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| 1 | The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala显示文摘The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 2 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 2 |
| 3 | An above-room-temperature switchable molecular dielectric with a large dielectric change between high and low dielectric states显示文摘Dielectric anisotropy of anilinium perchlorate is investigated at various temperatures. Crystal structures at different temperatures reveal that significant dielectric change between low and high dielectric states is closely related to the disorder of the anilinium cation and perchlorate anion at high dielectric state; meanwhile, the conductivity after phase transition also contributes a lot to the high dielectric state. | DU Yang HAO HuiMin ZHANG QianChong ZHAO HaiXia LONG LaSheng HUANG RongBin ZHENG LanSun | 2013 | Science China Chemistry2013，56，7： | 2 |
| 4 | Locally Resonant Cavity Cell Model for Electromagnetic Band-gap Structures显示文摘 | LI Long LI Bin LIU Haixia | 2006 | IEEE Transactions on Antennas and Propagation2006，54，1： | 1 |
| 5 | Energy balance and partition in Inner Mongolia steppe ecosystems with different land use types显示文摘 | Shiping Chen Jiquan Chen Guanghui Lin Wenli Zhang Haixia Miao Long Wei Jianhui Huang Xingguo Han | 2009 | Agricultural and Forest Meteorology2009，，11： | 1 |
| 6 | QSAR study onACE inhibitors by using OSC-PLS algorithm显示文摘 | LONG Haixia WANG Yuanqiang LIN Yong | 2010 | Journal of the ChineseChemical Society2010，57，3： | 1 |
| 7 | IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma显示文摘 | Jiankun Liu Yuzhong Duan Xiaoming Cheng Xi Chen Wei Xie Haixia Long Zhihua Lin Bo Zhu | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 8 | Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma显示文摘Objective:With the development of peptide-based cancer specific immunotherapy,the prediction of CTL epitopes from insulin-like growth factor-binding protein 7(IGFBP7) is very important for some research about tumor metastasis.Because HLA-A2.1-expressing individuals cover >50% in the population of China,we aimed at identifying IGFBP7-encoded peptide presented by HLA-A2.1.Methods:In our study,a HLA-A2.1 restricted CTL epitope was identified by using the following two-step procedure:(a) computer-based epitope prediction from the amino acid sequence of IGFBP7 antigen;(b) Validation with epitope molecular modeling.Results:We obtained four epitopes with high immunogenicity scores by all of the three algorithms,i.e.,BIMAS,SYFPEITHI and IMTECH.Each of the four candidates satisfied the criteria of the HLA-A2.1-restricted CTL epitopes in molecular modeling analysis.Conclusion:The combination of BIMAS,SYFPEITHI and IMTECH method can improve the prediction efficiency and accuracy.Due to this research herein,this four epitopes have potential value for further studied,also have potential application in peptide-mediated immunotherapy.These epitopes may be useful in the design of therapeutic peptide vaccine for lung carcinoma and as immunotherapeutic strategies against lung carcinoma after identified by immunology experiment. | Zhao Weipeng Long Haixia Zhu Bo Duan Yuzhong Chen Zhengtang | 2009 | Journal of Medical Colleges of PLA(China)2009，24，2： | 1 |
| 9 | A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network显示文摘The serotonin-transporter-linked polymorphic region(5-HTTLPR)is associated with mood disorders.This association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical control.In Caucasians,the short form is associated with this effect,but in Han Chinese we recently found that the long form is involved.Serotonin receptors have rich expression in default mode network(DMN)regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity(FC)in Caucasians.The present study has investigated whether there may also be anethnic difference in this influence of 5-HTTLPR on the DMN.We recruited 233 young Han Chinese subjects and calculated the resting-state default-network FC.Our study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex,right parahippocampal gyrus,left middle temporal gyrus,and increased FC in left precuneus(Pcu)compared to SS.The PCC-Pcu FC in L carriers was significantly negatively correlated with the depression scores.Our findings,therefore,suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the5-HTTLPR and DMN functional connectivity. | Haixia Long Bing Liu Bing Hou Chao Wang Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2014 | Chinese Science Bulletin2014，59，13： | 1 |
