|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization显示文摘 | Wanglin Lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu Zheng Liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang | 2014 | Nano Research2014，7，6： | 36 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Microstructure of premixed propane/air flame in the transition from laminar to turbulent combustion显示文摘In order to explore the flame structure and propagation behavior of premixed propane/air in the transi-tion from laminar to turbulent combustion, the high speed camera and Schlieren images methods were used to record the photograph of flame propagation process in a semi-vented pipe. Meanwhile, the super-thin thermocouple and ionization current probe methods were applied to detect the temperature distribution and reaction intensity of combustion reaction. The characteristics of propane/air flame propagation and microstructure were analyzed in detail by the experimental results coupled with chemical reaction thermodynamics. In the test, the particular tulip flame behavior and the formation process in the laminar-turbulent transition were disclosed clearly. From the Schlieren images and iron current results, one conclusion can be drawn that the small-scale turbulent combustion also appeared in laminar flame, which made little influence on the flame shape, but increased the flame thickness obviously. | CHEN XianFeng SUN JinHua LIU Yi LIU XuanYa CHEN SiNing LU ShouXiang | 2007 | Chinese Science Bulletin2007，52，5： | 9 |
| 4 | A lower bound on the total signed domination numbers of graphs显示文摘Let G be a finite connected simple graph with a vertex set V(G)and an edge set E(G). A total signed domination function of G is a function f:V(G)∪E(G)→{-1,1}.The weight of f is W(f)=∑x∈V(G)∪E(G))f(X).For an element x∈V(G)∪E(G),we define f[x]=∑y∈NT[x]f(y).A total signed domination function of G is a function f:V(G)∪E(G)→{-1,1} such that f[x]≥1 for all x∈V(G)∪E(G).The total signed domination numberγs*(G)of G is the minimum weight of a total signed domination function on G. In this paper,we obtain some lower bounds for the total signed domination number of a graph G and compute the exact values ofγs*(G)when G is Cn and Pn. | Xin-zhong LU Department of Mathematics,Zhejiang Normal University,Jinhua 321004,China | 2007 | Science China Mathematics2007，50，8： | 8 |
| 5 | Design,methodology,and baseline of whole city‑million scale children and adolescents myopia survey(CAMS)in Wenzhou,China显示文摘Background:Myopia is the most common visual impairment in children and adolescents worldwide.This study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey(CAMS),which will shed light on the further study of myopia from the level of epidemiology and precision medicine.Methods:We developed a novel population-based screening pattern,an intelligent screening process and internetbased information transmission and analysis system to carry out the survey consisting of school children in Wenzhou,China.The examination items include unaided distance visual acuity,presenting distance visual acuity,and noncycloplegic autorefraction.Myopia and high myopia were defined as spherical equivalent(SE)≤−1.00 diopters(D)and SE≤−6.00 D,respectively.Next,the reports of the vision checking were automatically sent to parents and the related departments.The CAMS project will be done two to four times annually with the support of the government.An online eyesight status information management system(OESIMS)was developed to construct comprehensive and efficient electronic vision health records(EVHRs)for myopia information inquiry,risk pre-warning,and further study.Results:The CAMS completed the first-round of screening within 30 days for 99.41%of Wenzhou students from districts and counties,in June 2019.A total of 1,060,925 participants were eligible for CAMS and 1,054,251(99.37%participation rate)were selected through data quality control,which comprised 1305 schools,and 580,609,251,050 and 170,967 elementary,middle,and high school students.The mean age of participants was 12.21±3.32 years(6-20 years),the female-to-male ratio was 0.82.The prevalence of myopia in elementary,middle,and high school students was 38.16%,77.52%,and 84.00%,respectively,and the high myopia incidence was 0.95%,6.90%,and 12.98%.Conclusions:The CAMS standardized myopia screening model involves automating large-scale information collection,data transmission,data analysis and early warning,thereby supporting myopia prevention and control.The entire survey reduced 90%of staff,cost,and time consumption compared with previous surveys.This will provide new insights for decision support for public health intervention. | Liangde Xu Youyuan Zhuang Guosi Zhang Yunlong Ma Jian Yuan Changseng Tu MiaoMiao Li Wencan Wang Yaru Zhang Xiaoyan Lu Jing Li Xinting Liu Zhengbo Xue Meng Zhou Jie Sun Jinhua Bao Ming Li Fan Lu Hong Wang Jianzhong Su Jia Qu | 2021 | Eye and Vision2021，8，1： | 7 |
