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| 1 | Association of Fusobacterium nucleatum with immunity andmolecular alterations in colorectal cancer显示文摘The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a differing set of somatic molecular alterations, influenced by diet, environmental and microbial exposures, and host immunity. Fusobacterium species are part of the human oral and intestinal microbiota. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum(F. nucleatum) in colorectal carcinoma tissue. Using 511 colorectal carcinomas from Japanese patients, we assessed the presence of F. nucleatum. Our results showed that the frequency of F. nucleatum positivity in the Japanese colorectal cancer was 8.6%(44/511), which was lower than that in United States cohort studies(13%). Similar to the United States studies, F. nucleatum positivityin Japanese colorectal cancers was significantly associated with microsatellite instability(MSI)-high status. Regarding the immune response in colorectal cancer, high levels of infiltrating T-cell subsets(i.e., CD3+, CD8+, CD45RO+, and FOXP3+ cells) have been associated with better patient prognosis. There is also evidence to indicate that molecular features of colorectal cancer, especially MSI, influence T-cell-mediated adaptive immunity. Concerning the association between the gut microbiome and immunity, F. nucleatum has been shown to expand myeloid-derived immune cells, which inhibit T-cell proliferation and induce T-cell apoptosis in colorectal cancer. This finding indicates that F. nucleatum possesses immunosuppressive activities by inhibiting human T-cell responses. Certain micro RNAs are induced during the macrophage inflammatory response and have the ability to regulate host-cell responses to pathogens. Micro RNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity through the inhibition of the antigen-presenting capacities of dendritic cells and T-cell proliferation in colorectal cancer cells. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment. Further investigation is needed to clarify the association of Fusobacterium with T-cells and micro RNA expressions in colorectal cancer. | Katsuhiko Nosho Yasutaka Sukawa Yasushi Adachi Miki Ito Kei Mitsuhashi Hiroyoshi Kurihara Shinichi Kanno Itaru Yamamoto Keisuke Ishigami Hisayoshi Igarashi Reo Maruyama Kohzoh Imai Hiroyuki Yamamoto Yasuhisa Shinomura | 2016 | World Journal of Gastroenterology2016，22，2： | 44 |
| 2 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 2 |
| 3 | Papillary glioneuronal tumor with minigemistocytic components and increased proliferative activity显示文摘 | Takashi Ishizawa Takashi Komori Junji Shibahara Keisuke Ishizawa Jun-ichi Adachi Ryo Nishikawa Masao Matsutani Takanori Hirose | 2006 | Human Pathology2006，，5： | 1 |
| 4 | Results of immunotherapy for patients with unexplained secondary recurrent abortions显示文摘 | Hiroshi Adachi Koichi Takakuwa Takuya Mitsui Keisuke Ishii Masaki Tamura Kenichi Tanaka | 2003 | Clinical Immunology2003，，3： | 1 |
| 5 | Closed-Loop Control of an XYZ Micro-Stage and Designing of Mechanical Structure for Reduction in Motion Errors显示文摘This paper presents a compact XYZ micro-stage driven by an impact driving mechanism.A moving body is translationally actuated along the X-,Y-,and Z-axes in millimeter-scale range and with nanometer-scale resolution.Cr-N thin-film strain sensors are integrated into the micro-stage for closed-loop positioning.Closed-loop control is also carried out.The motion errors in six degrees of freedom are also investigated for this micro-stage.It is clarified by analysis of finite element method that rotational motion errors around the driving axis are caused by torques due to tensions from the elastic hinges of microstage.The mechanical structure of XYZ micro-stage to cancel out the torque generated is proposed and the second prototype is fabricated.Although the rotational motion error is successfully suppressed in the second prototype,a rotational motion error of more than 0.1°remains due to remaining torque and assembly error of the elastic hinges.Then,in order to reduce the rotational motion error,the prototype is designed in which the location of elastic hinges is single-layered.By designing a mechanical structure in which torque is suppressed,all rotational motion errors are successfully reduced to less than 0.05°in the prototype with single-layer hinges. | Hiraku Matsukuma Keisuke Adachi Takuma Sugawara Yuki Shimizu Wei Gao Eiji Niwa Yoshihiro Sasaki | 2021 | Nanomanufacturing and Metrology2021，4，1： | 1 |
| 6 | Genetic variations in humans associated with differences in the course of hepatitis C显示文摘 | Takafumi Saito Guijin Ji Haruhide Shinzawa Kazuo Okumoto Etsuko Hattori Tohru Adachi Tadashi Takeda Kazuhiko Sugahara Jun-itsu Ito Hisayoshi Watanabe Koji Saito Hitoshi Togashi Keisuke Ishii Tadashi Matsuura Kiyoshi Inageda Masaaki Muramatsu Sumio Kawata | 2004 | Biochemical and Biophysical Research Communications2004，，2： | 1 |
| 7 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 1 |
| 8 | Body Characteristics of Professional Japanese Keirin Cyclists: Flexibility, Pelvic Tilt, and Muscle Strength显示文摘 | Yuto Tashiro Satoshi Hasegawa Shu Nishiguchi Naoto Fukutani Daiki Adachi Takayuki Hotta Saori Morino Hidehiko Shirooka Yuma Nozaki Hinako Hirata Moe Yamaguchi Seishiro Tasaka Tomohumi Matsushita Keisuke Matsubara Tomoki Aoyama | 2016 | Journal of Sports Science2016，4，6： | 0 |
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