| 10 | Immune response induced by hematoporphyrin derivatives mediated photodynamic therapy:Immunogenic cell death and elevated costimulatory molecules显示文摘Photodynamic therapy(PDT)not only destroys tumor cells directly but also induced anti-tumor immune response through damage-associated molecular patterns(DAMPs).It is reported that anti-tumor response was associated with light dose and photosensitizer used in PDT.In this study,4T1 tumor cells were implanted on both the right and left flanks of mice.Only the right tumor was treated by HpD-PDT,while the left tumor was not irradiated.The anti-tumor immune response induced by HpD-PDT was investigated.The expression of DAMPs and costimulatory molecules induced by HpD-PDT were tested by immuno fluorescence and flow cytometry in vivo.Different light doses of PDT were designed to treat 4T1 cells.The killing effect was assessed by CCK-8 kit and apoptosis kit.The expression of DAMPs on 4T1 cells after HpDPDT were evaluated by flow cytometry,western blot and ATP kit.This study showed that CD4^(+)T,CD8^(+)T and the production of IFN-γwere increased significantly on day 10 in righttumor after PDT treatment compared with control group.HpD-PDT enhanced the expression of calreticulin(CRT)on tumor tissue.Importantly,co-stimulatory molecular OX-40 and 4-1BB were elevated on CD8^(+)T cells.In vitro,immunogenic death of 4T1 cells was induced after PDT.Besides,the expression of DAMPs increased with the increasing of energy density.This study indicates that anti-tumor immune effect was induced by HpD-PDT.The knowledge of the involvement of CRT,ATP and co-stimulatory molecules uncovers important mechanistic insight into the anti-tumor immunogenicity.It was the first time that co-stimulatory molecules were investigated and found to elevate after PDT. | Shan Long Yibing Zhao Yuanyuan Xu Hui Li Hongyou Zhao Defu Chen Jing Zeng Haixia Qiu Xiaosong Li Ying Gu | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 1 |
| 11 | Locally Resonant Cavity Cell Model for Electromagnetic Band Gap Structures显示文摘 | LI Long LI Bin LIU Haixia | 2006 | IEEE Transactions on Antennas and Propagation2006，54，1： | 1 |
| 12 | Magnetoelectric effect generated through electron transfer from organic radical to metal ion显示文摘Magnetoelectric(ME)materials induced by electron transfer are extremely rare.Electron transfer in these materials invariably occurs between the metal ions.In contrast,ME properties induced by electron transfer from an organic radical to a metal ion have never been observed.Here,we report the ME coupling effect in a mononuclear molecule-based compound[(CH_(3))_(3)NCH_(2)CH_(2)Br][Fe(Cl_(2)An)_(2)(H_(2)O)_(2)](1)[Cl_(2)An=chloranilate,(CH_(3))_(3)NCH_(2)CH_(2)Br+=(2-bromoethyl)trimethylammonium].Investigation of the mechanism revealed that the ME coupling effect is realized through electron transfer from the Cl_(2)An to the Fe ion.Measurement of the magnetodielectric(MD)coefficient of 1 indicated a positive MD of up to~12%at 103.0Hz and 370 K,which is very different from that of ME materials with conventional electron transfer for which the MD is generally negative.Thus,the current work not only presents a novel ME coupling mechanism,but also opens a new route to the synthesis of ME coupling materials. | Xiaolin Liu Qiang Liu Haixia Zhao Guilin Zhuang Yanping Ren Tao Liu Lasheng Long Lansun Zheng | 2023 | National Science Review2023，10，4： | 0 |
