeson | 2002 | Autoimmunity Reviews2002，，5： | 1 |
| 12 | Purification of transmem- brane proteins from Saccharomyces cerevisiae for X-ray crystallography显示文摘 | Kathleen MC Nadia F Katrina R | 2010 | Protein Expr Purif2010，71，： | 1 |
| 13 | Agricultural as an upholder of cultural heritage?Conceptualizations and value judgements--A Norwegian perspective in international context显示文摘 | KAROLINE D KATRINA R BIRGITTE S | 2006 | Journal of Rural Studies2006，22，： | 1 |
| 14 | Control of postprandial hyperglycemia optimal use of short-acting insulin secretagogues 显示文摘 | Carroll Ahmad I Katrina R Mark R Burge | 2002 | Diabetes Care2002，25，： | 1 |
| 15 | Tailoring a graduate nurse program to meet the needs of our next generation nurses显示文摘 | Katrina AC Brigid R | 2011 | Nurse Education Today2011，31，1： | 1 |
| 16 | Cellular Pathways Regulating Responses to Compatible and Self-Incompatible Pollen in Brassica and Arabidopsis Stigmas Intersect at Exo70A1, a Putative Component of the Exocyst Complex(W)显示文摘 | Samuel Marcus A Chong Yolanda T Haasen Katrina E Aldea-Brydges May Grace Stone Sophia L Goring Daphne R | 2009 | Plant Cell2009，，9： | 1 |
| 17 | A new look at microbial leaching patterns on sulfide minerals 显示文摘 | Katrina J Hu EB Hamers R J | 2001 | FEMS Microbiol Ecol2001，34，： | 1 |
| 18 | Agricultural as an upholder of ctdtural heritage? Conceptualizations and value judgments: A Norwegian perspective in international context显示文摘 | Karoline D Katrina R Brigitte S | 2006 | Journal of Rural Studies2006，22，： | 1 |
| 19 | Chronic kidney disease :Doxercalciferol is as effective as calcitriol for the treatment of secondary hy- perparathyroidism in CKD 显示文摘 | Katrina R | 2010 | Nat Rev Nephrology2010，6，12： | 1 |
| 20 | Deletion of GSK-3[beta] in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation显示文摘 | Kerkela Risto Kockeritz Lisa MacAulay Katrina Zhou Jibin Doble Bradley W Beahm Cara Greytak Sarah Woulfe Kathleen Trivedi Chinmay M Woodgett James R Epstein Jonathan A Force Thomas Huggins Gordon S | 2008 | Journal of Clinical Investigation2008，，11： | 1 |
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