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| 1 | Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury显示文摘Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ± 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia. | Fuyong Li Shuai Han Yi Ma Fuxin Yi Xinmin Xu Yunhui Liu | 2014 | Neural Regeneration Research2014，9，2： | 15 |
| 2 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 3 | Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration显示文摘Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed. | Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo | 2020 | Regenerative Biomaterials2020，7，6： | 7 |
| 4 | Conceptual design,data model and key techniques of“3D Assistant”显示文摘Conceptual design, data model and key techniques of 'Geo-engineer 3D assistant', an underground 3D GIS oriented to geology and mine application, were discussed. In particular, the importance of high-order smoothing triangular pieces to surface's fine expression in geological modeling was emphasized. The contour mode is the most favorite mode of the three modes about surface expression: DEM, TIN and contour. Topology in underground 3D modeling with CAGD was compared. From the view of boundary and coboundary, which is soul of IS 19107 (Geographic information spatial schema), 3D underground topology was re-examined. | LI Qing-yuan1, ZHANG Xuan2, JIN Yang2, ZHOU Hui3, WANG Qian-jin3,WEI Zhan-yin1 1. Key Laboratory of Geo-Informatics, Chinese Academy of Surveying and Mapping, Beijing 100830, China 2. School of Geo-Science and Surveying Engineering, China University of Mining and Technology, Beijing 100083, China 3. School of Geomatics, Liaoning Technical University, Fuxin 123000, China | 2011 | 中国有色金属学会会刊:英文版2011，21，S3： | 4 |
| 5 | Geochemical characteristics of pyrolysis gas from epimetamorphic rocks in the northern basement of Songliao Basin,Northeast China显示文摘The Xushen gas field,located in the north of Songliao Basin,is a potential giant gas area for China in the future.Its proved reserves have exceeded 1000×10 8 m 3 by the end of 2005.But,the origin of natural gases from the deep strata is still in debating.Epimetamorphic rocks as a potential gas source are widely spreading in the northern basement of Songliao Basin.According to pyrolysis experiments for these rocks in the semi-confined system,gas production and geochemistry of alkane gases are discussed in this paper.The Carboniferous-Permian epimetamorphic rocks were heated from 300℃to 550℃,with temperature interval of 50℃.The gas production was quantified and measured for chemical and carbon isotopic compositions.Results show thatδ13C 1 is less than?20‰,carbon isotope trend of alkane gas isδ13C 1 <δ13C 2 <δ13C 3 orδ13C 1 <δ13C 2 >δ13C 3 ,these features suggest that the gas would be coal-type gas at high-over maturity,not be inorganic gas with reversal trend of gaseous alkanes (δ13C 1 >δ13C 2 >δ13C 3 ).These characteristics of carbon isotopes are similar with the natural gas from the basin basement,but disagree with gas from the Xingcheng reservoir.Thus,the mixing gases from the pyrolysis gas with coal-typed gases at high-over maturity or oil-typed gases do not cause the reversal trend of carbon isotopes.The gas generation intensity for epimetamorphic rocks is 3.0×10 8 ―23.8×10 8 m 3 /km 2 ,corresponding to Ro from 2.0%to 3.5%for organic matter. | YANG Chun 1 ,LUO Xia 2 ,LI Jian 2 ,LI ZhiSheng 2 ,LIU QuanYou 3 &Wang YuLin 4 1 Department of Earth Sciences,Zhejiang University,Hangzhou 310027,China 2 Research Institute of Petroleum Exploration and Development(Langfang Branch),Langfang 065007,China 3 Research Institute of Petroleum Exploration and Development,Beijing 100083,China 4 Department of Source and Environment,Liaoning Technical University,Fuxin 123000,China | 2008 | Science China Earth Sciences2008，51，S1： | 3 |
