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| 1 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 2 | Progress in material removal mechanisms of surface polishing with ultra precision显示文摘Chemical mechanical polishing (CMP) process is commonly regarded as the best method for achieving global planarization in the field of surface finishing with ultra-precision. The development of investigation on material removal mechanisms for different materials used in com-puter hard disk and ultra-large scale integration fabrication are reviewed here. The mechanisms underlying the interac-tion between the abrasive particles and polished surfaces during CMP are addressed, and some ways to investigate the polishing mechanisms are presented. | XU Jin LUO Jianbin LU Xinchun ZHANG Chaohui PAN Guoshun | 2004 | Chinese Science Bulletin2004，49，16： | 25 |
| 3 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 4 | TWO STEPS CHEMICAL-MECHANICAL POLISHING OF RIGID DISK SUBSTRATE TO GET ATOM-SCALE PLANARIZATION SURFACE显示文摘为了得到原子光滑的僵硬磁盘底层表面, ultra-finedalumina 泥浆和纳米,硅石泥浆被准备,并且二步(CMP ) 化学药品机械的擦亮在二泥浆的僵硬磁盘底层被学习。结果证明在在氧化铝泥浆的第一步 CMP 期间,高材料移动率被到达,并且平均粗糙( R_a )和擦亮的表面的平均起浪( W_a )能分别地从以前的 1.4 nm 和 1.6 nm 被减少到大约 0.6 nm 和 0.7 nm 。由使用纳米硅石泥浆并且在第二步 CMP 擦亮过程参数优化, R_a 和擦亮的表面的 W_a 能是进一步的分别地把 nm 和 0.06 nm 归结为 0,038。原子力量显微镜学(AFM ) 分析证明最后的擦亮的表面是极端光滑的 withoutmicro 缺点。 | LEI Hong LUO Jianbin LU Xinchun | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 11 |
| 5 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 6 | Synthesis and properties of novel gemini surfactant with short spacer显示文摘Cationic gemini surfactant dimethylene-1,2-bis(dodecyldiethylammonium bromide), referred to as C12C2C12(Et) was synthesized, and its surface property and aggregation behavior in aqueous solution were studied. The value of γ at the critical micelle concentration (γcmc) is much smaller than that of the surfactant homologues with longer spacer. Spherical and elongated micelles were formed in the aqueous solution of this gemini surfactant,and the spherical micelles were absolutely dominant compared to the elongated micelles at our studied concentration quantitatively. | LU Ting HUANG JianBin | 2007 | Chinese Science Bulletin2007，52，19： | 5 |
| 7 | Study of lubrication behavior of pure water for hydrophobic friction pair显示文摘The perfluorooctyltrichlorosilane molecular layer was self-assembled on glass plate. The tribological properties of the molecular layer in water were studied with the method of ball on disk. An interesting phenomenon was found that low friction coefficients of 0.02―0.08 were obtained when the friction pair was lubricated with only a water droplet. Whereas, when the friction pair was encircled with large amount of water or fully immersed in water, the friction coefficient was higher than that under a droplet lubrication. A mechanism of water droplet lubrication was proposed that the surface tension caused by the solid-liquid-air three-phase interface makes water molecules enter into the contact zone, which separates the two friction surfaces and provides a low friction coefficient. However, water film can hardly form when more water encircles the friction pair, due to the attraction between water molecules. | MA ZhiZuo ZHANG ChenHui LIU ShuHai LUO JianBin LU XinChun WEN ShiZhu | 2009 | Science China(Technological Sciences)2009，52，11： | 4 |
| 8 | Novel cued search strategy based on information gain for phased array radar显示文摘A search strategy based on the maximal information gain principle is presented for the cued search of phased array radars. First, the method for the determination of the cued search region, arrangement of beam positions, and the calculation of the prior probability distribution of each beam position is discussed. And then, two search algorithms based on information gain are proposed using Shannon entropy and Kullback-Leibler entropy, respectively. With the proposed strategy, the information gain of each beam position is predicted before the radar detection, and the observation is made in the beam position with the maximal information gain. Compared with the conventional method of sequential search and confirm search, simulation results show that the proposed search strategy can distinctly improve the search performance and save radar time resources with the same given detection probability. | Lu Jianbin Hu Weidong Xiao Hui Yu Wenxian | 2008 | Journal of Systems Engineering and Electronics2008，19，2： | 4 |
