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| 1 | Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen显示文摘Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is limited.The current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic GBC.Methods:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were retrieved.This retrospective study evaluated the clinical characteristics,survival outcomes and adverse events.Results:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were included.There were no significant differences between groups in baseline characteristics.The median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX group.Conclusions:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies. | Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui Xiang-Song Wu Lu Zou Xiao-Ling Song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang Wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 10 |
| 2 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 3 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 4 | Ethical Principles and Governance Technology Development of AI in China显示文摘Ethics and governance are vital to the healthy and sustainable development of artificial intelligence(AI).With the long-term goal of keeping AI beneficial to human society,governments,research organizations,and companies in China have published ethical guidelines and principles for AI,and have launched projects to develop AI governance technologies.This paper presents a survey of these efforts and highlights the preliminary outcomes in China.It also describes the major research challenges in AI governance research and discusses future research directions. | Wenjun Wu Tiejun Huang Ke Gong | 2020 | Engineering2020，6，3： | 8 |
| 5 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 6 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 7 | Notch signaling pathway mediates the immunomodulatory mechanism of Yangfei Huoxue decoction alleviating bleomycin-induced pulmonary fibrosis in rats显示文摘OBJECTIVE: To investigate the immunomodulatory mechanism by which Yangfei Huoxue decoction(YHD) alleviates bleomycin(BLM)-induced pulmonary fibrosis(PF) in rats.METHODS: Rats were randomly divided into two time-point groups(day 14 and 28), and each timepoint group comprised the following six subgroups: control, BLM, dexamethasone(DXM), YHD high dose(YHD-H), YHD middle dose(YHD-M), and YHD low dose(YHD-L). Haematoxylin and eosin and Masson staining, flow cytometry, enzymelinked immunosorbent assay, Western blotting and UPLC-QT of analyses were examined.RESULTS: The results showed that YHD reduced the degree of alveolar inflammation and fibrosis;downregulated the expression of CD28, CD80,CD86, Delta-like 1, Notch2, and Notch3;and upregulated the proportions of Th1/Th2 and Tc1/Tc2. The seven components of YHD were detected.CONCLUSION: The current study indicates that YHD mainly functions by regulating the immune system and that the molecular mechanism may be related to the regulation of the Notch signaling pathway. | Chen Hui Liu Xiao Su Yinxu Chang Ke Wu Haotian Su Guangbao Gong Jiening | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 7 |
| 8 | Inorganic arsenic contamination of rice from Chinese major rice-producing areas and exposure assessment in Chinese population显示文摘This study examined the total arsenic(Ast) and inorganic arsenic(Asi) content in the main rice growing area of China. The results were compared with other countries and then used for dietary exposure assessment. A total of 446 rice samples from 15 main rice-growing provinces and autonomous regions of China were collected and then divided into unpolished and polished rice. Total arsenic and arsenic species were analyzed in a total of 892 subsamples using inductively coupled plasma-mass spectrometry(ICP-MS) and high performance liquid chromatography(HPLC) coupled ICP-MS, respectively. National Ast means were 255 μg/kg of unpolished rice and 143 μg/kg of polished rice. Asi was found to be the predominant species and mean levels were 209 μg/kg of unpolished rice and 108 μg/kg of polished rice, respectively. Exposure assessment to Asi in polished rice has been calculated for the margin of exposure(MOE), which highlights the fact that Asi levels in the Chinese rice should arouse public health concern. | Xiaowei Li Ke Xie Bing Yue Yunyun Gong Yi Shao Xiaohong Shang Yongning Wu | 2015 | Science China(Information Sciences)2015，58，12： | 7 |