| 13 | DeepSVDNet:A Deep Learning-Based Approach for Detecting and Classifying Vision-Threatening Diabetic Retinopathy in Retinal Fundus Images显示文摘Artificial Intelligence(AI)is being increasingly used for diagnosing Vision-Threatening Diabetic Retinopathy(VTDR),which is a leading cause of visual impairment and blindness worldwide.However,previous automated VTDR detection methods have mainly relied on manual feature extraction and classification,leading to errors.This paper proposes a novel VTDR detection and classification model that combines different models through majority voting.Our proposed methodology involves preprocessing,data augmentation,feature extraction,and classification stages.We use a hybrid convolutional neural network-singular value decomposition(CNN-SVD)model for feature extraction and selection and an improved SVM-RBF with a Decision Tree(DT)and K-Nearest Neighbor(KNN)for classification.We tested our model on the IDRiD dataset and achieved an accuracy of 98.06%,a sensitivity of 83.67%,and a specificity of 100%for DR detection and evaluation tests,respectively.Our proposed approach outperforms baseline techniques and provides a more robust and accurate method for VTDR detection. | Anas Bilal Azhar Imran Talha Imtiaz Baig Xiaowen Liu Haixia Long Abdulkareem Alzahrani Muhammad Shafiq | 2024 | Computer Systems Science & Engineering2024，48，2： | 0 |
| 14 | Authors' response to “Maternal age as a potential explanation of the role of the L allele of the serotonin transporter gene in anxiety and depression in Asians”显示文摘In the letter to the editor,Dr.Comings et al.proposed a potential explanation of our findings that the L allele rather than S allele of 5-HTTLPR was associated with higher anxiety levels and reduced amygdala-prefrontal cortex(PFC)connectivity in Han Chinese[1],which demonstrated an‘allele reversal’in the genetics of the 5-HTTLPR gene in Asians | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Tianzi Jiang | 2014 | Neuroscience Bulletin2014，30，3： | 0 |
| 15 | Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity显示文摘Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the tumor microenvironment(TME)pose a major obstacle to the efficacy of immunotherapy.Myeloid cells,such as tumor-a ssociated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs). | Zefang Chen Xinyu Cheng Li Yang Xiaoming Cheng Bo Zhu Haixia Long | 2023 | Cancer Biology & Medicine2023，20，7： | 0 |
| 16 | Increasing Crop Quality and Yield with a Machine Learning-Based Crop Monitoring System显示文摘Farming is cultivating the soil,producing crops,and keeping livestock.The agricultural sector plays a crucial role in a country’s economic growth.This research proposes a two-stage machine learning framework for agriculture to improve efficiency and increase crop yield.In the first stage,machine learning algorithms generate data for extensive and far-flung agricultural areas and forecast crops.The recommended crops are based on various factors such as weather conditions,soil analysis,and the amount of fertilizers and pesticides required.In the second stage,a transfer learningbased model for plant seedlings,pests,and plant leaf disease datasets is used to detect weeds,pesticides,and diseases in the crop.The proposed model achieved an average accuracy of 95%,97%,and 98% in plant seedlings,pests,and plant leaf disease detection,respectively.The system can help farmers pinpoint the precise measures required at the right time to increase yields. | Anas Bilal Xiaowen Liu Haixia Long Muhammad Shafiq Muhammad Waqar | 2023 | Computers, Materials & Continua2023，76，8： | 0 |
| 17 | Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer显示文摘Photodynamic therapy(PDT)has limited effects in treating metastatic breast cancer.Immune checkpoints can deplete the function of immune cells;however,the expression of immune checkpoints after PDT is unclear.This study investigates whether the limited e±cacy of PDT is due to upregulated immune checkpoints and tries to combine the PDT and immune checkpoint inhibitor to observe the e±cacy.A metastatic breast cancer model was treated by PDT mediated by hematoporphyrin derivatives(HpD-PDT).The anti-tumor effect of HpD-PDT was observed,as well as CD4þT,CD8þT and calreticulin(CRT)by immunohistochemistry and immunofluorescence.Immune checkpoints on T cells were analyzed byflow cytometry after HpD-PDT.When combining PDT with immune checkpoint inhibitors,the antitumor effect and immune effect were assessed.For HpD-PDT at 100 mW/cm2 and 40,60 and 80 J/cm2,primary tumors were suppressed and CD4þT,CD8þT and CRT were elevated;however,distant tumors couldn't