|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City显示文摘Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis,which is a rare subject of research in the mainland of China.Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data(2010-2011).Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai.The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants.For lag06,a 10 μg/m3 increase in the concentrations of PM10,SO2,and NO2 corresponded to 0.94%(95% CI:0.83%,1.05%),11.12%(95% CI:10.76%,11.48%),and 4.84%(95% CI:4.49%,5.18%) increases in hospital visits for acute bronchitis,respectively.These associations appeared to be stronger in females(P<0.05).Between-age differences were significant for SO2(P<0.05),and between-season differences were also significant for SO2(P<0.05).Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened. | GUO Li Juan ZHAO Ang CHEN Ren Jie KAN Hai Dong KUANG Xing Ya | 2014 | Biomedical and Environmental Sciences2014，27，11： | 13 |
| 2 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 3 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 4 | Epidemiological Characteristics and Risk Factors of the Pertussis in Infants < 12 Months of Age in Tianjin, China显示文摘The epidemiologic characteristics of 631 infant pertussis cases<12 months,which accounted for57.42%of the total cases,were analyzed by descriptive epidemiology in Tianjin,between 2010and 2015.The incidence of infants was104.66/100,000,which was 118 times higher than in other age groups(P<0.001).The primary type of pertussis simultaneously presented in households was adult-to-infant(70.51%).The parents were identified as the source of infection in 80.18%of cases for infants.The positive rate of placental antibody transfer was 31.06%and 3.13%for3-month-old infants.Infants presented the highest age-specific pertussis incidence.The most important reason was parents were the important sources of infection,and secondly the lower level of antibodies in neonates and the rapid waning of maternal antibody titer. | HUANG Hai Tao GAO Zhi Gang LIU Yong WANG Li Juan LIU Yan Ping ZHANG Ying | 2017 | Biomedical and Environmental Sciences2017，30，7： | 7 |
| 5 | Preparation and characterization of porous TiO_2/ZnO composite nanofibers via electrospinning显示文摘多孔的 TiO2/ZnO 合成 nanofibers 被 electrospinning 技术成功地第一次准备了。它被锻烧 TiO2/ZnCl2/PVP 产生[PVP:poly (乙烯基 pyrrolidone )] nanofibers,是从 TiO2 的一个混合答案的 electrospun, ZnCl2 和 PVP。传播电子显微镜学(TEM ) 和衍射(XRD ) 分析的 X 光检查被用来识别 TiO2/ZnO nanofibers 和无机的 TiO2/ZnO 纤维的形成的形态学。TiO2/ZnO 纤维的多孔的结构被 N2 adsoption/desorption 等温线描绘。表面 photovoltage 光谱学(SPS ) 和揭示的大小预付多孔的 TiO2/ZnO 合成 nanofibers 和结果的性质的 photocatalytic 活动与纯 TiO2 nanofibers,纯 ZnO nanofibers 和 TiO2/ZnO nanoparticles 相比。 | Hai Ying Wang Yang Yang Xiang Li Li Juan Li Ce Wang | 2010 | Chinese Chemical Letters2010，21，9： | 5 |
| 6 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 7 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 8 | Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration显示文摘A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper.The second-order calibration method based on APTLD(alternating penalty trilinear decomposition) algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time.The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples. | Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian Yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu | 2010 | Chinese Chemical Letters2010，21，10： | 4 |
| 9 | In vitro Screening of Ginkgolic Acids for Antiparasitic Activity against Cryptosporidium andersoni显示文摘Cryptosporidium is a protozoan parasite belonging to the phylum Apicomplexa that causes self-limiting diarrhea in immunocompetent individuals, and it may also cause chronic and life-threatening diarrhea in those that are immunocompromised[1]. The two main routes of Cryptosporidium transmission are via water and food. At least 30 Cryptosporidium species have been confirmed, including C. andersoni, with more than 70 genotypes of undefined species. | Chidiebere E.UGWU JIANG Yan Yan WU Liang XU Yu Xin YIN Jian Hai DUAN Li Ping CHEN Sheng Xia LIU Hua PAN Wei QUAN Hong SHEN Yu Juan CAO Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，4： | 3 |
| 10 | Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study显示文摘Environmental exposure to heavy metals has been linked to a wide range of human health hazards.We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study(Jinchang Cohort)to directly evaluate metal exposure levels.Fifteen metals,namely As,Ba,Be,Cd,Cs,Cr,Co,Cu,Pb,Mn,Ni,Se,Tl,U,and Zn,were detected by inductively coupled plasma quadruple mass spectrometry.The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group,except Se and Zn,than other reported general or occupational populations.Further studies should address the effects of heavy metals on human health. | YANG Ai Min CHENG Zhi Yuan PU Hong Quan CHENG Ning LI Hai Yan LIU Si Min DING Jiao LI Juan Sheng HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2017 | Biomedical and Environmental Sciences2017，30，7： | 2 |
| 11 | Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and Urinary Glucose in a Chinese Population: A Multicenter Cross-Sectional Study显示文摘 | Juan Chen Hai Jian Guo Shan-Hu Qiu Wei Li Xiao-Hang Wang Min Cai Bei Wang Xiao-Ning Li Zi-Lin Sun | 2018 | Chinese Medical Journal2018，，14： | 2 |
