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| 1 | Relative Contributions of Boundary-Layer Meteorological Factors to the Explosive Growth of PM2.5 during the Red-Alert Heavy Pollution Episodes in Beijing in December 2016显示文摘Based on observations of urban mass concentration of fine particulate matter smaller than 2.5 μm in diameter(PM_(2.5)), ground meteorological data, vertical measurements of winds, temperature, and relative humidity(RH), and ECMWF reanalysis data, the major changes in the vertical structures of meteorological factors in the boundary layer(BL) during the heavy aerosol pollution episodes(HPEs) that occurred in winter 2016 in the urban Beijing area were analyzed. The HPEs are divided into two stages: the transport of pollutants under prevailing southerly winds, known as the transport stage(TS), and the PM_(2.5) explosive growth and pollution accumulation period characterized by a temperature inversion with low winds and high RH in the lower BL, known as the cumulative stage(CS). During the TS, a surface high lies south of Beijing, and pollutants are transported northwards. During the CS, a stable BL forms and is characterized by weak winds, temperature inversion, and moisture accumulation. Stable atmospheric stratification featured with light/calm winds and accumulated moisture(RH > 80%) below 250 m at the beginning of the CS is closely associated with the inversion, which is strengthened by the considerable decrease in near-surface air temperature due to the interaction between aerosols and radiation after the aerosol pollution occurs. A significant increase in the PLAM(Parameter Linking Aerosol Pollution and Meteorological Elements) index is found, which is linearly related to PM mass change. During the first 10 h of the CS, the more stable BL contributes approximately 84% of the explosive growth of PM_(2.5) mass. Additional accumulated near-surface moisture caused by the ground temperature decrease, weak turbulent diffusion, low BL height, and inhibited vertical mixing of water vapor is conducive to the secondary aerosol formation through chemical reactions, including liquid phase and heterogeneous reactions, which further increases the PM_(2.5) concentration levels. The contribution of these reaction mechanisms to the explosive growth of PM_(2.5) mass during the early CS and subsequent pollution accumulation requires further investigation. | junting zhong xiaoye zhang yaqiang wang junying sun yangmei zhang jizhi wang kaiyan tan xiaojing shen haochi che lu zhang zhouxiang zhang xuefei qi huarong zhao sanxue ren yang li | 2017 | Journal of Meteorological Research2017，31，5： | 25 |
| 2 | Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission显示文摘 | Xiaohong Shi Xuefei Wang Xixi Xu Yongliang Feng Shuzhen Li Shuying Feng Bo Wang Suping Wang | 2017 | Frontiers of Medicine2017，11，4： | 11 |
| 3 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 4 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 5 | Exploiting Geo-Social Correlations to Improve Pairwise Ranking for Point-of-Interest Recommendation显示文摘Recently, as location-based social network(LBSN) rapidly grow, point-of-interest(POI) recommendation has become an important way to help people locate interesting places. Nowadays, there have been deep studies conducted on the geographical and social influence in the point-of-interest recommendation model based on the rating prediction. The fact is, however, relying solely on the rating fails to reflect the user's preferences very accurately, because the users are most concerned with the list of ranked point-of-interests(POIs) on the actual output of recommender systems. In this paper, we propose a co-pairwise ranking model called Geo-Social Bayesian Personalized Ranking model(GSBPR), which is based on the pairwise ranking with the exploiting geo-social correlations by incorporating the method of ranking learning into the process of POI recommendation. In this model, we develop a novel BPR pairwise ranking assumption by injecting users' geo-social preference. Based on this assumption, the POI recommendation model is reformulated by a three-level joint pairwise ranking model. And the experimental results based on real datasets show that the proposed method in this paper enjoys better recommendation performance compared to other state-of-the-art POI recommendation models. | Rong Gao Jing Li Bo Du Xuefei Li Jun Chang Chengfang Song Donghua Liu | 2018 | China Communications2018，15，7： | 9 |
