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| 1 | Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B显示文摘Aim: To examine the effects ofAstragalus polysaccharide (APS), a component of an aqueous extract ofAstragalus membranaceus roots, on protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin-receptor (IR) signal transduction, and its potential role in the amelioration of insulin resistance. Methods: Ten-week-old fat-fed streptozotocin (STZ)-treated rats, an animal model of type Ⅱ diabetes mellitus (TIIDM), were treated with APS (400 mg/kg po) for 5 weeks. Insulin sensitivity was identified by the insulin-tolerance test. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle and liver were performed by immunoprecipitation or Western blotting. PTP1B activity was measured by an assay kit. Results: The diabetic rats responded to APS with a significant decrease in body weight, plasma glucose, and improved insulin sensitivity. The activity and expression of PTP1B were elevated in the skeletal muscle and liver of TIIDM rats. Thus the insulin signaling in target tissues was diminished. APS reduced both PTP1B protein level and activity in the muscle, but not in the liver of TIIDM rats. Insulin-induced tyrosine phosphorylation of the IR β-subunit and insulin receptor substrate-1 (IRS-1) were increased in the muscle, but not in the liver of APS-treated TIIDM rats. There was no change in the activity or expression of PTP1B in APS-treated normal rats, and blood insulin levels did not change in TIIDM rats after treatment with APS. Conclusion: APS enables insulin-sensitizing and hypoglycemic activity at least in part by decreasing the elevated expression and activity of PTP1B in the skeletal muscles of TIIDM rats. | YongWU Jing-pingOU-YANG KeWU YaWANG Yun-fengZHOU Chong-yuanWEN | 2005 | Acta Pharmacologica Sinica2005，26，3： | 58 |
| 2 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 3 | Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells显示文摘 | Ting Yang Yan Li Zhe Lyu Kewu Huang Chris J Corrigan Sun Ying Wei Wang Chen Wang | 2017 | Chinese Medical Journal2017，，17： | 12 |
| 4 | Group decision-making method based on entropy and experts cluster analysis显示文摘According to the aggregation method of experts' evaluation information in group decision-making,the existing methods of determining experts' weights based on cluster analysis take into account the expert's preferences and the consistency of expert's collating vectors,but they lack of the measure of information similarity.So it may occur that although the collating vector is similar to the group consensus,information uncertainty is great of a certain expert.However,it is clustered to a larger group and given a high weight.For this,a new aggregation method based on entropy and cluster analysis in group decision-making process is provided,in which the collating vectors are classified with information similarity coefficient,and the experts' weights are determined according to the result of classification,the entropy of collating vectors and the judgment matrix consistency.Finally,a numerical example shows that the method is feasible and effective. | Xuan Zhou Fengming Zhang Xiaobin Hui Kewu Li | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 12 |
| 5 | Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema显示文摘 | Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang Dai Huaping Wang Chen | 2014 | Chinese Medical Journal2014，，3： | 10 |
| 6 | Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3显示文摘 | Yang Zhong Xiaofeng Xue Zhiqiang Liu Yongshuo Ma Kewu Zeng Lida Han Jingjing Qi Dae-Kyun Ro Soren Bak Sanwen Huang Yuan Zhou Yi Shang | 2017 | Molecular Plant2017，10，7： | 7 |
| 7 | Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells显示文摘The aging of alveolar stem cells has been linked to many chronic lung diseases, including pulmonary fibrosis. However, the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized. Here we conducted a single-cell RNA sequencing(scRNA-seq) analysis of alveolar stem cells of 3-month-old and 12-month-old mice to characterize the aging effect on alveolar stem cells. Our results have shown that the transcriptomes of alveolar stem cells of 3-month-old and 12-month-old mice are not significantly different under the steady condition. However, after a bleomycin-induced lung injury, the alveolar stem cells of 12-month-old mice show enhanced inflammatory responses and decreased lipid metabolism. Our study suggests a close relationship among aging, lipid metabolism, inflammatory responses and chronic lung diseases. | Tingting Lv Kewu Jiang Jiawen Wang Nan Tang Huaping Dai Chen Wang | 2019 | Science China(Life Sciences)2019，62，8： | 6 |
