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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways显示文摘Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders. | Shuang Peng Nan Hang Wen Liu Wenjie Guo Chunhong Jiang Xiaoling Yang Qiang Xu Yang Sun | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 38 |
| 3 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 4 | Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines显示文摘In this paper,laboratory reports,medication rules,formulating principles,and research methods are summarized and analyzed,including single herb,compound herbs,and the problems in the prevention and treatment of osteoporosis(OP) within the past decade.With widely recognized efficacy,satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines(CHM).However,due to the complex constituents,the pharmacological activities and mechanism of CHM are not clear yet,and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the treatment.Accordingly,the research in the future should focus on the pharmacology and standardization of CHM in treating OP. | ZHAO Xiao-ling1,2,FENG Yu-xiong1,2,3,PENG Yong1,2 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China 2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines,Ministry of Education,Beijing 100193,China 3.College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530001,China | 2012 | Chinese Herbal Medicines2012，4，4： | 28 |
| 5 | Size and shape control of LiFePO4 nanocrystals for better lithium ion battery cathode materials显示文摘锂铁磷酸盐(LiFePO4 ) 是为锂离子电池,而是低电子电导率和单个散开隧道的潜在的高效率阴极材料因为锂离子在这材料的合成期间要求好粒子尺寸和形状控制。在这份报纸,有不同尺寸和形状的六 LiFePO4 nanocrystals 成功地在乙烯乙二醇被综合了。形成 LiFePO4 nanocrystals 与的增加顺序 Fe-PO4-Li 帮助主要 { 010 } 暴露的脸,并且增加 LiOH 的数量在粒子尺寸导致减少。六个不同 LiFePO4 粒子的电气化学的表演证明最有希望的 LiFePO4 nanocrystals 任何一个有占优势 { 010 } 脸暴露或高特定的区域,用小铁(II ) 氧化。 | Caiyun Nan Jun Lu Lihong Li Lingling Li Qing Peng Yadong Li | 2013 | Nano Research2013，6，7： | 25 |
| 6 | The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer显示文摘Background:N6-methyladenosine(m6A)RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors,including breast cancer.Fat mass and obesity-associated(FTO)enzyme,initially known as the obesity-related protein,is the first identified m6A demethylase.However,the relationship between FTO and breast cancer remains controversial.In this study,we aimed to elucidate the role and clinical significance of FTO in breast cancer and to explore the underlying mechanism.Methods:We first investigated the expression of FTO in breast cancer cell lines and tissues by quantitative reverse transcription-PCR(qRT-PCR),Western blotting,and immunohistochemistry.Wound healing assay and Transwell assay were performed to determine the migration and invasion abilities of SKBR3 and MDAMB453 cells with either knockdown or overexpression of FTO.RNA sequencing(RNA-seq)was conducted to decipher the downstream targets of FTO.qRT-PCR,luciferase reporter assay,and Western blotting were employed to confirm the existence of the FTO/miR-181b-3p/ARL5B axis.The biological function of ADP ribosylation factor like GTPase 5B(ARL5B)in breast cancer cells was evaluated by wound healing assay and Transwell invasion assay.Results:High FTO expression was observed in human epidermal growth factor receptor 2(HER2)-positive breast cancer,predicting advanced progression(tumor size[P<0.001],nuclear grade[P=0.001],peritumoral lymphovascular invasion[P<0.001),lymph node metastasis[P=0.002],and TNM stage[P=0.001])and poor prognosis.Moreover,FTO promoted cell invasion and migration in vitro.Mechanistically,RNA-seq and further confirmation studies suggested that FTO up-regulated ARL5B by inhibiting miR-181b-3p.We further verified that ARL5B also displayed carcinogenic activity in breast cancer cells.Conclusion:Our work demonstrated the carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway. | Yuanyuan Xu Shuang Ye Nan Zhang Shuhui Zheng Huatao Liu Kewen Zhou Ling Wang Yue Cao Peng Sun Tinghuai Wang | 2020 | Cancer Communications2020，40，10： | 24 |
