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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Chrysanthemum WRKY15-1 promotes resistance to Puccinia horiana Henn. via the salicylic acid signaling pathway显示文摘Chrysanthemum white rust disease,which is caused by the fungus Puccinia horiana Henn.,severely reduces the ornamental quality and yield chrysanthemum.WRKY transcription factors function in the disease-resistance response in a variety of plants;however,it is unclear whether members of this family improve resistance to white rust disease in chrysanthemum.In this study,using PCR,we isolated a WRKY15 homologous gene,CmWRKY15-1,from the resistant chrysanthemum cultivar C029.Real-time quantitative PCR(RT-qPCR)revealed that CmWRKY15-1 exhibited differential expression patterns between the immune cultivar C029 and the susceptible cultivar Jinba upon P.horiana infection.In addition,salicylic acid(SA)treatment strongly induced CmWRKY15-1 expression.Overexpression of CmWRKY15-1 in the chrysanthemum-susceptible cultivar Jinba increased tolerance to P.horiana infection.Conversely,silencing CmWRKY15-1 via RNA interference(RNAi)in C029 increased sensitivity to P.horiana infection.We also determined that P.horiana infection increased both the endogenous SA content and the expression of salicylic acid biosynthesis genes in CmWRKY15-1-overexpressing plants,whereas CmWRKY15-1 RNAi plants exhibited the opposite effects under the same conditions.Finally,the transcript levels of pathogenesis-related(PR)genes involved in the SA pathway were positively associated with CmWRKY15-1 expression levels.Our results demonstrated that CmWRKY15-1 plays an important role in the resistance of chrysanthemum to P.horiana by influencing SA signaling. | Mengmeng Bi Xueying Li Xin Yan Di Liu Ge Gao Pengfang Zhu Hongyu Mao | 2021 | Horticulture Research2021，8，1： | 9 |
| 3 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 4 | Simulation of dynamic fluid-solid interactions with an improved direct-forcing immersed boundary method显示文摘Dynamic fluid-solid interactions are widely found in chemical engineering,such as in particle-laden flows,which usually contain complex moving boundaries.The immersed boundary method(IBM) is a convenient approach to handle fluid-solid interactions with complex geometries.In this work,Uhlmann's direct-forcing IBM is improved and implemented on a supercomputer with CPU-GPU hybrid architecture.The direct-forcing IBM is modified as follows:the Poisson's equation for pressure is solved before evaluation of the body force,and the force is only distributed to the Cartesian grids inside the immersed boundary.A multidirect forcing scheme is used to evaluate the body force.These modifications result in a divergence-free flow field in the fluid domain and the no-slip boundary condition at the immersed boundary simultaneously.This method is implemented in an explicit finite-difference fractional-step scheme,and validated by 2D simulations of lid-driven cavity flow,Couette flow between two concentric cylinders and flow over a circular cylinder.Finally,the method is used to simulate the sedimentation of two circular particles in a channel.The results agree very well with previous experimental and numerical data,and are more accurate than the conventional direct-forcing method,especially in the vicinity of a moving boundary. | Shengbin Di Wei Ge | 2015 | Particuology2015，13，1： | 6 |
| 5 | Post-Orogenic Tectonic Evolution of the Jiangnan-Xuefeng Orogenic Belt:Insights from Multiple Geochronometric Dating of the Mufushan Massif,South China显示文摘The Mufushan massif, as continental intra-plate magmatites located in the Jiangnan-Xuefeng orogenic belt of the South China. The Mufushan massif constitutes the largest Mesozoic intrusive complex, intruded the Mesoproterozoic Lengjiaxi Formation. Multiple geochronometric dating was used to reconstruct their evolution from emplacement to exhumation. The Mufushan granitoids were emplaced at ~150 Ma(U-Pb zircon) as post-orogenic magmatites contributing to Triassic crustal thickening. Onset of regional extension at ~128 Ma(40Ar/39Ar white mica and biotite) manifests a tectonic regime switch. Intense exhumation prior to ~55 Ma was followed by