|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 2 | Preparation of polypropylene/montmorillonite nanocomposites by intercalative polymerization:Effect of in situ polymer matrix functionalization on the stability of the nanocomposite structure显示文摘The copolymerization of propylene and 5-hexenyl-9-borabicyclo[3.3.1]nonane (5-hexenyl-9-BBN) has been conducted with an MgCl2/TiCl4 catalyst intercalated in an organically modified montmorillonite (OMMT) with triethylaluminum (AlEt3) cocatalyst and diphenyldimethoxysilane (DDS) external donor. This polymerization process simultaneously results in both the exfoliation of MMT layers to realize the preparation of polypropylene (PP)/MMT nanocomposites and the implantation of reactive borane groups in the formed PP matrix. The polymer-borne borane groups have been able to undergo an effi-cient hydrolysis process under very mild reaction conditions (40℃, 3 h, in THF), introducing hydroxy groups into PP without sacrificing the polymerization-formed nanocomposite structure (the exfoliation of MMT). The resultant hydroxyl-functionalized PP/MMT nanocomposites exhibit enhanced structural stability against processing compared with those based on unfunctionalized PP matrix. | YANG KeFang HUANG YingJuan DONG JinYong | 2007 | Chinese Science Bulletin2007，52，2： | 9 |
| 3 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 4 | Human T-cell immunity against the emerging and re-emerging viruses显示文摘Over the past decade, we have seen an alarming number of high-profile outbreaks of newly emerging and re-emerging viruses.Recent outbreaks of avian influenza viruses, Middle East respiratory syndrome coronaviruses, Zika virus and Ebola virus present great threats to global health. Considering the pivotal role of host T-cell immunity in the alleviation of symptoms and the clearance of viruses in patients, there are three issues to be primarily concerned about T-cell immunity when a new virus emerges: first, does the population possess pre-existing T-cells against the new virus through previous infections of genetically relevant viruses; second, does a proper immune response arise in the patients to provide protection through an immunopathogenic effect; lastly, how long can the virus-specific immune memory persist. Herein, we summarize the current updates on the characteristics of human T-cell immunological responses against recently emerged or re-emerged viruses, and emphasize the necessity for timely investigation on the T-cell features of these viral diseases, which may provide beneficial recommendations for clinical diagnosis and vaccine development. | Min Zhao Hangjie Zhang Kefang Liu George F.Gao William J.Liu | 2017 | Science China(Life Sciences)2017，60，12： | 6 |
| 5 | Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab显示文摘 | Shuguang Tan Kefang Liu Yan Chai Catherine W.-H. Zhang Shan Gao George F. Gao Jianxun Qi | 2018 | Protein & Cell2018，9，1： | 6 |
| 6 | Omicron variant of SARS-CoV-2 imposes a new challenge for the global public health显示文摘Since its first discovery,the Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)has evoked another wave of infection and caused global concern and panic.Moreover,although the data are still limited,Omicron showed highly concerning characteristics,including higher transmissibility,extensive immune escape and potentially altered host range.We interpreted these characteristics based on currently available data and outlined some urgent questions,calling for a more comprehensive investigation. | Zepeng Xu Kefang Liu George F.Gao | 2022 | Biosafety and Health2022，4，3： | 1 |
| 7 | A prospective,multicenter survey on causes of chronic cough in China显示文摘 | LAI Kefang CHEN Ruchong LIN Jiangtao | 2013 | CHEST2013，143，3： | 1 |
