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| 1 | Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome显示文摘Regulatory T(Treg) cells, a subtype of immunosuppressive CD4^+T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3(FOXP3), a member of the forkhead-wingedhelix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particular, the mutation of FOXP3 can result in immune dysregulation,polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome, which is a rare genetic disease mostly diagnosed in early childhood and can soon be fatal. IPEX syndrome is related to several manifestations,including dermatitis, enteropathy, type 1 diabetes, thyroiditis, and so on. Here, we summarize some recent findings on FOXP3 regulation and Treg cell function. We also review the current knowledge about the underlying mechanism of FOXP3 mutant-induced IPEX syndrome and some latest clinical prospects.At last, this review offers a novel insight into the role played by the FOXP3 complex in potential therapeutic applications in IPEX syndrome. | Qianru Huang Xu Liu Yujia Zhang Jingyao Huang Dan Li Bin Li | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 2 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 3 | Overview of Relation between Mineral Nutrient Elements and Growth and Development of Fruit Trees显示文摘Mineral nutrition is the material basis for growth and development,yield and quality of fruit trees. It exerts a great effect on the growth and development,fruit quality,yield,and resistance of fruit trees. On the basis of reading a large number of references both at home and abroad,this paper elaborated the relationship between mineral nutrient elements and growth and fruit yield and quality of fruit trees,so as to make proper fertilizer mixing,balance the fertilizer application,promote growth and development of fruit trees,and increase the yield of fruit trees and improve the fruit quality. | Liping HUANG Qianru ZHANG Zheng ZHANG Rong YIN Jing ZHANG Ping YANG | 2017 | Asian Agricultural Research2017，9，10： | 7 |
| 4 | Effects of long-term fertilization on corn productivity and its sustainability in an Ultisol of southern China显示文摘 | Shan Huang Weijian Zhang Xichu Yu Qianru Huang | 2010 | Agriculture Ecosystems and Environment2010，，1： | 2 |
| 5 | A study on mental nurs- ing care of postoperative cervix cancer patients 显示文摘 | Lao Lifang Huang Xiufeng Xu Qianru | 2007 | Chinese Nursing Research2007，21，2： | 1 |
| 6 | Effects of long-term fertilization on corn productivity and its sustainability in an Ultisol of southern China显示文摘 | Shan Huang Weijian Zhang Xichu Yu Qianru Huang | 2010 | Agriculture, Ecosystems and Environment2010，，： | 1 |
| 7 | Soil aggregation and organic carbon fractions affected by long-term fertilization in a red soil of subtropical China显示文摘 | Huang Shan Peng Xianxian Huang Qianru | 2010 | Geoderma2010，154，34： | 1 |
| 8 | The effects of mineral fertilizer and organic manure on soil microbial community and diversity显示文摘 | Wenhui Zhong Ting Gu Wei Wang Bin Zhang Xiangui Lin Qianru Huang Weishou Shen | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 9 | The effects of mineral fertilizer and organic manure on soil microbial community and diversity显示文摘 | Wenhui Zhong Ting Gu Wei Wang Bin Zhang Xiangui Lin Qianru Huang Weishou Shen | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 10 | Genetic Insights into Glycine’s Protective Role Against CAD—European and East Asia,2015 and 2020显示文摘Introduction:The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease(CAD)using a two-step Mendelian randomization(MR)analysis.Methods:We analyzed data from genome-wide association studies(GWAS)conducted on European and East Asian populations.To assess the causal effects of circulating glycine levels on the risk of CAD.We used the inverse-variance weighting(IVW),weighted median(WM),MR-Egger,and Mendelian Randomization Pleiotropy RESidual Sum and Outlier(MR-PRESSO)methods.Furthermore,we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.Results:The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans[odds ratio(OR)=0.84,95%confidence interval(CI):0.72,−0.98;P=0.029]and East Asians:(OR=0.76,95%CI:0.66,−0.89;P=3.57×10−4).Sensitivity analysis confirmed the robustness of these findings.Additionally,our results suggest that about 6.06%of the observed causal effect is mediated through genetically predicted systolic blood pressure(SBP)in the European population.Discussion:Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD,and provide valuable methodological insights for the prevention and treatment of this condition. | Jiaying Yu Zhuolin Zhu Ting Wang Yuanhao Wei Lianjie Huang Qianru Zhang Yuting Zhang Yiran Wang Guiyou Liu Xiang Shu Rennan Feng | 2024 | China CDC weekly2024，6，9： | 0 |