| 7 | BMI, WC, WHtR, VFI and BFI: Which Indictor is the Most Efficient Screening Index on Type 2 Diabetes in Chinese Community Population显示文摘Objective Obesity is a major risk factor for type 2 diabetes, many indexes can be used to describes obesity and predict diabetes. This research attempts to identify the best indicator of obesity to screening diabetes in Chinese population. Methods A cross-sectional data of 8121 subjects aged 35-60 years were included in this research belongs to the Diabetes Appropriate Technology Intervention Study. Anthropometric indicators including body weight, height, waist circumferences (WC), body fat index (BFI) and visceral fat index (VFI) and blood biochemical indicators after an overnight fast [fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglycerol] were measured. BMI (body mass index) and Weight to Height Ratio was calculated. Results Subjects with obesity had a higher risk of physician diagnosed diabetes (OR=2.50, 95% CI 1.83-3.43), new diagnosed diabetes (OR=4.23, 95% CI 2.91-6.15) and pre-diabetes (OR=1.75, 95% CI 1.31-2.34) compared to those with normal Body mass index (BMI). There was a significant trend of increased risk of all diabetes status with increased waist circumference (WC). The waist-to-height ratio (WHtR) yielded the most significant association with new diagnosed diabetes and physician diagnosed diabetes than other indices. Conclusion Central obesity is significantly correlated with diabetes. VFI was most correlated with pre-diabetes while WHtR is an efficient screening index than BMI and WC in Chinese community diabetes screening. | MI Sheng Quan YIN Peng HU Nan LI Jian Hong CHEN Xiao Rong CHEN Bo YAN Liu Xia ZHAO Wen Hua | 2013 | Biomedical and Environmental Sciences2013，26，6： | 20 |
| 8 | Development of bone marrow mesenchymal stem cell culture in vitro显示文摘 | ZHANG Li PENG Li-pan WU Nan LI Le-ping | 2012 | Chinese Medical Journal2012，，9： | 15 |
| 9 | ZmCOL3, a CCT gene represses flowering in maize by interfering with the circadian clock and activating expression of ZmCCT显示文摘Flowering time is a trait vital to the adaptation of flowering plants to different environments.Here, we report that CCT domain genes play an important role in flowering in maize(Zea mays L.).Among the 53 CCT family genes we identified in maize, 28 were located in flowering time quantitative trait locus regions and 15 were significantly associated with flowering time, based on candidate-gene association mapping analysis.Furthermore, a CCT gene named ZmCOL3 was shown to be a repressor of flowering.Overexpressing ZmCOL3 delayed flowering time by approximately 4 d, in either long-day or short-day conditions.The absence of one cytosine in the ZmCOL3 3'UTR and the presence of a 551 bp fragment in the promoter region are likely the causal polymorphisms contributing to the maize adaptation from tropical to temperate regions.We propose a modified model of the maize photoperiod pathway, wherein ZmCOL3 acts as an inhibitor of flowering either by transactivating transcription of ZmCCT, one of the key genes regulating maize flowering, or by interfering with the circadian clock. | Minliang Jin Xiangguo Liu Wei Jia Haijun Liu Wenqiang Li Yong Peng Yanfang Du Yuebin Wang Yuejia Yin Xuehai Zhang Qing Liu Min Deng Nan Li Xiyan Cui Dongyun Hao Jianbing Yan | 2018 | Journal of Integrative Plant Biology2018，60，6： | 14 |