| 6 | Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells显示文摘砷三氧化物(ATO ) 能在肿瘤房间作为反肿瘤药导致区别和 apoptosis。间充质的干细胞(MSC ) 在骨头髓的造血作用起重要作用。许多报告证明了 MSC adipogenic 和 osteogenic 区别的混乱发生在一些疾病。然而,关于 MSC 上的 ATO 的效果的报告是有限的。在这研究,我们发现 1 M ATO 主要通过 p21 支持了 MSC 老朽,尽管它没在这剂量在 apoptosis 上有效果。而且, ATO 支持了 adipogenic 区别,但是在 MSC 禁止了 osteogenic 区别。我们的学习也显示出那 CCAAT/enhancer-binding 蛋白质 alpha C/EBP 和 peroxisome 激活 proliferator 的受体 gamma PPAR 可能涉及 ATO 导致的 adipogenic 和 osteogenic 区别的规定。我们的结果显示 ATO 可以由影响骨头髓微型环境施加反肿瘤效果。而且,它可以调整 MSC 的 adipogenic 和 osteogenic 区别。 | Huanchen Cheng Lin Qiu Hao Zhang Mei Cheng Wei Li Xuefei Zhao Keyu Liu Lei Lei Jun Ma | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 8 |
| 7 | Impact of tree diversity and environmental conditions on the survival of shrub species in a forest biodiversity experiment in subtropical China显示文摘Aims Although shrubs are an important component of forests,their role has not yet been considered in forest biodiversity experiments.In the biodiversity-ecosystem functioning(BEF)experiment with subtropical tree species in south-east China(BEF-China),we factorially combined tree with shrub species-diversity treatments.Here,we tested the hypotheses that shrub survival differs between the 10 planted shrub species,with lower survival rates of late-than early-successional species and is affected by environmental conditions,such as topography and top soil characteristics,as well as by biotic factors,represented by tree,shrub and herb layer characteristics.Methods We analyzed the survival of 42000 shrub individuals in 105 plots varying in tree and shrub species richness of the BEF-China project four years after planting.Shrub survival was analyzed with generalized linear mixed effects models at the level of individuals and with variance partitioning at the plot level.Random intercept and random slope models of different explanatory variables were compared with respect to the Bayesian Information Criterion(BIC).Important Findings Survival rates differed largely between the 10 shrub species,ranging from 26%to 91%for Ardisia crenata and Distylium buxifolium,respectively.Irrespective of species identity,single abiotic factors explained up to 5%of species survival,with a negative effect of altitude and slope inclination and a positive effect of the topsoil carbon to nitrogen ratio,which pointed to drought as the major cause of shrub mortality.In contrast,neither tree nor shrub richness affected shrub survival at this early stage of the experiment.Among the biotic predictors,only herb layer species richness and cover of the dominant fern species(Dicranopteris pedata)affected shrub survival.Overall,our models that included all variables could explain about 65%in shrub survival,with environmental variables being most influential,followed by shrub species identity,while tree species diversity(species richness and identity)and herb layer characteristics contributed much less.Thus,in this early stage of the experiment the biotic interactions among shrubs and between shrubs and trees have not yet overruled the impact of abiotic environmental factors. | Bo Yang Ying Li Bingyang Ding Sabine Both Alexandra Erfmeier Werner Härdtle Keping Ma Bernhard Schmid Thomas Scholten Gunnar Seidler Goddert von Oheimb Xuefei Yang Helge Bruelheide | 2017 | Journal of Plant Ecology2017，10，1： | 7 |
| 8 | Uncommon EGFR mutations in a cohort of Chinese NSCLC patients and outcomes of first-line EGFR-TKIs and platinum-based chemotherapy显示文摘Objective: Data on the clinical activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in patients with non-small-cell lung cancer(NSCLC) and uncommon EGFR mutations remain insufficient.This study aimed to investigate the effect of first-line EGFR-TKIs or platinum-based chemotherapy in NSCLC patients with uncommon EGFR mutations.Methods: We retrospectively enrolled 504 patients with EGFR-mutant NSCLC.The clinical characteristics and treatment outcomes were collected and compared between patients with common and uncommon EGFR-mutant NSCLC.Results: Seventy patients(13.9%) harboring uncommon EGFR mutations were included.Thirty of these patients received EGFR-TKIs and 40 received platinum-based chemotherapy as first-line therapy.The objective response rate(ORR) and median progression-free survival(m PFS) of