| 9 | Preliminary assessment of heavy metal contamination in surface water and sediments from Honghu Lake, East Central China显示文摘表面水和沉积里的重金属集中在湖北省从洪胡·莱克收集了,中国被分析,并且生态的风险根据沉积质量指南被评估。结果证明表面水里的重金属的平均集中是被评价:作为 > Zn > Cu > Cr > Pb > Ni > Cd > Hg。与在另外的河和背景价值里报导的结果比较,洪胡·莱克被弄脏由作为, Cr, Pb, Cu 和 Ni。大多数金属可能主要从在湖附近的化肥,工业自河和国内废水。重金属集中比在另外的区域在入口区域是相对更高的。当重要积极关联在 Zn, Cd 和 Pb 之间是在场的时,否定关联在很重的金属和 pH 之间被观察。在沉积核心,当时, Cu, Zn, Cr 和 Ni 显示出一个减少的趋势在场的 Cd 一个增加的趋势。减少作为,在由于在 1998 的洪水事件的 1990 年代力量的 Cu, Zn, Cr 和 Ni。生态的风险评价的分析基于沉积质量指南建议在从洪胡·莱克的大多数沉积的重金属有中等毒性,与 Cr being 最高的优先级污染物质[出版摘要] | Ying HU Shihua QI Chenxi WU Yanping KE Jing CHEN Wei CHEN Xiangyi GONG | 2012 | Frontiers of Earth Science2012，6，1： | 7 |
| 10 | Prevention of common bile duct injury during laparoscopic cholecystectomy显示文摘BACKGROUND:Since the widespread adoption of laparoscopic cholecystectomy(LC)in the late 1980s,a rise in common bile duct(CBD)injury has been reported.We analyzed the factors contributing to a record of zero CBD injuries in 10 000 consecutive LCs. METHODS:The retrospective investigation included 10 000 patients who underwent LC from July 1992 to June 2007. LC was performed by 4 teams of surgeons.The chief main surgeon of each team has had over 10 years of experience in hepatobiliary surgery.Calot's triangle was carefully dissected,and the relationship of the cystic duct to the CBD and common hepatic duct was clearly identified.A clip was applied to the cystic duct at the neck of the gallbladder and the duct was incised with scissors proximal to the clip.The cystic artery was dissected by the same method. Then,the gallbladder was dissected from its liver bed.A drain was routinely left at the gallbladder bed for 1-2 days postoperatively. RESULTS:No CBD injuries occurred in 10 000 consecutive LCs,and there were 16 duct leaks(0.16%).Among these, there were 10 Luschka duct leaks(0.1%)and 6 cystic duct leaks(0.06%).Four hundred thirty cases were converted to open cholecystectomy(OC),giving a conversion rate of 4.3%.After a mean follow-up of 17.5 months(range 6-24 months),no postoperative death due to LC occurred,and good results were observed in 95%of the patients. CONCLUSIONS:In our 10 000 LCs with zero CBD injuries, the techniques used and practices at our department have been successful.Surgeon's expertise in biliary surgery,preoperative imaging,precise operative procedures,and conversion from LC to OC when needed are important measures to prevent CBD injuries. | Ou, Zhi-Bing Li, Sheng-Wei Liu, Chang-An Tu, Bing Wu, Chuan-Xin Ding, Xiong Liu, Zuo-Jin Sun, Ke Feng, Hu-Yi Gong, Jian-Ping | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，4： | 5 |
| 11 | miR-410 induces both epithelial–mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer显示文摘Radiotherapy remains one of the major treatments for non-small cell lung cancer(NSCLC)patients;whereas intrinsic or acquired radioresistance limits its efficacy.Nevertheless,most studies so far have only focused on acquired resistance.The exact mechanisms of intrinsic radioresistance in NSCLC are still unclear.A few studies have suggested that epithelial–mesenchymal transition(EMT)is associated with radioresistance in NSCLC.However,little is known about whether the abnormal expression of specific microRNAs induces both EMT and radioresistance.We previously found that miR-410 has multiple roles as an oncomiRNA in NSCLC.In this study,we revealed that miR-410 overexpression promoted EMT and radioresistance,accompanied by enhanced DNA damage repair both in vitro and in vivo.Conversely,knockdown of miR-410 showed