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| 1 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 2 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 3 | Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction显示文摘 | Xiaoxiao Zhang Li Yuan Linli Qiu Yali Yang Qing Lv Lin Li Jing Wang Lin He Li Zhang Xinfang Wang Mingxing Xie Xu Yu Jin | 2016 | Frontiers of Medicine2016，10，4： | 10 |
| 4 | TRIM29 prevents hepatocellular carcinoma progression by inhibiting Wnt/β-catenin signaling pathway显示文摘TRIM29 plays an important role in many neoplasms.In this study,we aimed to elucidate its role in hepatocellular carcinoma (HCC) and explore the corresponding potential mechanism.The expression level of TRIM29 in HCC samples and hepatoma cell lines was detected.We found that TRIM29 was down-regulated in clinical HCC samples and cultured hepatoma cell lines by western blot analysis and quantitative polymerase chain reaction.In addition,we demonstrated that higher TRIM29 expression was associated with higher differentiation grade of HCC.To explore the effect of TRIM29 on hepatoma cells and its possible mechanisms,TRIM29-knockdown and overexpression cell models were constructed.The results showed that the depletion of TRIM29 promoted liver cancer cell proliferation,clone formation,migration and invasion in vitro probably through the Wnt/β-catenin signaling pathway.This study revealed the inhibitory roles of TRIM29 in HCC and the possible mechanisms. | Mingxing Xu Jingxiong Hu Boxuan Zhou Yuesi Zhong Nan Lin Ruiyun Xu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 9 |
| 5 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 6 | Enhancement of the immobilization and discrimination of DNA probe on a biosensor using gold nanoparticles显示文摘Nanoparticles have been widely utilized in biological research in recent years. 1,6-Hexanedithiol was used as the medium in this work to attach Au nanoparticles on thegold plates. We studied the immobilization and hybridization of DNA probes onto the resulted plates using the quartz crystal microbalance method. Approximately 3-5 times adsorption enhancement of HS-DNA on the plates was obtained under our experimental conditions. Using this DNA sensor, the sensitivity was promoted by approximately three times to 0.35μg/mL. | ZHAO Hongqiu LIN Lin TANG Ji’an DUAN Mingxing JIANG Long | 2001 | Chinese Science Bulletin2001，46，13： | 5 |
| 7 | Rural Informal Taxation in China:Historical Evolution and an Analytic Framework显示文摘The present paper examines the historical evolution of China's rural taxation system from the pre-reform period to the late 1990s. We propose that because of information asymmetry between the upper-level and the lower-level governments, local governments had to be granted some informal tax autonomy to fulfill the upper-level policy mandates. This easily led to excessive local informal taxation on farmers. As market liberalization of the grain sector progressed, the low-cost tax instruments implemented through the traditional approach of implicit taxation gradually eroded. Local governments in agricultural regions had to resort to informal fees collected directly from individual rural households while the more industrialized regions shifted to non-agricultural taxes that are less costly in terms of tax collection. Hence, political tension between farmers and local governments in agriculture- based regions emerged and rural tax reform became necessary. | Justin Yifu Lin Mingxing Liu | 2007 | China & World Economy2007，15，3： | 3 |
| 8 | Rock Breaking Performance of a Pick Assisted by High-pressure Water Jet under Different Configuration Modes显示文摘In the process of rock breaking, the conical pick bears great cutting force and wear, as a result, high-pressure water jet technology is used to assist with cutting. However, the effect of the water jet position has not been studied for rock breaking using a pick. Therefore, the models of rock breaking with different configuration modes of the water jet are established based on SPH combined with FEM. The effect of the water jet pressure, distance between the jet and the pick bit, and cutting depth on the rock breaking performance as well as a comparison of the tension and compression stress are studied via simulation; the simulation results are verified by experiments. The numerical and experimental results indicate that the decrease in the rates of the pick force obviously increases from 25 MPa to 40 MPa, but slowly after 40 MPa, and the optimal distance between the jet and the pick bit is 2 mm under the JFP and JSP modes. The JCP mode is proved the best, followed by the modes of JRP and JFP, and the worst mode is JSP. The decrease in the rates of the pick force of the JCP, JRP, JFP, and JSP modes are up to 30.96%, 28.96%, 33.46%, 28.17%, and 25.42%, respectively, in experiment. Moreover, the JSP mode can be regarded as a special JFP model when the distance between the pick-tip and the jet impact point is 0 mm. This paper has a dominant capability in introducing new numerical and experimental method for the study of rock breaking assisted by water jet and electing the best water jet position from four different configuration modes. | LIU Songyong LIU Xiaohui CHEN Junfeng LIN Mingxing | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 3 |
