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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Nanostructured thermoelectric materials:Current research and future challenge | Zhigang Chen Guang Han Lei Yang Lina Cheng Jin Zou | 2012 | Progress in Natural Science:Materials International2012，22，6： | 17 |
| 3 | The wheat MYB-related transcription factor TaMYB72 promotes flowering in rice显示文摘Through large-scale transformation analyses, Ta MYB72 was identified as a flowering time regulator in wheat. Ta MYB72 is a MYB family transcription factor localized to the nucleus. Three Ta MYB72 homologs,Ta MYB72-A, Ta MYB72-B and Ta MYB72-D, cloned from hexaploid wheat were mapped to the short arm of the group 6 chromosomes. Under the long-day conditions,over-expression of the Ta MYB72 in rice shortened the flowering time by approximately 12 d. Expression analyses suggest that Ta MYB72 may function through upregulation of florigen genes Hd3 a and RFT1. | Lichao Zhang Guoxiang Liu Jizeng Jia Guangyao Zhao Chuan Xia Lina Zhang Fu Li Qiang Zhang Chunhao Dong Shuangcheng Gao Longzhi Han Xiuping Guo Xin Zhang Jinxia Wu Xu Liu Xiuying Kong | 2016 | Journal of Integrative Plant Biology2016，58，8： | 8 |
| 4 | Pd/activated carbon sorbents for mid-temperature capture of mercury from coal-derived fuel gas显示文摘Higher concentrations of Hg can be emitted from coal pyrolysis or gasification than from coal combustion, especially elemental Hg. Highly efficient Hg removal technology from coal-derived fuel gas is thus of great importance. Based on the very excellent Hg removal ability of Pd and the high adsorption abilities of activated carbon(AC) for H2 S and Hg, a series of Pd/AC sorbents was prepared by using pore volume impregnation, and their performance in capturing Hg and H2 S from coal-derived fuel gas was investigated using a laboratory-scale fixed-bed reactor. The effects of loading amount, reaction temperature and reaction atmosphere on Hg removal from coal-derived fuel gas were studied. The sorbents were characterized by N2 adsorption, X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The results indicated that the efficiency of Hg removal increased with the increasing of Pd loading amount, but the effective utilization rate of the active component Pd decreased significantly at the same time. High temperature had a negative influence on the Hg removal. The efficiency of Hg removal in the N2–H2S–H2–CO–Hg atmosphere(simulated coal gas) was higher than that in N2–H2S–Hg and N2–Hg atmospheres, which showed that H2 and CO, with their reducing capacity, could benefit promote the removal of Hg. The XPS results suggested that there were two different ways of capturing Hg over sorbents in N2–H2S–Hg and N2–Hg atmospheres. | Dekui Li Jieru Han Lina Han Jiancheng Wang Liping Chang | 2014 | Journal of Environmental Sciences2014，26，7： | 8 |
| 5 | Effect of interaction between different CeO_(2)plane and platinum nanoparticles on catalytic activity of Pt/CeO_(2)in toluene oxidation显示文摘The plane exposure of support vitally affects the catalytic performance of the catalyst.In this work,CeO_(2)nanorods((110)plane exposure),nano-octahedrons((111)plane exposure)and nano-cubes((100)plane exposure)were prepared as the supports of Pt/CeO_(2)samples to investigate the effect of CeO_(2)plane exposure on total toluene oxidation.Characterizations reveal that the(110)plane of CeO_(2)is more helpful to the dispersion of Pt species,followed by(111)face.The improved dispersion of Pt species can enhance the metal-supports interaction,which promotes the electron transfer of CeO_(2)carrier to Pt nanoparticles and the adsorption-activation of O_(2),thereby facilitating the total oxidation of toluene via the Langmuir-Hinshelwood(L-H)mechanism.Therefore,Pt/CeO_(2)-r(nanorods)sample expresses excellent catalytic performance of toluene oxidation.Finally,the procedure of toluene total oxidation was studied by in-situ diffuse reflectance infrared Fourier transform(DRIFT)spectroscopy.We expect that this work can contribute to the development of an effective sample for the decomposition of volatile organic compounds(VOCs). | Shengsheng Chang Yong jia Yiqing Zeng Fuping Qian Lina Guo Shenghua Wu Jinli Lu Yunlong Han | 2022 | Journal of Rare Earths2022，40，11： | 6 |