the opposite effects.We further demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays,and the miR-410-induced EMT and radioresistance were reversed by PI3K,Akt,and mTOR inhibitors or by restoring the expression of PTEN in NSCLC cells.In addition,we preliminarily found that the expression of miR-410 was positively correlated with EMT and negatively associated with the expression of PTEN in NSCLC specimens.In summary,these results demonstrated that miR-410 is an important regulator on enhancing both NSCLC EMT and radioresistance by targeting the PTEN/PI3K/mTOR axis.The findings suggest that miR-410-induced EMT might significantly contribute to the enhanced radioresistance.Therefore,miR-410 may serve as a potential biomarker or therapeutic target for NSCLC radiotherapy. | Yue Yuan Hu Liao Qiang Pu Xixian Ke Xueting Hu Yongfang Ma Xinmei Luo Qianqian Jiang Yi Gong Min Wu Lunxu Liu Wen Zhu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 12 | Comparison of postoperative complications between internal and external pancreatic duct stenting during pancreaticoduodenectomy: a meta-analysis显示文摘Background:Two types of pancreatic duct stents are used to improve postoperative outcomes of pancreatic anastomosis.The aim of this meta-analysis was to evaluate and compare the postoperative outcomes of patients with internal or external stenting during pancreaticoduodenectomy(PD).Methods:We searched Pub Med,EMBASE,the Cochrane Library and Web of Science databases until the end of December,2014.Studies comparing outcomes of external vs.internal stent placement in PD were eligible for inclusion.Included literature was extracted and assessed by two independent reviewers.Results:Seven articles were identified for inclusion:three randomized controlled trials(RCTs)and four observational clinical studies(OCS).The meta-analyses revealed that use of external stents had advantage on reducing the incidences of pancreatic fistula(PF)in total[odds ratio(OR)=0.69;95%confidence interval(CI),0.48-0.99;P=0.04],PF in soft pancreas(OR=0.30;95%CI,0.16-0.56;P=0.0002)and delayed gastric emptying(DGE)(OR=0.58;95%CI,0.38-0.89;P=0.01)compared with internal stents.There were no significant differences in other postoperative outcomes between two stenting methods,including postoperative morbidity(OR=0.93;95%CI,0.39-2.23;P=0.88),overall mortality(OR=0.70;95%CI,0.22-2.25;P=0.55),and intra-abdominal collections(OR=0.67;95%CI,0.26-1.71;P=0.40).Conclusions:Based upon this meta-analysis,the use of external pancreatic stents might have potential benefit in reducing the incidence of PF and DGE.Due to the limited number of original studies,more RCTs are needed to further support our result and clarify the issue. | Fa-Yong Ke Xiang-Song Wu Yong Zhang Hong-Cheng Zhang Ming-Zhe Weng Ying-Bin Liu Christopher Wolfgang Wei Gong | 2015 | Chinese Journal of Cancer Research2015，27，4： | 4 |
| 13 | Coriander Genomics Database:a genomic,transcriptomic,and metabolic database for coriander显示文摘Coriander(Coriandrum sativum L.),also known as cilantro,is a globally important vegetable and spice crop.Its genome and that of carrot are models for studying the evolution of the Apiaceae family.Here,we developed the Coriander Genomics Database(CGDB,http://gffzzc8ce0bd092c048a1hxvcwcu9bvfp96cuu.ffgz.tsg.suse.edu.cn/)to collect,store,and integrate the genomic,transcriptomic,metabolic,functional annotation,and repeat sequence data of coriander and carrot to serve as a central online platform for Apiaceae and other related plants.Using these data sets in the CGDB,we intriguingly found that seven transcription factor(TF)families showed significantly greater numbers of members in the coriander genome than in the carrot genome.The highest ratio of the numbers of MADS TFs between coriander and carrot reached 3.15,followed by those for tubby protein(TUB)and heat shock factors.As a demonstration of CGDB applications,we identified 17 TUB family genes and conducted systematic comparative and evolutionary analyses.RNA-seq data