| 10 | Highly reactive, flexible yet green Se precursor for metal selenide nanocrystals: Se-octadecene suspension (Se-SUS)显示文摘在 octadecene (Se 怀疑) 的好硒粉末(100 或 200 网孔) 的暂停证明了是一位高效的、万用的、方便的、可再现的、还绿的硒先锋。Se 怀疑的优点从它的高度反应的化学性质和灵活性产生。这二个特征使与多样的作文和结构执行高质量的金属硒化物 nanocrystals 的合成可能,包括二进制代码,核心 / 壳,做的转变金属,和复杂作文 nanocrystals。这些成功进一步证明 Se 怀疑是为在高质量的硒化物 nanocrystals 的合成解决一些长期的挑战的一位强大的 Se 先锋。例如,Se怀疑成功地作为一位 Se 先锋被采用因为在高质量的核心/壳 nanocrystals 轰炸生长代替昂贵、高度有毒的先锋,例如Se磷化氢和 bis-trimethylsilyl 硒化物,与极大地降低的取向附生的温度(象 150 一样低???????????????? | Chaodan Pu Jianhai Zhou Runchen Lai Yuan Niu Wennuan Nan Xiaogang Peng | 2013 | Nano Research2013，6，9： | 12 |
| 11 | Changes in Photosystem Ⅱ Activity and Leaf Reflectance Features of Several Subtropical Woody Plants Under Simulated SO2 Treatment显示文摘光合的仪器上的模仿的 SO2 处理的效果在五副热带的森林植物被调查,也就是 Pinus massoniana 兰姆, Schima superba Gardn。et 捣烂, Castanopsis fissa (捣烂。前 Benth ) Rehd。et Wils, Acmena acuminatissima (Bl ) Merr et 佩里,和 Cryptocarya concinna Hance。在节沉浸于的叶以后,为 20 h ,全部的叶绿素( Chl )内容, Chl a/b ,最大的光化学的效率,和光化学的量的 0 , 20 , 50 ,和 100 mmol/L NaHSO3 所有五木质的植物的相片系统 II 让步被归结为不同的度,而黄体素内容( Chl 底)被增加。二保护的机制,也就是黄色色素周期(deepoxidation ) 和一个抗氧化剂系统(1,1-diphenyl-2-picrylhydrazyl 激进清除的能力) ,在在模仿的 SO2 处理下面的调整的度的显示出的差别。与控制(提取的水处理) 相比,修订规范的差别植被索引,一个叶反射索引,与增加 NaHSO3 的集中被降低。Cryptocarya concinna,在在华南的副热带的森林的迟了的继任阶段的主导的种,展出了更少的敏感到 NaHSO3。相反地, Pinus massoniana,先驱 heliophyte 种类,很产生 NaHSO3 处理。SO2 污染可以加速副热带的森林的继任,这被建议。 | Nan Liu Chang-Lian Peng Zhi-Fang Lin Gui-Zhu Lin Ling-Ling Zhang Xiao-Ping Pan | 2006 | Journal of Integrative Plant Biology2006，48，11： | 11 |
| 12 | A novel method for distinguishing fog and haze based on PM2.5, visibility, and relative humidity显示文摘Haze and fog are both low visibility events, but with different physical properties. Haze is caused by the increase of aerosol loading or the hygroscopic growth of aerosol at high relative humidity, whereas visibility degradation in fog is due to the light scattering of fog droplets, which are transited from aerosols via activation. Based on the difference of physical properties between haze and fog, this study presents a novel method to distinguish haze and fog using real time measurements of PM2.5, visibility, and relative humidity. In this method, a criterion can be developed based on the local historical data of particle number size distributions and aerosol hygroscopicity. Low visibility events can be classified into haze and fog according to this criterion. | MA Nan ZHAO ChunSheng CHEN Jing XU WanYun YAN Peng ZHOU XiuJi | 2014 | Science China Earth Sciences2014，57，9： | 10 |
| 13 | Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs显示文摘钾 2-(1-hydroxypentyl ) 安息香酸盐(dl-PHPB ) 是被用来治疗 ischemic 击的 3-n-butylphthalide (dl-NBP ) 支持药的一篇小说。当前, dl-PHPB 在在中国的阶段 II-III 临床的审判。在这研究,我们在 vitro 并且在 vivo 调查了变换和 dl-PHPB 的 pharmacokinetics 侧面。到 dl-NBP 的 dl-PHPB 的变换是 pH-dependent, 和钙依赖者,并且 paraoxonase 在老鼠血浆为变换作为主要的酶被识别。pharmacokinetics,织物分发和 dl-PHPB 的排泄被学习并且与在老鼠和狗的 dl-NBP 的平等者臼齿的剂量相比。在里面 vivo 研究证明 dl-PHPB 能快速并且完全被变换成 dl-NBP。在静脉内的 dl-PHPB 管理以后的变换 dl-NBP 的血浆集中时间功课是将近与那一样在平等者臼齿的 dl-NBP 以后。C 分别地,在在老鼠和狗的口头的 dl-PHPB 管理以后的 dl-NBP 的最大 和 AUC 比在口头的 dl-NBP 管理以后的那些在 60% 和 170% 是更高的。dl-PHPB 的织物分发的分析表明那变换 dl-NBP 首先在脂肪,大脑和胃被散布。在大脑, dl-NBP 的层次在 dl-PHPB 处理由以后是相对更高的口头上地比在有平等者臼齿的 dl-NBP 的处理以后。近似 dl-NBP 的 3%-4% 与 dl-PHPB 或 dl-NBP 在 dosing 以后在 72 h 以内被排泄,但是没有 dl-PHPB 在尿或排汇物排泄物被检测。我们的结果证明 dl-PHPB 的变换在口头或静脉内的管理以后是快的。而且, dl-PHPB 的 bioavailability 显然比 dl-NBP 的好。 | Jiang LI Shao-feng XU Ying PENG Nan FENG Ling WANG Xiao-liang WANG | 2018 | Acta Pharmacologica Sinica2018，39，2： | 10 |
