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| 1 | Effects of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper limb motor dysfunction in patients with subacute cerebral infarction显示文摘Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex(M1). The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction. | Jiang Li Xiang-min Meng Ru-yi Li Ru Zhang Zheng Zhang Yi-feng Du | 2016 | Neural Regeneration Research2016，11，10： | 31 |
| 2 | Efficacy of endoscopic treatment on patients with severe dysplasia/carcinoma in situ of esophageal squamous cell carcinoma: A prospective cohort study显示文摘Objective: To explore the natural history of severe dysplasia/carcinoma in situ(SD/CIS) patients and to evaluate the efficacy of endoscopic treatment to SD/CIS patients.Methods: Between January 2005 and December 2009, a population-based prospective screening program on esophageal squamous cell carcinoma(ESCC) was performed in Linzhou, China, with endoscopic screening plus iodine staining. All the eligible histologically confirmed SD/CIS patients were followed up through the door-todoor follow-up and local cancer registry. The endpoint was diagnosed as ESCC or the December 31 st, 2016.Kaplan-Meier survival analysis and Log-rank test were used to compare the survival rates among treated and untreated patients.Results: A total of 175 SD/CIS patients were enrolled and grouped by whether they received endoscopic treatment. Eleven-year cumulative incidence rates for untreated and treated SD/CIS patients were 10.7% [95%confidence interval(95% CI): 6.9-16.1] and 3.2%(95% CI: 1.4-7.0), respectively. The ESCC incidence free survival rate, and all-cause incidence and mortality free survival rates were all significantly higher in the treated patients vs. untreated patients(P=0.043, P=0.008 and P=0.015, respectively). The ESCC mortality free survival rate showed no significant differences between the two groups(P=0.847).Conclusions: The cumulative incidence rate of SD/CIS patients to ESCC was much lower than previously reported. The Kaplan-Meier survival analysis showed that endoscopic treatment could increase the ESCC and allcause disease-free survival rates of SD/CIS patients significantly. | Meng Wang Changqing Hao Shuanghua Xie Shanrui Ma Qing Ma Rongshou Zheng Ru Chen Xinqing Li Wenqiang Wei | 2019 | Chinese Journal of Cancer Research2019，31，2： | 4 |
| 3 | Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs显示文摘An in vitro blood-brain barrier(BBB) model is critical for enabling rapid screening of the BBB permeability of the drugs targeting on the central nervous system.Though many models have been developed, their reproducibility and renewability remain a challenge. Furthermore, drug transport data from many of the models do not correlate well with the data for in vivo BBB drug transport.Induced-pluripotent stem cell(i PSC) technology provides reproducible cell resources for in vitro BBB modeling.Here, we generated a human in vitro BBB model by differentiating the human i PSC(hi PSC) line GM25256 into brain endothelial-type cells. The model displayed BBB characteristics including tight junction proteins(ZO-1,claudin-5, and occludin) and endothelial markers(von Willebrand factor and Ulex), as well as high transendothelial electrical resistance(TEER)(1560 X.cm2±230 X.cm2) and c-GTPase activity. Co-culture with primary rat astrocytes significantly increased the TEER of the model(2970 X.cm2 to 4185 X.cm2). RNAseq analysis confirmed the expression of key BBB-related genes in the hi PSC-derived endothelial cells in comparison with primary human brain microvascular endothelial cells,including P-glycoprotein(Pgp) and breast cancer resistant protein(BCRP). Drug transport assays for nine CNS compounds showed that the permeability of non-Pgp/BCRP and Pgp/BCRP substrates across the model was strongly correlated with rodent in situ brain perfusion data for these compounds(R2= 0.982 and R2= 0.9973,respectively), demonstrating the functionality of the drug transporters in the model. Thus, this model may be used to rapidly screen CNS compounds, to predict the in vivo BBB permeability of these compounds and to study the biology of the BBB. | Yuan Li Xueying Sun Houfu Liu Liang Huang Guofeng Meng Yu Ding Wenji Su Jiaqi Lu Sophie Gong Georg C.Terstappen Ru Zhang Wandong Zhang | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 5 | Incidence of pocket hematoma after electrophysiological device placement:dual antiplatelet therapy versus low-molecular-weight heparin regimen显示文摘BackgroundGiven 要求双 antiplatelet 的病人的增加的数字(弹跳) 治疗和 electrophysiological 设备(EPD ) 放置, perioperative antiplatelet 管理是当前的挑战。