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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Planning for space station long-duration orbital mission under multi-constraints显示文摘An integrated nonlinear planning(NLP) model is built for space station long-duration orbital missions considering both the vehicle visiting schedules and the interaction effects between target phasing,vehicle return adjusting and Earth observation aiming.A two-level optimization approach is proposed to solve this complicated problem.The up-level problem employs the launch times of visiting vehicles as design variables,considers the constraints of crew rotations,resource resupplies and rendezvous launch windows,and is solved by a genetic algorithm.The low-level problems employ the maneuver impulses and burn times within each orbital mission as design variables,and a high-efficient shooting iteration method is proposed based on an analytical equation for the phase angle correction considering the J 2 perturbation.The results indicate that the integrated NLP model for space station long-duration orbital missions is effective,and the proposed optimization approach can obtain the optimal solutions that satisfy the multiple constraints and reduce the total propellant consumption. | LIN KunPeng LUO YaZhong ZHANG Jin TANG GuoJin | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 3 | Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell–cell contact inhibits proliferation of hepatic stellate cells显示文摘 | Si Chen linan Xu Nan Lin Weidong Pan Kunpeng Hu Ruiyun Xu | 2011 | Life Sciences2011，，25： | 1 |
| 4 | Isogeometric Boundary Element Analysis for 2D Transient Heat Conduction Problem with Radial Integration Method显示文摘This paper presents an isogeometric boundary element method(IGABEM)for transient heat conduction analysis.The Non-Uniform Rational B-spline(NURBS)basis functions,which are used to construct the geometry of the structures,are employed to discretize the physical unknowns in the boundary integral formulations of the governing equations.Bezier extraction technique is employed to accelerate the evaluation of NURBS basis functions.We adopt a radial integration method to address the additional domain integrals.The numerical examples demonstrate the advantage of IGABEM in dimension reduction and the seamless connection between CAD and numerical analysis. | Leilei Chen Kunpeng Li Xuan Peng Haojie Lian Xiao Lin Zhuojia Fu | 2021 | Computer Modeling in Engineering & Sciences2021，，1： | 1 |
| 5 | Six Subfamilies of Implementation-Friendly Barreto-Naehrig Curves显示文摘In this paper, we depict in detail six subfamilies of implementation-friendly Barreto-Naehrig(BN)elliptic curves by choosing six special congruency classes of the curve-finding search parameter. These curves have small curve constants, support efficient tower extension options of finite field required in fast pairing implementation and have obvious generators for the bilinear cycle group G1. The detailed description will supply the implementor with more choices of suitable BN curves. | CHEN Shan ZHANG Xusheng WANG Kunpeng LIN Dongdai | 2014 | Chinese Journal of Electronics2014，23，1： | 1 |
| 6 | Ground-Based Hyperspectral Stereoscopic Remote Sensing Network: A Promising Strategy to Learn Coordinated Control of O_(3) and PM_(2.5) over China显示文摘With the coming of the“14th Five-Year Plan,”the coordinated control of particulate matter with an aerodynamic diameter no greater than 2.5 lm(PM_(2.5))and O_(3) has become a major issue of air pollution prevention and control in China.The stereoscopic monitoring of regional PM_(2.5) and O_(3) and their precursors is crucial to achieve coordinated control.However,current monitoring networks are currently inadequate for monitoring the vertical profiles of both PM_(2.5) and O_(3) simultaneously and support air quality control.The University of Science and Technology of China(USTC)has established a nationwide ground-based hyperspectral stereoscopic remote sensing network based on multi-axis differential optical absorption spectroscopy(MAX-DOAS)since 2015.This