| 6 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 7 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 8 | Effects of grazing intensity on seed production of Caragana stenophylla along a climatic aridity gradient in the Inner Mongolia Steppe,China显示文摘As the increases of climatic aridity and grazing intensity,shrubs play an increasingly important role in grassland ecosystem in arid and semi-arid regions,and its abundance also generally increases.However,the effects of climatic aridity and grazing intensity on sexual reproduction of shrubs in grassland remain largely unclear.In order to understand the effects of grazing intensity and climatic drought stress,and their interaction on seed production of shrub species,we examined the seed number,seed weight and seed yield of Caragana stenophylla under three grazing intensities(fenced,mild grazing and severe grazing) across a climatic aridity gradient(semi-arid,arid,very arid and intensively arid zones) in the Inner Mongolia Steppe,northern China during 2012–2013.The seed number,seed weight and seed yield gradually increased from the semi-arid to the very arid zones,but decreased from the very arid to the intensively arid zones in fenced plots.The seed number and seed yield decreased from the semi-arid to the intensively arid zones in mild and severe grazing treatment plots,therefore,grazing enhanced the suppression effect of climatic aridity on seed production of C.stenophylla.The seed number and seed yield gradually decreased as grazing intensity increased.The seed weight was highest in severe grazing plots,followed by the mild grazing plots and then the fenced plots.Precipitation varied interannually during the study period.We observed that the seed number,seed weight and seed yield were lower in the low precipitation year(2013) than in the high precipitation year(2012).As climatic drought stress increased,the negative effects of grazing on seed production of C.stenophylla also gradually increased.Our results indicated that climatic drought stress may contribute to the encroachment of C.stenophylla shrub in arid zones by promoting its seed production.However,grazing had negative effects on sexual reproduction of C.stenophylla,and the combined effects of drought stress and grazing seriously suppressed sexual reproduction of C.stenophylla in the intensively arid zone. | XIE Lina CHEN Weizhong Christopher A GABLER HAN Lei GUO Hongyu CHEN Qing MA Chengcang GU Song | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 9 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 10 | 香蕉新品种“南天黄”在琼北试验研究显示文摘在海南省澄迈县香蕉产区开展抗香蕉枯萎病品种'南天黄'大田试验研究,测定果实性状变化、株产以及调查几种病害发生情况。结果表明,该品种生育期362 d,从抽蕾后至采收,可溶性糖呈增加趋势,维生素C变化反之;通过增施钾肥,最高株产达24.19 kg,枯萎病发病率仅为0.8%,与对照品种'巴西蕉'差异极显著。 | 何应对 林妃 王丽霞 殷晓敏 刘永霞 王必尊 苏璐 DING Zheli JING Tao HAN Lina | 2019 | 中国南方果树2019，48，3： | 4 |
| 11 | Sedimentology and Sequence Stratigraphy of Marine to Lacustrine Deltaic Deposits in a Craton Basin and Their Controlling Factors: Shan 2 Member–He 8 Member(Guadalupian–Lopingian, Permian), Southeast Ordos Basin, North China显示文摘The Shan 2 Member, Shan 1 Member and He 8 Member of the Mid–Late Permian Shanxi and lower Xiashihezi formations, in the southeastern Ordos Basin, together comprise ~150 m of deltaic deposits. This sequence records an overall evolution from deep marine environment to shallow lake associated with braided river, braided river delta and meandering river delta. Core description, well log interpretation, and stable isotope analysis, including carbon, oxygen and strontium, were conducted to understand the sedimentary evolution of Shan 2 to He 8 Member. The Shanxi Formation, which consists of the Shan 2 and Shan 1 members, is characterized by a tidal-influenced meandering river delta environment and a higher δ^(13)C value and ^(87)Sr?(^(86)Sr) ratio and a lower δ^(18)O value. The He 8 Member, the basal part of the Xiashihezi Formation, is featured by a braided river to braided river delta system and a lower δ^(13)C value, ^(87)Sr?(^(86)Sr) ratio, and a higher δ^(18)O value. Four third-order depositional sequences separated by five sequence boundaries are determined. Coarsening upward sequences of the Shan 2 Member–He 8 Member indicate a general regression trend, which can be correlated to global sea-level fall occurring during the Roadian–Wuchiapingian, as also evidenced by previous published zircon U–Pb results. The coal-bearing sequence(Shanxi Formation) to non-coal-bearing sequence(He 8 Member), as well as a decrease of ^(87)Sr?