| 6 | The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity显示文摘A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes,opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation,C1q also regulates cell differentiation,adhesion,migration,activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article,we discuss the basic properties of C1q,its expression,and classical and regulatory functions. | Jinhua Lu Boon King Teh Linda Wang Yinan Wang Yen Seah Tan Min Chern Lai Kenneth B. M. Reid | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 7 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 8 | On 3-colorability of planar graphs without adjacent short cycles显示文摘A short cycle means a cycle of length at most 7.In this paper,we prove that planar graphs without adjacent short cycles are 3-colorable.This improves a result of Borodin et al.(2005). | WANG YingQian 1,MAO XiangHua 1,LU HuaJing 2 & WANG WeiFan 1 1 College of Mathematics,Physics and Information Engineering,Zhejiang Normal University,Jinhua 321004,China 2 College of Basic Science,Ningbo Dahongying University,Ningbo 315175,China | 2010 | Science China Mathematics2010，53，4： | 4 |
| 9 | Effects of PyC shell thickness on the microstructure,ablation resistance of SiCnws/PyC-C/C-ZrC-SiC composites显示文摘SiC nanowires/pyrocarbon(SiCnws/PyC)core-shell structure toughenedC/C-ZrC-SiC composites were fabricated by CLVD process,and the influences of PyC shell thickness on the microstructure and ablation resistance of the composites were researched.The results presented that SiCnws/PyC core-shell structure had a linear shape,and the composites became dense with the increasing PyC thickness.When the thickness of PyC shell increased from 0 to 2.4μm,the density and thermal conductivity of the composites was improved gradually,but the coefficient of thermal expansion(CTE)decreased firstly and then increased.After the ablation test for 90 s,the ablation rates of the composites decreased continuously as the PyC thickness increased from 0 to 1.4μm,but increased when the PyC thickness was up to 2.4μm.Especially when the PyC thickness was 1.4μm,the linear and mass ablation rates of the composites were 71.25%and 63.01%lower than those of the composites without PyC shell.The reasons behind the remarkable improvement of anti-ablation property were that the proper PyC thickness could alleviate the CTE mismatch to promote the formation of complete oxide coating,improve the thermal conductivity to reduce heat corrosion and enhance the capability to limit the mechanical erosion. | Qinchuan He Hejun Li Xuemin Yin Jinhua Lu | 2021 | Journal of Materials Science & Technology2021，，12： | 4 |
| 10 | A MXene-functionalized paper-based electrochemical immunosensor for label-free detection of cardiac troponin I显示文摘Convenient,rapid,and accurate detection of cardiac troponin I(cTnI)is crucial in early diagnosis of acute myocardial infarction(AMI).A paper-based electrochemical immunosensor is a promising choice in this field,because of the flexibility,porosity,and cost-efficacy of the paper.However,paper is poor in electronic conductivity and surface functionality.Herein,we report a paper-based electrochemical immunosensor for the label-free detection of cTnI with the working electrode modified by MXene(Ti_(3)C_(2))nanosheets.In order to immobilize the bio-receptor(anti-cTnI)on the MXene-modified working electrode,the MXene nanosheets were functionalized by aminosilane,and the functionalized MXene was immobilized onto the surface of the working electrode through Nafion.The large surface area of the MXene nanosheets facilitates the immobilization of antibodies,and the excellent conductivity facilitates the electron transfer between the electrochemical species and the underlying electrode surface.As a result,the paper-based immunosensor could detect cTnI within a wide range of 5-100 ng/mL with a detection limit of 0.58 ng/mL.The immunosensor also shows outstanding selectivity and good repeatability.Our MXene-modified paper-based electrochemical immunosensor enables fast and sensitive detection of cTnI,which may be used in real-time and cost-efficient monitoring of AMI diseases in clinics. | Li Wang Yufeng Han Hongchen Wang Yaojie Han Jinhua Liu Gang Lu Haidong Yu | 2021 | Journal of Semiconductors2021，42，9： | 3 |
