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| 1 | ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC显示文摘PD-L1 plays an important role in inhibiting T-cell activity and driving tumor cell escape from immune surveillance by binding its ligand,PD-1,on T cells.1 Several intracellular and extracellular factors,such as interferon-γ(IFN-γ),MYC,transforming growth factorβ,and miR-200,may modulate PD-L1 expression by transcriptional and posttranscriptional mechanisms. | Chunyi Zhang Kunpeng Zhang Jie Gu Di Ge | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 2 | Effects of the grain size distribution on magnetic properties of magnetite: constraints from micromagnetic modeling显示文摘Magnetite is the most important magnetic mineral in paleomagnetism. Its magnetic properties are controlled by many factors, such as grain size distribution,shape and interactions. Traditional rock magnetic experiments, however, have great difficulty in decoupling the effects of these parameters. In this study, we attempted to investigate the effects of grain size distribution on magnetic properties of magnetite powders by using a micromagnetic method. The particle geometries used in the micromagnetic model were based on the grain size distribution observed in a synthetic magnetite powder. The simulated hysteresis parameters agree well with the experimental measurements and provide clear microstructures of the magnetic remanence. Our results show that grain size plays a more important role in affecting hysteresis parameters of magnetite assemblages than shape under effects of interactions. Uniform or vortex superstates formed by two or more particles are found and display different stabilities of magnetic recording in assemblages.Some domain structures of single-domain(SD) particles are reversed as the applied field decreases to zero. Small pseudo-single-domain particles behave as SD structures and may dominate the magnetic recordings. In all, micromagnetic modeling of grain size distributions provide a better understanding of magnetic assemblages consisting of nanoscale particles. | Kunpeng Ge Qingsong Liu | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 3 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 4 | Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice显示文摘SARS-CoV-2 infection is a global public health threat.Vaccines are considered amongst the most important tools to control the SARS-CoV-2 pandemic.As expected,deaths from SARS-CoV-2 infection have dropped dramatically with widespread vaccination.However,there are concerns over the duration of vaccine-induced protection,as well as their effectiveness against emerging variants of concern.Here,we constructed a recombinant chimpanzee adenovirus vectored vaccine expressing the full-length spike of SARS-CoV-2(Ad C68-S).Rapid and high levels of humoral and cellular immune responses were observed after immunization of C57BL/6J mice with one or two doses of Ad C68-S.Notably,neutralizing antibodies were observed up to at least six months after vaccination,without substantial decline.Single or double doses Ad C68-S immunization resulted in lower viral loads in lungs of mice against SARS-CoV-2 challenge both in the short term(21 days)and long-term(6 months).Histopathological examination of Ad C68-S immunized mice lungs showed mild histological abnormalities after SARS-CoV-2 infection.Taken together,this study demonstrates the efficacy and durability of the Ad C68-S vaccine and constitutes a promising candidate for clinical evaluation. | Mingqing Lu Kunpeng Liu Yun Peng Zhe Ding Yingwen Li Alexander Tendu Xue Hu Ge Gao Weiwei Guo Hang Liu Juhong Rao Jiaxuan Zhao Miaoyu Chen Zhiming Yuan Gary Wong Chao Shan Yanfeng Yao Jiaming Lan | 2022 | Virologica Sinica2022，37，4： | 0 |
| 5 | Magnetic Fabric Studies of Xiong'er Volcanic Rocks in Southern Margin of the North China Craton and its Implications显示文摘The Paleoproterozoic Xiong’er Group is composed of mafic to felsic volcanic rocks and minor sedimentary rocks,distributed along the southern margin of the North China craton(NCC).It is a key marker for | XU Huiru YANG Zhenyu PENG Peng GE Kunpeng ZHU Rixiang | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 0 |
| 6 | Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque显示文摘Dear Editor,COVID-19 caused by SARS-Co V-2,is still a big threat to human populations around the world.As of Jan 2022,over 292 million cases were reported worldwide with more than 5.4 million deaths.After it was first reported in China in December 2019,the virus kept circulating and evolving and several variants with different transmissibility emerged in different countries and regions(WHO,2021a). | Ge Gao Xue Hu Yiwu Zhou Juhong Rao Xiaoyu Zhang Yun Peng Jiaxuan Zhao Yanfeng Yao Kunpeng Liu Mengying Liang Hang Liu Fei Deng Han Xia Chao Shan Zhiming Yuan | 2022 | Virologica Sinica2022，37，2： | 0 |
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