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| 1 | The first offshore natural gas hydrate production test in South China Sea显示文摘Natural gas hydrates (NGH)is one of key future clean energy resources.Its industrialized development will help remit the huge demand of global natural gas,relieve the increasing pressure of the environment, and play a vital role in the green sustainable growth of human societies.Based on nearly two decades' studying on the reservoir characteristics in the South China Sea (SCS)and the knowledge of reservoir system,the China Geological Survey (CGS)conducted the first production test on an optimal target selected in Shenhu area SCS in 2017.Guided by the 'three-phase control'exploitation theory which focused on formation stabilization,technologies such as formation fluid extraction,well drilling and completing, reservoir stimulating,sand controlling,environmental monitoring,monitoring and preventing of secondary formation of hydrates were applied.The test lasted for 60 days from May 10^th when starting to pump, drop pressure and ignite to well killing on July 9^th,with gas production of 3.09×10^5 m^3 in total,which is a world record with the longest continuous duration of gas production and maximal gas yield.This successful test brings a significant breakthrough on safety control of NGH production. | Jin-fa Li Jian-liang Ye Xu-wen Qin Hai-jun Qiu Neng-you Wu Hai-long Lu Wen-wei Xie Jing-an Lu Fei Peng Zhen-qiang Xu Cheng Lu Zeng-gui Kuang Jian-gong Wei Qian-yong Liang Hong-feng Lu Bei-bei Kou | 2018 | China Geology2018，1，1： | 117 |
| 2 | High entropy defective fluorite structured rare-earth niobates and tantalates for thermal barrier applications显示文摘Rare-earth tantalates and niobates(REjTaO7 and REjNbO7)have been considered as promising candidate thermal barrier coating(TBC)materials in next generation gas-turbine engines due to their ultra-low thermal conductivity and better thermal stability than yttria-stabilized zirconia(YSZ).However,the low Vickers hardness and toughness are the main shortcomings of RE;TaO-and REjNbOr that limit their applications as TBC materials.To increase the hardness,high entropy(Yu3Ybu3Er/3)sTaOr,(Y13YbnErns)NbO,and(Sm1/6Eu1/6Y 1/6Yb1/6Lu1/6Er1/6)3(Nb1/2Ta1/2)O7 are designed and synthesized in this study.These high entropy ceramics exhibit high Vickers hardness(10.912.0 GPa),close thermal expansion coefficients to that of single-principal-component RE3TaO,and RE;NbO,(7.9×10^-6-10.8×10-6 C-1 at room temperature),good phase stability,and good chemical compatibility with thermally grown Al2O3,which make them promising for applications as candidate TBC materials. | Zifan ZHAO Heng CHEN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Wei XU Kuang SUN Zhjjian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，3： | 27 |
| 3 | The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia显示文摘Introduction Stroke is an important disease that is prevalent worldwide [1-3].Ischemic stroke accounts for 80%of stroke cases. Currently,evidence-based effective treatments for ischemic stroke are limited,and only intravenous throm- bolysis with Alteplase (a commercially available throm- bolytic agent)within 4.5 h of stroke onset and thrombectomy and arterial thrombolysis within 6-24h of onset are effective [4,5].However,because these two treatments have strict indications and certain risks (reper- fusion injury and bleeding)[5-8],there is an urgent need to develop new treatment methods.Thus,comprehensive elucidation of the molecular mechanisms underlying ischemic brain damage and the search for key signaling pathways and protein molecules are important for guiding the clinical treatment of ischemic stroke. | Zhaofei Dong Kuang Pan Jingrui Pan Qingxia Peng Yidong Wang | 2018 | Neuroscience Bulletin2018，34，6： | 17 |