| 14 | Phase-transfer interface promoted corrosion from PtNi10 nanoctahedra to Pt4Ni nanoframes显示文摘向 PtNi 的腐蚀的一条新奇二阶段的途径 < 潜水艇 class= “ a-plus-plus ” > 10 nanoctahedra 被开发了。在这策略,在油可溶的 PtNi 的 Ni 的活跃部件 < 潜水艇 class= “ a-plus-plus ” > 居住在上面的甲苯阶段,受不了蚀刻并且是的 10 nanoctahedra 然后由 ethylenediaminetetraacetate (EDTA ) 与协作转了进一个更低的水的阶段。由于 EDTA 支持的阶段转移接口的存在,腐蚀反应在温和条件下面以加速的率继续了。明确地,八面的磅的结果的产品 < 潜水艇 class= “ a-plus-plus ” > 4 Ni nanoframes 成功地第一次被制作,并且 PtNi < 潜水艇 class= “ a-plus-plus ” > 4 当 EDTA-2Na 的剂量被减少时,多孔的 octahedra 能被获得。在这个二阶段的系统的系统的研究以后,合作腐蚀机制被建议说明八面的磅的形成<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes ,从许多种类包含贡献(即, O <潜水艇class=“ a-plus-plus ”> 2 , H <潜水艇class=“ a-plus-plus ”> 2 O , H <啜class=“ a-plus-plus ”>+, OAm ,和 EDTA <潜水艇class=“ a-plus-plus ”> 4 )。由于磅的迷人的三维的几何学<潜水艇class=“ a-plus-plus ”> 4 Ni nanoframes 和 PtNi <潜水艇class=“ a-plus-plus ”> 4 多孔的 octahedra ,两个在太古的 PtNi 上侵蚀的 nanocrystals 显示出优异活动<潜水艇class=“ a-plus-plus ”>为在硝基苯的碱的媒介和加氢的乙醇 electrooxidation 的 10 nanoctahedra 。 | Yu Wang Yueguang Chen Caiyun Nan Lingling Li Dingsheng Wang Qing Peng Yadong Li | 2015 | Nano Research2015，8，1： | 10 |
| 15 | From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading显示文摘Integration of two or more biomolecules with synergetic and complementary effects on a material surface can help to obtain multi-functions for various biomedical applications.However,the amounts of biomolecules integrated and their physiological functions are compromised due to the limited surface anchoring sites.Herein,we propose a novel concept of film engineering strategy“from surface to bulk synergetic modification”.This new concept is realized by employing the surface amine groups of plasma polymerized allylamine(PPAm)film for grafting a molecule e.g.,thrombin inhibitor,bivalirudin(BVLD),meanwhile its bulk amine groups is used as a universal depot for storing and releasing therapeutic nitric oxide(NO)gas as supplement to the functions of BVLD.It is demonstrated that such a“from surface to bulk synergetic modification”film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions,giving rise to a highly endotheliummimetic thromboresistant property.We believe that our research provides a very promising strategy to deliver multifunctional surface versatilely that require NO release in combination with other properties,which will find broad biomedical applications in blood-contacting devices,and et al.Moreover,it also provides a brand-new film engineering strategy for tailoring surface multi-functionalities of a wide range of materials. | Tong Yang Zeyu Du Hua Qiu Peng Gao Xin Zhao Huaiyu Wang Qiufen Tu Kaiqin Xiong Nan Huang Zhilu Yang | 2020 | Bioactive Materials2020，5，1： | 10 |
| 16 | Flexible SnS nanobelts: Facile synthesis, formation mechanism and application in Li-ion batteries显示文摘 | Jun Lu | 2013 | Nano Research2013，6，1： | 9 |