patients treated with TKIs in the uncommon mutation group was significantly inferior to that in the common mutation group(ORR: 23.3% vs.51.8%,P=0.003; m PFS:7.1 vs.10.9 months,P<0.001).In the uncommon group,m PFS was similar between first-line EGFR-TKIs treatment and platinum-based chemotherapy(7.1 vs.6.1 months,P=0.893).In patients with EGFR G719 X or L861 Q mutations,the m PFS was longer in the first-line EGFR-TKIs treatment group than in the chemotherapy group,but the difference was not statistically significant(G719 X: 8.2 vs.5.8 months,P=0.061; L861 Q: 7.6 vs.4.1 months,P=0.872).Multivariate analyses identified adenocarcinoma(P=0.003) as the independent predictive factor for PFS in patients with uncommon EGFR mutations who were treated with first-line EGFR-TKIs.Conclusions: The current study demonstrated that the effect of first-line EGFR-TKIs was similar to that of platinum-based chemotherapy in patients with uncommon EGFR-mutant NSCLC.Adenocarcinoma was the independent predictive factor for PFS in uncommon EGFR-mutant NSCLC patients treated with first-line EGFRTKIs. | Jinpeng Shi Hui Yang Tao Jiang Xuefei Li Chao Zhao Limin Zhang Sha Zhao Xiaozhen Liu Yijun Jia Yan Wang Lei Xi Shijia Zhang Chunxia Su Shengxiang Ren Caicun Zhou | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 9 | Hydrolyzed seawater pearl tablet modulates the immunity via attenuating Th1/Th2 imbalance in an immunosuppressed mouse model显示文摘OBJECTIVE: To investigate whether Hydrolyzed Seawater Pearl tablet(HSPT) could modulate the Th1/Th2 imbalance in an immunosuppressed mouse model with Th1 to Th2 shift induced by Cyclosporine A(Cs A) which can be used in the clinical treatment of Th2 to Th1 shift diseases, and explore the possible mechanism for the adjuvant therapeutic efficacy of HSPT on recurrent respiratory infections(RRI) and acquired immune deficiency syndrome(AIDS).METHODS: The mice were randomly divided into six groups of five animals each, namely normal group, model group, lentinan polysaccharide tablet(LPT) group and three HPST treated groups. HPST treated groups were administered with HPST(0.51,1.02, 2.04 g/kg) via intragastric gavage(i.g) for 30 consecutive days. LPT used as reference drug for positive control, LPT group was administered with LPT(8.2 mg/kg) for 30 consecutive days. Normal group and model group were received distilled water. The animals in model group, LPT group and HPST treated groups were injected intraperitoneally with Cs A(50 mg/kg) to establish the immunosuppressed mice model with Th1 to Th2 shift on the20 th, 22 nd and 24 th day, one hour after the administration of the respective treatment. Animals were sacrificed one hour after the last administration to collect blood and splenic tissue. The proportion of T cells including CD8+ and CD4+ T cells, Th1 and Th2 in peripheral blood of experimental mice were measured by flow cytometric. The protein level in serum and m RNA level in splenic tissue of experimental mice for interleukin(IL)-2, IL-12, interferon-γ(IFN-γ), IL-4, IL-6, IL-10 and IL-13 were measured by enzyme linked immunosorbent assay and fluorescence quantitative polymerase chain reaction respectively.RESULTS: HSPT elevated the proportion of T cells including both CD8+ and CD4+ T cells, in which the proportion of Th1 and Th2 cells increased, while the ratio of Th1/Th2 cells decreased in peripheral blood of the immunosuppressed mouse model with Th1 to Th2 shift induced by Cs A. Furthermore,HSPT elevated both protein and m RNA level of Th1-type cytokines IL-2 and IFN-γ, while had no significant effect on protein and m RNA level of Th1-type cytokine IL-12 and Th2-type cytokines IL-4, IL-6, IL-10, IL-13 in mouse model.CONCLUSION: Our findings suggest that HSPT can increase proportion of T cells including both CD8+and CD4+T cells and induce Th2 to Th1 shift in both cells and cytokines, which probably was the mechanism to account for the adjuvant therapeutic efficacy of HSPT on RRI and AIDS. | LAN Taijin LUO Xuefei MO Mingyue CHEN Zhenxing LUO Fei HAN Siyin LIU Peng LIANG Zhongxiu ZHANG Ting LI Tianyi YAN Qiangqiang LIN Yong LIN Jiang | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 6 |
