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| 1 | Surgical vs percutaneous radiofrequency ablation for hepatocellular carcinoma in dangerous locations显示文摘AIM:To compare the long-term outcome of percutaneous vs surgical radiofrequency ablation(RFA) for hepatocellular carcinoma(HCC) in dangerous locations.METHODS:One hundred and sixty-two patients with HCC in dangerous locations treated with percutaneous or surgical RFA were enrolled in this study.The patients were divided into percutaneous RFA group and surgical RFA group.After the patients were regularly followed up for a long time,their curative rate,hospital stay time,postoperative complications and 5-year local tumor progression were compared and analyzed.RESULTS:No significant difference was observed in curative rate between the two groups(91.3% vs 96.8%,P = 0.841).The hospital stay time was longer and more analgesics were required while the incidence of bile duct injury and RFA-related hemorrhage was lower in surgical RFA group than in percutaneous RFA group(P < 0.05).The local progression rate of HCC in dangerous locations was significantly lower in surgical RFA group than in percutaneous RFA group(P = 0.05).The relative risk of local tumor progression was 14.315 in percutaneous RFA group.CONCLUSION:The incidence of severe postoperative complications and local tumor progression is lower after surgical RFA than after percutaneous RFA. | Ji-Wei Huang Roberto Hernandez-Alejandro Kristopher P Croome Lu-Nan Yan Hong Wu Zhe-Yu Chen Pankaj Prasoon Yong Zeng | 2011 | World Journal of Gastroenterology2011，17，1： | 14 |
| 2 | An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries显示文摘Peripheral nerve injuries(PNI) are caused by a range of etiologies and result in a broad spectrum of disability. While nerve autografts are the current gold standard for the reconstruction of extensive nerve damage, the limited supply of autologous nerve and complications associated with harvesting nerve from a second surgical site has driven groups from multiple disciplines, including biomedical engineering, neurosurgery, plastic surgery, and orthopedic surgery, to develop a suitable or superior alternative to autografting. Over the last couple of decades, various types of scaffolds, such as acellular nerve grafts(ANGs), nerve guidance conduits, and non-nervous tissues, have been filled with Schwann cells, stem cells, and/or neurotrophic factors to develop tissue engineered nerve grafts(TENGs). Although these have shown promising effects on peripheral nerve regeneration in experimental models, the autograft has remained the gold standard for large nerve gaps. This review provides a discussion of recent advances in the development of TENGs and their efficacy in experimental models. Specifically, TENGs have been enhanced via incorporation of genetically engineered cells, methods to improve stem cell survival and differentiation, optimized delivery of neurotrophic factors via drug delivery systems(DDS), co-administration of platelet-rich plasma(PRP), and pretreatment with chondroitinase ABC(Ch-ABC). Other notable advancements include conduits that have been bioengineered to mimic native nerve structure via cell-derived extracellular matrix(ECM) deposition, and the development of transplantable living nervous tissue constructs from rat and human dorsal root ganglia(DRG) neurons. Grafts composed of non-nervous tissues, such as vein, artery, and muscle, will be briefly discussed. | Nitesh P.Patel Kristopher A.Lyon Jason H.Huang | 2018 | Neural Regeneration Research2018，13，5： | 12 |
