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| 1 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 2 | MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ显示文摘 | Min He Zhenqun Xu Tong Ding Dong-Ming Kuang Limin Zheng | 2009 | Cellular & Molecular Immunology2009，6，5： | 12 |
| 3 | Performance analysis for range expansion in heterogeneous networks显示文摘In this paper,the uplink and downlink performance of a two tier heterogeneous network(HetNet)with range expansion(RE)is analyzed.Different from previous works,base stations(BSs)are modeled as a spatial Poisson point process.This model can not only capture the irregularity of the BS deployment but also lead to closed form expressions.With the analytical results,the impacts of several key parameters on the coverage and throughput performance are investigated.Our results justifies the effectiveness of RE and Pico deployment.Based on our analyses,certain attention should be made on the RE design to balance the uplink and downlink performance.Our analyses are corroborated by simulations and can thus serve as a flexible and quick guidance for system design without complicated and time consuming system level platform construction and simulation. | FEI ZeSong DING HaiChuan XING ChengWen NI JiQing KUANG JingMing | 2014 | Science China(Information Sciences)2014，57，8： | 11 |
| 4 | Grinding force and surface quality in creep feed profile grinding of turbine blade root of nickel-based superalloy with microcrystalline alumina abrasive wheels显示文摘Creep feed profile grinding of the fir-tree blade root forms of single crystal nickel-based superalloy was conducted using microcrystalline alumina abrasive wheels in the present study. The grinding force and the surface quality in terms of surface topography, subsurface microstructure,microhardness and residual stress obtained under different grinding conditions were evaluated comparatively. Experimental results indicated that the grinding force was influenced significantly by the competing predominance between the grinding parameters and the cross-sectional root workpiece profile. In addition, the root workpiece surface, including the root peak and valley regions, was produced with the large difference in surface quality due to the nonuniform grinding loads along the root workpiece profile in normal section. Detailed results showed that the surface roughness, subsurface plastic deformation and work hardening level of the root valley region were higher by up to25%, 20% and 7% in average than those obtained in the root peak region, respectively, in the current investigation. Finally, the superior parameters were recommended in the creep feed profile grinding of the fir-tree blade root forms. This study is helpful to provide industry guidance to optimize the machining process for the high-valued parts with complicated profiles. | Qing MIAO Wenfeng DING Weijie KUANG Changyong YANG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 10 |
| 5 | Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines显示文摘单性生殖的胚胎的茎(足) 细胞为学习位于印的 genomic 下面的分子的机制提供一个珍贵试管内模型系统。然而,足房间的 thepluripotency 和父亲一般地表示的印的基因的表示侧面一直不是充分探索了。在这研究,三根老鼠足房间线被建立,在扩大文化的这些房间的区别潜力被评估。无差别的房间有正常核型和同型结合的染色体,并且表示了 ES-cell-specific 分子的标记。房间在超过 50 个段落以后仍然保持无差别并且展出了 pluripotentdifferentiation 能力。确定的 ES 房间的所有三根线生产了 teratomas;ES 房间的二根线生产了怪物和细菌线传播。而且,在这些房间的父亲一般地表示的印的基因 Snrpn, U2af1-rs1, Peg3,影响, Zfp127, Dlk1 和 Mest 的激活被检测。父亲一般地表示的印的基因被发现在单性生殖的联盟者的胚囊阶段被表示的一些激活胚胎试管内,他们的表示水平与扩大的足细胞培养增加了。而且,我们在足房间的这些父亲一般地表示的印的基因的激活在 ther 的甲基化与一个变化被联系的数据表演鼓舞了差别 methylated 区域。这些调查结果为足房间的 thepluripotency 提供直接证据并且在足房间表明在脱氧核糖核酸甲基化模式和父亲一般地表示的印的基因的激活之间的协会。因此,确定的 ES 房间线为在哺乳动物的开发学习 epigenetic 规定提供一个珍贵模型。 | Hua Jiang Bowen Sun Weicheng Wang Zhihong Zhang Furong Gao Guilai Shi Bing Cui XiangyinKong Zhao He Xiaoyan Ding Ying Kuang Jian Fei Yi Juan Sun Yun Feng Ying Jin | 2007 | Cell Research2007，17，9： | 10 |
