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| 1 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 2 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 3 | Human T-cell immunity against the emerging and re-emerging viruses显示文摘Over the past decade, we have seen an alarming number of high-profile outbreaks of newly emerging and re-emerging viruses.Recent outbreaks of avian influenza viruses, Middle East respiratory syndrome coronaviruses, Zika virus and Ebola virus present great threats to global health. Considering the pivotal role of host T-cell immunity in the alleviation of symptoms and the clearance of viruses in patients, there are three issues to be primarily concerned about T-cell immunity when a new virus emerges: first, does the population possess pre-existing T-cells against the new virus through previous infections of genetically relevant viruses; second, does a proper immune response arise in the patients to provide protection through an immunopathogenic effect; lastly, how long can the virus-specific immune memory persist. Herein, we summarize the current updates on the characteristics of human T-cell immunological responses against recently emerged or re-emerged viruses, and emphasize the necessity for timely investigation on the T-cell features of these viral diseases, which may provide beneficial recommendations for clinical diagnosis and vaccine development. | Min Zhao Hangjie Zhang Kefang Liu George F.Gao William J.Liu | 2017 | Science China(Life Sciences)2017，60，12： | 6 |
| 4 | Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab显示文摘 | Shuguang Tan Kefang Liu Yan Chai Catherine W.-H. Zhang Shan Gao George F. Gao Jianxun Qi | 2018 | Protein & Cell2018，9，1： | 6 |
| 5 | Effects of tempera- ture on simultaneous nitrification and denitrifieation via nitrite in a sequencing batch biofilm reaetor显示文摘 | Zhang Liqiu Wei Chaohai Zhang Kefang | 2009 | Bioprocess & Biosystems Engi- neering2009，32，2： | 1 |
| 6 | Use of dewa-tered municipal sludge on Canna growth in pot experiments with a barren clay soil显示文摘 | Shugeng LI Kefang Zhang Shaoqi Zhou | 2009 | Waste Management2009，29，6： | 1 |
| 7 | Use of dewatered municipal sludge on Canna growth in pot experiments with a barren clay soil显示文摘 | Shugeng Li Kefang Zhang Shaoqi Zhou Liqiu Zhang Qiuli Chen | 2008 | Waste Management2008，，6： | 1 |
| 8 | cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors显示文摘cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net. | Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu | 2021 | Neuroscience Bulletin2021，37，10： | 0 |
| 9 | Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has an extremely broad host range that includes hippopotami,which are phylogenetically closely related to whales.The cellular ACE2 receptor is one of the key determinants of the host range.Here,we found that from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain(RBD)of both SARS-C oV and SARS-C oV-2 and facilitate the trans duction of SARS-C oV and SARS-C oV-2 pseudo viruses into ACE2-expressing cells.We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2,respectively,bound to the RBDs,revealing that they have similar binding modes to human ACE2 when it comes to the SARS-C oV-2 RBD and SARS-C oV RBD.Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-C oV-2,which deserves further careful investigation and study.It will provide an early warning for the prospective monitoring of marine mammals. | Shihua Li Ruirui Yang Di Zhang Pu Han Zepeng Xu Qian Chen Runchu Zhao Xin Zhao Xiao Qu Anqi Zheng Liang Wang Linjie Li Yu Hu Rong Zhang Chao Su Sheng Niu Yanfang Zhang Jianxun Qi Kefang Liu Qihui Wang George F.Gao | 2022 | National Science Review2022，9，9： | 0 |
| 10 | Construction of diverse C–S/C–Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions显示文摘A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfo-nate under mild conditions is disclosed.This practical method provides a facile access to a series of unsym-metrical thioethers with low catalyst loading,good functional group tolerance,and excellent chemo-selectivity. | Yong Liu Shuya Xing Jing Zhang Wen Liu Yuenian Xu Yan Zhang Kefang Yang Lei Yang Kezhi Jiang Xinxin Shao | 2022 | Organic Chemistry Frontiers2022，9，5： | 0 |
| 11 | Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation显示文摘Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously threatened.The coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of COVID-19.However,the efficacy is compromised by the SARS-CoV-2 evolvement and mutation.Here we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and BQ1.1.Furthermore,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μM.The mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)simulations.Interestingly,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune dysregulation.This work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19. | Yang Yi Wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Hang Yang Min Ye | 2024 | Journal of Pharmaceutical Analysis2024，14，1： | 0 |
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