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| 1 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 2 | 显示文摘 | Mitsuhiro Shibata Takayuki Kobayashi Ryutoku Yosomiya | 2000 | European Polymer Journal2000，36，： | 2 |
| 3 | Preparation of non-woven nanofibem of Bombyx moil silk:Samia Cynthia ricini silk and recombinant hybrid silk with eleetrospinning method显示文摘 | OHGO Kosuke ZHAO Chenhua KOBAYASHI Mitsuhiro | 2003 | Polymer2003，，44： | 1 |
| 4 | Preparation of non-woven nanofibers of Bombyx mori silk, Samia cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | Kosuke Ohgo Chenhua Zhao Mitsuhiro Kobayashi | 2003 | Polymer2003，，44： | 1 |
| 5 | Excellent Prognosis of Patients with Solitary T1N0M0 Papillary Thyroid Carcinoma Who Underwent Thyroidectomy and Elective Lymph Node Dissection Without Radioiodine Therapy显示文摘 | Yasuhiro Ito Hiroo Masuoka Mitsuhiro Fukushima Hiroyuki Inoue Minoru Kihara Chisato Tomoda Takuya Higashiyama Yuuki Takamura Kaoru Kobayashi Akihiro Miya Akira Miyauchi | 2010 | World Journal of Surgery2010，，6： | 1 |
| 6 | Clinicopathological study of primary biliary cirrhosis with nterface hepatitis compared to autoimmune hepatitis显示文摘AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH features.METHODS:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined.The activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3.The infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions.RESULTS:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in PBC.CD3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC.The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in AIH.CD20+cells were mainly found in the portal tracts and,occasionally,at the interface in both diseases.Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in PBC.No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH.While most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with AIH.CONCLUSION:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical. | Mio Kobayashi Yuko Kakuda Kenichi Harada Yasunori Sato Motoko Sasaki Hiroko Ikeda Mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma | 2014 | World Journal of Gastroenterology2014，20，13： | 1 |
| 7 | Development of consensus statements for the diagnosis and management of intestinal Beh?et’s disease using a modified Delphi approach显示文摘 | Kenji Kobayashi Fumiaki Ueno Seiji Bito Yasushi Iwao Tsuneo Fukushima Nobuo Hiwatashi Masahiro Igarashi Bun-ei Iizuka Takahide Matsuda Toshiyuki Matsui Takayuki Matsumoto Akira Sugita Mitsuhiro Takeno Toshifumi Hibi | 2007 | Journal of Gastroenterology2007，，9： | 1 |
| 8 | Characterization of critical factors influencing gene expression of two types of fatty acid-binding proteins (L-FABP and Lb-FABP) in the liver of birds显示文摘 | Atsushi Murai Mitsuhiro Furuse Kohji Kitaguchi Kohji Kusumoto Yuki Nakanishi Misato Kobayashi Fumihiko Horio | 2009 | Comparative Biochemistry and Physiology, Part A2009，，2： | 1 |
| 9 | Hafnium trifluoromethanesulfonate Hf(OTf)4 as an efficient catalyst in the Fries rearrangement and direct aeylation of phenol and naphthol derivatives显示文摘 | Kobayashi Shu Moriwaki Mitsuhiro Haehiya Iwao | 1996 | Tetrahedron Letters1996，37，12： | 1 |
| 10 | Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population显示文摘 | Fumihiko Takeuchi Masato Isono Tomohiro Katsuya Ken Yamamoto Mitsuhiro Yokota Takao Sugiyama Toru Nabika Akihiro Fujioka Keizo Ohnaka Hiroyuki Asano Yukio Yamori Shuhei Yamaguchi Shotai Kobayashi Ryoichi Takayanagi Toshio Ogihara Norihiro Kato | 2010 | Circulation2010，，21： | 1 |
| 11 | Preparation of non-woven nanofibers of Bombyx mori silk, Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | Kosuke Ohgo Zhao Chen-hua Mitsuhiro Kobayashi | 2002 | Polymer2002，44，2003： | 1 |
| 12 | Prepara- tion of non - woven nanofibers of Bombyx mori silk, Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method 显示文摘 | Kosuke Ohgo Chanhua Zhao Mitsuhiro Kobayashi | 2003 | Polymer2003，44，： | 1 |
| 13 | Preparation of non-woven nanofibers of Bombyx mori silk ,Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | Kosuke Ohgo Chenhua Zhao Mitsuhiro Kobayashi | 2003 | Polymer2003，44，： | 1 |
| 14 | Evaluation of cytologically benign solitary thyroid nodules by ultrasonography: A retrospective analysis of 1877 cases显示文摘 | Minoru Kihara Mitsuyoshi Hirokawa Hiroo Masuoka Tomonori Yabuta Hisakazu Shindo Takuya Higashiyama Mitsuhiro Fukushima Osamu Yamada Yuuki Takamura Yasuhiro Ito Kaoru Kobayashi Akihiro Miya Akira Miyauchi | 2012 | Auris Nasus Larynx2012，，： | 1 |
| 15 | Prepa ration of non-woven nanofibers of Bombyx mori silk ,Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | Kosuke Ohgo Chenhua Zhao Mitsuhiro Kobayashi | 2003 | Polymer2003，44，： | 1 |
| 16 | Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers显示文摘 | Nobumoto Tomioka Keiko Morita Nozomi Kobayashi Mitsuhiro Tada Tomoo Itoh Soichiro Saitoh Masao Kondo Norihiko Takahashi Akihiko Kataoka Kazuaki Nakanishi Masato Takahashi Toshiya Kamiyama Michitaka Ozaki Takashi Hirano Satoru Todo | 2010 | Cancer Genetics and Cytogenetics2010，，1： | 1 |
| 17 | Preparation of non-woven nanofibers of Bombyxmori silk ,Samia Cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | KosukeOhgo ChenhuaZhao Mitsuhiro Kobayashi | 2003 | Polymer2003，，44： | 1 |
| 18 | Early and late stroke after mitral valve replacement with a mechanical prosthesis:Risk factor analysis of a 24- year experience显示文摘 | Bando KO Kobayashi J Mitsuhiro H | 2003 | Thorac Cardiovasc Surg2003，126，： | 1 |
| 19 | Preparation of non-woven nanofibers of Bombyx mori silk, Samia cynthia ricini silk and recombinant hybrid silk with electrospinning method显示文摘 | Kosuke Ohgo Chenhua Zhao Mitsuhiro Kobayashi | 2003 | Polymer2003，44，： | 1 |
| 20 | Primary Hepatic Leiomyosarcoma in a Woman After Renal Transplantation: Report of a Case显示文摘 | Hideto Fujita Masato Kiriyama Taiichi Kawamura Toru Ii Shigeru Takegawa Shotaro Dohba Yasuhiko Kojima Mitsuhiro Yoshimura Akihiko Kobayashi Satoru Ozaki Kishichiro Watanabe | 2002 | Surgery Today2002，，5： | 1 |
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