| 6 | Causal Inference显示文摘Causal inference is a powerful modeling tool for explanatory analysis,which might enable current machine learning to become explainable.How to marry causal inference with machine learning to develop explainable artificial intelligence(XAI)algorithms is one of key steps toward to the artificial intelligence 2.0.With the aim of bringing knowledge of causal inference to scholars of machine learning and artificial intelligence,we invited researchers working on causal inference to write this survey from different aspects of causal inference.This survey includes the following sections:“Estimating average treatment effect:A brief review and beyond”from Dr.Kun Kuang,“Attribution problems in counterfactual inference”from Prof.Lian Li,“The Yule–Simpson paradox and the surrogate paradox”from Prof.Zhi Geng,“Causal potential theory”from Prof.Lei Xu,“Discovering causal information from observational data”from Prof.Kun Zhang,“Formal argumentation in causal reasoning and explanation”from Profs.Beishui Liao and Huaxin Huang,“Causal inference with complex experiments”from Prof.Peng Ding,“Instrumental variables and negative controls for observational studies”from Prof.Wang Miao,and“Causal inference with interference”from Dr.Zhichao Jiang. | Kun Kuang Lian Li Zhi Geng Lei Xu Kun Zhang Beishui Liao Huaxin Huang Peng Ding Wang Miao Zhichao Jiang | 2020 | Engineering2020，6，3： | 8 |
| 7 | Complementary transmissive ultra-thin meta-deflectors for broadband polarization-independent refractions in the microwave region显示文摘Polarization manipulation is a significant issue for artificial modulation of the electromagnetic(EM) wave, but general mechanisms all suffer the restriction of inherent symmetric properties between opposite handedness.Herein, a strategy to independently and arbitrarily manipulate the EM wave with orthogonal circular polarizations based on a metasurface is proposed, which effectually breaks through traditional symmetrical characteristics between orthogonal handedness. By synthesizing the propagation phase and geometric phase, the appropriate Jones matrix is calculated to obtain independent wavefront manipulation of EM waves with opposite circular polarizations. Two transmissive ultra-thin meta-deflectors are proposed to demonstrate the asymmetrical refraction of transmitted circularly polarized waves in the microwave region. Simulated transmitted phase front and measured far-field intensity distributions are in excellent agreement, indicating that the transmitted wave with different polarizations can be refracted into arbitrary and independent directions within a wide frequency band(relative bandwidth of 25%). The results presented in this paper provide more freedom for the manipulation of EM waves, and motivate the realizations of various polarization-independent properties for all frequency spectra. | YUEYI YUAN KUANG ZHANG XUMIN DING BADREDDINE RATNI SHAH NAWAZ BUROKUR QUN WU | 2019 | Photonics Research2019，7，1： | 5 |