| 3 | Addressing Moderated Mediation Hypotheses: Theory, Methods, and Prescriptions显示文摘 | Kristopher J. Preacher Derek D. Rucker Andrew F. Hayes | 2007 | Multivariate Behavioral Research2007，，1： | 9 |
| 4 | Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome显示文摘AIM:To examine the effect of gastric bypass surgery on cardiometabolic health among women with polycystic ovarian syndrome(PCOS).METHODS:Retrospective medical chart review identified women(n = 389) with PCOS who underwent Roux-en-Y gastric bypass surgery from 2001-2009 in one surgical practice.Separate repeated measures linear mixed models were fit using the MIXED procedureto assess mean change in cardiometabolic disease risk factors from before to 1-year after surgery and were evaluated by ethnicity [Hispanic,non-Hispanic black(NHB) and white(NHW)].RESULTS:The majority of the sample was Hispanic(66%,25% NHB,9% NHW).Mean body mass index significantly improved 1 year post-surgery for all ethnic groups(45.5 to 35.5 kg/m2 for Hispanics,46.8 to 37.7 kg/m2 for NHB and 45.7 to 36.7 kg/m2 for NHW,P < 0.001).Among Hispanic women mean total cholesterol(198.1 to 160.2 mg/dL),low-density lipoproteins(LDL) cholesterol(120.9 to 91.0 mg/dL),triglycerides(148.6 to 104.8 mg/dL),hemoglobin A1c(6.2% to 5.6%),alanine aminotransferase(28.1 to 23.0 U/L) and aspartate aminotransferase(23.5 to 21.6 U/L) decreased significantly(P < 0.001).Among NHB,mean total cholesterol(184.5 to 154.7 mg/dL),LDL cholesterol(111.7 to 88.9 mg/dL) and triglycerides(99.7 to 70.0 mg/dL) decreased significantly(P < 0.05).Among NHW,mean total cholesterol(200.9 to 172.8 mg/dL) and LDL cholesterol(124.2 to 96.6 mg/dL),decreased significantly(P < 0.05).Pairwise ethnic group comparisons of all cardiometabolic outcomes adjusted for age and type of surgery before and 1 year after surgery showed no statistical difference between the three groups for any outcome.CONCLUSION:Cardiometabolic disease risk improvements vary by ethnicity and obesity may impact glucose tolerance and liver function changes more in Hispanic women with PCOS vs non-Hispanic women. | Carley A Gomez-Meade Adriana Carrillo Gabriela Lopez-Mitnik Sarah E Messiah Kristopher L Arheart Nestor de la Cruz-Muoz | 2013 | World Journal of Diabetes2013，4，3： | 6 |
| 5 | Arterial vs venous blood gas differences during hemorrhagic shock显示文摘AIM: To characterize differences of arterial(ABG) and venous(VBG) blood gas analysis in a rabbit model of hemorrhagic shock. METHODS: Following baseline arterial and venous blood gas analysis, fifty anesthetized, ventilated New Zealand white rabbits were hemorrhaged to and maintained at a mean arterial pressure of 40 mm Hg until a state of shock was obtained, as defined by arterial p H ≤ 7.2 and base deficit ≤-15 mmol/L. Simultaneous ABG and VBG were obtained at 3 minute intervals. Comparisons of p H, base deficit, p CO2, and arteriovenous(a-v) differences were then made between ABG and VBG at baseline and shock states. Statistical analysis was applied where appropriate with a significance of P < 0.05. RESULTS: All 50 animals were hemorrhaged to shockstatus and euthanized; no unexpected