| 9 | Tribological properties of La_2O_3 and CeO_2 doped CoCrW coatings deposited by supersonic plasma spraying显示文摘A novel supersonic plasma spraying was used to prepare rare earth oxides doped CoCrW coatings. X-ray diffractometer, contact surface profiler, hardness tester, micro-friction and -wear tester and en- vironmental scanning electron microscope equipped with energy dispersive X-ray spectroscopy were employed to investigate the phase structure, surface morphology, microhardness, friction and wear properties of the sprayed coatings. The results show that rare earth oxide doped coatings have high microhardness and excellent tribological properties. Furthermore, the friction and wear mechanisms of sprayed coatings are also discussed. | ZHANG ZhenYu LU XinChun LUO JianBin | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 10 | Achievement of a near-perfect smooth silicon surface显示文摘During the ultra large scale integration(ULSI)process,the surface roughness of the polished silicon wafer plays an important role in the quality and rate of production of devices.In this work,the effects of oxidizer,surfactant,polyurethane pad and slurry additives on the surface roughness and topography of chemical-mechanical planarization(CMP)for silicon have been investigated.A standard atomic force microscopy(AFM)test method for the atomic scale smooth surface was proposed and used to measure the polished silicon surfaces.Finally,compared with the theoretical calculated Ra value of 0.0276 nm,a near-perfect silicon surface with the surface roughness at an atomic scale(0.5)was achieved based on an optimized CMP process. | LI Jing LIU YuHong DAI YuanJing YUE DaChuan LU XinChun LUO JianBin | 2013 | Science China(Technological Sciences)2013，56，11： | 3 |
| 11 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 12 | Improvement in the risk assessment of oral leukoplakia through morphology-related copy number analysis显示文摘Oral leukoplakia is the most common type of oral potentially malignant disorders and considered a precursor lesion to oral squamous cell carcinoma.However,a predictor of oral leukoplakia prognosis has not yet been identified.We investigated whether copy number alteration patterns may effectively predict the prognostic outcomes of oral leukoplakia using routinely processed paraffin sections.Comparison of copy number alteration patterns between oral leukoplakia with hyperplasia(HOL,n=22)and dysplasia(DOL,n=21)showed that oral leukoplakia with dysplasia had a higher copy number alteration rate(86%)than oral leukoplakia with hyperplasia(46%).Oral leukoplakia with dysplasia exhibited a wider range of genomic variations across all chromosomes compared with oral leukoplakia with hyperplasia.We also examined a retrospective cohort of 477 patients with oral leukoplakia with hyperplasia with detailed follow-up information.The malignant transformation(MT,n=19)and leukoplakia recurrence(LR,n=253)groups had higher frequencies of aneuploidy events and copy number loss rate than the free of disease(FD,n=205)group.Together,our results revealed the association between the degree of copy number alterations and the histological grade of oral leukoplakia and demonstrated that copy number alteration may be effective for prognosis prediction in oral leukoplakia patients with hyperplasia. | Xiaotian Li Lu Liu Jianyun Zhang Ming Ma Lisha Sun Xuefen Li Heyu Zhang Jianbin Wang Yanyi Huang Tiejun Li | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 13 | Cued search algorithm with uncertain detection performance for phased array radars显示文摘A cued search algorithm with uncertain detection performance is proposed for phased array radars.Firstly,a target search model based on the information gain criterion is presented with known detection performance,and the statistical characteristic of the detection probability is calculated by using the fluctuant model of the target radar cross section (RCS).Secondly,when the detection probability is completely unknown,its probability density function is modeled with a beta distribution,and its posterior probability distribution with the radar observation is derived based on the Bayesian theory.Finally simulation results show that the cued search algorithm with a known RCS fluctuant model can achieve the best performance,and the algorithm with the detection probability modeled as a beta distribution is better than that with a random selected detection probability because the model parameters can be updated by the radar observation to approach to the real value of the detection probability. | Jianbin Lu Hui Xiao Zemin Xi Mingmin Zhang | 2013 | Journal of Systems Engineering and Electronics2013，24，6： | 2 |