monitoring network provides a significant opportunity for the regional coordinated control of PM_(2.5) and O_(3) in China.One-year vertical profiles of aerosol,NO_(2) and HCHO monitored from four MAX-DOAS stations installed in four megacities(Beijing,Shanghai,Shenzhen,and Chongqing)were used to characterize their vertical distribution differences in four key regions,Jing–Jin–Ji(JJJ),Yangtze River Delta(YRD),Pearl River Delta(PRD),and Sichuan Basin(SB),respectively.The normalized and yearly averaged aerosol vertical profiles below 400 m in JJJ and PRD exhibit a box shape and a Gaussian shape,respectively,and both show exponential shapes in YRD and SB.The NO_(2) vertical profiles in four regions all exhibit exponential shapes because of vehicle emissions.The shape of the HCHO vertical profile in JJJ and PRD was Gaussian,whereas an exponential shape was shown in YRD and SB.Moreover,a regional transport event occurred at an altitude of 600–1000 m was monitored in the southwest–northeast pathway of the North China Plain(NCP)by five MAX-DOAS stations(Shijiazhuang(SJZ),Wangdu(WD),Nancheng(NC),Chinese Academy of Meteorological Sciences(CAMS),and University of Chinese Academy of Sciences(UCAS))belonging to the above network.The aerosol optical depths(AOD)in these five stations decreased in the order of SJZ>WD>NC>CAMS>UCAS.The short-distance regional transport of NO2 in the 700–900 m layer was monitored between WD and NC.As an important precursor of secondary aerosol,the peak of NO_(2) air mass in WD and NC all occurred 1 h earlier than that of aerosol.This was also observed for the short-distance regional transport of HCHO in the 700–900 m layer between NC and CAMS,which potentially affected the O_(3) concentration in Beijing.Finally,CAMS was selected as a typical site to determine the O_(3)–NO_(x)–volatile organic compounds(VOCs)sensitivities in vertical space.We found the production of O_(3) changed from predominantly VOCs-limited conditions to mainly mixed VOCs–NO_(x)-limited condition from the 0–100 m layer to the 200–300 m layer.In addition,the downward transport of O_(3) could contribute to the increase of ground surface O_(3) concentration.This ground-based hyperspectral stereoscopic remote sensing network provide a promising strategy to support management of PM_(2.5) and O_(3) and their precursors and conduct attribution of sources. | Cheng Liu Chengzhi Xing Qihou Hu Qihua Li Haoran Liu Qianqian Hong Wei Tan Xiangguang Ji Hua Lin Chuan Lu Jinan Lin Hanyang Liu Shaocong Wei Jian Chen Kunpeng Yang Shuntian Wang Ting Liu Yujia Chen | 2022 | Engineering2022，，12： | 0 |
| 7 | Flexible and Robust Functionalized Boron Nitride/Poly(p‑Phenylene Benzobisoxazole)Nanocomposite Paper with High Thermal Conductivity and Outstanding Electrical Insulation显示文摘With the rapid development of 5G information technology,thermal conductivity/dissipation problems of highly integrated electronic devices and electrical equipment are becoming prominent.In this work,“high-temperature solid-phase&diazonium salt decomposition”method is carried out to prepare benzidine-functionalized boron nitride(m-BN).Subsequently,m-BN/poly(pphenylene benzobisoxazole)nanofiber(PNF)nanocomposite paper with nacremimetic layered structures is prepared via sol–gel film transformation approach.The obtained m-BN/PNF nanocomposite paper with 50 wt%m-BN presents excellent thermal conductivity,incredible electrical insulation,outstanding mechanical properties and thermal stability,due to the construction of extensive hydrogen bonds andπ–πinteractions between m-BN and PNF,and stable nacre-mimetic layered structures.Itsλ∥andλ_(⊥)are 9.68 and 0.84 W m^(-1)K^(-1),and the volume resistivity and breakdown strength are as high as 2.3×10^(15)Ωcm and 324.2 kV mm^(-1),respectively.Besides,it also presents extremely high tensile strength of 193.6 MPa and thermal decomposition temperature of 640°C,showing a broad application prospect in high-end thermal management fields such as electronic devices and electrical equipment. | Lin Tang Kunpeng Ruan Xi Liu Yusheng Tang Yali Zhang Junwei Gu | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 8 | Microwave heating as a universal method to transform confined molecules into armchair graphene nanoribbons显示文摘Armchair graphene nanoribbons(AGNRs)with sub-nanometer width are potential materials for the fabrication of novel nanodevices thanks to their moderate direct band gaps.AGNRs are usually synthesized by polymerizing precursor molecules on substrate surface.However,it is time-consuming and not suitable for large-scale production.AGNRs can also be grown by transforming precursor molecules inside single-walled carbon nanotubes(SWCNTs)via furnace annealing,but the obtained AGNRs are normally twisted.In this work,microwave heating is applied for transforming precursor molecules into AGNRs.The fast heating process allows synthesizing the AGNRs in seconds.Several different molecules were successfully transformed into AGNRs,suggesting that it is a universal method.More importantly,as demonstrated by Raman spectroscopy,aberrationcorrected high-resolution transmission electron microscopy and theoretical calculations,less twisted AGNRs are synthesized by the microwave heating than the furnace annealing.Our results reveal a route for rapid production of AGNRs in large scale,which would benefit future applications in novel AGNRs-based semiconductor devices. | Haoyuan Zhang Yingzhi Chen Kunpeng Tang Ziheng Lin Xuan Li Hongwei Zhang Yifan Zhang Chi Ho Wong Chi Wah Leung Chee Leung Mak Yuan Hu Weili Cui Kecheng Cao Lei Shi | 2023 | Nano Research2023，16，7： | 0 |
| 9 | MXRA7 is involved in megakaryocyte differentiation and platelet production显示文摘Matrix remodeling is a critical process in hematopoiesis.The biology of MXRA7,as a matrix remodeling associated gene,has still not been reported in hematopoietic process.Public databases showed that MXRA7 expressed in hematopoietic stem cells,suggesting that it may be involved in hematopoiesis.We found that the amounts of megakaryocytes were lower in bone marrow and spleen from Mxra7−/−mice compared with that from wild-type mice.Knock-out of MXRA7 also reduced the amount of platelet in peripheral blood and affected the function of platelets.Knock-out of MXRA7 inhibited hematopoietic stem/progenitor cells differentiate to megakaryocytes possibly through down-regulating the expression of GATA-1 and FOG-1.Moreover,knockdown of MXRA7 in MEG-01 cells could inhibit the cell proliferation and cell apoptosis.Knockdown of MXRA7 inhibited the differentiation of MEG-01 cells and proplatelet formation through suppressing the ERK/MAPK signaling pathway and the expression ofβ-tubulin.In conclusion,the current study demonstrated the potential significance of MXRA7 in megakaryocyte differentiation and platelet production.The novel findings proposed a new target for the treatment of platelet-related diseases,and much more investigations are guaranteed to dissect the mechanisms of MXRA7 in megakaryocyte differentiation and platelet production. | Zhenjiang Sun Benfang Wang Ying Shen Kunpeng Ma Ting Wang Yiqiang Wang Dandan Lin | 2023 | Blood Science2023，5，3： | 0 |
| 10 | The mortise and tenon structure enabling lamellar carbon composites of ultra-high bending strength显示文摘Carbon materials are important but find little application in bending components due to their unsatisfy-ing bending strength(300-500 MPa).To fabricate carbon composites of high bending strength is a tough task,even using carbon fibers(CFs)structures as reinforcements.Here we report lamellar carbon com-posites of ultra-high bending strength(>1.2 GPa)produced from CFs cloths coated with nano-diamond(ND)particles by spark plasma sintering(SPS).When NDs are sandwiched between CFs cloths,some ND particles penetrate into interstices between CFs.During the sintering,the ND particles are transformed into graphite onions;this transformation is associated with an active state of carbon atoms participating in the change.As a result,the carbon onions strongly bond the CFs together,helping consolidate the com-pacts into strong lamellar carbon composite bulks.The produced graphite onions from the NDs located at crossings of CFs tows form a robust mortise and tenon structure,which helps the bending strength of the lamellar composite from the compact of 40 wt.%NDs exceed 1.2 GPa.The as-prepared compos-ite possesses the highest specific bending strength of all current high temperature structural materials reported so far.This work may pave a new way for high performance carbon materials. | Zhaojun Li Kunpeng Lin Hailiang Fang Hui Yu Junzhuo Wang Yimin Miao Lianjun Wang Jianlin Li Wan Jiang | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