(^(86)Sr), suggest a trend from humid to arid climates. A combined effect of sea-level drop and a small uplift at the end of Shanxi Formation are proposed. | SHAN Xin YU Xinghe Peter CLIFT LI Yalong JIN Lina SU Dongxu DU Yonghui ZHOU Jinsong HAN Xiaoqin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 12 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 13 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsbovwpuo55n9k669u.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 14 | hELP3 Subunit of the Elongator Complex Regulates the Transcription of HSP70 Gene in Human Cells显示文摘人的 Elongator 建筑群显著地类似于它在几个方面的酵母对应物。在以前的研究,我们分析了人的延伸蛋白质的功能 3 (hELP3 ) 由使用的人的 Elongator 的子单元一在里面 vivo 酵母 complementationsystem.However,为在在人的房间调整基因表达的 hELP3 功能的直接证据没被获得。在这研究,我们使用了 hELP3 反感觉寡核苷酸禁止者将 hELP3gene 表示击倒在人的 293T 房间调查它的函数。结果证明 hELP3 mRNA 和蛋白质的那特定的减小引起了 HSP70-2 基因表达的重要抑制,并且这被伴随由嘘一 H3 hypoacetylation 和减少的 RNA 聚合酶 II 在 theHSP70-2 的密度基因。而且,数据也证明 hELP3 施加了 transcriptional 规章在 HSP70-2 基因上通过它的存在直接工作。在这份报告介绍的数据在人的房间在 HSP70-2 基因 transcriptionalelongation 提供进一步的卓见和 hELP3 的函数的直接证据。 | Qiuju HAN Xiaozhe HOU Dongmei SU Lina PAN Jizhou DUAN Liguo CUI Baiqu HUANG Jun LU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 3 |
| 15 | Sirtl regulates testosterone biosynthesis in Leydig cells via modulating autophagy显示文摘Dear Editor,Steroid hormones are crucial signal molecules that regulate a large number of physiological and developmental pro-cesses.Testosterone is the key steroid hormone required for the development of male characteristics and also supports the physiology of the male reproductive system(Sinclair et al.,2015).Testosterone is primarily produced by the Leydig cells residing in the testicular interstitium.The cholesterol acts as a substrate for the biosynthesis of testosterone.Since steroidogenic cells are capable of stor-ing only very ltte hormone,rapid synthesis of hormone requires the mobilization of the precursor cholesterol,chiefly stored as intracellular lipid droplets(LDs)(Danielsen et al.,2016).Leydig cells are the major sites to produce testos-terone,there are extremely active autophagy in them,and a decline in steroidogenesis has also been associated with the decline of autophagic flow.Moreover,the disruption of autophagy leads to decreased intracellular LDs,and there-fore affects testosterone synthesis in the Leydig cells(Danielsen et al..2016;Gao et al,2018). | Muhammad Babar Khawar Chao Liu Fengyi Gao Hui Gao Wenwen Liu Tingting Han Lina Wang Guoping Li Hui Jiang Wei Li | 2021 | Protein & Cell2021，12，1： | 3 |
| 16 | Geochemical and Grain-Sized Implications for Provenance Variations of the Central Yellow Sea Muddy Area Since the Middle Holocene显示文摘Based on high-resolution analysis to a 280-cm long sediment core obtained from the muddy area in the central Yellow Sea, we examined the provenance of muddy sediments and discussed the changing marine sedimentary environment since the middle Holocene. The results indicated that fine-grained sediments in the muddy area were mainly derived from the Huanghe(Yellow River) and Changjiang(Yangtze River) with considerable stepwise variations during the past 6.6 kyr. The Yellow Sea Warm Current was initiated at 6 kyr when the sea level was high together with the enhanced East Asian Winter Monsoon. These in combination established the framework of shelf circulation in the Yellow Sea that began to trap the river-derived fine-grained sediments. From 4.9 kyr to 2.8 kyr, both the Kushiro Current and East Asian Monsoon were significantly weakened, reducing the delivery of Changjiang sediments to the muddy area. As a result, the sediments were mainly originated from the Huanghe. From 2.8 kyr to 1.5 kyr the continuously weakened East Asian Winter Monsoon and enhanced Yellow Sea Warm Current entrapped more fine-grain sediments. Whereas the enhanced East Asian Winter Monsoon and the human caused increase in sediment load of the Huanghe since 1.5 kyr, and direct delivery of Huanghe sediments to the Yellow Sea during 1128–1855 AD might dominated the sedimentation in the study area. The stepwise variations of the sediment provenance and composition of the Central Yellow Sea muddy sediments are of importance to understanding the formation of muddy deposit in the central Yellow Sea and the associated variations of marine environment since the middle Holocene. | AI Lina HAN Zongzhu WU Xiao SAITO Yoshiki WANG Houjie | 2020 | Journal of Ocean University of China2020，19，3： | 3 |