| 4 | Formations of groundwater hydrogeochemistry in a karst system during storm events as revealed by PCA显示文摘High-frequency samples have been collected at Jiangjia Spring, the outlet of Qingmuguan underground river system (QURS) in Chongqing in late April, 2008. The variations of hydrogeochemical compositions are found responding rapidly to storm events. Principal component analysis (PCA) of the 20 variables is employed to interpret the relationships with specific processes that control the groundwater hydrogeochemical formations. Through PCA, 84.961% of the total amount information is extracted to indicate the formations of groundwater hydrogeochemical features in QURS during storm events. The first component separates the soil erosion (i.e., increases in turbidity and concentrations of Al3+, TFe, TMn, Ba2+ and NO2?), and dilution effect (i.e., decreases in specific conductance and concentrations of HCO3?, Ca2+ and Sr2+), accounting for 41.495% of the variability in the data. The second component indicates residual fertilizers and duck’s waste from farmlands (i.e., increases in specific conductance and concentrations of Na+, NO3-, PO43-,K+and Cl-), contributing to 37.449%. The dissolution of dolomite and dolomitic limestone makes up 6.017%. During the first rainfall event, the groundwater quality is mainly affected by residual fertilizers and duck’s waste from farmlands, whereas in the second rainfall event, it is mainly affected by increased turbidity and ionic concentrations caused by soil erosion. | YANG PingHeng YUAN DaoXian YUAN WenHao KUANG YingLun JIA Peng HE QiuFang | 2010 | Chinese Science Bulletin2010，55，14： | 14 |
| 5 | Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration显示文摘在到女繁殖的道的从男性的旅行,哺乳动物的精子经验自然渗透的减少(例如在老鼠,从 ~ 在到 ~ 的尾 epididymis 的 415 mOsm 在子宫的洞的 310 mOsm ) 。精子演变为活动性激活利用这张力减退的暴露,同时高效地沉默张力减退的房间胀大的否定影响。以前的生理并且药理学研究显示出那个离子控制隧道的水流入 / 流出活跃地涉及精子的过程体积规定;然而,没有特定的精子蛋白质为这快速的 osmoadaptation 被发现负责。这里,我们报导 aquaporin3 (AQP3 ) 是在老鼠和人的一条精子水隧道。Aqp3 缺乏的精子响应张力减退显示出正常活动性激活,但是显示增加的危险到张力减退的房间胀大,在进入以后,由增加的尾巴弯曲描绘了子宫。精子缺点是在男性女性的繁殖的道转变期间响应生理的张力减退的应力胀大的损害精子体积规定和进步房间的结果。微速摄影的成像表明房间体积扩大在细胞质的微滴开始,强迫尾巴到有角并且由于机械膜段形成像发卡的结构。尾巴变丑妨碍了精子移植进输卵管,导致损害授精并且减少了男富饶。这些数据为精子作为一条必要的膜小径建议 AQP3 平衡 “ 的规章的卷减少(RVD ) ; trade-off”在在生理的张力减退之上胀大的精子活动性和房间之间,从而优化 postcopulatory 精子行为。 | Qi Chen Hongying Peng Li Lei Ying Zhang Haibin Kuang Yujing Cao Qi-xian Shi Tonghui Ma Enkui Duan | 2011 | Cell Research2011，21，6： | 13 |
| 6 | Adaptive subsequence adjustment with evolutionary asymmetric path-relinking for TDRSS scheduling显示文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system(TDRSS), there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio.A model of nonhomogeneous parallel machines scheduling problems with time window(NPM-TW) is firstly built up for the TDRSS,considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite(TDRS). Then,an adaptive subsequence adjustment(ASA) framework with evolutionary asymmetric path-relinking(Ev APR) is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure(GRASP) algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR. | Peng Lin Linling Kuang Xiang Chen Jian Yan Jianhua Lu Xiaojuan Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 12 |
| 7 | Combined vascular resection and analysis of prognostic factors for hilar cholangiocarcinoma显示文摘BACKGROUND: Hilar cholangiocarcinoma(HCCA) is a devastating malignancy arising from the bifurcation of the hepatic duct,whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors. METHODS: Clinical data of 154 HCCA patients who had been treated from January 2005 to December 2012 were retrospectively analyzed. The patients were divided into three groups based on vascular resection: those without vascular resection; those with portal vein resection alone and those with hepatic artery resection. The survival and complication rates were compared among the three groups. Multivariate analysis was made to determine prognostic factors.RESULTS: No significant differences were found in survival and complication rates among the three groups(P>0.05). Multivariate analysis showed that 3 factors were related to survival: lymph node metastasis,tumor size(>2.5 cm),and positive resection margin.CONCLUSIONS: Vascular resection improved the survival rate of patients with HCCA involving the hepatic artery or portal vein. Lymph node metastasis,tumor size(>2.5 cm) and positive resection margin were poor prognostic factors in patients with HCCA. | Shu-Tong Wang Shun-Li Shen Bao-Gang Peng Yun-Peng Hua Bin Chen Ming Kuang Shao-Qiang Li Qiang He Li-Jian Liang | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 12 |