| 8 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 9 | Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis显示文摘Iloperidone 是被 CYP2D6, CYP3A4,和 cytosolic 酶主要使产生代射变化的不正常的抑制精神的药。以前的研究证明 CYP2D6 的广泛、差的 metabolizers 展出 iloperidone 和它的代谢物的不同血浆集中。这研究的目的是开发一个父母代谢物人口 pharmacokinetic (PPK ) 模型确定在中国精神分裂症 patients.Methods 的 iloperidone 和它的代谢物的 pharmacokinetics 上的 CYP2D6 *10 等位基因的效果:七十个中国精神分裂症病人被注册,从谁有限的血样品在 d 上被收集 15 (0 h ) 并且 d 28 (在药管理以后的 0, 4 和 12 h ) 。iloperidone 和它的代谢物 M 1(P-88 ) 和 M 2(P-95 ) 的血浆集中同时用验证 HPLCMS 试金被检测。CYP2D6 *10 (rs1065852 ) genotyping 被执行。一个 PPK 模型用 NONMEM 软件(版本 7.2 ) 从病人基于数据被开发。有一阶的吸收和消除的一个一个分隔空间模型被用来描述与 iloperidone 和它的 metabolites.Results 有关的 pharmacokinetic 数据:有 CYP2D6 *10 T/T 遗传型的病人与 C/C 或 C/T 遗传型比病人有 iloperidone 和 M 1, 的显著地更高的集中和 M 2 的更低的集中。CYP2D6 *10 遗传型为 iloperidone 的转变影响了消除常数到代谢物 M 1(K 23) 和 M 2(K 24) 。有 T/T 遗传型的病人的 K 23 价值是与 C/C 或 C/T 遗传型象病人的一样大的 1.34 褶层。分别地,有 C/T 和 T/T 遗传型的病人的 K 24 价值是 0.693-fold, 和 0.492 褶层象有 C/C genotype.Conclusion 的病人的一样低:CYP2D6 *10 变化在中国精神分裂症病人影响 iloperidone 和它的代谢物的 pharmacokinetics,建议为有 CYP2D6 *10 变化的病人的 iloperidone 的临床的剂量需要被优化。 | Qi PEI Lu HUANG Jie HUANG Jing-kai GU Yun KUANG Xiao-cong ZUO Jun-jie DING Hong-yi TAN Cheng-xian GUO Shi-kun LIU Guo-ping YANG | 2016 | Acta Pharmacologica Sinica2016，37，11： | 4 |
| 10 | Electron-withdrawing functional ligand promotes CO2 reduction catalysis in single atom catalyst显示文摘Electrochemical carbon dioxide reduction reaction (CO2RR) powered by renewable electricity offers an attractive approach to reduce carbon emission and at the same time produce valuable chemicals/fuels.To design efficient CO2 reduction electrocatalyst,it is important to understand the structure-activity relationship.Herein,we design a series of single Co atoms electrocatalysts with well-defined active sites electronic structures,which exhibit outstanding CO2RR activity with controllable selectivity to CO.Experimental and density functional theory (DFT) calculation studies show that introducing nitro (amino) ligand next to single Co atom catalytic center with electron-withdrawing (electron-donating) capability favors (hinders) CO2 reduction catalysis.This work provides an in-depth understanding of how functional ligand affects the splitting of transition metal 3d electron orbital,thereby changing the electron transfer from transition metal active site to CO2,which is closely related to the Gibbs free energy of the rate-determining step (CO2+e^-+*→*CO2^-). | Xinyi Ren Song Liu Huicong Li Jie Ding Linghui Liu Zhichong Kuang Ling Li Hongbin Yang Fuquan Bai Yanqiang Huang Tao Zhang Bin Liu | 2020 | Science China Chemistry2020，63，12： | 3 |
| 11 | Fretting wear behaviour of machined layer of nickel-based superalloy produced by creep-feed profile grinding显示文摘Fretting wear has an adverse impact on the fatigue life of turbine blade roots.The current work is to comparatively investigate the fretting wear behaviour of the nickel-based superalloy surfaces produced by polishing and creep-feed profile grinding,respectively,in terms of surface/subsurface fretting damage,the friction coefficient,wear volume and wear rate.Experimental results show that the granulated tribolayer aggravates the workpiece wear,while the flat compacted tribolayer enhances the wear resistance ability of workpiece,irrespective of whether the workpiece is processed by polishing or grinding.However,the wear behaviors of tribolayers are different.For the polished surface,when the normal load exceeds 100 N,the main defects are crack,rupture,delamination and peeling of workpiece materials;the wear mechanism changes from severe oxidative wear to fatigue wear and abrasive wear when the loads increase from 50 to 180 N.As for the ground surface,the main wear mechanism is abrasive wear.Particularly,the ground surface possesses better wear-resistant ability than the polished surface because the former has the lower values in coefficient friction(0.23),wear volume(0.06×10^(6)μm^(3))and wear rate(0.25×10^(-16)Pa^(-1)).Finally,an illustration is given to characterize the evolution of wear debris on such nickel-based superalloy on the ground surface. | Weijie KUANG Qing MIAO Wenfeng DING Yanjun ZHAO Biao ZHAO Xuebing WEN Shaopeng LI | 2022 | Chinese Journal of Aeronautics2022，35，10： | 3 |
