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| 1 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 2 | Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy显示文摘Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically. | Youn Son Chung Yong Woo Chung Sun You Moon Su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park | 2008 | World Journal of Gastroenterology2008，14，6： | 10 |
| 3 | Reprogramming fibroblasts into induced pluripotent stem cells with Bmil显示文摘 | Jai-Hee Moon June Seok Heo Jun Sung Kim Eun Kyoung Jun Jung Han Lee Aeree Kim Jonggun Kim Kwang Youn Whang Yong-Kook Kang Seungeun Yeo Hee-Joung Lim Dong Wook Han Dong-Wook Kim Sejong Oh Byung Sun Yoon Hans R Scholet Seungkwon You | 2011 | Cell Research2011，21，9： | 6 |
| 4 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 5 | Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial显示文摘BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(H.pylori)eradication rates afforded by the standard triple therapy.Thus,2-wk firstline four-drug regimens must be considered.AIM To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and compliance.METHODS Patients infected with H.pylori were prospectively randomized to receive mBCQT or CT for 2 wk.mBCQT featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice daily.CT included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice daily.The 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm eradication.If either the histological or rapid urease test was positive,H.pylori infection was diagnosed.RESULTS The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ significantly.On intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The H.pylori eradication rates of the 2-wk mBCQT and CT regimens are high.Most patients show good compliance,and more CT than mBCQT patients experience adverse events. | So Jeong Kim Jun-Won Chung Hyun Sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park | 2019 | World Journal of Gastroenterology2019，25，46： | 2 |
| 6 | Nanog-induced dedifferentiation of p53-deficient mouse astrocytes into brain cancer stem-like cells显示文摘 | Jai-Hee Moon Suhyun Kwon Eun Kyoung Jun Aeree Kim Kwang Youn Whang Hyunggee Kim Sejong Oh Byung Sun Yoon Seungkwon You | 2011 | Biochemical and Biophysical Research Communications2011，，： | 1 |
| 7 | Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice显示文摘 | Sun Haeng Park Ji Hyun Kim Se Jin Park Sun Sik Bae Young Whan Choi Jin Woo Hong Byung Tae Choi Hwa Kyoung Shin | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 8 | Intramedullary spinal cord metastases: a single-institution experience显示文摘 | Sung Sook Lee Min Kyoung Kim Sun Jin Sym Sang Wee Kim Woo Kun Kim Sung-Bae Kim Jin-Hee Ahn | 2007 | Journal of Neuro - Oncology2007，，1： | 1 |
| 9 | Structural and electrical properties of Sb-doped p-type ZnO thin films fabricated by RF magnetron sputtering显示文摘 | Dong Hun Kim Nam Gyu Cho Kyoung Sun Kim Seungho Han Ho Gi Kim | 2009 | Journal of Electroceramics (-)2009，，1： | 1 |
| 10 | Control- oriented model for intake shock position dynamics in ramjet engine 显示文摘 | IK Soo Park SUN Kyoung Kim JUNG Woo Park | 2011 | Journal of Propulsion and Power2011，27，2： | 1 |
| 11 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 12 | The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins显示文摘 | Joo Heon Kim Sun Young Yoon Chang-Nam Kim Joung Hyuck Joo Sang Kyoung Moon In Seong Choe Yong-Kyung Choe Jae Wha Kim | 2003 | Cancer Letters2003，，2： | 1 |
| 13 | Nonsteroidal anti‐inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer显示文摘 | Chang Mo Moon Ji‐Hee Kwon Ji Suk Kim Sun‐Hee Oh Kyoung Jin Lee Jae Jun Park Sung Pil Hong Jae Hee Cheon Tae Il Kim Won Ho Kim | 2013 | Int J Cancer2013，，3： | 1 |
| 14 | Anti-atherosclerotic effects of Polygonum aviculare L. ethanol extract in ApoE knock-out mice fed a Western diet mediated via the MAPK pathway显示文摘 | Sun Haeng Park Yoon-Young Sung Kyoung Jin Nho Ho Kyoung Kim | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 15 | 韩国赤松林龄序列的生物量及碳氮储量显示文摘调查了韩国6种不同林龄(10,27,30,32,44和71年生)赤松林(Pinus densiflora)的生物量、碳含量和氮含量.采用收割法采集30株个体作为样本,其中有12株挖掘了全部的根系,采集植物体地上、地下部分、凋落物(CWD)、地被物及矿质土壤样品(0-30cm)进行分析.结果显示,树木生物量最大的是林龄71年生的样地(202.8t/ha),最小的是林龄10年生的样地(18.4t/ha);林龄71年生样地的矿质土壤碳、氮储量均高于其他样地,这可能与该样地较高的土壤碳、氮密度有关.生态系统总碳、氮储量从林龄10年生的样地(18.8tC/ha和1.3tN/ha)到林龄71年生的样地(201.4tC/ha和8.5tN/ha)逐渐增高.生态系统总碳储量和树木碳储量都呈现出随着林龄S型增长的趋势,而凋落物、地被物和矿质土壤的氮含量则未显示出随林龄变化而显著变化的趋势.本结果对了解赤松林碳、氮储量的现状及预测未来的生长变化提供有效依据. | NOH Nam Jin SON Yowhan LEE Sue Kyoung SEO Kyung Won HEO Su Jin YI Myong-Jong PARK Pil Sun KIM Rae Hyun SON Yeong Mo LEE Kyeong Hak | 2010 | 中国科学:生命科学2010，40，7： | 1 |
| 16 | Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment显示文摘 | Se Young Park Hyung Jeong Kim Ki Rim Kim Sun Kyoung Lee Chang Ki Lee Kwang-Kyun Park Won-Yoon Chung | 2014 | Toxicology and Applied Pharmacology2014，，： | 1 |
| 17 | Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: A crucial role for the CYP2B6*6 allele显示文摘 | In Cheol Hwang Ji Young Park Hong Yup Ahn Kyoung Kon Kim Heuy Sun Suh Ki Dong Ko Kyoung-Ah Kim | 2014 | Clinica Chimica Acta2014，，： | 1 |
| 18 | Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles显示文摘 | Dong‐Eog Kim Jeong‐Yeon Kim In‐Cheol Sun Dawid Schellingerhout Su‐Kyoung Lee Cheol‐Hee Ahn Ick Chan Kwon Kwangmeyung Kim | 2013 | Ann Neurol2013，，5： | 1 |
| 19 | The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms显示文摘 | Ji Hyun Kim Sun Haeng Park Young Whan Kim Jung Min Ha Sun Sik Bae Guem San Lee Su In Cho Byung Tae Choi Hwa Kyoung Shin | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 20 | Intramedullary spinal cord metastases: a single-institution experience显示文摘 | Sung Sook Lee Min Kyoung Kim Sun Jin Sym Sang Wee Kim Woo Kun Kim Sung-Bae Kim Jin-Hee Ahn | 2007 | Journal of Neuro - Oncology2007，，1： | 1 |
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