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| 1 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 2 | Oxidative removal of acetaminophen using zero valent aluminum-acid system:Efficacy,influencing factors,and reaction mechanism显示文摘Commercial available zero valent aluminum under air-equilibrated acidic conditions(ZVAl/H+/air system) demonstrated an excellent capacity to remove aqueous organic compounds.Acetaminophen(ACTM),the active ingredient of the over-the-counter drug Tylenol?,is widely present in the aquatic environment and therefore the treatment of ACTM-contaminated water calls for further research.Herein we investigated the oxidative removal of ACTM by ZVAl/H+/air system and the reaction mechanism.In acidic solutions(pH < 3.5),ZVAl displayed an excellent capacity to remove ACTM.More than 99% of ACTM was eliminated within 16 hr in pH 1.5 reaction solutions initially containing 2.0 g/L aluminum and 2.0 mg/L ACTM at 25 ± 1℃.Higher temperature and lower pH facilitated ACTM removal.The addition of different iron species Fe0,Fe2+ and Fe3+ into ZVAl/H+/air system dramatically accelerated the reaction likely due to the enhancing transformation of H2O2 to HO.via Fenton's reaction.Furthermore,the primary intermediate hydroquinone and the anions formate,acetate and nitrate,were identified and a possible reaction scheme was proposed.This work suggested that ZVAl/H+/air system may be potentially employed to treat ACTM-contaminated water. | HonghuaZhang Beipei Cao Wanpeng Liu Kunde Lin Jun Feng | 2012 | Journal of Environmental Sciences2012，24，2： | 9 |
| 3 | Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats显示文摘The Nogo receptor is an essential factor for neuronal apoptosis, but the changes in Nogo receptor expression in the retina and the effects of the Nogo receptor on retinal ganglion cell apoptosis in diabetes mellitus remain unclear. We found that Nogo receptor expression was mainly visible in retinal ganglion cells of a rat model of diabetes mellitus induced by streptozotocin. At 12 weeks after onset of diabetes mellitus, Nogo receptor and Rho kinase expression significantly increased in the retina, and retinal ganglion cell apoptosis was apparent. When RNA interference was used to suppress Nogo receptor expression in rat retina, Rho kinase expression was obviously inhibited, and retinal ganglion cell apoptosis was evidently reduced in rats with diabetes mellitus. These results indicate that upregulation of Nogo receptor expression is an important mechanism of retinal ganglion cell apoptosis in rats with diabetes mellitus. | Xuezheng Liu Zhongfu Zuo Wanpeng Liu Zhiyun Wang Yang Hou Yunjie Fu Yuzhi Han | 2014 | Neural Regeneration Research2014，9，8： | 9 |
| 4 | Suppressor of Runnerless Encodes a DELLA Protein that Controls Runner Formation for A=sexual Reproduction in Strawberry显示文摘 | Julie C. Caruana John W. Sittmann Wanpeng Wang Zhongchi Liu | 2018 | Molecular Plant2018，11，1： | 6 |
| 5 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 6 | Effect of interstitial carbon and nitrogen on corrosion of FeCoCrNi multi-principal element alloys made by selective laser melting显示文摘The corrosion behaviors of selective laser melted(SLMed)FeCoCrNi multi-principal element alloys(MPEAs)with carbon or nitrogen addition in 0.5 M H_(2)SO_(4) solution were investigated.Both C and N ad-dition refined the grains and introduced a heterogeneous structure in SLMed FeCoCrNi MPEA,but they had opposite effects on the corrosion behavior.The doped carbon participated as nano-sized carbides in SLMed MPEA,and localized galvanic corrosion occurred,degrading the corrosion resistance.The doped nitrogen was gathered with chromium and formed CrN chemical clusters in SLMed MPEA,and a protec-tive passive film with a higher Cr_(2)O_(3)/Cr(OH)_(3) ratio formed,which improved corrosion resistance. | Wenyu Chen Rui Zhou Wanpeng Li Yen-Hsiang Chen Tzu-Hsiu Chou Xu Wang Yong Liu Yuntian Zhu J.C.Huang | 2023 | Journal of Materials Science & Technology2023，，17： | 2 |
| 7 | Catalytic activity of Ru/Al2O3 for ozonation of dimethyl phthalate in aqueous solution显示文摘 | ZHOU Yunrui ZHU Wanpeng LIU Fudong el al | 2007 | Chemosphere2007，66，1： | 1 |
| 8 | Desulfurization of mod- el gasoline by bioinspired oleophilie nanocomposite membranes 显示文摘 | Li Ben Liu Wanpeng Wu Hong | 2012 | Journal of Membrane Science2012，415，： | 1 |
| 9 | Transparent Yb:(LuxSc1–x)2O3 ceramics sintered from carbonate co-precipitated powders显示文摘 | LIU Wanpeng KOU Huamin LI Jiang | 2015 | Ceram Int2015，41，63： | 1 |