| 11 | Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution显示文摘Pistachio is a nut crop domesticated in the Fertile Crescent and a dioecious species with ZW sex chromosomes.We sequenced the genomes of Pistacia vera cultivar(cv.)Siirt,the female parent,and P.vera cv.Bagyolu,the male parent.Two chromosome-level reference genomes of pistachio were generated,and Z and W chromosomes were assembled.The ZW chromosomes originated from an autosome following the first inversion,which occurred approximately 8.18 Mya.Three inversion events in the W chromosome led to the formation of a 12.7-Mb(22.8%of the W chromosome)non-recombining region.These W-specific sequences contain several genes of interest that may have played a pivotal role in sex determination and contributed to the initiation and evolution of a ZW sex chromosome system in pistachio.The W-specific genes,including defA,defA-like,DYT1,two PTEN1,and two tandem duplications of six VPS13A paralogs,are strong candidates for sex determination or differentiation.Demographic history analysis of resequenced genomes suggest that cultivated pistachio underwent severe domestication bottlenecks approximately 7640 years ago,dating the domestication event close to the archeological record of pistachio domestication in Iran.We identified 390,211,and 290 potential selective sweeps in 3 cultivar subgroups that underlie agronomic traits such as nut development and quality,grafting success,flowering time shift,and drought tolerance.These findings have improved our understanding of the genomic basis of sex determination/differentiation and horticulturally important traits and will accelerate the improvement of pistachio cultivars and rootstocks. | Salih Kafkas Xiaokai Ma Xingtan Zhang Hayat Topc¸u Rafael Navajas-Pérez Ching Man Wai Haibao Tang Xuming Xu Mortaza Khodaeiaminjan Murat Güney Aibibula Paizila Harun Karcı Xiaodan Zhang Jing Lin Han Lin Roberto de la Herrán Carmelo Ruiz Rejón Jerson Alexander García-Zea Francisca Robles Coral del Val Muñoz Agnes Hotz-Wagenblatt Xiangjia Jack Min HakanÖzkan Elmira Ziya Motalebipour Hatice Gozel Nergiz C¸oban Nesibe Ebru Kafkas Andrej Kilian HuaXing Huang Xuanrui Lv Kunpeng Liu Qilin Hu Ewelina Jacygrad William Palmer Richard Michelmore Ray Ming | 2023 | Plant Communications2023，4，3： | 0 |
| 12 | Unification of identifiers in the Sea-Cloud system显示文摘 | Zheng HE Kunpeng BAI Dongdai LIN Chuankun WU | 2018 | Frontiers of Computer Science2018，12，4： | 0 |
| 13 | Solubility of iron(Ⅲ) and nickel(Ⅱ) acetylacetonates in supercritical carbon dioxide显示文摘As a common precursor for supercritical CO_(2)(scCO_(2))deposition techniques,solubility data of organometallic complexes in scCO_(2)is crucial for the preparation of nanocomposites.Recently,metal acetylacetonates have shown great potential for the preparation of single-atom catalytic materials.In this study,the solubilities of iron(Ⅲ)acetylacetonate(Fe(acac)3)and nickel(Ⅱ)acetylacetonate(Ni(acac)2)were measured at the temperature from 313.15 to 333.15 K and in the pressure range of 9.5–25.2 MPa to accumulate new solubility data.Solubility was measured using a static weight loss method.The semi-empirical models proposed by Chrastil and Sung et al.were used to correlate the solubility data of Fe(acac)3 and Ni(acac)2.The equations obtained can be used to predict the solubility of the same system in the experimental range. | Haixin Sun Jianlei Qi Jianfei Sun Lin Li Kunpeng Yu Jintao Wu Jianzhong Yin | 2024 | Chinese Journal of Chemical Engineering2024，65，1： | 0 |
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