deposited in the CGDB also suggest dose compensation effects of gene expression in coriander.CGDB allows bulk downloading,significance searches,genome browser analyses,and BLAST searches for comparisons between coriander and other plants regarding genomics,gene families,gene collinearity,gene expression,and the metabolome.A detailed user manual and contact information are also available to provide support to the scientific research community and address scientific questions.CGDB will be continuously updated,and new data will be integrated for comparative and functional genomic analysis in Apiaceae and other related plants. | Xiaoming Song Fulei Nie Wei Chen Xiao Ma Ke Gong Qihang Yang Jinpeng Wang Nan Li Pengchuan Sun Qiaoying Pei Tong Yu Jingjing Hu Xinyu Li Tong Wu Shuyan Feng Xiu-Qing Li Xiyin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 14 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 15 | Fast-growing procedure for perovskite films in planar heterojunction perovskite solar cells显示文摘A fast-growing procedure(FGP) to fabricate perovskite films with large grain sizes is described in this article. In the FGP method, the perovskite precursor solution is coated onto the substrates at a temperature of 240 8C. The solvent in the precursor solution evaporates quickly in about 2 s, resulting in the rapid formation of a perovskite film without further annealing process. Millimeter-scale perovskite grain clusters are obtained in the film. Based on such perovskite films, fabricated planar heterojunction perovskite solar cells give a power conversion efficiency(PCE) above 8%. | Tang-Hao Liu Ke Chen Qin Hu Jiang Wu De-Ying Luo Shuang Jia Rui Zhua Qi-Huang Gong | 2015 | Chinese Chemical Letters2015，26，12： | 4 |
| 16 | A novel splice site mutation of CRYBA3/A 1 gene associated with congenital cataract in a Chinese family显示文摘● AIM: To identify the disease-causing mutation responsible for the presence of congenital cataract in a Chinese family. ● METHODS: The study recruited a four-generation Chinese pedigree affected by autosomal dominant congenital cataract(ADCC). Family history and the history of cataract extraction were recorded. Blood samples were collected from individuals for DNA extraction. Direct sequencing of congenital cataract-associated genes was performed. Single-strand conformational polymorphism and bioinformatic analysis were conducted to further study the mutation. ● RESULTS: Direct sequencing revealed a novel splice site mutation of c.30-2 A>G in the CRYBA3/A1 gene. The mutation co-segregated within all affected individuals in the family and was not found in unaffected members or 100 unrelated normal controls. These results were further confirmed by single-strand conformational polymorphism and bioinformatic analysis using the Human Splicing Finder and Max Ent online software and Annovar computer software.● CONCLUSION: c.30-2 A>G mutation of CRYBA3/A1 gene is a novel mutation and broadens the genetic spectrum of ADCC. | Meng-Han Wu Yin-Hui Yu Qin-Long Hao Xiao-Hua Gong Ke Yao | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 3 |
| 17 | γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer显示文摘 | Pin Wu Dang Wu Chao Ni Jun Ye Wuzhen Chen Guoming Hu Zhen Wang Changrong Wang Zhigang Zhang Wenjie Xia Zhigang Chen Ke Wang Tao Zhang Jinghong Xu Yuehua Han Ting Zhang Xianguo Wu Jianwei Wang Weihua Gong Shu Zheng Fuming Qiu Jun Yan Jian Huang | 2014 | Immunity2014，，5： | 2 |