| 8 | Enhanced N-doping in mesoporous carbon for efficient electrocatalytic CO2 conversion显示文摘The capability of electrocatalytic reducti on of carbon dioxide(CO2)using nitrogen(N)-doped carb on strongly depe nds on the N-dopi ng level and their types.In this work,we developed a strategy to generate mesoporous N-doped carb on frameworks with tun able configurati ons and contents of N dopants,by using a secondary doping process via the treatment of N,N-dimethylformamide(DMF)solvent.The obtained mesoporous N-doped carbon(denoted as MNC-D)served as an efficient electrocatalyst for electroreduction of CO2 to CO.A high Faradaic efficiency of^92%and a partial current density for CO of-6.8 mA·cm^-2 were achieved at a potential of-0.58 V vs.RHE.Electrochemical analyses further revealed that the active sites within the N-doped carb on catalysts were the pyridinic N and defects gen erated by the DMF treatme nt,which enhan ced the activati on and adsorpti on CO2 molecules.Our study suggests a new approach to develop efficie nt carb on-based catalysts for potential scalable CO2 reduction reaction(CO2RR)to fuels and chemicals. | Min Kuang Anxiang Guan Zhengxiang Gu Peng Han Linping Qian Gengfeng Zheng | 2019 | Nano Research2019，12，9： | 11 |
| 9 | Microalloying Al alloys with Sc:a review显示文摘As a kind of important light alloys,the Al alloys exhibit mechanical properties that are closely related to the microstructures.Changing the main alloying elements and adjusting heat treatments are usually approaches to tune the microstructure and hence artificially control the mechanical properties.However,the windows for the two approaches have become quite narrow,after extensive studies in the last half of century.Microalloying has become the most promising strategy to further modify the microstructure and improve the mechanical properties of Al alloys,among which the element of scandium(Sc)is especially powerful.In this paper,the recent progresses in Al alloys microalloyed with Sc are briefly reviewed,focusing on the microstructural characterization,strengthening response,and underlying mechanisms.The possible key research points are also proposed for the further development of Al alloys microalloyed with Sc and other rare earth elements. | Jin-Yu Zhang Yi-Han Gao Chong Yang Peng Zhang Jie Kuang Gang Liu Jun Sun | 2020 | Rare Metals2020，39，6： | 10 |
| 10 | High-entropy(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3:A promising thermal/environmental barrier material for oxide/oxide composites显示文摘Yttrium aluminum perovskite(YAl O3)is a promising candidate material for environmental barrier coatings(EBCs)to protect Al2 O3 f/Al2 O3 ceramic matrix composites(CMCs)from the corrosion of high-temperature water vapor in combustion environments.Nevertheless,the relatively high thermal conductivity is a notable drawback of YAl O3 for environmental barrier coating application.Herein,in order to make REAl O3 more thermal insulating,a novel high-entropy rare-earth aluminate ceramic(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 was designed and synthesized.The as-prepared(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 ceramic possesses close thermal expansion coefficient(9.02×10-6/oC measured from room temperature to 1200℃)to that of Al2 O3.The thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 at room temperature is 4.1 W·m-1K-1,which is almost one third of the value of YAl O3.Furthermore,to effectively prevent the penetration of water vapor from possible pores/cracks of coating layer,which are often observed in T/EBCs,a tri-layer EBC system REAl O3/RE3 Al5 O12/(Al2 O3 f/Al2 O3 CMCs)is designed.Close thermal expansion coefficient to Al2 O3 and low thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3,as well as the formation of dense garnet layer at(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3/Al2 O3 interface,indicate that this new type of high-entropy ceramic is suitable as a candidate environmental barrier coating material for Al2 O3 f/Al2 O3 CMCs. | Zifan Zhao Heng Chen Huimin Xiang Fu-Zhi Dai Xiaohui Wang Wei Xu Kuang Sun Zhijian Peng Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，12： | 9 |
