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| 1 | Roles of lipoprotein receptors in the entry of hepatitis C virus显示文摘Infection by hepatitis C virus(HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multistep complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type Ⅰ and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection. | Jingya Lyu Hitomi Imachi Kensaku Fukunaga Takuo Yoshimoto Huanxiang Zhang Koji Murao | 2015 | World Journal of Hepatology2015，7，24： | 3 |
| 2 | Cervical spondylosis: Evaluation of microstructural changes in spinal cord white matter and gray matter by diffusional kurtosis imaging显示文摘 | Masaaki Hori Satoshi Tsutsumi Yukimasa Yasumoto Masanori Ito Michimasa Suzuki Fumine S. Tanaka Shinsuke Kyogoku Masanobu Nakamura Takashi Tabuchi Issei Fukunaga Yuriko Suzuki Koji Kamagata Yoshitaka Masutani Shigeki Aoki | 2014 | Magnetic Resonance Imaging2014，，： | 2 |
| 3 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 4 | Lipoprotein (a) as a risk factor for silent cerebral infarction in hemodialysis patients显示文摘 | Naoya Fukunaga Futoshi Anan Koji Kaneda Tomoko Nawata Tetsunori Saikawa Hironobu Yoshimatsu | 2008 | Metabolism2008，，： | 1 |
| 5 | Bax to Bcl - 2 ratio and Ki - 67 index are useful predictors of neoadjuvant ehemoradiation therapy in bladder cancer显示文摘 | Hiroaki Matsumoto Takashi Wada Koji Fukunaga | 2004 | Jpn J Clin Oncol2004，34，3： | 1 |
| 6 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 7 | Somatostatin suppresses ghrelin secretion from the rat stomach显示文摘 | Mitsushi Shimada Yukari Date Muhtashan S Mondal Koji Toshinai Takuya Shimbara Kyoko Fukunaga Noboru Murakami Mikiya Miyazato Kenji Kangawa Hironobu Yoshimatsu Hisayuki Matsuo Masamitsu Nakazato | 2003 | Biochemical and Biophysical Research Communications2003，，3： | 1 |
| 8 | High-dose remifentanil suppresses stress response associated with pneumoperitoneum during laparoscopic colectomy显示文摘 | Koji Watanabe Kunitomo Kashiwagi Tomonari Kamiyama Makiko Yamamoto Masaki Fukunaga Eiichi Inada Yoichiro Kamiyama | 2014 | Journal of Anesthesia2014，，： | 1 |
| 9 | Complete Response of Highly Advanced Colon Cancer with Multiple Lymph Node Metastases to Irinotecan Combined with UFT: Report of a Case显示文摘 | Yujiro Fujie Masataka Ikeda Iwao Seshimo Koji Ezumi Taishi Hata Tatsushi Shingai Masayoshi Yasui Osamu Takayama Hiroki Fukunaga Masakazu Ikenaga Ichiro Takemasa Hirofumi Yamamoto Masayuki Ohue Mitsugu Sekimoto Seiichi Hirota Morito Monden | 2006 | Surgery Today2006，，12： | 1 |
| 10 | The CD4 + CD28 null and the regulatory CD4 + CD25 High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy显示文摘 | Yoko Yokoyama Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Masaki Iimuro Koji Yoshida Risa Kikuyama Kyouichi Kato Kazuko Nagase Shirou Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Cytokine2011，，2： | 1 |
| 11 | Angle of covered self-expandable metallic stents after placement is a risk factor for recurrent biliary obstruction显示文摘BACKGROUND Studies have shown that covered self-expandable metallic stents(CSEMS)with a low axial forces after placement can cause early recurrent biliary obstruction(RBO)due to precipitating sludge formation.AIM To ascertain whether the angle of CSEMS after placement is a risk factor for RBO in unresectable distal malignant biliary obstruction(MBO).METHODS Between January 2010 and March 2019,261 consecutive patients underwent selfexpandable metallic stent insertion by endoscopic retrograde cholangiopancreatography at our facility,and 87 patients were included in this study.We evaluated the risk factors for RBO,including the angle of CSEMS after placement as the primary outcome.We measured the obtuse angle of CSEMS after placement on an abdominal radiograph using the SYNAPSE PACS system.We also evaluated technical and functional success,adverse events,time to RBO(TRBO),non-RBO rate,survival time,cause of RBO,and reintervention procedure as secondary outcomes.RESULTS We divided the patients into two cohorts based on the presence or absence of RBO.The angle of CSEMS after placement(per 1°and per 10°)was evaluated using the multivariate Cox proportional hazard analysis,which was an independent risk factor for RBO in unresectable distal MBO[hazard ratio,0.97 and 0.71;95%confidence interval(CI):0.94-0.99 and 0.54-0.92;P=0.01 and 0.01,respectively].For early diagnosis of RBO,the cut-off value of the angle of CSEMS after placement using the receiver operating characteristic curve was 130°[sensitivity,50.0%;specificity 85.5%;area under the curve 0.70(95%CI:0.57-0.84)].TRBO in the<130°angle group was significantly shorter than that in the≥130°angle group(P<0.01).CONCLUSION This study suggests that the angle of the CSEMS after placement for unresectable distal MBO is a risk factor for RBO.These novel results provide pertinent information for future stent management. | Kojiro Tanoue Hirotsugu Maruyama Yuki Ishikawa-Kakiya Yosuke Kinoshita Kappei Hayashi Masafumi Yamamura Masaki Ominami Yuji Nadatani Shusei Fukunaga Koji Otani Shuhei Hosomi Fumio Tanaka Noriko Kamata Yasuaki Nagami Koichi Taira Toshio Watanabe Yasuhiro Fujiwara | 2022 | World Journal of Hepatology2022，14，5： | 0 |
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