| 10 | Strengthening and ductilization of laminate dual-phase steels with high martensite content显示文摘The steels with excellent strength and ductility are expected to be achieved by tailoring the microstructural features.In this work,laminate dual-phase(DP)steels with high martensite content(laminate HMDP steels)were produced by a combination of warm rolling and intercritical annealing.Influence of rolling strain and annealing temperature on the microstructural evolution and mechanical properties of laminate HMDP steels were systematically studied.The strength of HMDP steels was significantly improved to~1.6 GPa associated with a high uniform elongation of 7%,as long as the laminate structure is maintained.The strengthening and ductilizing mechanisms of laminate HMDP steels are discussed based on the influence of laminate structure and the high martensite content,which promote the development of internal stresses and can be correlated to the Bauschinger effect as measured by the cyclic loadingunloading-reloading experiments.Detailed transmission electron microscopy(TEM)observation was applied to characterize the dislocation structure in the deformed ferrite. | Bo Gao Rong Hu Zhiyi Pan Xuefei Chen Yi Liu Lirong Xiao Yang Cao Yusheng Li Qingquan Lai Hao Zhou | 2021 | Journal of Materials Science & Technology2021，，6： | 4 |
| 11 | Propane dehydrogenation catalyzed by in-situ partially reduced zinc cations confined in zeolites显示文摘Propane dehydrogenation(PDH), employing Pt-or Cr-based catalysts, represents an emerging industrial route for propylene production. Due to the scarcity of platinum and the toxicity of chromium, alternative PDH catalysts are being pursued. Herein, we report the construction of Zn-containing zeolite catalysts,namely Zn@S-1, for PDH reaction. Well-isolated zinc cations are successfully trapped and stabilized by the Si-OH groups in S-1 zeolites via in-situ hydrothermal synthesis. The as-prepared Zn@S-1 catalysts exhibit good dehydrogenation activity, high propylene selectivity, and regeneration capability in PDH reaction under employed conditions. The in-situ partial reduction of zinc species is observed and the partially reduced zinc cations are definitely identified as the active sites for PDH reaction. | Linjun Xie Rui Wang Yuchao Chai Xuefei Weng Naijia Guan Landong Li | 2021 | Journal of Energy Chemistry2021，30，12： | 4 |
| 12 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 13 | Development of DArT markers for a linkage map of flue-cured tobacco显示文摘Tobacco(Nicotiana tabacum) is one of the most economically important nonfood crops,and flue-cured tobacco accounts for approximately 80% of world tobacco production.An extremely narrow genetic diversity in the tobacco pool has led to a low efficiency of PCR-based molecular markers(such as AFLP and SSR).Diversity Arrays Technology(DArT) is a high-throughput hybridisation-based marker system that has been developed in many plants including wheat,which,like tobacco,has a complex genome.In this study,we developed a tobacco DArT chip that included 7680 representative sequence tags based on typical tobacco accessions.The 1076 DArT markers of flue-cured tobacco were identified and most(82.1%) of their polymorphism information contents(PICs) were greater than 0.4.An integrated linkage map that included 851 markers(238 DArT and 613 SSR),which is the highest density map of flue-cured tobacco to date,was constructed.This chip-based DArT system provides an alternative in high-throughput marker genotyping for tobacco. | LU XiuPing GUI YiJie XIAO BingGuang LI YongPing TONG ZhiJun LIU Yun BAI XueFei WU WeiRen XIA Ling HUTTNER Eric KILIAN Adrzej FAN LongJiang | 2013 | Chinese Science Bulletin2013，58，6： | 4 |
| 14 | Modulation Recognition in Maritime Multipath Channels:A Blind Equalization-Aided Deep Learning Approach显示文摘Modulation recognition has been long investigated in the literature,however,the performance could be severely degraded in multipath fading channels especially for high-order Quadrature Amplitude Modulation(QAM)signals.This could be a critical problem in the broadband maritime wireless communications,where various propagation paths with large differences in the time of arrival are very likely to exist.Specifically,multiple paths may stem from the direct path,the reflection paths from the rough sea surface,and the refraction paths from the atmospheric duct,respectively.To address this issue,we propose a novel blind equalization-aided deep learning(DL)approach to recognize QAM signals in the presence of multipath propagation.The proposed approach consists of