| 11 | Gold nanoparticle-based paper sensor for ultrasensitive and multiple detection of 32 (fluoro)quinolones by one monoclonal antibody显示文摘为快速、同时的察觉(fluoro ) quinolones,认出 32 的广泛地特定的 monoclonal 抗体(mAb )(fluoro ) quinolone 抗菌素作为 hapten 用 norfloxacin 衍生物和 sarfloxacin 衍生物的混合物被准备。基于黄金, nanoparticles (AuNPs ) 当时是的 immunochromatographic 脱衣与山羊反老鼠抗体和抗原(联合到 ovalbumin 的 sarfloxacin ) 集合了,过去常分别地形成 C 线和 T 线。这抗原与竞争(fluoro ) 在与 mAbs 孵化的一件样品的 quinolones 用 AuNPs 标记。长带能检测 32 ( fluoro ) quinolones 包括 oxolinic 酸, nalidixic 酸, miloxacin , pipemidic 酸, piromidic 酸, rosoxacin , cinoxacin , norfloxacin , pefloxacin , lomfloxacin , enofloxacin , fleroxacin , ciprofloxacin , enrofloxacin , dafloxacin , orbifloxacin , sparfloxacin , gemifloxacin , besifloxacin , balofloxacin , gatifloxacin ,在在 10 mi 以内的牛奶的 moxifloxacin , nadifloxacin , ofloxacin , marbofloxacin , flumequine , pazufloxacin , prulifloxacin , sarafloxacin , difloxacin , trovafloxacin ,和 tosufloxacin 从 1 ~ 100 ng/mL 和察觉的限制的长带范围的截止价值是 0.1-10 ng/mL。长带不包括四圜素, sulfamethazine,氨比西林,抗生素的一种,黄麴毒素 B1,或 gentamicin 与抗菌素做跨 react。简言之,这 immunochromatographic 脱衣是为主要屏蔽的一个很有用的工具(fluoro ) 在牛奶的 quinolones。 | Juan Peng Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，1： | 9 |
| 12 | Causal Inference显示文摘Causal inference is a powerful modeling tool for explanatory analysis,which might enable current machine learning to become explainable.How to marry causal inference with machine learning to develop explainable artificial intelligence(XAI)algorithms is one of key steps toward to the artificial intelligence 2.0.With the aim of bringing knowledge of causal inference to scholars of machine learning and artificial intelligence,we invited researchers working on causal inference to write this survey from different aspects of causal inference.This survey includes the following sections:“Estimating average treatment effect:A brief review and beyond”from Dr.Kun Kuang,“Attribution problems in counterfactual inference”from Prof.Lian Li,“The Yule–Simpson paradox and the surrogate paradox”from Prof.Zhi Geng,“Causal potential theory”from Prof.Lei Xu,“Discovering causal information from observational data”from Prof.Kun Zhang,“Formal argumentation in causal reasoning and explanation”from Profs.Beishui Liao and Huaxin Huang,“Causal inference with complex experiments”from Prof.Peng Ding,“Instrumental variables and negative controls for observational studies”from Prof.Wang Miao,and“Causal inference with interference”from Dr.Zhichao Jiang. | Kun Kuang Lian Li Zhi Geng Lei Xu Kun Zhang Beishui Liao Huaxin Huang Peng Ding Wang Miao Zhichao Jiang | 2020 | Engineering2020，6，3： | 8 |
| 13 | Mesozoic basins and associated palaeogeographic evolution in North China显示文摘In North China, the Mesozoic terrestrial basins, sedimentary palaeogeography and tectonic settings involved five evolutionary stages:(1) the Early-Middle Triassic,(2) the Late Triassic to Early-Middle Jurassic,(3) the Late Jurassic to early Early Cretaceous,(4) the middle-late Early Cretaceous and(5) the Late Cretaceous. The regional punctuated tectonic events occurred during these evolutionary stages. During the Early-Middle Triassic(stage 1), the Xingmeng Orogenic Belt(XMOB, i.e., eastern part of Central Asia Orogenic Belt, CAOB) of the northern North China was settled in the transition of tectonic environment from syn-orogenic compression to post-orogenic extension with intensive uplifting. It is a main provenance in the unified Ordos-North China Basin.The united continental plate of China and the Qinling-Dabie-Sulu Orogenic Belt formed due to convergence and collision between the North China Plate and the Yangtze Plate along two suture zones of the Mianlue and the Shangdan in the terminal Middle Triassic. During the Late Triassic to the Early-Middle Jurassic(stage 2), the Late Triassic mafic or alkaline rocks and intrusions occurred on the northern and southern margins of North China Craton(NCC) and XMOB, implying that intensified extension happened all over the North China(early phase of stage 2). Additionally, in the late phase of stage 2, the basic volcanicfilling faulted basins were widely distributed in the northeastern North China during the EarlyMiddle Jurassic, including a series of small- to medium-sized basins with coal-bearing strata and some volcanic rocks in other areas of North China, which was the result of subduction of the Palaeo-Pacific Plate during the Early-Middle Jurassic. An active continental margin with accretionary complex developed in the eastern Heilongjiang of