| 12 | Trend Analysis of Cancer Mortality in the Jinchang Cohort, China,2001-2010显示文摘Objective To describe the baseline data of cancers in the Jinchang Cohort, this paper examined trends in cancer mortality among adults investigated in Jinchang, Gansu province from 2001 to 2010. Methods Mortality data were collected from company departments through administrative documents, death certificates, etc. Trend analyses of cancer mortality were performed on the basis of 925 cancer deaths between 2001 and 2010. Results The crude mortality rate of cancer continuously increased from 161.86 per 100,000 in 2001 to 315.32 per 100,000 in 2010, with an average increase of 7.69% per year in the Jinchang Cohort(16.41% in females compared to 6.04% in males), but the age-standardized mortality rate increased only in females. Thirteen leading cancers accounted for 92.10% of all cancer deaths. The five leading causes of cancer mortality in males were lung, gastric, liver, esophageal, and colorectal cancer, whereas those in females were lung, liver, gastric, breast, and esophageal cancer. Conclusion The overall cancer mortality rate increased from 2001 to 2010 in the Jinchang Cohort, with greater rate of increase in females than in males. Lung, breast, and gastric cancer, in that order, were the leading causes of increased cancer mortality in females. | QU Hong Mei BAI Ya Na CHENG Ning DAI Min ZHENG Tong Zhang WANG Dennis LI Hai Yan HU Xiao Bin LI Juan Sheng REN Xiao Wei SHANG Hui | 2015 | Biomedical and Environmental Sciences2015，28，5： | 2 |
| 13 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 14 | Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers显示文摘Objective To study the association between metal exposure and risk of diabetes and prediabetes among Chinese workers exposed to metals.Methods We used data obtained from the baseline survey of the Jinchang Cohort Study of workers in Jinchang Industry,the largest nickel production company in China.A total of 42,122 workers ≥20 years of age were included in the study.A standardized,structured questionnaire was used to collect epidemiological information.Physical examinations and laboratory tests were conducted to evaluate the health status of the participants and to measure various biomarkers including blood sugar,lipids,and urinary metal concentrations.Logistic regression was used to study the association between occupational groups categorized according to the measured metal levels(office workers,low-level;mining/production workers,mid-level;and smelting/refining workers,high-level)and risk of diabetes and prediabetes.Results The overall prevalence of diabetes and prediabetes was 7.5% and 16.8%,respectively.The adjusted odds ratios for diabetes among mining/production workers and smelting/refining workers compared to office workers were 1.5(95% CI:1.3,1.7)and 3.8(95% CI:3.4,4.3),respectively.No association was observed between these occupational groups and prediabetes in this study.Conclusion Occupations associated with higher levels of metal exposure were associated with an increased risk of diabetes in this cohort.More studies are needed to confirm this observed association. | YANG Ai Min CHENG Ning PU Hong Quan LIU Si Min LI Juan Sheng BASSIG Bryan A. DAI Min LI Hai Yan HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2015 | Biomedical and Environmental Sciences2015，28，12： | 2 |
| 15 | Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion,migration and invasion in hepatocellular carcinoma cells显示文摘 | Xiao-Ming Bai Wei Zhang Ning-Bo Liu Hui Jiang Ke-Xin Lou Tao Peng Juan Ma Li Zhang Hai Zhang Jing Leng | 2009 | Oncology Reports2009，，1： | 1 |
| 16 | Effect of Mechanical Activation on Extracting Indium from Neutral Leach Residue of Zinc Calcine显示文摘 | Zhang Yan Juan Li Xuan Hai Pan Liu Ping Wei Yan Song | 2011 | Advanced Materials Research2011，，201： | 1 |
| 17 | Structure of Cytochromec and Its Platinum-modified Derivatives by Fourier Transform Infrared Spectroscopy显示文摘StructureofCytochromecandItsPlatinum┐modifiedDerivativesbyFourierTransformInfraredSpectroscopyJIANGLi-juana,SUNWei-yina,FANGJ... | JIANG Li juan a , SUN Wei yin a , FANG Jiang lin b , SHU Mou hai a and TANG Wen xia a ** ( aState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing, 210093) | 1997 | Chemical Research in Chinese Universities1997，13，2： | 1 |
| 18 | Simuhaneous quantitation of aconitine, mesaconitine, hypaconitine,benzoyla- conine, benzoylmesaconine and benzoylhypaconine in human plasmaby liquid chromatography-tandem nmss spectrometry and pharmacokinetics evaluation of 'SHEN-FU' injectable powder 显示文摘 | Zhang Fan Tang Ming hai Chen Li juan | 2008 | Chromatogr B2008，873，： | 1 |
| 19 | Study on Fractal Characteristic of Surface Micro-Topography of Micro-WEDM显示文摘 | Ding Hai Juan Guo Li Bin Zhang Zhi Hang Cui Hai | 2009 | Applied Mechanics and Materials2009，，16： | 1 |
| 20 | Enhanced giant dielectric response in Sr[(Fe 0.5 Nb 0.5 ) 1?x Ti x ]O 3 solid solutions显示文摘 | Zhuo Wang Yong Fei Wen Liang Liang Zhang Hai Juan Li Yong Ping Pu | 2014 | Journal of Materials Science: Materials in Electronics2014，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员