slow denudation and peneplanation for the next 37 Ma(~55–18 Ma). Accelerated cooling since ~18 Ma may have been caused by a far-field effect of the collision between IndiaAsia Plate or the Pacific-Plate subduction. Through a multi-geochronometric approach, this study provides a new comprehensive model for the cause of the intra-plate magmatism formation in the South China, and also established a reliable geochronological framework of the post-orogenic tectonic evolutions of the Jiangnan-Xuefeng orogenic belt. | Chuanbo Shen Di Hu Kyoungwon Min Chaoqun Yang Xiaowei Zeng Hongyang Fu Xiang Ge | 2020 | Journal of Earth Science2020，31，5： | 4 |
| 6 | Fluorinated 1,8-naphthalimides:Synthesis,solid structure and properties显示文摘Three fluorinated 1,8-napthalimides were synthesized from acenaphthene.Their structures were characterized by NMR and EI-MS analyses.The structures of compounds 1b and 1c were also confirmed by X-ray diffraction analysis,which showed that they possessed different packing models.Their optoelectronic properties were investigated.The results indicated that all of the naphthalimides possess good solubility and low LUMO energy level,which make them good solution processing candidates in n-type semiconductor. | Jie Huang Di Wu Hao-Jie Ge Sheng-Hua Liu Jun Yin | 2014 | Chinese Chemical Letters2014，25，10： | 4 |
| 7 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 8 | LncRNA C9orf139 can regulate the growth of pancreatic cancer by mediating the miR-663a/Sox12 axis显示文摘BACKGROUND Recent studies have proved the important role of many oncogenic long noncoding RNAs(lncRNAs) in the progression of pancreatic cancer, but little is known about the mechanisms of tumor suppression in pancreatic cancer.AIM To evaluate the function of tumor suppressor lncRNA C9orf139 in pancreatic cancer progression and to study the underlying mechanism.METHODS We assigned 54 patients with pancreatic ductal adenocarcinoma treated at our hospital to the patient group and 30 normal subjects undergoing physical examination to the control group. RT-qPCR was used to measure the relative expression of C9orf139 in the tissue and serum of patients, in an attempt to investigate the prognostic value of C9orf139 in pancreatic cancer patients. The luciferase reporter gene assay was performed to determine the interaction between C9orf139 and miR-663 a. The biological function of C9orf139 was assessed by in vitro assays and in vivo subcutaneous tumor formation tests in animal models. To figure out the molecular mechanism of C9orf139 to act on miR-663 a/Sox12, RNA pull-down, Western blot assay, RNA immunoprecipitation assay, and co-immunoprecipitation assay were performed.RESULTS C9orf139 level significantly increased in the tissue and serum of patients, which had clinical diagnostic value for pancreatic cancer. Patients with high C9orf139 expression had a higher risk of progressing to stage Ⅲ + Ⅳ, lymph node metastasis, and poor differentiation. Cox regression analysis suggested that C9orf139, tumor-node-metastasis stage, and lymph node metastasis were independent prognostic factors in patients. The underlying mechanism of C9orf139 was that it promoted the growth of pancreatic cancer cells by modulating the miR-663 a/Sox12 axis.CONCLUSION C9orf139 is highly expressed in pancreatic cancer, qualified to be used as a potential diagnostic and prognostic marker for pancreatic cancer. Its promotion of pancreatic cancer cell growth is achieved by mediating the miR-663 a/Sox12 axis. | Jin-Nian Ge Di Yan Chun-Lin Ge Min-Jie Wei | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 3 |
| 9 | Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment显示文摘Low pressure,low oxygen concentration,and intense ultraviolet(UV)radiation in high-altitude environments,can cause oxidative stress which can trigger mountain sickness.A recent study demonstrated that hydrogen gas with a good permeability in biological membranes can treat various disorders by exerting its selective anti-oxidation and anti-inflammatory effects,indicating that hydrogen therapy plays a role | SHI Qing Hai WEI Wei RAN Ji Hua WANG Si Yuan LIU Zheng Xiang GE Di CHEN Ping FU Jian Feng | 2015 | Biomedical and Environmental Sciences2015，28，3： | 3 |