| 11 | Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression显示文摘Objective:To explore the molecular mechanisms of antitumor properties of triptolide,a bioactive component isolated from the Chinese herb Tripterygium wolfordii Hook F.Methods:Human fibrosarcoma HT-1080 cells were treated with different doses of triptolide for 72 h.Then the expression and activity of matrix metalloproteinase(MMP)-2 and -9 were measured and the invasiveness of triptolide-treated HT-1080 cells was compared with that of anti-MMP-9- treated HT-1080 cells.Results:18 nmol/L triptolide inhibited the gene expression and activity of MMP-9,but not those of MMP-2,in HT-1080 cells.In addition,both 18 nmol/L triptolide and 3μg/mL anti-MMP-9 significantly reduced the invasive potential of HT-1080 cells,by about 50%and 35%, respectively,compared with the control.Whereas there was no significant difference between the effect of 18 nmol/L triptolide and that of anti-MMP-9 on invasive potential of HT-1080 cells. Conclusions:These data suggest that triptolide inhibits tumor cell invasion partly by reducing MMP-9 gene expression and activity. | Shengbo Yang Can Gu Guiying Zhang Jian Kang Haiquan Wen QianJin Lu Jinhua Huang | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 3 |
| 12 | Control Effect of Several Replacement Plants on Invasive Weed Eupatorium adenophorum Spreng显示文摘To select the suitable plant species controlling Eupatorium adenophorum in hilly area,ecological adaptability,competitiveness and control efficacy of many replacement plants with economic value in Guizhou Province of China were studied.The results showed that the coverage of Paspalum wetsfeteini and Dolichos lablab were 100% and 93%,which increased by 3.70 and 3.44 times compared with Lolium perenne,respectively;their relative crowding coefficient with E.adenophorum were 7.09 and 22.78,which increased by 2.43 and 7.80 times compared with L perenne,respectively.Using excavation method,the control efficacies of replacement plants were 99.3 % and 96.9%,respectively,while the control efficacy of replacement plants using mowing method was lower than 66.4%.The overwintering rate of P.wetsfeteini in the following year was 95% ;its coverage was still 100% and its control efficacy against E.adenophorum remained over 99%.D.lablab was difficult to survive the winter in the north region beyond 26.2°N,so it could only be applied as annual replacement plant.The coverage of Setaria anceps,Cajanus cajan and other test plants were less than 90%,with poor control efficacy against E.adenophorum. | Lu Xiangyang Wang Qiuxia Zhang Jinhua Zuo Xiangbing Liu Bin | 2013 | Plant Diseases and Pests2013，4，2： | 3 |
| 13 | Performance of Co/MgO catalyst for CO_2 reforming of toluene as a model compound of tar derived from biomass gasification显示文摘Catalytic performances of the CO2 reforming of toluene on Co/Mg O catalysts with different cobalt loadings were evaluated in a fluidized-bed reactor. The results showed that the conversion of toluene and the stability of Co/Mg O increased, but the apparent reaction rate decreased at the initial stage with increasing the amount of metallic Co formed from the reduction of Co/Mg O catalysts at 700°C. The deactivation of Co/Mg O catalysts was mainly resulted from that a part of the metallic Co was oxidized by CO2 and could not be re-reduced by H2 at reaction temperature. Therefore, the excess metallic Co on the higher Co loading catalysts was beneficial to the catalyst stability. | Xiuxiu Bao Meng Kong Wen Lu Jinhua Fei Xiaoming Zheng | 2014 | Journal of Energy Chemistry2014，23，6： | 3 |