在这研究,我们在经历的病人在 EPD 放置以后调查了袖珍 hematoma 形成的发生弹跳治疗或其他的 low-molecular-weight 肝磷脂(LMWH ) regimen.MethodsThis 临床的观察学习从 2010 年 7 月被执行到 2012 年 7 月。总共, 171 个病人在满足包括标准以后在分析被注册。这些病人被划分成二个组:86 个病人被对待与弹跳治疗在设备培植,和 DAP 治疗的时候被中止 5 ~ 7 天并且在另外的 85 个病人在设备培植前用 enoxaparin 代替了。腺苷磷酸盐(自动数据处理) 调停了血小板聚集和 arachidonic 导致酸的血小板聚集外科手术前地被测试。我们把在二个组和袖珍 hematoma 开发的协会之间的袖珍 hematoma 的发生与调停自动数据处理的血小板聚集和 arachidonic 作比较在继续的病人的袖珍 hematoma 的导致酸的血小板 aggregation.ResultsThe 发生弹跳在用 LMWH 代替了双 antiplatelet 政体的病人是比那低的(3.49%对16.47%分别地;X 2= 6.66, P <0.01 ) 。在继续的病人之中弹跳治疗,没有袖珍 hematomas,在有袖珍 hematomas 的病人的调停自动数据处理的血小板聚集抑制的率在病人比那高。没有经历的病人弹跳或 enoxaparin 治疗得了袖珍感染, thromboembolic 事件,或另外的严肃的复杂并发症。多重逻辑回归分析表明那 LMWH 治疗是为袖珍 hematoma 的发展的一个独立风险因素(RR = 0.054, 95%CI = 0.012-0.251 ) 。而且,经历 LMWH 治疗的病人比是弹跳对待 individuals.ConclusionContinuance 的多半更是 5.1 褶层开发袖珍 hematomas 弹跳治疗不在 EPD 以后增加袖珍 hematoma 形成的风险放置。 | Yan CHEN Yun-Tao LI Ming-Dong GAO Ze-Chun ZENG Jin-Rong ZHANG Hong-Liang CONG Yin LIU Ru ZHAO Le-Feng WANG Xin-Cun YANG Kang MENG | 2014 | Journal of Geriatric Cardiology2014，11，3： | 3 |
| 6 | Detecting Photographic Cropping Based on Vanishing Points显示文摘 | MENG Xianzhe NIU Shaozhang YAN Ru LI Yezhou | 2013 | Chinese Journal of Electronics2013，22，2： | 2 |
| 7 | An Encapsulation of the Rare Earth Complex in Modified Mesoporous Molecular Sieve MCM-41显示文摘The encapsulation of a rare earth (RE) complex Eu(DBM)3phen in modified Si- MCM41 with 3 -aminopropyltriethoxy st.lane is reported for the first time. The luminescence intensity of the RE complex in the modified Si-MCM-41 is about 9 times as strong as in unmodified Si- MCM41 and the luminescence of the RE complex in the modified Si-MCM-41 has good color purity. | Qing Hong XU Lian She FU Lian Sheng LI Hong Jie ZHANG Qing Quo MENG Ru Ren XU Key Laboratory of Inorganic Synthesis & Preparative Chemistry, Department of Chemistry, Jilin University, Changchun 130023 Key Laboratory of Rare Earth Chemistry & Physic | 2000 | Chinese Chemical Letters2000，11，9： | 1 |
| 8 | Vapor phase epitaxy of PbS single-crystal films on water-soluble substrates and application to photodetectors显示文摘Lead sulfide(PbS),a typical functional semiconductor material,has attracted serious attention due to its great potential in optoelectronics applications.However,controllable growth of PbS single-crystal film still remains a great challenge.Here,we report heteroepitaxial growth of large-scale highly crystalline PbS films on alkali salt(NaCl and KCl)substrates via chemical vapor deposition(CVD).Structural characterizations demonstrate that the as-grown PbS films exhibit an atomically sharp interface with the underlying substrates.The epitaxial relationships between the epilayers and substrates were determined to be PbS(100)//NaCl(100)or KCl(100),PbS[010]//NaCl[010]or KCl[010].Owing to the high solubility of alkali salt,the epitaxial PbS films can be rapidly released from the underlying substrates and transferred to other substrates of interest while maintaining good integrity and crystallinity,the process of which is particularly attractive in the fields of electronics and optoelectronics.Furthermore,photodetectors based on the transferred PbS films were fabricated,exhibiting a high photoresponsivity of 7.5 A/W,a detectivity of 1.44×10^(12)Jones,and a rapid response time of approximately 0.25 s.This work sheds light on the batch production,green transfer,and optoelectronic application of PbS films. | Yifan Wang Jing Xia Xuanze Li Fan Ru Xue Chen Ze Hua Ruiwen Shao Xuecong Wang Wenjun Zhang Chun-Sing Lee Xiangmin Meng | 2022 | Nano Research2022，15，6： | 1 |
| 9 | Correlation between Li+ adsorption capacity and the preparation conditions of spinel lithium manganese precursor显示文摘 | WANG Lu MA Wei LIU Ru LI Hai-yan MENG Chang-gong | 2006 | Solid State Ionics2006，177，17： | 1 |