| 12 | Relation between seed size in different plant species and response of their seedlings to double CO_2显示文摘ATMOSPHERIC CO2 concentration is predicted to increase to 700μL/L by the middle of the 21st century. The impacts of raising CO2 on vegetation and ecosystem have been intensively studied. It is well known that C3 species and C4 species responded much differently to double CO2. Potential enhancement of photosynthesis efficiency induced by double CO2 in C3 plants was almost 66%, but in C4 plants only 4%. The response to double CO2 in C3 species might | DING Li, ZHANG Chonghao, BAI Kezhi and KUANG Tingyun1 Department of Biology, Beijing Normal University, Beijing 100875, China 2. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China | 1997 | Chinese Science Bulletin1997，42，4： | 2 |
| 13 | Topotactically constructed nickel-iron(oxy)hydroxide with abundant in-situ produced high-valent iron species for efficient water oxidation显示文摘The low efficiency of oxygen evolution reaction(OER) is regarded as one of the major roadblocks for metal-air batteries and water electrolysis.Herein,a high-performance OER catalyst of NiFe_(0.2)(oxy)hydroxide(NiFe_(0.2)-O_(x)H_(y)) was developed through topotactic transformation of a Prussian blue analogue in an alkaline solution,which exhibits a low overpotential of only 263 mV to reach a current density of 10 mA cm^(-2) and a small Tafel slope of 35 mV dec-1.Ex-situ/operando Raman spectroscopy results indicated that the phase structure of NiFe_(0.2)-O_(x)H_(y) was irreversibly transformed from the type of α-Ni(OH)_(2) to γ-NiOOH with applying an anodic potential,while ex-situ/operando 57Fe Mossbauer spectroscopic studies evidenced the in-situ production of abundant high-valent iron species under OER conditions,which effectively promoted the OER catalysis.Our work elucidates that the amount of high-valent iron species in-situ produced in the NiFe(oxy)hydroxide has a positive correlation with its water oxidation reaction performance,which further deepens the understanding of the mechanism of NiFe-based electrocatalysts. | Zhichong Kuang Song Liu Xuning Li Meng Wang Xinyi Ren Jie Ding Rile Ge Wenhui Zhou Alexandre IRykov Moulay TSougrati Pierre-Emmanuel Lippens Yanqiang Huang Junhu Wang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 14 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 15 | Anion Exchange Membrane Based on Interpenetrating Polymer Network with Ultrahigh Ion Conductivity and Excellent Stability for Alkaline Fuel Cell显示文摘A high-performance anion exchange membrane(AEM)is critical for the development of alkaline fuel cell.In this work,AEMs with an interpenetrating polymer network(IPN)are synthesized.An electron microscope clearly reveals a highly efficient“ion channel”network,which is constructed with a small amount of cation exchange groups.This specially designed ion channel leads to extraordinary hydroxide conductivity(e.g.,257.8 mS cm^(-1) at 80℃)of IPN AEMs at moderate ion exchange capacity(IEC=1:75 mmol g^(-1)),as well as excellent long-term alkaline stability at harsh condition which showed that 81%of original conductivity can be retained after a long time for 1248 hours.Moreover,a remarkable peak power density of 1.20 Wcm^(-2)(0.1 MPa backpressure)with nonprecious metal(FeNx-CNTs)as oxygen reduction reaction(ORR)catalyst in a fuel cell test was achieved.This work offers a general strategy to prepare high-performance AEMs based on IPN structure design. | Lingping Zeng Qian He Yunchuan Liao Shangyi Kuang Jianchuan Wang Wei Ding Qiang Liao Zidong Wei | 2020 | Research2020，，1： | 2 |