| 10 | Improving forest burn severity estimations with partial least squares regression and orthogonal signal correction methods in Daxing'an Mountains,China显示文摘Several indices and simple empirical models and ratios of single band from pre-and post-fire Landsat images have been developed to estimate and/or map burn severity.However,these models and indices are usually site-,time-and vegetation-dependent and their applications are limited.The Daxing'an Mountains range has the largest forested area in China and is prone to wildfires.Whether or not the existing models can effectively characterize the burn severity over a large region is unclear.In this study,we used the orthogonal signal correction method based on partial least squares regression(PLSR)to select those variables that better interpret the variance of burn severity.A new index and other commonly used indices were used to construct a new,multivariate PLSR model which was compared with the popular single variable models,according to three assessment indices:relative root mean square error(RMSE%),relative bias(R E%)and Nash–Sutcliffe efficiency(NSE%).The results indicate that the multivariate PLSR model performed better than the other single variable models with higher NSE%(68.2%vs.67.8%)and less RE%(3.7%vs.-8.7%),while achieving almost the same R MSE%.We also discuss the spectral characteristics of the four selected variables for constructing the multivariate PLSR model and their correlation with the field burn severity data.The new model developed from this study should help to better understand the patterns of forest burn severity and assist in vegetation restoration efforts in the region. | Cunyong Ju Tijiu Cai Wenhong Li Ge Sun Chengliang Lei Xueying Di Xiuling Man | 2021 | Journal of Forestry Research2021，32，3： | 2 |
| 11 | A Large Solitary Fibrous Tumor of the Mediastinum显示文摘 | Chunlai Lu Di Ge | 2006 | Chinese Journal of Clinical Oncology2006，3，6： | 2 |
| 12 | Regularity of Nitrogen Accumulation in Soybean and Its Simulation显示文摘Nitrogen(N) is considered as an important yield and quality-determining factor in soybean production.The objective of the current experiment was to determine the regularity of N accumulation and its simulation among different varieties.This work was conducted with frame tests(pot without bottom),and three cultivars,HH41,SN14,HN40,and one feed soybean variety MSD was used as materials.The results showed that the regularity of N accumulation in four varieties with the same tendency increased during the whole growth period,which was up to the maximum when the plant was harvested.The longer growth period was,the higher N accumulation of cultivars was,HN40>SN14>HH41,N accumulation of MSD was the highest because of the property for feed soybean.Regularity of N accumulation in plants could be accurately described by the Logistic equation.During the growth there was a period when N accumulation in the whole plant occurred at an intense rate.The time of onset and its duration varied with different varieties.The maximum daily N accumulation was on seed filling stage,pod bearing stage,seed filling stage and pod bearing stage in HH41,SN14,HN40 and MSD,respectively. | YAO Yubo JIN Xijun DI Wei GE Huiling MA Chunmei GONG Zhenping | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，1： | 2 |
| 13 | ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC显示文摘PD-L1 plays an important role in inhibiting T-cell activity and driving tumor cell escape from immune surveillance by binding its ligand,PD-1,on T cells.1 Several intracellular and extracellular factors,such as interferon-γ(IFN-γ),MYC,transforming growth factorβ,and miR-200,may modulate PD-L1 expression by transcriptional and posttranscriptional mechanisms. | Chunyi Zhang Kunpeng Zhang Jie Gu Di Ge | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 14 | Overproduction of reactive oxygen species involved in the pathogenicity of Fusarium in potato tubers显示文摘 | Gaihong Bao Yang Bi Yongcai Li Zonghong Kou Lingang Hu Yonghong Ge Yi Wang Di Wang | 2014 | Physiological and Molecular Plant Pathology2014，，： | 2 |