| 6 | The changes of renewable water resources in China during 1956 –2010显示文摘Water is a critical natural resource upon which all social and economic activities and ecosystem functions depend. With a surprising social and economic development in the past decades, water has become an important constraint for China's sustainable development, and a matter concerning economic security, ecological security and national security of the country. Understanding the changes of water resources is greatly helpful in analyzing the impacts of climatic change, formulating plans for utilization and protection of water resources, and making water resource decisions. Based on China's national water resources assessment, the Mann-Kendall's test, and Morlet wavelet, we analyzed the changing trends and periods of China's renewable water resources during 1956–2010. The results as following:(1) There is no significant change trend of water resources on the countrywide scale during the period 1956–2010, the total water resources show a slight increasing trend, and the national annual average water resources during the period 1991–2010 increased by 1% relative to that of the period 1961–1990.(2) The changes of water resources in different level-I water resource regions vary significantly. Annual average water resources of the Haihe River and Yellow River regions in the northern China decreased 19% and 17% respectively in the past 20 years. Water resource increased in Southern and Northwestern rivers regions, particularly in the Northwest rivers region, with the increasing amplitude by nearly 10% in the past 20 years.(3) The inter-annual variation of national water resource became larger in the past 20 years, as compared with that of the period 1961–1990. The coefficients of water resource variation increased in Northwestern and Southwestern rivers regions, while the inter-annual variation tended to decrease in the Haihe and the Yellow River regions where significant decline of water resources happened.(4) A 14-year quasi-periodicity of the national water resource variation was detected, overlapping with various periodicities of water resources of different level-I water resource regions. Remarkable uniformity exists between the first or secondary primary periodicity of water resource variation in adjacent level-I water resource regions. | LI YuanYuan CAO JianTing SHEN FuXin XIA Jun | 2014 | Science China Earth Sciences2014，57，8： | 3 |
| 7 | A survey on hearing acuity of centenarians in Hainan Province显示文摘Objective: This study aimed to investigate hearing acuity of centenarians in Hainan Province and provide basis for interventional considerations.Method: Door-to-door follow-up was conducted to investigate hearing acuity of centenarians(aged 100 years or above) in Hainan Province. Physical examination, pure tone audiometry and acoustic impedance test were performed, and the results were analyzed.Result: A total of 460 centenarians(920 ears) were tested by pure tone audiometry. The rate of normal hearing was 0.2%, the rate of mild hearing loss was 1.5%, 12% for moderate hearing loss, 33.9% for moderate to severe hearing loss, 37.4% for severe hearing loss is and 15% for profound hearing loss. Acoustic impedance test was performed in 340 centenarians(668 ears). Tympanogram was type A in 41.2% of the ears, type As in 34.1% ears,type Ad in 6.4%, type B in 11.8%, and type C in 4.9% of the ears, while no response was elicited in 1.5% of the ears.Conclusion: Age related sensorineural hearing loss is prevalent among centenarians in Hainan Province. A probably beneficial intervention may be the use of hearing aids for effective communication. | Jianhui Li Hui Zhao Bangqing Huang Shanshan Zhang Kaihua Sun Xinying Jiang Fuxin Luan | 2018 | Journal of Otology2018，13，4： | 2 |
| 8 | Mass transfer characteristics of membraneous gas distributor 显示文摘 | LI Lin DING Fuxin YUAN Naiju | 1994 | Chinese J Chem Eng1994，2，1： | 1 |
| 9 | Ranking with decision tree显示文摘 | XIA Fen ZHANG Wensheng LI Fuxin | 2008 | Knowledge and Information Systems2008，17，3： | 1 |
| 10 | Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells显示文摘 | Mincai Li Liangzu Yu Tonghui She Yapin Gan Fuxin Liu Zhengwu Hu Yongbin Chen Suqin Li Hongli Xia | 2012 | European Journal of Pharmacology (-)2012，，1： | 1 |