| 11 | A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma显示文摘Objective:The immunoscore,which is used to quantify immune infiltrates,has greater relative prognostic value than tumor,node,and metastasis(TNM)stage and might serve as a new system for classification of colorectal cancer.However,a comparable immunoscore for predicting lung adenocarcinoma(LUAD)prognosis is currently lacking.Methods:We analyzed the expression of 18 immune features by immunohistochemistry in 171 specimens.The relationship of immune marker expression and clinicopathologic factors to the overall survival(OS)was analyzed with the Kaplan-Meier method.A nomogram was developed by using the optimal features selected by least absolute shrinkage and selection operator(LASSO)regression in the training cohort(n=111)and evaluated in the validation cohort(n=60).Results:The indicators integrated in the nomogram were TNM stage,neuron-specific enolase,carcino-embryonic antigen,CD8 center of tumor(CT),CD8 invasive margin(IM),Fox P3 CT,and CD45 ROCT.The calibration curve showed prominent agreement between the observed 2-and 5-year OS and that predicted by the nomogram.To simplify the nomogram,we developed a new immune-serum scoring system(I-SSS)based on the points awarded for each factor in the nomogram.Our I-SSS was able to stratify same-stage patients into different risk subgroups.The combination of I-SSS and TNM stage had better prognostic value than the TNM stage alone.Conclusions:Our new I-SSS can accurately and individually predict LUAD prognosis and may be used to supplement prognostication based on the TNM stage. | Qiujuan Huang Tongyuan Qu Lisha Qi Changxu Liu Yuhong Guo Qianru Guo Guangning Li Yalei Wang Wenshuai Zhang Wei Zhao Danyang Ren Leina Sun Shengguang Wang Bin Meng Baocun Sun Bin Zhang Wenjuan Ma Wenfeng Cao | 2021 | Cancer Biology & Medicine2021，18，2： | 0 |
| 12 | Longitudinal proteomic investigation of cOVID-19 vaccination显示文摘Although the development of covID-19 vaccines has been a remarkable success,the heterogeneous individual antibody generation and decline over time are unknown and still hard to predict.In this study,blood samples were collected from 163 participants who next received two doses of an inactivated COvVID-19 vaccine(CoronaVac)at a 28-day interval.Using TMT-based proteomics,we identified 1,715 serum and 7,342 peripheral blood mononuclear cells(PBMCs)proteins.We proposed two sets of potential biomarkers(seven from serum,five from PBMCs)at baseline using machine learning,and predicted the individual seropositivity 57 days after vaccination(AUC=0.87).Based on the four PBMC's potential biomarkers,we predicted the antibody persistence until 180 days after vaccination(AUC=0.79).Our data highlighted characteristic hematological host responses,including altered lymphocyte migration regulation,neutrophil degranulation,and humoral immune response.This study proposed potential blood-derived protein biomarkers before vaccination for predicting heterogeneous antibody generation and decline after coVID-19 vaccination,shedding light on immunization mechanisms and individual booster shot planning. | Yingrui Wang Qianru Zhus Rui Sun Xiao Yi Lingling Huang Yifan Hu Weigang Ge Huanhuan Gao xinfu Ye Yu Song Li Shao Yantao Li Jie Li Tiannan Guo Junping Shi | 2023 | Protein & Cell2023，14，9： | 0 |
| 13 | Dysprosium regulated platinum particles as a bimetallic alloy catalyst for oxygen reduction reaction显示文摘Pt rare earth compounds have recently been investigated as potential substitutes.In this study,the hydrogen reduction method was used to prepare the Pt-Dy bimetallic catalyst,and a number of characterizations were conducted for structure and morphological research.The high resolutiontransmission electron microscopy(HR-TEM)and X-ray diffraction results show that Pt-Dy composite material exists in the form of various alloys and has a clear spherical shape.The majority of the metals in the composite catalyst appear in the zero valent state,and the binding energy of Pt shifts significantly,according to an X-ray photoelectron spectroscopy measurement.Impressively,Pt-Dy alloy produces excellent mass activity of 594 A/g compared to commercial Pt/C catalyst(162.8 A/g)for oxygen reduction process.Furthermore,after an accele rated durability test,the catalytic activity loss for Pt-Dy alloy catalyst reaches 20%while commercial Pt/C reduces 56%. | Qianru Liu Juan Qin Fengyun Huang Dawei Zhang Liheng Chen Feng Yin | 2023 | Journal of Rare Earths2023，41，8： | 0 |