| 15 | Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells显示文摘Chronic infection with hepatitis B virus(HBV)remains a global health concern despite the availability of vaccines.To date,the development of effective treatments has been severely hampered by the lack of reliable,reproducible,and scalable in vitro modeling systems that precisely recapitulate the virus life cycle and represent virus-host interactions.With the progressive understanding of liver organogenesis mechanisms,the development of human induced pluripotent stem cell(iPSC)-derived hepatic sources and stromal cellular compositions provides novel strategies for personalized modeling and treatment of liver disease.Further,advancements in three-dimensional culture of self-organized liver-like organoids considerably promote in vitro modeling of intact human liver tissue,in terms of both hepatic function and other physiological characteristics.Combined with our experiences in the investigation of HBV infections using liver organoids,we have summarized the advances in modeling reported thus far and discussed the limitations and ongoing challenges in the application of liver organoids,particularly those with multi-cellular components derived from human iPSCs.This review provides general guidelines for establishing clinical-grade iPSC-derived multi-cellular organoids in modeling personalized hepatitis virus infection and other liver diseases,as well as drug testing and transplantation therapy. | Di Cao Jian-Yun Ge Yun Wang Tatsuya Oda Yun-Wen Zheng | 2021 | World Journal of Gastroenterology2021，27，29： | 2 |
| 16 | Involvement of the crebellum in sequential finger movement learning:Evidence from functional magnetic resonance imaging显示文摘Whether the cerebellum is involved in volun-tary motor learning or motor performance is the subject of a new debate. Using functional magnetic resonance imaging (fMRI), we examined cerebellar activation in eight volun-teers before and after an extended period of training. Activa-tion volume on both sides of cerebellum after learning was significantly reduced compared to that before learning even under the same motor frequency. Remarkably, while motor frequency for the training sequence was significantly higher than the control sequence after 41 d of learning, activation in the cerebellum for both sequences, with respect to activation loci and volumes, was very similar. These results suggest that the cerebellum was involved in motor learning but not motor performance. Changes of cerebellar activation from training thus appear to be associated with learning but not with im-provement on task performance. | ZHU Yihong DI Haibo YUAN Yi REN Jin'ge YU Wei ZHANG Zhaoqi GAO Jiahong WENG Xuchu CHEN Yizhang | 2005 | Chinese Science Bulletin2005，50，17： | 2 |
| 17 | Techno-economic Analysis of Contingency Reserve Allocation Scheme for Combined UHV DC and AC Receiving-End Power System显示文摘In a UHV DC and AC combined system the UHVDC’s blocking fault becomes the most serious load balance contingency of the receiving end power system due to its large capacity.The amount of contingency reserve thus is largely increased.This paper proposes three distinct schemes for allocating contingency reserve to cover the power shortage caused by UHVDC’s blocking fault,and compares the economic cost of these schemes.An operation simulation method using a unit commitment technique is proposed for evaluating the operation costs associated with increasing contingency reserve.A real case study for a Jiangsu Province power system in China is presented to demonstrate that the best scheme is to share the contingency reserve with neighborhood power systems through the transmission capacity of UHVAC lines. | Di Wu Ning Zhang Chongqing Kang Yi Ge Zhenjian Xie Junhui Huang | 2016 | CSEE Journal of Power and Energy Systems2016，2，2： | 2 |
| 18 | MAPKK-independent activation of p38 alpha mediated by TABl-dependent autophosphorylation of p38alpha 显示文摘 | GE B Gram H Di PF | 2002 | Science2002，295，5558： | 1 |
| 19 | Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat 显示文摘 | Romani R De Medio GE Di Tullio S | 2009 | J Lipid Res2009，50，10： | 1 |
| 20 | Very large common fragile site genes and their potential role in cancer development 显示文摘 | Ge G Smith DI | 2014 | Cell Mol Life Sci2014，71，23： | 1 |
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