loss occurred. Significant differences were noted between baseline and shock states in blood gases for the following parameters: p H was significantly decreased in both arterial(7.39 ± 0.12 to 7.14 ± 0.18) and venous blood gases(7.35 ± 0.15 to 6.98 ± 0.26, P < 0.05), base deficit was significantly increased for arterial(-0.9 ± 3.9 m Eq/L vs-17.8 ± 2.2 m Eq/L) and venous blood gasses(-0.8 ± 3.8 m Eq/L vs-15.3 ± 4.1 m Eq/L, P < 0.05). p CO2 trends(baseline to shock) demonstrated a decrease in arterial blood(40.0 ± 9.1 mm Hg vs 28.9 ± 7.1 mm Hg) but an increase in venous blood(46.0 ± 10.1 mm Hg vs 62.8 ± 15.3 mm Hg), although these trends were non-significant. For calculated arteriovenous differences between baseline and shock states, only the p CO2 difference was shown to be significant during shock.CONCLUSION: In this rabbit model, significant differences exist in blood gas measurements for arterial and venous blood after hemorrhagic shock. A widened p CO2 a-v difference during hemorrhage, reflective of poor tissue oxygenation, may be a better indicator of impending shock. | Kristopher Burton Williams Ashley Britton Christmas Brant Todd Heniford Ronald Fong Sing Joseph Messick | 2014 | World Journal of Critical Care Medicine2014，3，2： | 6 |
| 6 | Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis显示文摘干细胞(hPSC ) 人口着急地在基本研究并且在基于房间的治疗应用为质量控制被需要的为孤立人的 pluripotent 的快速、可靠的方法。用 lectin 数组,我们分析了从 26 件 hPSC 样品和 22 件区分的房间样品提取的 glycoproteins,并且与是足够的把 hPSCs 与许多 non-pluripotent 房间类型区分开来的特殊有约束力的签名识别了 lectins 的一个小组。这些特定的 biomarkers 被所有 12 人的胚胎的干细胞和检验的 14 件人的导致的 pluripotent 干细胞样品分享,不管起源,文化条件,体的房间类型 reprogrammed,或使用的 reprogramming 方法的实验室。我们演示了由检测有调停 lectin 的染色的一张区分的房间人口由荧光显微镜学和流动 cytometry,并且由充实并且清除跟随了的在内的 hPSCs 有约束力的特定的 lectin 的一个实际应用程序从用调停 lectin 的房间分离的混合房间人口的可行 hPSCs。全球基因表示分析显示出特定的 fucosyltransferases 和 sialyltransferases 的联系 pluripotency 的微分表示,它可以在蛋白质 glycosylation 和 lectin 绑定位于这些差别下面。一起拿,我们的结果证明蛋白质 glycosylation 在 pluripotent 和 non-pluripotent 房间之间更加不同,并且证明 lectins 可以被用作 biomarkers 从混合房间人口在干细胞人口并且为可行 hPSCs 的移动监视 pluripotency。 | Yu-ChiehWang MasatoNakagawa IbonGaritaonandia IleanaSlavin GulsahAltun Robert MLacharite Kristopher LNazor Ha TTran Candace LLynch Trevor RLeonardo YingLiu Suzanne EPeterson Louise CLaurent ShinyaYamanaka Jeanne FLoring | 2011 | Cell Research2011，21，11： | 5 |
| 7 | Performance of silver nanoparticles in the catalysis of the oxygen reduction reaction in neutral media: Efficiency limitation due to hydrogen peroxide escape显示文摘为在盖住柠檬酸盐的银 nanoparticles 的中立 pH 的氧减小反应(ORR ) 的 electrocatalytic 活动(直径 = 18 nm ) 在玻璃质的碳(GC ) 上支持了 voltammetrically 被调查。使用新方法,由粘住形成一个随机的 nanoparticle 数组和 voltammetric 实验的 nanoparticles 的底层的修正被 GC 电极的沉浸同时执行在一浸透空气 0.1 M NaClO4 答案(pH = 5.8 ) 包含化学上综合的 nanoparticles。产生 nanoparticle 数组的试验性的 voltammograms 根据氧的二质子的、二电子的减小用自做的节目被模仿到第一电子转移是率决定的氢过氧化物。在银电极的情况中,产生的氢过氧化物进一步部分被减少经由异构的分解流水。在银 macroelectrode 和银 nanoparticles 上获得的结果的比较显示那,为在这研究采用的银 nanoparticles 和粒子报道(0.035%0.457%) , ORR 电极动力学更慢并且在玻璃质的支持碳的 nanoparticles 上更大的氢过氧化物的生产比上体积银。 | Christopher C. M. Neumann Eduardo Laborda Kristina Tschulik Kristopher R. Ward Richard G. Compton | 2013 | Nano Research2013，6，7： | 5 |
| 8 | Addressing Moderated Mediation Hypotheses: Theory, Methods, and Prescriptions显示文摘 | Kristopher J. Preacher Derek D. Rucker Andrew F. Hayes | 2007 | Multivariate Behavioral Research2007，，1： | 4 |