| 17 | Effect of diacylglycerol acyltransferase 2overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation显示文摘Background:Fatty acid(FA) composition is the most important parameter affecting the flavor and nutritional value of the meat.The final and the only committed step in the biosynthesis of triglycerides is catalyzed by diacylglycerol acyltransferase 2(DGAT2).The role of DGAT2 in lipid accumulation has been demonstrated in adipocytes,However,little is known about the effect of DGAT2 on the FA composition of these cells.Methods:To investigate the role of DGAT2 in regulating lipid accumulation,FA composition and the expression of adipogenic genes,we cloned the open reading frame of the porcine DGAT2 gene and established 3T3-L1 cells that overexpressed DGAT2.Cells were then cultured in differentiation medium(DM) without FA,with a mixture of FAs(FA-DM),or containing a ^(13)C stable isotope-labeled FA mixture(IFA-DM).The FA composition of adipocytes was analyzed by gas chromatography-mass spectrometry and gas chromatography-isotope ratio mass spectrometry.Quantitative PCR and western blotting were employed to detect expression of adipogenic genes in 3T3-L1 adipocytes cultured with FA-DM for 12 d.Results:The triacylglyceride(TAG) content was significantly higher in 3T3-L1 adipocytes overexpressing DGAT2 than in control cells.When cultured in DM or FA-DM for 12 d,cells overexpressing DGAT2 showed a higher proportion of unsaturated FAs(C16:1 and C18:1).However,when cells overexpressing DGAT2 were cultured with FA-DM for30 min,the FA composition was almost identical to that of controls.Further,the proportion of stable isotope-labeled FAs were similar in 3T3-L1 adipocytes overexpressing DGAT2 and control cells cultured in IFA-DM for 12 d.These results collectively indicate that the higher proportion of mono-unsaturated FAs,C16:1 and C18:1,may originate from de novo FA synthesis but not from the uptake of specific FAs from the medium.This hypothesis is further supported by evidence that both mRNA and protein expression of genes involved in FA synthesis(ACACA,FASN,SCD1,and A-FABP)were significantly higher in cells overexpressing DGAT2 than in control cells.Conclusions:In conclusion,our study revealed that TAG accumulation,the proportion of MUFAs,and the expression of adipogenic genes were higher in 3T3-L1 cells overexpressing DGAT2 than in control cells. | Zhiqi Zhang Gang Shu Xiaotong Zhu Junming Guo Han Cai Songbo Wang Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Li Yuan Qingyan Jiang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 3 |
| 18 | Enhancement of Arachidonic Acid Production by Mortierella isabellina Through Protoplast Regeneration Mutagenesis显示文摘A developed method was used for the enhancement of arachidonic acid production by M. isabellina. An orthogonal, rotatable and central composite design was applied to determine the optimum conditions for protoplast regeneration mutagenesis. The results showed that a commixture enzyme (cellulase and glusulase) at the concentration of 4%, enzymolysis temperature at 30℃ and enzymolysis time on 7.5 h were the optimal conditions, in which the lethality of M. isabellina spores was 78.4%. After mutagenesis and re-screenings, M. isabellina mutant Y-69 was obtained. GC analysis showed that the yield of arachidonic acid by Y-69 (2.92 g · L-1) was 3.56 times higher than that of the wild-type strain (0.82 g · L-1). Pass generation tests showed that the properties of Y-69 by mutation were readily inherited. | LI Lina YU Changqing HAN Yuxi | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，2： | 3 |
| 19 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 20 | Experimental drugs for treatment of autoimmune myocarditis显示文摘 | Han Lina Guo Shuli Wang Yutang Yang Liming Liu Siyu | 2014 | Chinese Medical Journal2014，，15： | 2 |
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