two modules:A blind equalization module and a subsequent DL network which employs the structure of ResNet.With predefined searching step-sizes for the blind equalization algorithm,which are designed according to the set of modulation formats of interest,the DL network is trained and tested over various multipath channel parameter settings.It is shown that as compared to the conventional DL approaches without equalization,the proposed method can achieve an improvement in the recognition accuracy up to 30%in severe multipath scenarios,especially in the high SNR regime.Moreover,it efficiently reduces the number of training data that is required. | Xuefei Ji Jue Wang Ye Li Qiang Sun Chen Xu | 2020 | China Communications2020，17，3： | 4 |
| 15 | Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers显示文摘Alternative splicing is a tightly regulated process that contributes to cancer development.CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several cancers.However,whether deregulated expression of CRNDE is common and which isoforms are mainly involved in cancers remain unclear.In this study,we report that CRNDE is aberrantly expressed in the majority of solid and hematopoietic malignancies.The investigation of CRNDE expression in normal samples revealed that CRNDE was expressed in a tissue- and cell-specific manner.Further comparison of CRNDE expression in 2938 patient samples from 15 solid and hematopoietic tumors showed that CRNDE was significantly overexpressed in 11 malignancies,including 3 reported and 8 unreported,and also implicated that the overexpressed isoforms differed in various cancer types.Furthermore,anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and primary samples,and even had different impacts on the expression of CRNDE isoforms.Finally,experimental profiles of 12 alternatively spliced isoforms demonstrated that the spliced variant CRNDE-g was the most highly expressed isoform in multiple cancer types.Collectively,our results emphasize the cancer-associated feature of CRNDE and its spliced isoforms,and may provide promising targets for cancer diagnosis and therapy. | Xuefei Ma Wei Zhang Rong Zhang Jingming Li Shufen Li Yunlin Ma Wen Jin Kankan Wang | 2019 | Frontiers of Medicine2019，13，3： | 3 |
| 16 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 17 | Inhibiting effect of tungstic compounds on glucose hydrogenation over Ru/C catalyst显示文摘The effect of acid component including various conventional acids and tungstic compounds on glucose hydrogenation over a series of binary catalyst system containing Ru/C catalyst was investigated. The results showed that HCl, H2SO4, H3BO3, H3PO4, and HNO3 had negligible effect, while all the tungstic compounds imposed inhibiting effects on the hydrogenation of glucose over Ru/C catalyst, and the suppressing effect followed the order of H2WO4>HPW>WO3>AMT>HSi W. This order is the same as the order of ethylene glycol(EG) yields in the one-pot conversion of glucose to EG, suggesting the important role of competition between glucose hydrogenation and retro-aldol condensation in controlling the selectivity of EG. | Junying Zhang Baolin Hou Xuefei Wang Zhenlei Li Aiqin Wang Tao Zhang | 2015 | Journal of Energy Chemistry2015，24，1： | 3 |
| 18 | Attitudes toward forest diversity and forest ecosystem services—a cross-cultural comparison between China and Switzerland显示文摘Aims Despite the current interest in services provided by ecosystems and the role of biodiversity,the relationship among human attitudes,biodiversity and ecosystem services has hardly been investigated.Moreover,few studies have examined attitudes toward nature in cross-cultural comparisons.This study investigates the attitudes of Chinese and Swiss people,both environmental experts and laypersons,toward forest biodiversity and ecosystem services.Methods Overall,640 people in China and Switzerland were interviewed with the help of a standardized questionnaire.In each country,the study population was equally divided into an urban(80 city dwellers and 80 environmental science students)and a rural(80 forest visitors and 80 farmers)study group.The 15-minute interviews took place in the cities of Beijing and Zurich and in the rural forested areas of Dujiangyan,Sichuan Province and Lake Sempach,canton Lucerne.Attitudes toward forest biodiversity were investigated with the help of color photographs that depicted