| 14 | Tectonic unit divisions based on block tectonics theory in the South China Sea and its adjacent areas显示文摘Identifying distinct tectonic units is key to understanding the geotectonic framework and distribution law of oil and gas resources.The South China Sea and its adjacent areas have undergone complex tectonic evolution processes,and the division of tectonic units is controversial.Guided by block tectonics theory,this study divide the South China Sea and its adjacent areas into several distinguished tectonic units relying on known boundary markers such as sutures(ophiolite belts),subduction-collision zones,orogenic belts,and deep faults.This work suggests that the study area is occupied by nine stable blocks(West Burma Block,Sibumasu Block,LanpingSimao Block,Indochina Block,Yangtze Block,Cathaysian Block,Qiongnan Block,Nansha Block,and Northwest Sulu Block),two suture zones(Majiang suture zone and Southeast Yangtze suture zone),two accretionary zones(Sarawak-Sulu accretionary zone and East Sulawesi accretionary zone),one subduction-collision zone(RakhineJava-Timor subduction-collision zone),one ramp zone(Philippine islands ramp zone),and six small oceanic marginal sea basins(South China Sea Basin,Sulu Sea Basin,Sulawesi Sea Basin,Banda Sea Basin,Makassar Basin,and Andaman Sea Basin).This division reflects the tectonic activities,crustal structural properties,and evolutionary records of each evaluated tectonic unit.It is of great theoretical and practical importance to understand the tectonic framework to support the exploration of oil and gas resources in the South China Sea and its adjacent areas. | Zhengxin Yin Zhourong Cai Cheng Zhang Xiaofeng Huang Qianru Huang Liang Chen | 2021 | Acta Oceanologica Sinica2021，40，9： | 0 |
| 15 | Nitric oxide-generating self-assembling peptide hydrogel coating for enhancing hemocompatibility of blood-contacting devices显示文摘Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generation was reported to realize up-regulation of cyclic guanosine monophosphate(c GMP)and improve hemocompatibility for diverse metal materials.We first introduce the active centre selenocysteine of glutathione peroxidase(GPx)to the self-assembling peptide(RADA)4,obtaining a functionalized hydrogel.Then the hydrogel is directly coated on the 316L stainless steel(SS)for catalytically generating NO from endogenous s-nitrosothiols(RSNO).The generated NO endows the coated surface with regulation of platelet behavior and reduction of plasmatic coagulation activation and complement system activation,hence improving antithrombotic ability in vitro and ex vivo.Overall,our NO-generating hydrogel coating surface engineering strategy provides a novel solution to remove the obstacle about thrombosis of blood-contacting devices in clinic. | Hao Li Qianru Guo Qiufen Tu Kaiqin Xiong Wei Wang Lei Lu Wentai Zhang Nan Huang Zhilu Yang | 2022 | Journal of Materials Science & Technology2022，，36： | 0 |
| 16 | A cluster of mutagenesis revealed an osmotic regulatory role of the OsPIP1 genes in enhancing rice salt tolerance显示文摘Aquaporins play important regulatory roles in improving plant abiotic stress tolerance.To better understand whether the Os PIP1 genes collectively dominate the osmotic regulation in rice under salt stress,a cluster editing of the Os PIP1;1,Os PIP1;2 and Os PIP1;3 genes in rice was performed by CRISPR/Cas9 system.Sequencing showed that two mutants with Cas9-free,line 14 and line 18 were successfully edited.Briefly,line 14 deleted a single C base in both the Os PIP1;1 and Os PIP1;3 genes,and inserted a single T base in the Os PIP1;2 gene,respectively.While line 18 demonstrated an insertion of a single A base in the Os PIP1;1gene and a single T base in both the Os PIP1;2 and Os PIP1;3 genes,respectively.Multiplex editing of the Os PIP1 genes significantly inhibited photosynthetic rate and accumulation of compatible metabolites,but increased MDA contents and osmotic potentials in the mutants,thus delaying rice growth under salt stress.Functional loss of the Os PIP1 genes obviously suppressed the expressions of the Os PIP1,Os SOS1,Os CIPK24 and Os CBL4 genes,and increased the influxes of Na+and effluxes of K^(+)/H^(+)in the roots,thus accumulating more Na+in rice mutants under salt stress.This study suggests that the Os PIP1 genes are essential modulators collectively contributing to the enhancement of rice salt stress tolerance,and multiplex editing of the Os PIP1 genes provides insight into the osmotic regulation of the PIP genes. | Leyuan Tao Bing Wang Shichao Xin Wei Li Shengcai Huang Laihua Liu Jing Cui Qianru Zhang Xianguo Cheng | 2023 | The Crop Journal2023，11，4： | 0 |
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