| 14 | 14.46% Efficiency small molecule organic photovoltaics enabled by the well trade-off between phase separation and photon harvesting显示文摘Small molecule organic photovoltaics(SMPVs) were prepared by utilizing liquid crystalline donor material BTR-Cl and two similar optical bandgap non-fullerene acceptor materials BTP-BO-4 F and Y6.The BTPBO-4 F and Y6 have the similar optical bandgap and different absorption coefficients.The corresponding binary SMPVs exhibit different short circuit current density(/sc)(20.38 vs.23.24 mA cm^(-2)),and fill factor(FF)(70.77% vs.67.21%).A 14.46% power conversion efficiency(PCE) is acquired in ternary SMPVs with 30 wt% Y6,companied with a JSC of 24.17 mA cm^(-2) a FF of 68.78% and an open circuit voltage(Voc) of 0.87 V.The improvement on PCE of ternary SMPVs should originate from the well trade-off between phase separation and photon harvesting of ternary active layers by incorporating 30 wt% Y6 in acceptors.This work may deliver insight onto the improved performance of SMPVs by superposing the superiorities of binary SMPVs with similar optical bandgap acceptors into one ternary cell. | Chunyu Xu Haiyan Chen Zijin Zhao Jinhua Gao Xiaoling Ma Shirong Lu Xiaoli Zhang Zeyun Xiao Fujun Zhang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 15 | Ultrahigh rate capability of 1D/2D polyaniline/titanium carbide(MXene)nanohybrid for advanced asymmetric supercapacitors显示文摘High energy density and enhanced rate capability are highly sought-after for supercapacitors in today's mobile world.In this work,polyaniline/titanium carbide(MXene)(PANI/Ti3C2Tx)nanohybrid is synthesized through a facile and cost-effective self-assembly of.one-dimensional(10)PANI nanofibers and two-dimensional(20)Ti3C2Tx nanosheets.PANl!Ti3C2Tx delivers greatly improved specific capacitance,ultrahigh rate capability(67%capacitance retention from 1 to 100 A·g^(-1))as well as good cycle stability.Electrochemical kinetic analysis reveals that PANI/Ti3C2Tx is featured with surface capacitance-dominated process and has a quasi-reversible kinetics at high scan rates,giving rise to an ultrahigh rate capability.By using PANl!Ti3C2Tx as positive electrode,an 1.8 V aqueous asymmetric supercapacitor(ASC)is successfully assembled,showing a maximum energy density of 50.8 Wh·kg^(-1)·(at 0.9 kW-kg-1)and a power density of 18 kW·kg^(-1)(at 26 Wh·kg^(-1)).Moreover,an 3.0 V organic ASC is also elaborately fabricated,·by using PANI/Ti3C2Tx,achieving an ultrahigh energy density of 67.2 Wh·kg^(-1)(at 1.5 kW·kg^(-1))and a power density of 30 kW·kg^(-1)·(at 26.8 Wh·kg^(-1)).The present work not only improves fundamental understanding of the structure-property relationship towards ultrahigh rate capability electrode materials,but also provides valuable guideline for the rational design of high-performance:energy storage devices with both high energy and power densities. | Jinhua Zhou Qi Kang Shuchi Xu Xiaoge Li Cong Liu Lu Ni Ningna Chen Chunliang Lu Xizhang Wang Luming Peng Xuefeng Guo Weiping Ding Wenhua Hou | 2022 | Nano Research2022，15，1： | 2 |
| 16 | Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis显示文摘Background:The association between type 2 diabetes mellitus(T2DM)and the risk of esophageal cancer remains unclear.The present study aimed to evaluate the impact of T2DM on short-term outcomes and long-term survival in patients with esophageal squamous cell cancer(ESCC).Methods:The present retrospective study included 862 patients diagnosed with ESCC between January 2001 and December 2010.Among them,280 patients had T2DM.A 1:1 propensity score-matched cohort consisting of 280 patients with and 280 without T2DM was selected from the 862 patients.The associations between T2DM and clinico-pathologic characteristics were assessed using theχ2 or Fisher’s exact test.Survival of ESCC patients with and without T2DM was calculated by using the Kaplan-Meier method and compared by using the Cox regression model between the two groups.Results:The occurrence rate of anastomotic leakage was significantly higher in patients with T2DM than in those without T2DM(P<0.001).In the subgroup with weight loss rate≤5.05%,ESCC patients with T2DM had a signifi-cant longer overall survival than did those without T2DM(P=0.003),whereas in the subgroup with weight loss rate>5.05%,the patients without T2DM showed a longer survival(P=0.001).Univariate and multivariate analysis results showed that T2DM was not an independent prognostic factor for patient survival.Conclusions:Type 2 diabetes mellitus is not an independent prognostic factor in patients with ESCC.However,the combination of T2DM with severe weight loss would be a predictor of poor prognosis. | Wang Yao Yuqi Meng Mingjian Lu Wenzhe Fan Jinhua Huang Jiaping Li Zhihua Zhu | 2018 | Cancer Communications2018，38，1： | 2 |