| 8 | High-throughput development and applications of the compositional mechanical property map of the β titanium alloys显示文摘By a combination of the nanoindentation and electron probe microanalysis(EPMA)techniques,the traditional diffusion couple technique is extended to map the mechanical property of β-type Ti alloys over a wide composition range,which can be utilized to develop very versatile novel bio-Ti alloys for hard tissue re placements in arti ficial bones,joints,and dental implants.To create complete single-phase composition ranges of Ti-based bcc solid solution,12 types of bcc Ti-Nb-Zr-Mo/Ti-Nb-Zr-Ta quaternary diffusion couples were fabricated and annealed at 1273 K for 25 h.In this way,the composition-mechanical property relationships in the vast composition space of Ti-based alloys were established using EPMA and nanoindentation probes.Notably,the measured composition-dependent Young’s moduli,hardness,and elastic recovery as well as the derived ratio of hardness to Young’s modulus,and the ratio of the cube of hardness to the square of Young’s modulus,in the developed compositional mechanical property database,were visualized in a five-dimensional scatter plot.This enables an effective tool to screen the Ti-Nb-Zr-based alloys fororthopedic and dental applications according to different clinical requirements,and to rationalize the fundamental mechanical relationships in the rapid development of β-Ti alloys. | Jinfeng Ling Dandan Huang Kewu Bai Wei Li Zhentao Yu Weimin Chen | 2021 | Journal of Materials Science & Technology2021，，12： | 3 |
| 9 | Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase显示文摘Diabetes have been shown to cause progressive neuronal injury with pain and numbness via advanced glycation end-products(AGEs)-induced neuronal cell apoptosis;however, the valuable drug targets for diabetic neuropathy have been poorly reported so far. In this study, we discovered a natural small-molecule schisandrol A(SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase(V-ATPase) in lysosome was identified as a crucial cellular target of SolA. Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification.Interestingly, SolA-induced lysosome pH downregulation resulted in a mitochondrial-lysosomal crosstalk by selectively promoting mitochondrial BH3-only protein BIM degradation, thereby preserving mitochondrial homeostasis and neuronal cells survival. Collectively, our findings reveal ATP6V0D1 is a valuable pharmacological target for diabetes-associated neuronal injury via controlling lysosomal acidification, and also provide the first small-molecule template allosterically activating V-ATPase for preventing diabetic neuropathy. | Xiaoqing Zhou Shaoyang Zhao Tingting Liu Lu Yao Meimei Zhao Xiaoming Ye Xiaowen Zhang Qiang Guo Pengfei Tu Kewu Zeng | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 10 | Antioxidant,Hypoglycemic and Hypolipidemic Activities of Sambucus williamsii Seed Oil显示文摘[Objectives] To explore the antioxidant activity of Sambucus williamsii seed oil. [Methods]DPPH scavenging method and Prussian blue method( total reducing power) were used. S. williamsii seed oil has antioxidant activity. In the DPPH scavenging free radical experiment,S. williamsii oil showed the ability to scavenge free radicals,and its scavenging ability had linear relationship with oil concentration( R =0. 999 6). Besides,the IC_(50) value of S. williamsii seed oil scavenging DPPH free radicals was 61. 30 ± 0. 88 mg/mL. In the total reducing power measurement experiment,the S. williamsii seed oil has a reducing ability,and its reducing ability is proportional to the oil concentration,and has the concentration dependence. Through studying the inhibitory effect of S. williamsii seed oil on α-glucosidase,the hypoglycemic activity of S. williamsii seed oil was determined. The ability of samples to inhibit α-glucosidase was judged through measuring the absorbance at 400 nm of the reaction system. [Results]In the concentration range of 1. 56-25. 00 mg/mL,the S. williamsii seed oil can effectively inhibit α-glucosidase,and the inhibition rate was 62. 66%-85. 22%. The animal in vivo experiment was used to determine the hypolipidemic activity of the S. williamsii seed oil. First,a high fat modelwas established,S. williamsii seed oil was given through intragastric administration. Then,total cholesterol( TC),triglyceride( TG),high-density lipoprotein cholesterol( HDL-C),and low density lipoprotein cholesterol( LDL-C) were measured. Through comparison of high,medium and low dose groups of S. williamsii seed oil with the high fat modelcontrol group,it was found that the TC,TG,LDL-C levels were significantly decreased( P < 0. 01) and the HDL-C levels were significantly increased( P < 0. 05),indicating that S. williamsii seed oil can effectively reduce the levels of TC,TG,LDL-C in the serum of hyperlipidemic mice,and effectively inhibit the decrease of HDL-C level,thus S. williamsii seed oil can reduce blood lipids in mice,namely,has hypolipidemic effects. In addition,the greater the dose of S. williamsii seed oil,the more obvious the effect of blood lipid levels in mice,indicating that the hypolipidemic effect of S. williamsii seed oil was dose dependent. [Conclusions] S. williamsii seed oil has reducing ability,and there is a significant dose-effect relationship in the concentration range of 2-10 mg/mL. As natural plant oil,S. williamsii seed oil has the advantages of good stability,small toxic and side effects,and strong effect,and has high value of developing new antioxidants. | Wei HU Hui LI Kewu LIU | 2018 | Medicinal Plant2018，9，5： | 2 |