China, Japan and the Far East of Russia at that time. However, in the end of the Early-Middle Jurassic, because of the Yanshanian orogeny characterized by complicated thrust and fold, the previous unified OrdosNorth China Basin was separated by the northeast-oriented Great Xing'an Range and Taihang Mountain uplifted linearment. The differential evolution of basins and sedimentary palaeogeography between eastern and western North China was initiated, and was interpreted to result in the closure of Okhotsk Ocean and the subduction of Palaeo-Pacific Plate(late stage 2). During the Late Jurassic(the early phase of stage 3), a variety of faulted basins occurred in the Yanshan and Yinshan areas in the northeastern North China. In Yanshan area, basins were filled with thickened intermediate volcanic rocks and purple-red coarse-grained clastic rocks. In contrast, only thick layered sedimentary rocks with rare volcanic rocks developed in the Yinshan faulted basins, the Ordos Basin and basins in sourthern North China. XMOB wasthe main provenance of the Early Mesozoic basins in the North China, while the Ordos Basin and the Hefei Basin were partly supplied by the northern Qinling Orogenic Belt. During the Late Jurassic-early Early Cretaceous(the late phase of stage 3), the northern and northeastern North China experienced extensional movement after the subduction of the Palaeo-Pacific Plate, the closure of the Mongolia-Okhotsk Ocean and the subsequent Yanshanian orogeny. At the same time, a NE-oriented, giant rift basin system(NE Asia Rift) extended from the Yanshan to the western Great Xing'an Range, where rift basins were filled with the regional, NE-oriented, thick coarse-grained clastic rocks and a belt of volcanic rocks. In the meantime, the eastern and northeastern China and most areas of NCC were presented as highland terrains. During the middle-late Early Cretaceous(stage 4), rift basins developed and accumulated alluvial sediments and interbedded alkaline volcanic rocks in the western and northern North China, including Yingen, Ejinaqi and Erlian regions. Basins were formed on both sides of the Tan-Lu Fault Zone under a striking-slipping force. Furthermore, faulted basins developed in the Yishu Fault Zone of Shandong(central Tan-Lu Fault Zone) as well, where dinosaur fauna flourished. Basic volcanic rocks and fluvial-lacustrine sediments were deposited in small- or medium-sized rift basins in the northeastern China. The Songliao Basin was a typical giant basin that was mainly filled with late Early Cretaceous lacustrine sediments. A group of rift basins occurred in the Sanjiang area, central Heilongjiang Province, northeastern China. From the middle-late Early Cretaceous to the Late Cretaceous(stage 5), depositional and subsiding center of the basins constantly shifted southeastwards in Heilongjiang Province. The tectonic setting changed into the Palaeo-Pacific continental margin in north and northeastern China. Besides, during the Late Mesozoic, a huge terrestrial biota, mainly dinosaur fauna, dominated in North China. The Yanliao biota of the Middle-Late Jurassic and the Jehol biota of the Early Cretaceous are characterized by feathered dinosaurs, primitive birds, mammals, pterosaur, insects and plants(angiosperms). In northeastern Asia, this Late Mesozoic tectonic background, palaeogeoraphy and palaeoecology were shared by East China, Korean Peninsula, Japan and the Far East of Russia. | Yong-Qing Liu Hong-Wei Kuang Nan Peng Huan Xu Peng Zhang Neng-Sheng Wang Wei An | 2015 | Journal of Palaeogeography2015，4，2： | 7 |
| 14 | Effects of Formulated Fertilizer Synergist on Abscisic Acid Accumulation, Proline Content and Photosynthetic Characteristics of Rice under Drought显示文摘To investigate the effects of formulated fertilizer synergist on the drought tolerance in rice,pot experiment was conducted to analyze the photosynthetic characteristics and the accumulation of abscisic acid(ABA)and proline in middle-season rice variety Peiliangyou 93.The synergist could improve the net photosynthetic rate,and coordination between the water loss and the CO2 absorption as well as reduce the harmful effect on photosynthetic process under drought conditions.Under drought,the ABA accumulated massively both in roots and leaves,while the ABA content in roots was far higher than that in leaves.The results indicate that synergist could increase the ABA accumulation,but reduce the proline accumulation in rice plant under drought. | WANG Shao-xian XIA Shi-tou PENG Ke-qin KUANG Feng-chun CAO Yong XIAO Lang-tao | 2007 | Rice science2007，14，1： | 7 |