| 10 | Effects of Litter Removal and Addition on Soil Nitrogen Mineralization of Eucalyptus Plantation显示文摘[Objectives]This study was conducted to understand the process of soil nitrogen mineralization in Eucalyptus plantations,and to identify the characteristics of soil nitrogen mineralization with different litter inputs.[Methods]With the soil of the Eucalyptus plantation in Fusui County,Guangxi as the research object,the soil nitrogen mineralization of the Eucalyptus plantation under different litter treatments(removing litter,adding litter and retaining litter)was studied by PVC tube closed-top in-situ incubation.[Results]①After 1 year of litter treatment,the inorganic nitrogen(NH_(4)^(+)-N+NO_(3)^(-)-N)in the soil of different treatments ranked as adding litter(20.15 mg/kg)>retaining litter(16.02 mg/kg)>removing litter(11.60) mg/kg),and the differences reached a significant level(P<0.05).②After 30 d of in-situ incubation,there were significant differences in soil nitrate nitrogen content before and after incubation in the three treatments(removing litter,adding litter,and retaining litter)before and after incubation(P<0.05),but no significant differences were observed in soil ammonium nitrogen content(P>0.05).Soil nitrate nitrogen contents increased from 1.47,2.01 and 1.72 mg/kg before incubation to 3.66,6.73 and 5.02 mg/kg,respectively,and soil ammonium nitrogen content increased from 11.60,20.15 and 16.02 mg/kg before incubation to 13.65,21.54 and 17.18 mg/kg,respectively.The net nitrogen mineralization quantities of the three treatments were 4.24,6.11 and 4.46 mg/kg,respectively,and the net nitrogen mineralization rates from large to small were adding litter[0.180 mg/(kg·d)]>retaining litter[0.141 mg/(kg·d)]>removing litter[0.125 mg/(kg·d)].Therefore,both removal and addition of litter affected the soil nitrogen input and nitrogen mineralization rate of the Eucalyptus plantation,thereby affecting soil nitrogen availability and the ability of soil to maintain plant-available nitrogen.[Conclusions]This study provides a theoretical basis for nutrient management in Eucalyptus plantations,especially nitrogen nutrient management. | Wanpeng LU Hongying LIU Chunning LI Bin HE | 2022 | Agricultural Biotechnology2022，11，3： | 1 |
| 11 | Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions显示文摘Photo-catalytic oxidation of intracellular nicotinamide adenine dinucleotide(2'-phosphate)(NAD(P)H)has attracted much attention for cancer therapy.However,the general oxygen-dependent mechanism heavily depresses the efficacy in hypoxic tumors.To solve this problem,herein platinum nanoparticles(Pt NPs)with catalase-like(CAT-like)and catalytic H_(2)evolution activities were introduced as a powerful assistant to enhance the photo-catalytic NAD(P)H oxidation of Ru1([Ru(phen)2(PIP-OCH_(3))]^(2+),phen=1,10-phenanthroline,PIP-OCH_(3)=2-(4-methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline)under hypoxic and even oxygen-free conditions.Firstly,Pt NPs can transform the original and in situ formed H_(2)O_(2)once again into O_(2)by the CAT-like activity,thus relieving tumor hypoxia and realizing cyclic utilization(at least in part)of the precious oxygen in hypoxia.Secondly,Pt NPs can also be served as H_(2)evolution catalysts while using Ru1 as the photosensitizer and NAD(P)H as the electron and proton donor.In this process,NAD(P)H is oxidized without the participation of oxygen,which can provide an effective way even under oxygen-free conditions.Via co-encapsulation of Rul and Pt NPs in bovine serum albumin(BSA)with tumor targeting ability,the resultant Ru/Pt@BSA could photo-catalyze intracellular NAD(P)H oxidation under hypoxic conditions(3%O_(2)),and exhibited an efficient and selective anticancer activity both in vitro and in vivo.Our results may provide new sights for efficient and targeted cancer treatment underhypoxic conditions. | Xuwen Da Xiulian Liu Chao Li Yatong Peng Yao Jian Wanpeng Zhou Yunli Xu Yao Wu Xuesong Wang Qianxiong Zhou | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 12 | Exploring the regulatory roles of circular RNAs in Alzheimer's disease显示文摘Circular RNAS(circRNAs)are a type of covalently closed,single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes.Growing evidence has shown that circRNAs play critical roles in Alzheimer's disease(AD)and may have therapeutic potentials for this disease.CircRNAs play regulatory roles in neural functions and neurological disorders through diverse mechanisms,including acting as microRNA sponges or interacting with proteins to regulate selective splicing or transcription,as well as through epigenetic modification.In this review,we discuss the biogenesis and functions of circRNAs and the research progress on circRNAS in AD to advance the understanding of how circRNAs contribute to this neurological disorder. | Yuan Zhang Yanfang Zhao Ying Liu Man Wang Wanpeng Yu Lei Zhang | 2020 | Translational Neurodegeneration2020，9，3： | 0 |