both monocultures and speciesrich forests typical for China and Switzerland.Attitudes toward ecosystem services were investigated with the help of 13 statements on provisioning,regulating,cultural and supporting services of forests.Important Findings On average,Chinese participants showed no strong preferences for biodiversity,whereas the Swiss clearly preferred species-rich forests over monocultures.However,Chinese environmental science students did prefer species-rich forests and attributed to them a higher conservation value because of their higher biodiversity.Although there were no strong preferences for Chinese versus Swiss forests,all participants correctly answered that Chinese forests are more species rich in terms of plants and animals and thus found them less boring and more interesting,but also less managed,than Swiss forests.All participants highly valued the ecosystem services provided by forests;especially the regulating and supporting ones.Environmental science students and farmers placed more importance on the provisioning services,whereas city dwellers and forest visitors emphasized more on the regulating services.The disjuncture between the high ecological quality of species-rich forests and their low attractiveness to Chinese study participants points to a potential conflict between conservation policies and the public’s preferences.A better communication of ecosystem services provided by forest biodiversity to the public might change these preferences in favor of ecological quality,as already observed among Chinese environmental science students. | Petra Lindemann-Matthies Dominique Keller Xuefei Li Bernhard Schmid | 2014 | Journal of Plant Ecology2014，7，1： | 3 |
| 19 | A Novel Ratio-Based Parallel DEA Approach for Evaluating the Energy and Environmental Performance of Chinese Transportation Sectors显示文摘As a high-energy-consumption and high-CO2-emission industry in China,the transportation sector has been under increasing pressure to improve its performance.This paper develops a novel parallel DEA approach to measure Chinese transportation sector's energy and environmental performance (EEP) over all possible weights,which is to avoid the risk of using the extreme or the most favorable weights in performance evaluation.In our method,the transportation sector is consisted of two parallel subsystems (passenger transportation and freight transportation) with shared inputs and undesirable shared outputs.All possible weights are considered in the EEP evaluation,then the EEP of a transportation sector is represented by a ranking interval.Finally,the proposed approach is applied to the transportation sectors in 30 Chinese provinces.Results show that the best and the worst ranking of most provinces vary greatly.Besides,the EEP of most provinces is hard to dominate others strictly,but the general tendency is the EEP of eastern provinces better than western provinces.Furthermore,the EEP difference of some adjacent provinces with similar features is distinct.These findings are not all the same as previous studies,which verifies the necessity of considering all possible weights in performance evaluation.Therefore,our method provides a new point of view in performance evaluation and can give more robust results for decision makers. | Xiyang Lei Lin Li Xuefei Zhang Qianzhi Dai Yelin Fu | 2019 | Journal of Systems Science and Systems Engineering2019，28，5： | 3 |
| 20 | SARS-CoV-2 spike protein interacts with and activates TLR41显示文摘Dear Editor,Accumulating clinical data suggest the main causes of death by COVID-19 include respiratory failure and the onset of sepsis.1 Importantly,sepsis has been observed in nearly all deceased patients.2,3,4,5 It remains elusive how SARS-CoV-2 infection results in viral sepsis in humans.Toll-like receptor 4(TLR4)mediates anti-gram-negative bacterial immune responses by recognizing lipopolysaccharide(LPS)from bacteria.6 We recently found that SARS-CoV-2 infection provoked an anti-bacterial like response at the very early stage of infection via TLR4.However,the identity of the original trigger initiating these abnormal immune responses during SARS-CoV-2 infection is unknown. | Yingchi Zhao Ming Kuang Junhong Li Ling Zhu Zijing Jia Xuefei Guo Yaling Hu Jun Kong Hang Yin Xiangxi Wang Fuping You | 2021 | Cell Research2021，31，7： | 3 |
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