| 8 | Efficient Preparation of Isotactic Polypropylene/Montmorillonite Nanocomposites by in Situ Polymerization Technique via a Combined Use of Functional Surfactant and Metallocene Catalysis显示文摘 | Yang Kefang Huang Yingjuan Dong Jinyong | 2007 | Polymer2007，48，21： | 1 |
| 9 | Copolymerization of Ethylene and 10-Undecen-1-ol Using A MontmorilloniteIntercalated Metallocene Catalyst:Synthesis of Polyethylene/ Montmorillonite Nanocomposites with Enhanced Structural Stability显示文摘 | Huang Yingjuan Yang Kefang Dong Jinyong | 2006 | Macromol Rapid Commun2006，27，15： | 1 |
| 10 | Effects of tempera- ture on simultaneous nitrification and denitrifieation via nitrite in a sequencing batch biofilm reaetor显示文摘 | Zhang Liqiu Wei Chaohai Zhang Kefang | 2009 | Bioprocess & Biosystems Engi- neering2009，32，2： | 1 |
| 11 | Diarylprolinol silyl ether catalyzed asymmetric Friedel-Crafts alkylation of indoles with α,β- enhanced enantioselectivity and mechanistic investigations显示文摘 | Yang Kefang | 2011 | Eur J Org Chem2011，2011，1： | 1 |
| 12 | Efficient Preparation of Isotactic Polypropylene/Montmorillonite Nanocomposites by in Situ Polymerization Technique via a Combined Use of Functional Surfactant and Metallocene Catalysis显示文摘 | Yang Kefang Huang Yingjuan Dong Jinyong | 2007 | Polymer2007，48，21： | 1 |
| 13 | Triptolide induced apoptosis of Eosinophils in airway of allergic guinea pigs显示文摘 | Wang ChangZheng Lai KeFang Gu XiaoMing | 1999 | J Chin Pharm Sci1999，8，3： | 1 |
| 14 | Identification of a cancer stem cell?like side population in the HeLahuman cervical carcinoma cell line显示文摘 | Kefang Wang Jianfang Zeng Lijing Luo Jiaxin Yang Jie Chen Bin Li Keng Shen | 2013 | Oncology Letters2013，，6： | 1 |
| 15 | Wireless magnetoelastic physical,chemical,and biological sensors显示文摘 | Grimes C A Zeng Kefang | 2007 | IEEE Transactions on Magnetics2007，43，6： | 1 |
| 16 | Analysis of Milk Tea as a New Mixed Drug Substance in China显示文摘Among the popular mixed drugs in China,the oral solution shenxianshui and the floury drug milk tea have recently emerged.In 2014,123 bags of milk tea included in 14 cases were tested qualitatively and quantitatively,and the test results provided a basis for drug detection,prosecution,and sentencing.More than two drug components were detected in milk tea,which was characterized as a fragrant beige,yellow,or brown powder.The detection rates of methylamphetamine(MA),3,4-methylenedioxymethamphetamine(MDMA),and ketamine in milk tea were 36.6%,50.4%,and 76.4%,respectively,and the concentrations of MA,MDMA,and ketamine were 0.2-5.1,3.2-30.1,and 0.8-176.3 mg/g,respectively,in quantitative testing. | Binling Zhu Liang Meng Kefang Zheng | 2017 | Journal of Forensic Science and Medicine2017，3，1： | 1 |
| 17 | Efficient Preparation of Isotactic Polypropylene/Montmorillonite Nano- composites by in Situ Polymerization Technique via a Com- bined Use of Functional Surfactant and Metallocene Catalysis显示文摘 | Yang Kefang Huang Yingjuan Dong Jinyong | 2007 | Polymer2007，48，21： | 1 |
| 18 | Inspection and analysis of mixed drugs recently seized in China显示文摘 | Binling Zhu Liang Meng Kefang Zheng | 2014 | Forensic Science International2014，，242： | 1 |
| 19 | Use of dewa-tered municipal sludge on Canna growth in pot experiments with a barren clay soil显示文摘 | Shugeng LI Kefang Zhang Shaoqi Zhou | 2009 | Waste Management2009，29，6： | 1 |
| 20 | Use of dewatered municipal sludge on Canna growth in pot experiments with a barren clay soil显示文摘 | Shugeng Li Kefang Zhang Shaoqi Zhou Liqiu Zhang Qiuli Chen | 2008 | Waste Management2008，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员