| 9 | Atomic and electronic basis for the serrations of refractory high-entropy alloys显示文摘Refractory high-entropy alloys present attractive mechanical properties,i.e.,high yield strength and fracture toughness,making them potential candidates for structural applications.Understandings of atomic and electronic interactions are important to reveal the origins for the formation of high-entropy alloys and their structure−dominated mechanical properties,thus enabling the development of a predictive approach for rapidly designing advanced materials.Here,we report the atomic and electronic basis for the valence−electron-concentration-categorized principles and the observed serration behavior in high-entropy alloys and highentropy metallic glass,including MoNbTaW,MoNbVW,MoTaVW,HfNbTiZr,and Vitreloy-1 MG(Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5)).We find that the yield strengths of high-entropy alloys and high-entropy metallic glass are a power-law function of the electron-work function,which is dominated by local atomic arrangements.Further,a reliance on the bonding-charge density provides a groundbreaking insight into the nature of loosely bonded spots in materials.The presence of strongly bonded clusters and weakly bonded glue atoms imply a serrated deformation of high-entropy alloys,resulting in intermittent avalanches of defects movement. | William Yi Wang Shun Li Shang Yi Wang Fengbo Han Kristopher A.Darling Yidong Wu Xie Xie Oleg N.Senkov Jinshan Li Xi Dong Hui Karin A.Dahmen Peter K.Liaw Laszlo J.Kecskes Zi-Kui Liu | 2017 | npj Computational Materials2017，，1： | 3 |
| 10 | CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer显示文摘 | Albrecht Neesse Kristopher K. Frese Tashinga E. Bapiro Tomoaki Nakagawa Mark D. Sternlicht Todd W. Seeley Christian Pilarsky Duncan I. Jodrell Suzanne M. Spong David A. Tuveson | 2013 | Proceedings of the National Academy of Sciences2013，，30： | 3 |
| 11 | 冷轧材料的各向异性对断裂性能的影响显示文摘为研究材料在冷轧过程中产生各向异性现象对断裂性能的影响,本文通过Ⅰ,Ⅱ型复合到纯Ⅱ型加载及有限元计算,研究了冷轧材料的各向异性对裂纹初始扩展规律和断裂性能的影响。结果表明,这种弱各向异性确实会影响材料的断裂形态。在垂直和平行于轧制的方向上,材料具有不同的断裂力学性状,且当K_I/K_I>1时,2种不同取向的试样大致沿τ_(max)方向开裂;当K_I/K_I<1时,裂纹会发生尖锐转折并呈Ⅰ型方式断裂。文中也给出了利用复合加载下的P-CMOD曲线确定裂纹临界开裂点的一种简单实验方法。 | 陈枫 Kristoph Zaremba | 1997 | 中南工业大学学报1997，28，5： | 3 |
| 12 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 13 | Evaluation of cardiac hypertrophy in the setting of sudden cardiac death显示文摘Ventricular hypertrophy is a common pathological finding at autopsy that can act as a substrate for arrhythmogenesis.Pathologists grapple with the significance of ventricular hypertrophy when assessing the sudden and unexpected deaths of young people and what it could mean for surviving family members.The pathological spectrum of left ventricular hypertrophy (LVH) is reviewed herein.This article is oriented to the practiring autopsy pathologist to help make sense of various patterns of increased heart musde,particularly those that are not clearly cardiomyopathic,yet present in the setting of sudden cardiac death.The article also reviews factors influencing arrhythmogenesis as well as genetic mutations most commonly associated with ventricular hypertrophy,especially those associated with hypertrophic cardiomyopathy (HCM). | Kristopher S.Cunningham Danna A.Spears Melanie Care | 2019 | Forensic Sciences Research2019，4，3： | 2 |