| 9 | Improvements on physical conditions of bauxite residue following application of organic materials显示文摘Soil formation and ecological rehabilitation is the most promising strategy to eliminate environmental risks of bauxite residue disposal areas. Its poor physical structure is nevertheless a major limitation to plant growth. Organic materials were demonstrated as effective ameliorants to improve the physical conditions of bauxite residue. In this study, three different organic materials including straw(5% W/W), humic acid(5% W/W), and humic acidacrylamide polymer(0.2% and 0.4%, W/W) were selected to evaluate their effects on physical conditions of bauxite residue pretreated by phosphogypsum following a 120-day incubation experiment. The proportion of 2-1 mm macro-aggregates, mean weight diameter(MWD) and geometric mean diameter(GWD) increased following organic materials addition, which indicated that organic materials could enhance aggregate stability. Compared with straw, and humic acid, humic acid-acrylamide polymer application had improved effects on the formation of water-stable aggregates in the residues. Furthermore, organic materials increased the total porosity, total pore volume and average pore diameter, and reduced the micropore content according to nitrogen gas adsorption(NA) and mercury intrusion porosimetry(MIP)analysis, whilst enhancing water retention of the residues based on water characteristic curves. Compared with traditional organic wastes, humic acid-acrylamide polymer could be regarded as a candidate according to the comprehensive consideration of the additive amount and the effects on physical conditions of bauxite residue. These findings could provide a novel application to both Ca-contained acid solid waste and high-molecular polymers on ecological rehabilitation at disposal areas. | Ying Guo Yuzhen Ye Feng Zhu Rui Xue Xianchao Zhang Mingxing Zhu William Hartley Lin Guo Shengguo Xue | 2022 | Journal of Environmental Sciences2022，34，6： | 2 |
| 10 | Reverse Apolipoprotein A-I Mimetic Peptide R-D4F Inhibits Neointimal Formation Following Carotid Artery Ligation in Mice显示文摘 | Lin Du Xinkai Qu Haixia Zhen Rujun Li Jun Wang Mingxing Chen Pei Zhao Zhengang Zhang Kaizheng Gong | 2013 | The American Journal of Pathology2013，，： | 1 |
| 11 | Fabrication of superhydrophobic Cu surfaces with tunable regular micro and random nano-scale structures by hybrid laser texture and chemical etching显示文摘 | Changsheng Dong Yu Gu Minlin Zhong Lin Li Kursad Sezer Mingxing Ma Wenjin Liu | 2011 | Journal of Materials Processing Tech2011，，7： | 1 |
| 12 | Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering显示文摘 | Shan-Chang Chueh Sung-Jan Lin Chih-Chiang Chen Mingxing Lei Ling Mei Wang Randall Widelitz Michael W Hughes Ting-Xin Jiang Cheng Ming Chuong | 2013 | Expert Opinion on Biological Therapy2013，，3： | 1 |
| 13 | Synthesis of Fe - based bulk metallic glasses with low purity materials by multi - metalloids addition 显示文摘 | YONG Hu MINGXING Pan LIN LIU | 2003 | Mater Lett2003，57，18： | 1 |
| 14 | Effect of Ce addition on ignition point of AM50 alloy powders显示文摘 | Zhou Hong Wang Mingxing Li Wei Wang Lin Zhao Yu | 2006 | Materials Letters2006，，27： | 1 |
| 15 | Urban Metabolic Efficiencies and Elasticities of Chinese Cities显示文摘Urban metabolism is a complex system of materials, energy, population and environment, which usually can be measured by the Emergy Synthesis(ES) and the Slacks-Based Measure(SBM) approach. In this paper, by employing the two approaches of ES and SBM, as well as metabolic evolution index, urban metabolic stocks, efficiencies and elasticity of 31 Chinese cities are evaluated in a systematic way. The results imply that over the last decade(2000–2010), most of the cities, such as Chongqing, Nanjing, Shijiazhuang, Hangzhou, were experiencing drastic urban metabolic efficiency decline accompanied with a moderate decrease of industrial outputs. By contrast, metropolises and specialized cities have improved their urban metabolic performances, with higher output-input ratio and fewer undesirable outputs. However, their exported emergy experienced a substantial increase as well. It is concluded that local urban management might develop policies to diversify urban renewable supplies and address the undesirable output problems. The urban emergy of renewable resources should be specified as a prime focus for future research. In addition, mechanisms of different urban metabolic models will also be necessary for researchers. | SONG Tao CAI Jianming YANG Zhenshan CHEN Mingxing LIN Jing | 2016 | Chinese Geographical Science2016，26，6： | 1 |
| 16 | Effect of Ce addition on ignition point of AM50 alloy powders显示文摘 | Zhou Hong Wang Mingxing Li Wei Wang Lin Zhao Yu | 2006 | Materials Letters2006，，27： | 1 |
| 17 | Rural taxation and government regulation in China显示文摘 | Ran Tao Justin Yifu Lin Mingxing Liu Qi Zhang | 2004 | Agricultural Economics2004，，2： | 1 |
| 18 | Two Giant Right Coronary Artery Aneurysms with Fistula to the Left Ventricle: Preliminary Diagnosis by Echocardiography显示文摘 | Yuman Li Mingxing Xie Xinfang Wang Qing Lv YaLi Yang Lin He | 2015 | Echocardiography2015，，6： | 1 |
| 19 | Rural Taxation and Government Regulation: Economic Analysis and Policy Implications显示文摘 | Lin Yifu Tao Ran Liu Mingxing | 2002 | Beijing:Peking University2002，39，3： | 1 |
| 20 | Decentralization and local governance in the context of China's transition 显示文摘 | Lin Yifu Tao Ran Liu Mingxing | 2005 | Perspectives2005，6，2： | 1 |
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