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| 1 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015,21,9: | 8 |
| 2 | Transcriptional factors, Mafs and their biological roles显示文摘The Maf family of transcription factors is characterized by a typical b Zip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcriptionfactors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs. | Mariko Tsuchiya Ryoichi Misaka Kosaku Nitta Ken Tsuchiya | 2015 | World Journal of Diabetes2015,6,1: | 5 |
| 3 | Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid)显示文摘 | Kosaku S Giridhar V | 1993 | Carcinogenesis1993,14,: | 2 |
| 4 | Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis显示文摘 | Kosaku Nitta Takashi Akiba Koichi Suzuki Keiko Uchida Ryo-Ichiro Watanabe Kazuhiro Majima Takanao Aoki Hiroshi Nihei | 2004 | American Journal of Kidney Diseases2004,,4: | 2 |
| 5 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012,4,7: | 2 |
| 6 | Delayed perforation occurring after endoscopic submucosal dissection for early gastric cancer显示文摘 | Kenji Ikezawa Tomoki Michida Kiyoshi Iwahashi Kosaku Maeda Masafumi Naito Toshifumi Ito Kazuhiro Katayama | 2012 | Gastric Cancer2012,,1: | 2 |
| 7 | Interleukin-1β messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature显示文摘 | Kosaku K Katina C Elizabeth V | 2002 | Neurosurgery2002,51,1: | 1 |
| 8 | Adenoma of the rectum with multiple foci of signet-ring cell carcinoma显示文摘 | Dr. Takuji Nakamura M.D. Gen-Ichi Nakano M.D. Kosaku Sakamoto M.D | 1983 | Diseases of the Colon & Rectum1983,,8: | 1 |
| 9 | Characteristics of immoblized lipases in oil and fats Industry显示文摘 | Kosaku Dainon | 2001 | J Olei Sci2001,1,8: | 1 |
| 10 | A novel type of PdM C-catalyzed hydrogenation using a catalyst poison: Chemoselective inhibition of the hydrogenolysis for O -benzyl protective group by the addition of a nitrogen-containing base显示文摘 | Hironao Sajiki Kosaku Hirota | 1998 | Tetrahedron1998,,46: | 1 |
| 11 | Birkhoff's Ergodic Theorem and the Maximal Ergodic Theorem显示文摘 | Yosida Kosaku Kakutani Shizuo | 1939 | Proc Japan Acad1939,,15: | 1 |
| 12 | CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers显示文摘 | Koji Kono Hiromichi Kawaida Akihiro Takahashi Hidemitsu Sugai Kosaku Mimura Naoto Miyagawa Hideo Omata Hideki Fujii | 2006 | Cancer Immunology Immunotherapy2006,,9: | 1 |
| 13 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013,,1: | 1 |
| 14 | Role of HY zeolite mesopores in hydrocracking of heavy oils 显示文摘 | Sato Koichi Nishimura Yoichi Honna Kosaku | 2001 | Journal of Catalysis2001,200,2: | 1 |
| 15 | Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis显示文摘 | Kosaku Nitta Takashi Akiba Koichi Suzuki Keiko Uchida Ryo-Ichiro Watanabe Kazuhiro Majima Takanao Aoki Hiroshi Nihei | 2004 | American Journal of Kidney Diseases2004,,4: | 1 |
| 16 | Chemoselective control of hydrogenation among aromatic carbonyl and benzyl alcohol derivatives usingPd/C(en)catalyst显示文摘 | Kazuyuki Hattori Hironao Sajiki Kosaku Hirota | 2001 | Tetrahedron2001,57,23: | 1 |
| 17 | Role of HY zeolite mesopores in hydrocracking of heavy oils显示文摘 | Sato Kochi Nishimara Yoichi Honna Kosaku | 2001 | J catal2001,200,: | 1 |
| 18 | The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term hemodialysis显示文摘 | Kosaku Nitta Takashi Akiba Keiko Uchida Akira Kawashima Wako Yumura Takashi Kabaya Hiroshi Nihei | 2003 | American Journal of Kidney Diseases2003,,2: | 1 |
| 19 | Possible role of single-voxel 1H-MRS in differential diagnosis of suprasellar tumors显示文摘 | Mikhail F. Chernov Takakazu Kawamata Kosaku Amano Yuko Ono Takashi Suzuki Ryoichi Nakamura Yoshihiro Muragaki Hiroshi Iseki Osami Kubo Tomokatsu Hori Kintomo Takakura | 2009 | Journal of Neuro - Oncology2009,,2: | 1 |
| 20 | Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent显示文摘 | Hironao Sajiki Takashi Ikawa Kosaku Hirota | 2004 | Organic Letters2004,6,26: | 1 |