| 18 | Comprehe nsive an alysis of SSRs and database construction using all complete gene-cod ing sequences in major horticultural and represe ntative plants显示文摘Simple sequence repeats(SSRs)are one of the most important genetic markers and widely exist in most species.Here,we identified 249,822 SSRs from 3,951,919 genes in 112 plants.Then,we conducted a comprehensive analysis of these SSRs and constructed a plant SSR database(PSSRD).Interestingly,more SSRs were found in lower plants than in higher plants,showing that lower plants needed to adapt to early extreme environments.Four specific enriched functional terms in the lower plant Chlam^tdomonas reinhardtii were detected when it was compared with seven other higher plants.In addition,Guanylate_cyc existed in more genes of lower plants than of higher plants.In our PSSRD,we constructed an interactive plotting function in the chart interface,and users can easily view the detailed information of SSRs.All SSR information,including sequences,primers,and annotations,can be downloaded from our database.Moreover,we developed Web SSR Finder and Batch SSR Finder tools,which can be easily used for identifying SSRs.Our database was developed using PHP,HTML,J avaScript,and MySQL,which are freely available at http://gffzz2f37412cb23c469dhxvcwcu9bvfp96cuu.ffgz.tsg.suse.edu.cn/.We conducted an analysis of the Myb gene families and flowering genes as two applications of the PSSRD.Further analysis indicated that whole-genome duplication and whole-genome triplication played a major role in the expansion of the Myb gene families.These SSR markers in our database will greatly facilitate comparative genomics and functional genomics studies in the future. | Xiaoming Song Qihang Yang Yun Bai Ke Gong Tong Wu Tong Yu Qiaoying Pei Weike Duan Zhinan Huang Zhiyuan Wang Zhuo Liu Xi Kang Wei Zhao Xiao Ma | 2021 | Horticulture Research2021，8，1： | 2 |
| 19 | Integration of the metabolome and transcriptome reveals the metabolites and genes related to nutritional and medicinal value in Coriandrum sativum显示文摘Coriandrum sativum(Coriander) or Chinese parsley is a culinary herb with multiple medicinal effects, which is widely used in cooking and traditional medicine. It is enriched with essential oils and anti-oxidant compounds with unknown significance. To explore the untapped reservoir of Coriander, we studied the transcriptome and metabolic profiles from three developmental stages. Here, we identified 10 tyrosine metabolic pathway-related genes(TMPRGs), six porphyrins and chlorophyll metabolic pathway-related genes(PCMPRGs), and five Vitamin E metabolic pathway-related genes(VEMPRGs). These genes were associated with the early development of Coriander. Our analysis suggests that these pathways are involved in the production of critical phenolic metabolites. Furthermore, we constructed the interaction network between these pathway-related genes and transcription factors(TFs), which supported the regulatory pathways for phenolic metabolites. Interestingly, we identified several nutritional or medicinally relevant metabolites, including 59 phenols, two polyamines, 12 alkaloids, and one terpenoid. The higher concentrations of metabolites were from caffeic acid, agmatine, and its derivatives. We found higher levels of caffeic acid and agmatine at 30 days compared to 60 or 90 days. This study provides evidence to stimulate further investigation of the role of these metabolites in medicinal and nutritional research. | WU Tong FENG Shu-yan YANG Qi-hang Preetida J BHETARIYA GONG Ke CUI Chun-lin SONG Jie PING Xiao-rui PEI Qiao-ying YU Tong SONG Xiao-ming | 2021 | Journal of Integrative Agriculture2021，20，7： | 2 |
| 20 | Preparation of silybin 23-esters and evaluation of their inhibitory ability against LPO and DNA protective properties显示文摘Twelve 23-esterified silybin derivatives with different patterns of substituents such as aromatic and aliphatic groups(1-12) were designed and synthesized.The antioxidative properties of these compounds were evaluated.The modified silybin analogues exhibited improved inhibitory effects against rat liver homogenate lipid peroxidation compared to silybin,with exception of the trimethoxylated ester(5) and the aliphatic one(9).Compounds 3,5,7,8 and 11 displayed their protective properties on DNA cleavage in a dose-dependent manner. | Ke Xin Huang Jing Xu Gong Wei Xiong Lei Xiang Yang Feng Wang Qiao Feng Tao Yi Hang Wu Xiao Kun Li Joachim Stockigt Yu Zhao Jia Qu | 2009 | Chinese Chemical Letters2009，20，9： | 2 |
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