| 11 | Effects of simultaneously doped and deposited Ag on the photocatalytic activity and sur- face states of TiO2 显示文摘 | BAI Fuxin LI Qiangjing | 2005 | The Journal of Physical Chemistry B2005，109，7： | 1 |
| 12 | Oscore: a combined score to reduce false negative rate for peptide identification in tandem mass spectrometry analysis 显示文摘 | Shao Chen Sun Wei Li Fuxin | 2009 | J Mass Spectrom2009，44，： | 1 |
| 13 | Ranking with decision tree显示文摘 | Fen Xia Wensheng Zhang Fuxin Li Yanwu Yang | 2008 | Knowledge and Information Systems2008，，3： | 1 |
| 14 | The high frequency acoustic radiation from the boundary layer of an axisymmetric body显示文摘The mechanism of acoustic radiation from the boundary layer of an axisymmetric body is analyzed, and its sound pressure spectrum is predicted. It is shown that the acoustic radiation results from the transition region and the turbulent boundary layer; and that the acoustic radiation from transition region is predominant at low frequencies; while the turbulent boundary layer has the decisive effect on acoustic radiation at high frequencies. The calculated values are in good agreement with the experimental data. | LI Fuxin MA Lin (College of Marine Engineering, Northwestern Polytechnical University Xi’an 710072) MA Zhiming (College oj Navy Aeronautics Engineering Qingdao 266001) | 2001 | Chinese Journal of Acoustics2001，20，2： | 1 |
| 15 | Climate Suitability Assessment of Human Settlements for Regions along the Belt and Road显示文摘Climate is one important environmental variable that affects human life.As the regions along the Belt and Road(B&R)encompass vast territories and large populations,it is significant to assess climate suitability for human settlements,which will influence the migration of various surrounding countries.We selected seven regions including 65 countries along the B&R for the research area and adopted the temperature-humidity index(THI),to assess the climate suitability.We analyzed the spatial characteristics of THI and the correlation between population distribution and THI,the results of which enabled us to adjust the THI classification criteria.We finally assessed the climate suitability of each region.The results reveal that outside the Qinghai-Tibet Plateau,the THI values generally tend to decrease from west to east as longitude increases and downward with increasing latitude.The population distribution is significantly correlated with the THI.Regions with relative suitable climate,including high suitability areas(HASs),moderately suitable areas(MSAs)and low suitability areas(LSAs),account for 50.62%of the total area and encompass in excess of 90%of total population.These areas are widely distributed in the southern regions of 45°N latitude,again with the exception of the Qinghai-Tibet Plateau.Critical suitable area includes 19.48%of the entire area and 8.98%of total population.The non-suitable area accounts for less than 30%of total area,concentrated in the cold high-latitude and high-altitude areas. | LIN Yumei LI Peng FENG Zhiming YANG Yanzhao YOU Zhen ZHU Fuxin | 2021 | Chinese Geographical Science2021，31，6： | 1 |
| 16 | Analysis of bacterial communities on aging flue-cured tobacco leaves by 16S rDNA PCR-DGGE technology显示文摘 | ZHAO Mingqin WANG Baoxing LI Fuxin | 2007 | Applied Microbiology and Biotechnology2007，73，6： | 1 |
| 17 | TASC: Topic-adaptive Sentiment Classification on Dynamic Tweets 显示文摘 | Liu Shenghua Cheng Xueqi Li Fuxin | 2015 | IEEE Transacations on Knowledge and Data Engineering2015，27，6： | 1 |
| 18 | Concanavalin A captured glycoproteins in healthy human urine显示文摘 | Wang Linjie LI Fuxin Sun Wei | 2006 | Molecular & Cellular Proteomics2006，5，3： | 1 |
| 19 | Expression and biological role of CIP2A in human astrocytoma显示文摘 | Fuxin Yi Weimin Ni Weixian Liu Jinyang Bai Wenbin Li | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 20 | Resonance scattering spectroscopy of gold nanoparticle显示文摘 | Zhiliang Jiang Zhongwei Feng Tingsheng Li Fang Li Fuxin Zhong Jiyun Xie Xianghui Yi | 2001 | Science in China Series B: Chemistry2001，，2： | 1 |
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