| 17 | Ginsenoside Rb1 Attenuates Isoflurane/surgery-induced Cognitive Dysfunction via Inhibiting Neuroinflammation and Oxidative Stress显示文摘Objective Anesthetic isoflurane plus surgery has been reported to induce cognitive impairment. The underlying mechanism and targeted intervention remain largely to be determined. Ginsenoside Rb1 was reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rb1 can attenuate isoflurane/surgery-induced cognitive dysfunction via inhibiting neuroinflammation and oxidative stress. Methods Five-months-old C57BL/6J female mice were treated with 1.4% isoflurane plus abdominal surgery for two hours. Sixty mg/kg ginsenoside Rb1 were given intraperitoneally from 7 days before surgery. Cognition of the mice were assessed by Barnes Maze. Levels of postsynaptic density-95 and synaptophysin in mice hippocampus were measured by Western blot. Levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in mice hippocampus were measured by ELISA. Results Here we show for the first time that the ginsenoside Rb1 treatment attenuated the isoflurane/surgery-induced cognitive impairment. Moreover, ginsenoside Rb1 attenuated the isoflurane/surgery-induced synapse dysfunction. Finally, ginsenoside Rb1 mitigated the isoflurane/surgery-induced elevation levels of reactive oxygen species, tumor necrosis factor-α and interleukin-6 in the mice hippocampus. Conclusion These results suggest that ginsenoside Rb1 may attenuate the isoflurane/surgery-induced cognitive impairment by inhibiting neuroinflammation and oxidative stress pending future studies. | MIAO Hui Hui ZHANG Ye DING Guan Nan HONG Fang Xiao DONG Peng TIAN Ming | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 18 | Significant coastline changes in China during 1991–2015 tracked by Landsat data显示文摘In China,following national economic reform and the opendoor policy in 1978,there has been a rapid industrialization and urbanization of coastal regions which has dramatically changed the environment and ecosystems in these areas[1].Regions with rapidly growing economies,such as Shanghai and Shenzhen,face the double pressure of limited land area and population growth, | Nan Xu Peng Gong | 2018 | Science Bulletin2018，63，14： | 9 |
| 19 | A LysM Receptor Heteromer Mediates Perception of Arbuscular Mycorrhizal Symbiotic Signal in Rice显示文摘Symbiotic microorganisms improve nutrient uptake by plants.To initiate mutualistic symbiosis with arbus-cular mycorrhizal(AM)fungi,plants perceive Myc factors,including lipochitooligosaccharides(LCOs)and short-chain chitooligosaccharides(CO4/CO5),secreted by AM fungi.However,the molecular mechanism of Myc factor perception remains elusive.In this study,we identified a heteromer of LysM receptor-like kinases consisting of OsMYR1/OsLYK2 and OsCERK1 that mediates the perception of AM fungi in rice.CO4 directly binds to OsMYR1,promoting the dimerization and phosphorylation of this receptor complex.Compared with control plants,Osmyr1 and Oscerk1 mutant rice plants are less sensitive to Myc factors and show decreased AM colonization.We engineered transgenic rice by expressing chimeric receptors that respectively replaced the ectodomains of OsMYR1 and OsCERK1 with those from the homologous Nod factor receptors MtNFP and MtL YK3 of Medicago truncatula.Transgenic plants displayed increased cal-cium oscillations in response to Nod factors compared with control rice.Our study provides significant mechanistic insights into AM symbiotic signal perception in rice.Expression of chimeric Nod/Myc recep-tors achieves a potentially important step toward generating cereals that host nitrogen-fixing bacteria. | Jiangman He Chi Zhang Huiling Dai Huan Liu Xiaowei Zhang Jun Yang Xi Chen Yayun Zhu Dapeng Wang Xiaofeng Qi Weichao Li Zhihui Wang Guoyong An Nan YU Zuhua He Yong-Fei Wang Youli Xiao Peng Zhang Ertao Wang | 2019 | Molecular Plant2019，12，12： | 9 |
| 20 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
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