| 15 | Molar-Tooth Structure from the Mesoproterozoic Wumishan Formation in Lingyuan,Yanshan Region,North China,and Geological Implications显示文摘Although its origin has not yet reached a consensus so far,MTS(Molar-Tooth Structure) has been documented for more than 100 years.Current study reports a discovery of MTS from the Mesoproterozoic Wumishan Formation,Lingyuan,Yanshan Region,North China,and the features and geological implications of MTS are further discussed.Here,straitigraphic horizons of MTS's occurrences show that it was mainly located within the top part of the Wumishan Formation,i.e.,limestone unit.Four kinds of morphology of MTS,i.e.,fine fusiform,debris,ribbon,ptigmatic and nodular(irregular),were recognized and thought to be highly related to the sedimentary environments and facies.Geochemistry of MTS including oxides,trace elements and C,O and Sr isotopes indicates that the horizons of MTS-bearing is of higher Sr/Ba and Ca/Mg ratios,lower positive δ13C and highly negative δ18O values than the adjacent stratigraphic levels of rare MTS.Lithology,morphology and geochemistry of MTS in the Wumishan Formation suggest that MTS occurs mainly in shallow subtidal near the storm wave base,which is typically characterized by warm temperature,oversaturated calcium carbonate seawater and high organic productivity.Furthermore,occasional enrichment of algae bacteria here is more favorable for the calcification of calcium oozes and catalytic for MTS.C isotope composition of the Wumishan Formation and MTS of this study is well correlated with that of the Mesoproterozoic Belt Supergroup,North America and Riphean,Siberia,suggesting that MTS acts as a sedimentary record responding to global changes and is a perfect indicator in Precambrian stratigraphic correlation worldwide. | KUANG Hongwei LIU Yongqing PENG Nan LUO Shunshe LI Jiahua CEN Chao CHEN Mingpei | 2012 | Acta Geologica Sinica(English Edition)2012，86，1： | 7 |
| 16 | Preparation and characterization of chitosan porous microcarriers for hepatocyte culture显示文摘BACKGROUND: The bioartificial liver (BAL) is considered a possible alternative method for treating liver failure. The core of the BAL system is culturing liver cells in vitro with high density and activity. Microcarrier culture is a mode of high-density culture. We set out to prepare a novel porous microcarrier to improve the activity of liver cells in vitro. METHODS: Chitosan was used to prepare a novel porous spherical microcarrier with interconnected structure. The chitosan porous microcarriers (CPMs) were modified with gelatin to improve their biocompatibility. CPMs were co-cultured with liver cells, HL-7702 (L-02), to evaluate their effect on cell culture. RESULTS: The average size of the CPMs was about 400 μm in diameter and their apertures were less than 30 μm. The pores of the microcarrier were interconnected. After fixation by sodium tripolyphosphate, the structure of the first freeze-dried CPMs was stable. To further improve the biocompatibility, the surface of CPMs was modified with gelatin through chemical crosslinking (GM-CPMs). Comparing the proliferation curves of L-02 cells cultured on simple CPMs, GM-CPMs and tissue culture polystyrene (TCPS, a mode of planar cell culture), the proliferation rates were similar in the first 5 days and the cells proliferated until day 8 in culture with microcarriers. The OD value of liver cells cultured on GM-CPMs was 1.97-fold higher than that on TCPS culture at day 8. Levels of urea and albumin in supernatants of cells cultured on GM-CPMs increased steadily for 8 days, and were clearly higher than those of cells cultured on TCPS (P<0.05).CONCLUSIONS: The novel CPMs were promising microcarriers for hepatocyte culture and the GM-CPM seemed better. Porous microcarrier culture was beneficial for hepatocyte function and activity. | Xu-Bo Wu, Cheng-Hong Peng, Fang Huang, Jie Kuang, Song-Lin Yu, Ya-Dong Dong and Bao-San Han Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of