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| 1 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Current techniques for AB0-incompatible living donor liver transplantation显示文摘For a long time, it was considered medical malpractice to neglect the blood group system during transplantation. Because there are far more patients waiting for organs than organs available, a variety of attempts have been made to transplant AB0-incompatible(AB0i) grafts. Improvements in AB0 i graft survival rates have been achieved with immunosuppression regimens and plasma treatment procedures. Nevertheless, some grafts are rejected early after AB0 i living donor liver transplantation(LDLT) due to antibody mediated rejection or later biliary complications that affect the quality of life. Therefore, the AB0 i LDLT is an option only for emergency situations, and it requires careful planning. This review compares the treatment possibilities and their effect on the patients' graft outcome from 2010 to the present. We compared 11 transplant center regimens and their outcomes. The best improvement, next to plasma treatment procedures, has been reached with the prophylactic use of rituximab more than one week before AB0 i LDLT. Unfortunately, no standardized treatment protocols are available. Each center treats its patients with its own scheme. Nevertheless, the transplant results are homogeneous. Due to refined treatment strategies, AB0 i LDLT is a feasible option today and almost free of severe complications. | Silke Rummler Astrid Bauschke Erik B?rthel Heike Jütte Katrin Maier Patrice Ziehm Christina Malessa Utz Settmacher | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 3 | Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA显示文摘 | Maren Kuhne Martin Dippong Sabine Flemig Katrin Hoffmann Kristin Petsch J?rg A. Schenk Hans-J?rg Kunte Rudolf J. Schneider | 2014 | Journal of Immunological Methods2014，，： | 1 |
| 4 | High-resolution 1D moire s as counterfeit security features显示文摘A moireis an interference pattern that appears when two different periodic structures are overlaid.The image created is extremely sensitive to small variations in the original layers and is thus very interesting for anti-counterfeit protection.We present a microfabricated 1D moire enabling complex high-resolution patterns as a significantly improved security feature that cannot be reproduced using standard printing methods.Furthermore,we demonstrate,theoretically and experimentally,that a microscopic deviation from the original design results in a macroscopic variation in the moire that is clearly visible to the naked eye.The record resolution achieved in the elements fabricated and the increased design freedom,make these high-resolution moires excellent candidates for a variety of visually appealing security applications. | Victor J Cadarso Sylvain Chosson Katrin Sidler Roger D Hersch Jurgen Brugger | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 5 | Larval food plants can regulate the cabbage moth, Mamestra brassicae population显示文摘 | Luule M Eha K Katrin J | 2013 | Bulletin of Insectology2013，66，1： | 1 |
| 6 | TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease显示文摘 | Timo Rath Katrin Menendez Menendez Marion Kügler Lisa Hage Christian Wenzel Richard Schulz Jürgen Graf Lutz N?hrlich Elke Roeb Martin Roderfeld | 2012 | Digestive and Liver Disease2012，，9： | 1 |
| 7 | Microemulsions in technical processes显示文摘 | Schwuger I J Katrin Stickdorn | 1995 | Chem Rev1995，95，： | 1 |
| 8 | TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway显示文摘 | Katrin Hess Alexey Ushmorov J?rg Fiedler Rolf E. Brenner Thomas Wirth | 2009 | Bone2009，，2： | 1 |
| 9 | Novel ENU-induced eye mutations in the mouse: models for human eye disease 显示文摘 | Thaung C Katrine W Brown J C | 2002 | Human Molecular Genetics2002，11，7： | 1 |
| 10 | High bacterial diversity in permanently cold marine sediments 显示文摘 | Katrin Ravenschlag Kerstin Sahm Pernthaler J | 1999 | Applied and environmental microbiology1999，65，9： | 1 |
| 11 | Unilateral regulation of bilateral trade in greenhouse gas emission permits显示文摘 | KATRIN REHDANZ RICHARD S J TOL | 2004 | Ecological Economics2004，，4： | 1 |
| 12 | Encephalitis, myelitis, and acute disseminated encephalomyehtis (ADEM) : Case definitions and guidelines for collection, analysis, and presentation of immunization safety data 显示文摘 | James J Sejvar Katrin S | 2007 | Original Research Article2007，25，31： | 1 |
| 13 | Novel ENU-induced eye mutations in the mouse: models for human eye disease显示文摘 | Caroline T katrine W Brown J C | 2002 | Human Molecular Genetics2002，11，7： | 1 |
| 14 | Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter显示文摘Dear Editor,Telomeres are located at the ends of chromosomes and are essential for chromosome stability and replication.They progressively get shorter with cell division,eventually resulting in cell proliferation arrest.The process is considered a barrier to tumor occurrence[1,2].Abnormally activated telomerase with constitutive telomerase reverse transcriptase(TERT)expression is a hallmark of almost all human tumors[3].Some genomic alterations in the human TERT(hTERT)promoter are associated with activation of hTERT transcription in various cancer types[4]. | Beiping Miao Chaoyang Zhang Nadine Stroh Lukas Brenner Katrin Hufnagel Jörg DHoheisel Obul Reddy Bandapalli | 2021 | Cancer Communications2021，41，12： | 1 |
| 15 | Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts显示文摘 | Dominik Kobold Anka Grundmann Fabio Piscaglia Christoph Eisenbach Katrin Neubauer Jürgen Steffgen Giuliano Ramadori Thomas Knittel | 2002 | Journal of Hepatology2002，，5： | 1 |
| 16 | Use of a serum-free medium for long-term storage of human corneas. Influence on endothelial cell density and corneal metabolism显示文摘 | Britta Hempel Jürgen Bednarz Katrin Engelmann | 2001 | Graefe’s Archive for Clinical and Experimental Ophthalmology2001，，10： | 1 |
| 17 | Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)显示文摘 | Stephan Zangos Katrin Eichler J?rn O. Balzer Ralf Straub Renate Hammerstingl Christopher Herzog Thomas Lehnert Mathias Heller Axel Thalhammer Martin G. Mack Thomas J. Vogl | 2007 | European Radiology2007，，2： | 1 |
| 18 | Characterisation of a new infec-tious full-length cDNA clone of BVDV genotype 2and generationof virus mutants显示文摘 | Katrin M Iona R Zemke J | 2010 | Veterinary Microbiology2010，142，： | 1 |
| 19 | Stroke MRI in Intracerebral Hemorrhage: Is There a Perihemorrhagic Penumbra?显示文摘 | Peter D. Schellinger Jochen B. Fiebach Katrin Hoffmann Kristina Becker Berk Orakcioglu Rainer Kollmar Eric Jüttler Peter Schramm Stefan Schwab Klaus Sartor Werner Hacke | 2003 | Stroke: Journal of the American Heart Association2003，，7： | 1 |
| 20 | Technologies for Value Creation: An Exploration of Remote Diagnostics Systems in the Manufacturing Industry 显示文摘 | Katrin J Ulrika H W Jonny H | 2008 | Information Systems Journal2008，18，3： | 1 |
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