| 11 | Fractional Fourier domain equalization for single carrier broadband wireless systems显示文摘In this paper,a novel single carrier equalization approach in the fractional Fourier domain(FRFD) is proposed.It can remove all the inter-symbol interference(ISI) and avoid the considerable noise enhancement of the frequency domain-zero forcing(FD-ZF) equalizer.As the fractional Fourier transform makes a chirp spread,the impulse response of the deep fading channel may be flattened in some orders of the FRFD while it would be greatly attenuated in the FD.By searching for an optimal order under certain criterion,we take advantages of the ZF algorithm to mitigate the effects of the ISI completely.This approach can overcome the contradiction between the ISI mitigation and the noise enhancement of the FD-ZF equalizer.Theoretical analysis and simulation results show that the proposed FRFD-ZF equalizer can achieve a significant performance and have the same computation cost O(N log N) as the conventional FD linear equalizer,especially in the frequencyselective deep-fading channels. | HUANG KeWu TAO Ran WANG Yue | 2012 | Science China(Information Sciences)2012，55，10： | 2 |
| 12 | High Robust Broadcasting over DTMB-A with Low-rate LDPC Codes显示文摘As the 2nd generation digital terrestrial television broadcasting(DTTB)standard,digital terrestrial/television multimedia broadcasting-advanced(DTMB-A)can provide higher spectrum efficiency and transmission reliability by adopting flexible frame structure and advanced forward error correction coding compared with the 1 st generation DTTB systems.In order to increase the flexibility and robustness of the DTTB network,the frequency reuse scheme of factor one(reuse-1)is proposed,where the same RF channel is used by different stations covering the adjacent service areas.However,it demands a very low carrier-tonoise ratio(C/N)threshold below 0 dB at the DTTB physical layer.In this paper,a robust broadcasting technique is proposed based on DTMB-A with newly designed low-rate low density parity check(LDPC)codes.By adopting quasi-cyclic(QC)Raptor-like structure and progressive lifting method,the high performance low-rate LDPC codes are designed supporting multiple code lengths.Both density-evolution analyses and laboratory measurements demonstrate that DTMB-A with low-rate coding can complete the demodulation reliably with the C/N threshold below0 d B,which is one important necessary condition to support frequency reuse-1 scheme. | Chao Zhang Kewu Peng Zhitong He Yonglin Xue Hui Yang | 2022 | China Communications2022，19，3： | 2 |
| 13 | Hydrolytic dynamics of pesticide N'-(2,4-dimethylphenyl)-N-methylformamidine in aquatic solution显示文摘HydrolyticdynamicsofpesticideN'-(2,4-dimethylphenyl)-N-methylformamidineinaquaticsolution￥MoHanhong;YangKewu;AnFengchun;LiuYe... | Mo Hanhong Yang Kewu An Fengchun Liu Ye (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 14 | Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages显示文摘This study aimed to characterize the chemical composition of a new sulfated polysaccharide from the red alga Gracilaria chouae and evaluate its activation effects on RAW264.7 macrophages.It showed that the obtained G.chouae polysaccharide(GCP-3A)was a sulfated acidic polysaccharide with a molecular weight of 11.87 kDa. | Feifei LI Kehai LIU Kewu LIU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 1 |
| 15 | Assessment of the Zn-Fe-Al system for kinetic study of galvanizing显示文摘 | Bai Kewu Wu Ping | 2002 | Journal of Alloys and Compounds2002，347，： | 1 |
| 16 | Labeling optimization for BICM-ID systems 显示文摘 | YANG Zhixing XIE Qiuliang PENG Kewu el al | 2010 | IEEE Comrnunications Letters2010，14，11： | 1 |
| 17 | Embedded image compression based on wavelet pixel classification and sorting 显示文摘 | Peng Kewu Kieffer J C | 2004 | IEEE Transactions on Image Processing2004，13，8： | 1 |
| 18 | Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: Effects of phos- pholipids显示文摘 | HADINOTO K PHANAPAVUDHIKUL P KEWU Z | 2007 | lnt J Pharm2007，333，12： | 1 |
| 19 | Cr(Ⅲ) removal from simulated solution using hydrous magnesium oxide coated fly ash: Optimization by response surface methodology (RSM)显示文摘Hydrous magnesium oxide coated fly ash(MFA) has environmental remediation potential by providing a substrate for the adsorption of aqueous Cr(Ⅲ). Aqueous Cr(Ⅲ) adsorption onto MFA was examined as a function of MFA dosage, p H and initial Cr(Ⅲ) concentration with the Box–Behnken approach used for experimental design and optimization using response surface methodology(RSM). p H and dosage(dosage and concentration) have significant interactive effects on Cr(Ⅲ) adsorption efficiency. Analysis of variance shows that the response surface quadratic model is highly significant and can effectively predict the experimental outcomes. Cr(Ⅲ) removal efficiency of 98% was obtained using optimized conditions of MFA dosage, p H and initial Cr(Ⅲ) concentration of 1.57 g·L^(-1), 4.11 and 126 mg·L^(-1), respectively. Cr(Ⅲ) adsorption onto MFA is mainly attributed to the interaction between Cr(Ⅲ) and the functional group \\OH of the hydrous magnesium oxide, in all probability caused by chemisorptions. The results of this study can conduce to reveal the interactions between Cr(Ⅲ) pollutant and MFA characteristics, posing important implications for the cost-effective alternative adsorption technology in the treatment of heavy metal containing wastewater. | Min Xia Chunsong Ye Kewu Pi Defu Liu Andrea R. Gerson | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 1 |
| 20 | First-principles study of Sn and Ca doping in CuInO2 显示文摘 | Liu Li Bai Kewu Gong Hao | 2005 | Phys Rev B: Condens Matter Mater Phys2005，72，12： | 1 |
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