| 13 | Ergochaeglobosins A—E, Unprecedented Heterodimers of Cytochalasan and Ergosterol from Chaeglobosin globosum P2-2-2显示文摘Five novel heterodimers of cytochalasan and ergosterol,ergochaeglobosins A—E,were isolated from an endophytic fungus Chaetomium globosum P2-2-2.Ergochaeglobosin A(1) possesses an unprecedented 5/6/13/6/5/6/6/6 fused octacyclic ring system,and ergochaeglobosins B(2) and C(3) form a unique 5/6/13/6/6/6/6/5 fused octacyclic ring system,whereas ergochaeglobosins D(4) and F(5) are the first cytochalasan heterodimers formed via a N-1′/C-3′′single bond.Their structures with absolute configurations were established by extensive spectroscopic analyses,single-crystal X-ray diffraction,and ECD calculations.The plausible biogenetic pathway of 1—5 was postulated.Compound 1 exhibited inhibitory effects against ConA-induced T cells and LPS-induced B cells proliferation with IC50 values of 19.2 and 14.1μmol/L,respectively.Co-treatment of 3(20μmol/L)with TRAIL(150 ng/mL)could significantly decrease the cell viability of A549 by 24.9%comparing with monotherapy of 3(20μmol/L). | Xiaogang Peng Junjun Liu Chunlun Qin Qian Wu Wanpeng Li Fatemeh Mohammadipanah Hanli Ruan | 2022 | Chinese Journal of Chemistry2022，40，16： | 0 |
| 14 | Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway显示文摘In the mammalian heart,cardiomyocytes are forced to withdraw from the cell cycle shortly after birth,limiting the ability of the heart to regenerate and repair.The development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac renewal.With the continuous development of genetic lineage tracking technology,it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic,juvenile,and adult stages of cardiogenesis,but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial infarction.It implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury,which offers hope for the clinical treatment of myocardial infarction.However,the regeneration frequency and source of cardiomyocytes are still low,and the mechanism of regulating cardiomyocyte proliferation remains further explained.It is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart regeneration.Here,we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart regeneration.In addition,myocardial transcription factors,non-coding RNAs,cyclins,and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte proliferation.Ultimately,awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases. | Tao Wang Xinzhe Chen Kai Wang Jie Ju Xue Yu Wanpeng Yu Cuiyun Liu Yin Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
| 15 | Overexpression of ZxABCG11 from Zygophyllum xanthoxylum enhances tolerance to drought and heat in alfalfa by increasing cuticular wax deposition显示文摘Drought and heat stresses cause yield losses in alfalfa,a forage crop cultivated worldwide.Improving its drought and heat tolerance is desirable for maintaining alfalfa productivity in hot,arid regions.Cuticular wax forms a protective barrier on aerial surfaces of land plants against environmental stresses.ABCG11encodes an ATP binding cassette(ABC) transporter that functions in the cuticular wax transport pathway.In this study,Zx ABCG11 from the xerophyte Zygophyllum xanthoxylum was introduced into alfalfa by Agrobacterium tumefaciens-mediated transformation.Compared to the wild type(WT),transgenic alfalfa displayed faster growth,higher wax crystal density,and thicker cuticle on leaves under normal condition.Under either drought or heat treatment in greenhouse conditions,the plant height and shoot biomass of transgenic lines were significantly higher than those of the WT.Transgenic alfalfa showed excellent growth and 50% greater hay yield than WT under field conditions in a hot,arid region.Overexpression of Zx ABCG11 up-regulated wax-related genes and resulted in more cuticular wax deposition,which contributed to reduction of cuticle permeability and thus increased water retention and photosynthesis capacity of transgenic alfalfa.Thus,overexpression of Zx ABCG11 can simultaneously improve biomass yield,drought and heat tolerance in alfalfa by increasing cuticular wax deposition.Our study provides a promising avenue for developing novel forage cultivars suitable for planting in hot,arid,marginal lands. | Linbo Liu Aike Bao Hujun Li Wanpeng Bai Haishuang Liu Ye Tian Yiying Zhao Fangchen Xia Suomin Wang | 2023 | The Crop Journal2023，11，4： | 0 |
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