be inhibited and survival could not be prolonged.Immune checkpoints on T cells,especially PD1 and LAG-3 after HpD-PDT,were upregulated,which may explain the reason for the limited HpD-PDT effect.After PDT combined with anti-PD1 antibody,but not with anti-LAG-3 antibody,both the primary and distant tumors were signi-cantly inhibited and the survival time was prolonged,additionally,CD4þT,CD8þT,IFN-þCD4þT and TNF-þCD4þT cells were signi-cantly increased compared with HpD-PDT.HpD-PDT could not combat metastatic breast cancer.PD1 and LAG-3 were upregulated after HpD-PDT.Anti-PD1 antibody,but not anti-LAG-3 antibody,could augment the antitumor effect of HpD-PDT for treating metastatic breast cancer. | Shan Long Yibing Zhao Yuanyuan Xu Bo Wang Haixia Qiu Hongyou Zhao Jing Zeng Defu Chen Hui Li Jiakang Shao Xiaosong Li Ying Gu | 2024 | Journal of Innovative Optical Health Sciences2024，17，1： | 0 |
| 18 | Generation and regulation of two-dimensional autofocusing Airy beams based on holographic metasurfaces显示文摘This paper proposes a new method to generate a two-dimensional(2D)Airy beam and Airy autofocusing beam by using the scalar holographic metasurface with amplitude-phase modulation in the microwave band.The proposed holographic metasurface comprises subwavelength patch unit cells with a period of fewer than 1/8 wavelengths,which means that it has the finer sampling for electromagnetic waves and can simultaneously achieve precise modulations for the amplitude and phase of electromagnetic waves.Firstly,the 2D-Airy beam with quasi-non-diffraction and selfbending characteristics is generated,from which the holographic metasurface is designed to realize four different 2D-Airy beams with the same focus,achieving the 2D-Airy autofocusing beam in the microwave frequency.The holographic metasurface for Airy beam generation has high efficiency and an ultra-lower profile.Meanwhile,for applying the Airy beam in wireless power transfer(WPT),the efficiency of the generated Airy beam and Airy autofocusing beam is calculated for the first time in the microwave field.The simulation results show that the efficiency of the 2D-Airy beam can reach 66%at 150 mm away from the metasurface,while the efficiency of the 2D-Airy autofocusing beam at the focus,which is 280 mm from the metasurface,can reach 35%.The theoretical,simulated,and measured results show that the proposed method and holographic metasurfaces can flexibly achieve the special characteristics of self-autofocusing and self-bending Airy beams in the microwave domain,providing an effective path for wireless power transfer(WPT)scenario with radial obstructions. | Song Zhang Hao Xue Yicen Li Jiaqi Han Haixia Liu Long Li Tie Jun Cui | 2023 | Journal of Information and Intelligence2023，1，3： | 0 |
| 19 | Generalized system function analysis of resonant behavior of electromagnetic open systems显示文摘The generalized system function, H(s), directly associated with the radiated or scattered fields is presented to effectively analyze the special resonant behavior of electromagnetic open systems in this paper, which is adaptively constructed by using the model-based parameter estimation (MBPE) technique in the complex frequency domain. By analyzing the characteristics of complex zeros, poles and residues of H(s) in a finite operational frequency band, we can effectively determine resonant frequencies and resonant intensity of electromagnetic open systems. It is known that an analysis of Q-factor of antenna and scattering systems has been an interesting and challenging problem. Based on H(s) and the complex frequency ω theories, a complex frequency method for Q-factor of electromagnetic open systems is presented in this paper. Some examples of the practical antenna arrays are given to illustrate the applications and validity of the generalized system function theory proposed by this paper. | LI Long LIU Haixia SHI Yan LIANG Changhong | 2005 | Science in China(Series F)2005，48，5： | 0 |
| 20 | A Similar-Curve Based Auto-sorting Algorithm for Panoramic Images显示文摘 | XIANG Yao LONG Haixia ZOU Beiji MENG Zhigang | 2011 | Chinese Journal of Electronics2011，20，4： | 0 |
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