| 10 | Computation offloading and resource allocation for UAV-assisted IoT based on blockchain and mobile edge computing显示文摘Recently,Internet of Things(IoT)have been applied widely and improved the quality of the daily life.However,the lightweight IoT devices can hardly implement complicated applications since they usually have limited computing resource and just can execute some simple computation tasks.Moreover,data transmission and interaction in IoT is another crucial issue when the IoT devices are deployed at remote areas without manual operation.Mobile edge computing(MEC)and unmanned aerial vehicle(UAV)provide significant solutions to these problems.In addition,in order to ensure the security and privacy of data,blockchain has been attracted great attention from both academia and industry.Therefore,an UAV-assisted IoT system integrated with MEC and blockchain is pro-posed.The optimization problem in the proposed architecture is formulated to achieve the optimal trade-off between energy consumption and computation latency through jointly considering computa-tion offloading decision,spectrum resource allocation and computing resource allocation.Consider-ing this complicated optimization problem,the non-convex mixed integer problem can be transformed into a convex problem,and a distributed algorithm based on alternating direction multiplier method(ADMM)is proposed.Simulation results demonstrate the validity of this scheme. | 赵铖泽 LI Meng SUN Enchang HUO Ru LI Yu ZHANG Yanhua | 2022 | High Technology Letters2022，28，1： | 1 |
| 11 | Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway显示文摘Mounting evidence demonstrates that hydrogen sulfide(H2S)promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells(ECs).This study aims to investigate the favorable action of H2S on endothelial function in senescence by inhibiting the production of inflammatory molecules.Senescent ECs exhibit a reduction in H2S,endothelial nitric oxide synthase(eNOS)and peroxisome proliferator-activated receptorδ(PPARδ),coupled with increased inflammatory molecules,sodium glucose transporter type 2(SGLT2)and phosphorylation of STAT3,which could be reversed by the administration of a slow but sustained release agent of H2S,GYY4137.Decreased production of eNOS and upregulated p-STAT3 and SGLT2 levels in senescent ECs are reversed by replenishment of the SGLT2 inhibitor EMPA and the PPARδagonist GW501516.The PPARδantagonist GSK0660 attenuates eNOS expression and increases the production of p-STAT3 and SGLT2.However,supplementation with GYY4137 has no beneficial effect on GSK0660-treated ECs.GYY4137,GW501516 and EMPA preserve endothelialdependent relaxation(EDR)in D-gal-treated aortae,while GSK0660 destroys aortic relaxation even with GYY4137 supplementation.In summary,senescent ECs manifest aggravated the expressions of the inflammatory molecules SGLT2 and p-STAT3 and decreased the productions of PPARδ,eNOS and CSE.H2S ameliorates endothelial dysfunction through the anti-inflammatory effect of the PPARδ/SGLT2/p-STAT3 signaling pathway in senescent ECs and may be a potential therapeutic target for anti-ageing treatment. | Danyang Tian Jinqi Meng Lin Li Hongmei Xue Qi Geng Yuxin Miao Meng Xu Ru Wang Xiangjian Zhang Yuming Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 1 |
| 12 | The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes显示文摘 | Guijing Liu Shoubao Ma Shaoke Li Ru Cheng Fenghua Meng Haiyan Liu Zhiyuan Zhong | 2010 | Biomaterials2010，，29： | 1 |
| 13 | Ge surface passivation by GeO_2 fabricated by N_2O plasma oxidation显示文摘In this paper, Ge surface passivation by Ge O2 grown by N2 O plasma oxidation is presented and experimentally demonstrated. Results show that stoichiometrically Ge O2 can be achieved by N2 O plasma oxidation at 350°C. The transmission electron microscope observation reveals that the Ge O2/Ge interface is automatically smooth and the thickness of Ge O2is~0.9 nm with 120 s N2 O plasma oxidation. The interface state density of Ge surface after N2 O plasma passivation is about~3×1011 cm-2e V-1. With Ge O2 passivation,the hysteresis of MOS capacitor with Al2O3 as gate dielectric is reduced to~55 m V, compared to 130 m V of the untreated one. The Fermi-level at Ge O2/Ge interface is unpinned, and the surface potential is effectively modulated by the gate voltage, which is promising for high performance NMOSFETs fabrication. | LIN Meng AN Xia LI Ming YUN QuanXin LI Min LI Zhi Qiang LIU PengQiang ZHANG Xing HUANG Ru | 2015 | Science China(Information Sciences)2015，58，4： | 1 |