| 14 | Matrix metalloproteinase-9 deletion is associated with decreased mid-term vein wall fibrosis in experimental stasis DVT显示文摘 | Kristopher B. Deatrick Andrea Obi Catherine E. Luke Megan A. Elfline Vikram Sood Gilbert R. Upchurch Farouc Jaffer Thomas W. Wakefield Peter K. Henke | 2013 | Thrombosis Research2013，，： | 2 |
| 15 | Klebsiella pneumoniae liver abscess: a new invasive syndrome显示文摘 | L Kristopher Siu Kuo-Ming Yeh Jung-Chung Lin Chang-Phone Fung Feng-Yee Chang | 2012 | The Lancet Infectious Diseases2012，，11： | 2 |
| 16 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 17 | 健康教育和减轻应激训练对慢性乙型肝炎患者应激水平的影响比较显示文摘目的:比较健康教育与减轻应激训练对慢性乙型肝炎(简称慢性乙肝)患者应激水平的影响。方法:将120名门诊慢性乙肝患者随机分成对照组、健康教育组、减轻应激训练组,每组30名,在对照组接受门诊医护人员的一般信息咨询和处理的基础上,健康教育组和减轻应激训练组分别进行为期4个月的健康教育和减轻应激训练,在干预前后,采用乙肝应激量表(PSSH)评定三组患者的应激水平。结果:干预前后对照组PSSH得分差异无统计学意义(P>0.05),健康教育组和减轻应激训练组PSSH得分差异有统计学意义(P<0.01);减轻应激训练组的实验处理效果优于健康教育组的,差异具有统计学意义(P<0.01)。结论:对于降低慢性乙肝患者的应激水平,减轻应激训练比健康教育效果更佳。 | 曾慧 曾慧 Kristopher Fennie 姚树桥 张丽平 赵晓敏 | 2009 | 湖南医科大学学报(社会科学版)2009，11，4： | 2 |
| 18 | Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity显示文摘Propolis is commonly used in traditional Chinese medicine.Studies have demonstrated the therapeutic effects of propolis extracts and its major bioactive compound caffeic acid phenethyl ester(CAPE)on obesity and diabetes.Herein,CAPE was found to have pharmacological activity against nonalcoholic fatty liver disease(NAFLD)in diet-induced obese mice.CAPE,previously reported as an inhibitor of bacterial bile salt hydrolase(BSH),inhibited BSH enzymatic activity in the gut microbiota when administered to mice.Upon BSH inhibition by CAPE,levels of tauro-β-muricholic acid were increased in the intestine and selectively suppressed intestinal farnesoid X receptor(FXR)signaling.This resulted in lowering of the ceramides in the intestine that resulted from increased diet-induced obesity.Elevated intestinal ceramides are transported to the liver where they promoted fat production.Lowering FXR signaling was also accompanied by increased GLP-1 secretion.In support of this pathway,the therapeutic effects of CAPE on NAFLD were absent in intestinal FXR-deficient mice,and supplementation of mice with C16-ceramide significantly exacerbated hepatic steatosis.Treatment of mice with an antibiotic cocktail to deplete BSH-producing bacteria also abrogated the therapeutic activity of CAPE against NAFLD.These findings demonstrate that CAPE ameliorates obesity-related steatosis at least partly through the gut microbiota-bile acid-FXR pathway via inhibiting bacterial BSH activity and suggests that propolis enriched with CAPE might serve as a promising therapeutic agent for the treatment of NAFLD. | Xian-chun Zhong Ya-meng Liu Xiao-xia Gao Kristopher W.Krausz Bing Niu Frank J.Gonzale Cen Xie | 2023 | Acta Pharmacologica Sinica2023，44，1： | 2 |
| 19 | Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet显示文摘 | Naoki Tanaka Shogo Takahashi Zhong-Ze Fang Tsutomu Matsubara Kristopher W. Krausz Aijuan Qu Frank J. Gonzalez | 2014 | BBA - Molecular and Cell Biology of Lipids2014，，11： | 1 |
| 20 | Bringing the Excitement and Motivation of Research to Students; Using Inquiry and Research- Based Learning in a Year-Long Biochemistry Laboratory 显示文摘 | Kristopher K Jennifer S Mark A | 2010 | Bio- chemistry and Molecular Biology Education2010，5，38： | 1 |
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