| 17 | NiCoLDH nanosheets grown on MOF-derived Co_(3)O_(4) triangle nanosheet arrays for high-performance supercapacitor显示文摘Hierarchical Co_(3)O_(4)@NiCoLDH nanosheets(NSs)were prepared on carbon cloth through a multistep method,containing Metal-organic frameworks(MOF)-templated thermal annealing and electrodeposition.The triangle-shaped Co_(3)O_(4 NSs)were firstly obtained by thermal treatment of MOF templates in air.Then,ultrathin NiCoLDH_(NSs)were in-situ electrodeposited on the surface of Co_(3)O_(4NSs),constructing a core-shell structure.Benefiting the unique hierarchical structure,high conductivity of Co_(3)O_(4 NSs)core and large surface area of NiCoLDHNSs shell,the Co_(3)O_(4)@NiCoLDH_(NSs)array served as supercapacitor electrode exhibits excellent electrochemical properties,such as high specific capacitance of 1708 F g^(-1)(850 C g^(-1))at a current density of 1 A g^(-1),good rate capability,and excellent cycling stability.Further,the asymmetric supercapacitor assembled by Co_(3)O_(4)@NiCoLDH_(NSs)and activated carbon,also displays superior electrochemical perfo rmance with high energy density and power density.Remarkably,the strategy of constructing core-shell structure based on MOF templates could be extended to other electrochemical fields. | Xuemin Yin Hejun Li Ruimei Yuan Jinhua Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 2 |
| 18 | Cohort study of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in China:evaluation of risk models and new predictor of pulmonary consolidation on computed tomography显示文摘Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare but severe diseases.This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China.Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included.Results showed that the severity-of-illness score for TEN(SCORTEN)had a good discrimination(area under the receiver operating characteristic curve(AUC),0.78),and it was superior to auxiliary score(AS)and ABCD-10,which indicates age,bicarbonate level,cancer,dialysis,and 10%involved body surface area(AUC,0.69 and 0.68,respectively).The calibration of SCORTEN(Hosmer-Lemeshow goodness-of-fit test,P=0.69)was also better than that of AS(P=0.25)and ABCD-10(P=0.55).SCORTEN and ABCD-10 were similar(Brier score(BS),0.04 and 0.04)in terms of accuracy of predictions.In addition,the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality.Refined models were formed using the variables and this imaging appearance.The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN(0.74 vs.0.78,P=0.23;0.74 vs.0.78,P=0.30,respectively).Therefore,SCORTEN showed good discrimination performance,calibration,and accuracy,and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available. | Yanhong Shou Lu Yang Yongsheng Yang Xiaohua Zhu Feng Li Bo Yin Yingyan Zheng Jinhua Xu | 2021 | Frontiers of Medicine2021，15，4： | 2 |
| 19 | Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation显示文摘Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium.For blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate the interaction with trophectoderm.Any perturbation during this process will result in implantation failure or long-term adverse pregnancy outcomes.Endocrine steroid hormones,which function through nuclear receptors,combine with the local molecules produced by the uteri or embryo to facilitate implantation.The insulin-like growth factor(IGF)signaling has been reported to play a vital role during pregnancy.However,its physiological function during implantation remains elusive.This study revealed that mice with conditional deletion of Igflr gene in uteri suffered from subfertility,mainly due to the disturbed uterine receptivity and abnormal embryo implantation.Mechanistically,we uncovered that in response to the nidatory estrogen on D4 of pregnancy,the epithelial IGF1R,stimulated by the stromal cell-produced IGF1,facilitated epithelial STAT3 activation to modulate the epithelial depolarity.Furthermore,embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R,which was critical for the transcription of Cox2 and normal attachment reaction.In brief,our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process. | Chan Zhou Meiying Lv Peike Wang Chuanhui Guo Zhangli Ni Haili Bao Yedong Tang Han Cai Jinhua Lu Wenbo Deng Xiaoyu Yang Guoliang Xia Haibin Wang Chao Wang Shuangbo Kong | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 20 | Contactless probing of the intrinsic carrier transport single-walled carbon nanotubes显示文摘 | Yize Stephanie Li Jun Ge Jinhua Cai Jie Zhang Wei Lu Jia Liu Liwei Chen | 2014 | Nano Research2014，7，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员