| 14 | Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB显示文摘Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B. | YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling CAO Wei Hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui | 2024 | Biomedical and Environmental Sciences2024，37，3： | 0 |
| 15 | Oyster Protein Hydrolysate Alleviates Cadmium Toxicity by Restoring Cadmium-Induced Intestinal Damage and Gut Microbiota Dysbiosis in Mice via Its Abundance of Methionine,Tyrosine,and Glutamine显示文摘As a typical heavy metal contaminant in food,cadmium(Cd)easily enters the human food chain via crop production,and therefore,threatens human health[1].Intestinal absorption is the principal route for Cd entry into the body,and therefore,intestinal tissue become the primary target for Cd toxicity[2].Previous studies showed that acute Cd exposure damaged intestinal tight junctions,resulting in gut barrier destruction and alterations in gut microbiota[3].Thus,the effective prevention of Cd-induced intestinal damage has become a major research challenge. | WANG Jing Wen FANG Zhi Jia LI Yong Bin HUANG Lin Ru SUN Li Jun LIU Ying WANG Ya Ling LIAO Jian Meng | 2022 | Biomedical and Environmental Sciences2022，35，7： | 0 |
| 16 | Folic Acid Supplementation in Chinese Periconceptional Population:Results from the SPCC Study显示文摘Objective To determine the prevalence and determinants of folic acid(FA)supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.Methods This was a cross-sectional study based on the Shanghai PreConception Cohort(SPCC)study.Data on FA supplementation and socio-demographic features were collected using questionnaires.Couples visiting clinics for pre-pregnancy examination and pregnant women at<14 gestational weeks were recruited in Shanghai,China,between March 2016 and September 2018.Results Among the pregnancy planners,42.4%(4,710/11,099)women and 17.1%(1,377/8,045)men used FA supplements,while 93.4%(14,585/15,615)of the pregnant women used FA supplements.FA supplement use was higher in female pregnancy planners who were older(RR:1.13,95%CI:1.08–1.18),had higher education(RR:1.71,95%CI:1.53–1.92),and were residing in urban districts(RR:1.06,95%CI:1.01–1.11)of FA supplementation;female pregnancy planners with alcohol consumption(RR:0.95,95%CI:0.90–0.99)had lower odds of FA supplementation.In early pregnancy,women with higher educational level(RR:1.04,95%CI:1.03–1.06),who underwent pre-pregnancy examination(RR:1.02,95%CI:1.01–1.03)had higher odds of using an FA supplement;older aged(RR:0.99,95%CI:0.98–0.99),and multigravida(RR:0.97,95%CI:0.96–0.98)had lower odds of FA supplementation.Conclusion Although the majority of pregnant women took FA supplements,more than half of the women planning for pregnancy did not.Urgent strategies are needed to improve pre-conception FA supplementation. | WANG Ding Mei ZHANG Yi JIANG Yuan YE Ying HUANG Xiang Yuan LI Meng Ru JI Mi ZHAO Zheng Shan CHEN Xiao Tian SHENG Wei MA Xiao Jing ALLEN Stephen WANG Duo Lao YAN Wei Li HUANG Guo Ying 无 | 2020 | Biomedical and Environmental Sciences2020，33，8： | 0 |
| 17 | The Association between LINC00511 Variants and Breast Cancer Susceptibility among the Han Chinese Population显示文摘Objective LINC00511 has been considered an oncogene for breast cancer,however,the association between LINC00511 Single nucleotide polymorphisms(SNPs)and breast cancer risk remains unclear.Methods A total of 504 breast cancer patients and 505 cancer-free controls were genotyped for 12 LINC00511 SNPs.A logistic regression analysis was conducted to explore the association between LINC00511 SNPs and breast cancer susceptibility,adjusting for reproductive factors.A haplotype analysis and interaction analysis were applied to assess the role of LINC00511 in breast cancer.Results LINC00511 SNPs were significantly correlated with breast cancer.The TT genotype of rs11657109 reduced the risk of breast cancer(OR:0.454,95%CI:0.212-0.970),while the AG and GG genotypes of rs17780195 played a protective role(OR:0.723,95%CI:0.539-0.970;OR:0.398,95%CI:0.184-0.860,respectively).The mutation of rs9906859 