| 14 | A new lubrication equation for ultra-thin gas film in hard disk drives显示文摘To overcome the complicated and time-consuming difficulties of current models, a new lubrication equation based on boundary velocity slip model for solving the ultra-thin film gas lubrication in hard disk drives is proposed by adopting the nanoscale effect function, Np. The present model is easy to calculate and applicable at nanoscale.The results of numerical calculations indicate that the present model produces a close approximation to that of the exact Boltzmann model. | PENG Yongqing LU Xinchun LUO Jianbin | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，z1： | 1 |
| 15 | Preparation of α - alumina- g - polyacrylamide composite abrasive and chemical mechanical polishing behavior显示文摘 | Hong Lei Haishen Lu Jianbin Luo | 2008 | Thin Solid FiLms2008，516，10： | 1 |
| 16 | Structural Characterization of lignin in the process of cooking of cornstalk with solid alkali and active oxygen显示文摘 | Yang Qiulin Shi Jianbin Lin Lu | 2012 | Journal of Agricultural and Food Chemistry2012，60，18： | 1 |
| 17 | Lercanidipine hydrochloride versus felodipine sustained-release for mild-to-moderate hypertension: a multi-center, randomized clinical trial显示文摘 | Ying Wu Mengdan Xu Hao Wang Xin Xu Shuiping Zhao Mei Zhang Huigen Jin Jinchuan Yan Bangning Wang Jianbin Gong Xiang Lu Jianqiang Peng Qiuyan Dai | 2014 | Current Medical Research & Opinion2014，，1： | 1 |
| 18 | Influence of pH,immersion time,and benzotriazole concentration on copper corrosion in citric acid based slurries显示文摘Copper corrosion in citric acid based slurries with or without benzotriazole (BTA) was investigated as a function of the slurry pH,immersion time and BTA concentration by static etching and electrochemical experiments.The chemical composition of the corroded surface was determined using X-ray photoelectron spectroscopy (XPS).The static etching rate of copper in a H2O2 +citric acid+BTA slurry was lower than that in a H2O2 +citric acid slurry at pH 4.4-8.When the pH of the slurry was >8 or <4.4,the results were reversed and the static etching rate of copper increased when BTA was added to the H2O2 +citric acid slurry.The inhibitory effect of BTA in the H2O2 +citric acid slurry at pH 6 increased with the increasing immersion time of the copper.The corrosion current density of copper gradually decreased with increasing BTA concentration in slurry. | LU XiaoRen LU XinChun LUO JianBin | 2011 | Chinese Science Bulletin2011，56，11： | 1 |
| 19 | Preparation of a-alumina-g-polyacrylamide composite abrasive and chemical mechanical polishing behavior 显示文摘 | Lei Hong Lu Haishen Luo Jianbin | 2008 | Thin Solid Films2008，516，10： | 1 |
| 20 | Programming bare-metal accelerators with heterogeneous threading models:a case study of Matrix-3000显示文摘As the hardware industry moves toward using specialized heterogeneous many-core processors to avoid the effects of the power wall,software developers are finding it hard to deal with the complexity of these systems.In this paper,we share our experience of developing a programming model and its supporting compiler and libraries for Matrix-3000,which is designed for next-generation exascale supercomputers but has a complex memory hierarchy and processor organization.To assist its software development,we have developed a software stack from scratch that includes a low-level programming interface and a high-level OpenCL compiler.Our low-level programming model offers native programming support for using the bare-metal accelerators of Matrix-3000,while the high-level model allows programmers to use the OpenCL programming standard.We detail our design choices and highlight the lessons learned from developing system software to enable the programming of bare-metal accelerators.Our programming models have been deployed in the production environment of an exascale prototype system. | Jianbin FANG Peng ZHANG Chun HUANG Tao TANG Kai LU Ruibo WANG Zheng WANG | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，4： | 1 |
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