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| 1 | Treatment of Cerebral Vasospasm with Intra-arterial Fasudil Hydrochloride显示文摘 | Kazuhiro Tanaka Hiroaki Minami Masaaki Kota Keiichi Kuwamura Eiji Kohmura | 2005 | Neurosurgery2005，，2： | 1 |
| 2 | The novel bladder preservation therapy BOAI-CDDP-radiation (OMC-regimen):A new treatment option for invasive bladder cancer patients with lymph node metastasis显示文摘 | Haruhito Azuma Teruo Inamoto Kiyoshi Takahara Hayahito Nomi Hajime Hirano Naokazu Ibuki Hiroshi Uehara Kazumasa Komura Koichiro Minami Taizo Uchimoto Kenkichi Saito Tomoaki Takai Naoki Tanda Kazuhiro Yamamoto Yoshihumi Narumi Satoshi Kiyama | 2014 | International Journal of Oncology2014，，： | 1 |
| 3 | Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells显示文摘 | Isaya Hashimoto Keiichi Koizumi Mikiko Tatematsu Takayuki Minami Seiji Cho Nobuhiro Takeno Akitoshi Nakashima Hiroaki Sakurai Shigeru Saito Kazuhiro Tsukada Ikuo Saiki | 2008 | European Journal of Cancer2008，，7： | 1 |
| 4 | Exome-wide variation in a diverse barley panel reveals genetic associations with ten agronomic traits in Eastern landraces显示文摘Barley(Hordeum vulgare ssp.vulgare)is one of the first crops to be domesticated and is adapted to a wide range of environments.Worldwide barley germplasm collections possess valuable allelic variations that could further improve barley productivity.Although barley genomics has offered a global picture of allelic variation among varieties and its association with various agronomic traits,polymorphisms from East Asian varieties remain scarce.In this study,we analyze exome polymorphisms in a panel of 274 barley varieties collected worldwide,including 137 varieties from East Asian countries and Ethiopia.We reveal the underlying population structure and conduct genome-wide association studies for 10 agronomic traits.Moreover,we examin genome-wide associations for traits related to grain size such as awn length and glume length.Our results demonstrate the value of diverse barley germplasm panels containing Eastern varieties,highlighting their distinct genomic signatures relative to Western subpopulations. | June-Sik Kim Kotaro Takahagi Komaki Inoue Minami Shimizu Yukiko Uehara-Yamaguchi Asaka Kanatani Daisuke Saisho Ryuei Nishii Alexander ELipka Takashi Hirayama Kazuhiro Sato Keiichi Mochida | 2023 | Journal of Genetics and Genomics2023，50，4： | 0 |
| 5 | Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata显示文摘Background Guidelines recommend that all patients with upper gastrointestinal bleeding(UGIB)undergo endoscopy within 24 h.It is unclear whether a subgroup may benefit from an urgent intervention.We aimed to evaluate the influence of endoscopic hemostasis and urgent endoscopy on mortality in UGIB patients with high-risk stigmata(HRS).Methods Consecutive patients with suspected UGIB were enrolled in three Japanese hospitals with a policy to perform endoscopy within 24 h.The primary outcome was 30-day mortality.Endoscopic hemostasis and endoscopy timing(urgent,6h;early,>6h)were evaluated in a regression model adjusting for age,systolic pressure,heart rate,hemoglobin,creatinine,and variceal bleeding in multivariate analysis.A propensity score of 1:1 matched sensitivity analysis was also performed.Results HRS were present in 886 of 1966 patients,and 35 of 886(3.95%)patients perished.Median urgent-endoscopy time(n=769)was 3.0h(interquartile range[IQR],2.0–4.0 h)and early endoscopy(n紏117)was 12.0h(IQR,8.5–19.0 h).Successful endoscopic hemostasis and urgent endoscopy were significantly associated with reduced mortality in multivariable analysis(odds ratio[OR],0.22;95%confidence interval[CI],0.09–0.52;P=0.0006,and OR,0.37;95%CI,0.16–0.87;P=0.023,respectively).In a propensity-score-matched analysis of 115 pairs,adjusted comparisons showed significantly lower mortality of urgent vs early endoscopy(2.61%vs 7.83%,P<0.001).Conclusions A subgroup of UGIB patients,namely those harboring HRS,may benefit from endoscopic hemostasis and urgent endoscopy rather than early endoscopy in reducing mortality.Implementing triage scores that predict the presence of such lesions is important. | Masayasu Horibe Eisuke Iwasaki Juntaro Matsuzaki Fateh Bazerbachi Tetsuji Kaneko Kazuhiro Minami Seiichiro Fukuhara Tatsuhiro Masaoka Naoki Hosoe Yuki Ogura Shin Namiki Yasuo Hosoda Haruhiko Ogata Takanori Kanai | 2021 | Gastroenterology Report2021，9，6： | 0 |
| 6 | Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition显示文摘The clinical outcomes of adolescents with avoidant/restrictive food intake disorder(ARFID)remain unclear.Furthermore,no report has compared the characteristics of ARFID and restricting-type anorexia nervosa(R-AN)in elementary-school students on total parenteral nutrition(TPN).This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and 2019.Patients with ARFID(two boys and seven girls)and R-AN(13 girls)were hospitalized because of rapid physical deterioration,and nutrition therapy was continued without withdrawal.The ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization;furthermore,the monthly weight gain during hospitalization was significantly higher,and no relapse was observed.Early physical improvement in ARFID resulted in good recovery.In conclusion,TPN can be easily introduced to patients with ARFID,in whom aversive eating is a concern,and is a suitable treatment for ARFID. | Akira Tamura Koichi Minami Yuko Tsuda Hiroshi Tsujimoto Takayuki Ichikawa Kazuhiro Mizumoto Hiroyuki Suzuki | 2021 | Pediatric Investigation2021，5，4： | 0 |
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