may also lead to a reduction in breast cancer susceptibility(OR:0.682,95%CI:0.520-0.894).Furthermore,LINC00511 SNPs(rs4432291,rs1558535,rs17780195 and rs9906859)are associated with the HER-2 status(P<0.05 for all).The interaction of rs9906859,breastfeeding and age increased the breast cancer risk by 4.318(OR:5.318,95%CI:2.214-12.774).Conclusions LINC00511 SNPs were associated with the risk of breast cancer.There was an association between LINC00511 SNPs and the HER-2 status.There were interactions between LINC00511 SNPs and reproductive factors that affected the risk of breast cancer. | Fei Fei Chong Jing Jing Cao Yan Li Wang Qiu Yu Sun Meng Meng Song Xiao Ru Jiang Kai Juan Wang Lin Ping Xu Chun Hua Song | 2020 | Journal of Nutritional Oncology2020，5，2： | 0 |
| 18 | Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf显示文摘Kenaf is considered to have great potential for remediation of heavy metals in ecosystems.However,studies on molecular mechanisms of root Cd accumulation and tolerance are still inadequate.In this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd stress.This study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid peroxidation.Compared with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding sites.There were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two cultivars.Phenylpropanoid biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation analysis.DEGs associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in soil.These genes might have played key roles in kenaf Cd tolerance and Cd accumulation.Moreover,HcZIP2 was identified to be involved in Cd uptake and transport in kenaf.Our findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf. | Shan Cao Meng Wang Jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang Jiao Yue Xia Wu Qijing Wu Hui Zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 19 | Application of Ginkgo biloba L. Extract at the Early Stage of Tumor Development Helps Cyclophosphamide Inhibit the Growth of Tumor Cells显示文摘Globally,breast cancer is the second major cause of cancer death among women[1].Cyclophosphamide(CTX)is a common chemotherapeutic agent for patients with breast cancer who have undergone surgery.CTX metabolites act by disrupting deoxyribonucleic acid and by arresting the cell cycle of tumor cells,which results in their apoptosis or growth inhibition[2].However,CTX triggers the production of excessive amounts of reactive oxygen species(ROS),which produces various side effects in different organs or systems[3].In the initial stage of cancer development,ROS may promote the expansion of cancerous cells by modifying apoptosis-related genes[4].Furthermore,ROS will activate the NF-κB pathway and NF-κB-dependent genes that are involved in apoptosis and cell adhesion,which are implicated in multiple aspects of cancer development[5].ROS,as a survival or apoptotic signal to cancer cells,is determined by the dosage,duration,type,and site of ROS production[6]. | YANG Jing Hui MENG Fan Zhu BESELER Cheryl L LI Hao LIU Xiao Mei GUO Yin Pei QIN Li Li ZUO Ru Yue REN Shu Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 0 |
| 20 | Research progress on low-power artificial intelligence of things(AIoT)chip design显示文摘An artificial intelligence of things(AIoT)chip is a critical hardware component in edge devices that supports data acquisition and processing in the artificial intelligence(AI)era.In this paper,we introduce the architecture and circuit techniques for AIoT systems as well as the design challenges associated with them.To address the design challenges,we describe our design approaches to improve energy efficiency from the standpoints of system architecture,AI computing,and data acquisition circuits.Meanwhile,we present our most recent research progress and state-of-the-art AIoT chip demonstrations at a prestigious conference.Our design techniques improve power and energy efficiency by orders of magnitude on corresponding state of the arts(SOTA),allowing for an advanced AIoT chip design. | Le YE Zhixuan WANG Tianyu JIA Yufei MA Linxiao SHEN Yihan ZHANG Heyi LI Peiyu CHEN Meng WU Ying LIU Yiqi JING Hao ZHANG Ru HUANG | 2023 | Science China(Information Sciences)2023，66，10： | 0 |
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