General Surgery, Central Hospital, Minhang District, Shanghai 201100, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 17 | Stratigraphy and Geochronology of Vertebrate Fossil-Bearing Jurassic Strata from Linglongta,Jianchang County,Western Liaoning,Northeastern China显示文摘Northeastern China contains widely distributed Jurassic terrestrial strata that have yielded many spectacular mammal and pterosaur fossils, in addition to feathered dinosaur fossils and more recent discoveries from Jianchang, particularly from western Liaoning. However, the fossil-bearing stratigraphic succession, regional correlation, and age estimates of the fossils found in Jianchang County and nearby areas have been contentious. Here, we report on the vertebrate fossil-bearing Jurassic stratigraphy from Linglongta, Jianchang County, western Liaoning, including a SHRIMP U-Pb zircon date unambiguously associated with the fossil horizons. The primary goal was to determine the vertebrate fossil-bearing succession. A further aim was to provide age estimations for the fossil-bearing horizon as well as the earliest appearance of feathered dinosaurs, the eutherian-placental clade, and transitional pterosaurs. Field investigations showed that the vertebrate fossil-bearing stratigraphic succession in Jianchang County mainly consists of basal andesites overlain by rhythmic tuffs and tuffaceous lacustrine sediments, with the upper intermediate or acidic lavas interbedded with laminated more or less tuffaceous lacustrine deposits. This sequence correlates well with the Middle Jurassic Lanqi/Tiaojishan Formation in northeastern China. Detailed and accurate field observations showed that the well-preserved vertebrate fossils were buried in either the middle or the upper fine-grained laminated lacustrine deposits. Previous and current SHRIMP U-Pb zircon dates provide an age estimation of 161-159 Myr for the fossil-bearing horizon and vertebrates. This indicates that the earliest appearance of feathered dinosaurs here was more than 159 Myr ago and unquestionably older than Archaeopteryx from Germany, making these the earliest known feathered dinosaurs in the world. Furthermore, the eutherian-placental clade and the known transitional pterosaurs first emerged no later than 161 Myr. The vertebrate assemblage unearthed recently from Linglongta and neighboring areas in Jianchang County belongs to the Daohugou Biota. In addition to feathered dinosaurs, this biota was characterized by mammals, primitive pterosaurs, insects, and plants and was present in Inner Mongolia, western Liaoning, and northern Hebei in northeastern China during the Middle-Late Jurassic. | PENG Nan LIU Yongqing KUANG Hongwei JIANG Xiaojun XU Huan | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 6 |
| 18 | Analysis and Prediction of Influence Imposed on Jiaozhou Bay Tidal Currents and Tidal Energy of M_2 Tidal System by Jiaozhou Bay Reclamation显示文摘The 3-D ECOMSED ocean model was applied to establish a time-dependent boundary model for Jiaozhou Bay (JZB), in which the operator-splitting technique was used and the ‘dry and wet’ method was introduced. The influence caused by JZB reclamation on the surface level, residual currents, tidal system and tidal energy of M2 tidal system were predicted and analyzed. The results show that JZB reclamation has slight impact on the M2 tidal system, in which the variation of amplitude and phase is less than 1%.The changes of the currents and residual currents in Qian Bay and near the reclamation areas are greater, but in other areas the changes are smaller, in which the currents have a change of around 1%, while the residual currents change ranges from 1.82%–9.61%. After reclamation, the tidal energy fluxes increase by 2.62%–5.24% inside and outside the JZB mouth, but decrease by 20.21%–87.23% near Qian Bay and the reclamation area. | LOU Angang HU Yuebo KUANG Liang ZHANG Xueqing DU Peng | 2009 | Journal of Ocean University of China2009，8，1： | 5 |
| 19 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 20 | Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR显示文摘Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy. | Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
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