| 16 | Overexpression of CREPT confers colorectal cancer sensitivity to fluorouracil显示文摘AIM To investigate expression of cell cycle-related and expression-elevated protein in tumor(CREPT) in colorectal cancer(CRC) and determine its prognostic value in response to 5-fluorouracil(5-FU).METHODS The relative expression of CREPT in CRC tumor samples was determined using immunohistochemistry. The protein content in cell lines was analyzed by immunoblotting. Cell viability was measured with the CCK-8 assay. Cell cycle and apoptosis analyses were performed with flow cytometry.RESULTS CREPT was overexpressed in CRC tissues and correlated with histological grade. Clinicopathological analysis indicated that CREPT was positively related to tumor progression. Exogenous expression of CREPT stimulated cell proliferation and accelerated the cell cycle. More importantly, high expression of CREPT sensitized CRC cells to 5-FU treatment. Furthermore, we demonstrated that 5-FU elicited significant apoptosis in CREPT-positive cells.CONCLUSION Aberrant overexpression of CREPT contributes to tumorigenesis of CRC by promoting cell proliferation and accelerating the cell cycle, and confers sensitivity to 5-FU. CREPT is a potential prognostic biomarker for 5-FU in CRC. | Yan-Shen Kuang Yi Wang Li-Dan Ding Liu Yang Ying Wang Si-Han Liu Bing-Tao Zhu Xu-Ning Wang Hong-Yi Liu Jun Li Zhi-Jie Chang Yin-Yin Wang Bao-Qing Jia | 2018 | World Journal of Gastroenterology2018，24，4： | 2 |
| 17 | Application of bilateral supraclavicular artery island flaps in the repair of hypopharyngeal and cervical skin defects:a case report显示文摘To the Editor:In advanced head and neck malignancies,especially in patients who relapse after comprehensive treatment such as a history of neck surgery or radiotherapy,tumors can simultaneously invade both the mucosa and skin.Reconstruction of penetrating defects formed after tumor resection must achieve the following goals:(1)Reconstruction of the digestive tract to restore swallowing function.(2)Provide soft tissue for repair of important structures in the neck,that is,to re-build the skin of the neck.We used bilateral supraclavicular artery island flaps to repair a large area of skin with mucosal defects in the neck of a patient with advanced laryngeal malignancy after surgery,and with satisfactory post-operative results. | Jing Zhou Yi-Ming Ding Meng-Jiao Zhou Yun-Xun Kuang Ting-Yao Ma Xiao-Hong Chen | 2020 | Chinese Medical Journal2020，，11： | 2 |
| 18 | New Discovery of Molar Tooth Structures in the Kangjia Formation at Benxi,Liaoning and its Significance显示文摘Objective The Jilin-Liaoning area has widely spread Meso-and Neoproterozoic sediments and is always a focused area for researching Precambrian geology.Previous study has achieved a series of results about Neoproterozoic stratigraphy in this area,but the lack of precise geochronological data and signs of stratigraphic correlation has resulted in the long controversial stratigraphic age and regional correlation.During recent years,we have conducted large amounts of stratigraphic and sedimentary research about the Neoproterozoic | WU Hao DING Xiaozhong LIU Yanxue KUANG Hongwei | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 1 |
| 19 | 查看详情显示文摘 | Ding Bojiang Kuang Guangli Shan Jiafang | | 0，，： | 1 |
| 20 | Osteosarcoma metastasis: prospective role of ezrin显示文摘 | Yuanjin Zhang Ling Zhang Guofu Zhang Songbai Li Jun Duan Jie Cheng Guozhen Ding Chibing Zhou Jie Zhang Pengcheng Luo Dongbing Cai Lianghong Kuang Yichun Zhou Liqun Tong Xiangdong Yu Lifang Zhang Lijun Xu Li Yu Xiaomei Shi Aihong Ke | 2014 | Tumor Biology2014，，6： | 1 |
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